Nicotinic acid adenine dinucleotide phosphate (NAADP) and endolysosomal two-pore channels modulate membrane excitability and stimulus-secretion coupling in mouse pancreatic β cells

Journal of Biological Chemistry

Volumn 290, Issue 35, 2015, Pages 21376-21392

  Arredouani, Abdelilah ^a,h   Ruas, Margarida ^a   Collins, Stephan C ^e,g   Parkesh, Raman ^a   Clough, Frederick ^a   Pillinger, Toby ^a   Coltart, George ^a   Rietdorf, Katja ^a   Royle, Andrew ^a   Johnson, Paul ^c   Braun, Matthias ^g   Zhang, Quan ^g   Sones, William ^g   Shimomura, Kenju ^d   Morgan, Anthony J ^a   Lewis, Alexander M ^a   Chuang, Kai Ting ^a   Tunn, Ruth ^a   Gadea, Joaquin ^a   Teboul, Lydia ^b   Heister, Paula M ^a   Tynan, Patricia W ^a   Bellomo, Elisa A ^e   Rutter, Guy A ^f   Rorsman, Patrik ^g   Churchill, Grant C ^a   Parrington, John ^a   Galione, Antony ^a   more..

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b Medical Research Council Harwell Institute   (United Kingdom)

^c JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e CENTRE DES SCIENCES DU GOÛT ET DE L ALIMENTATION   (France)

^f HAMMERSMITH HOSPITAL   (United Kingdom)

^g CHURCHILL HOSPITAL   (United Kingdom)

^h HAMAD BIN KHALIFA UNIVERSITY   (Qatar)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CHEMICAL ACTIVATION; CYTOLOGY; DEPOLARIZATION; ELECTROPHYSIOLOGY; GLUCOSE; INSULIN; MAMMALS; NUCLEOTIDES; PHYSIOLOGY;

GLUCOSE CONCENTRATION; INSULIN SECRETION; INTRACELLULAR STORES; MEMBRANE POTENTIALS; NICOTINIC ACID ADENINE DINUCLEOTIDE PHOSPHATE; PANCREATIC BETA CELLS; PHARMACOLOGICAL INHIBITION; STIMULUS RESPONSE;

CALCIUM;

BAFILOMYCIN; CALCIUM CHANNEL; CALCIUM ION; GLUCOSE; INSULIN; MESSENGER RNA; NICOTINIC ACID ADENINE DINUCLEOTIDE PHOSPHATE; NICOTINIC ACID ADENINE DINUCLEOTIDE PHOSPHATE ACETOXYMETHYL ESTER; POTASSIUM ION; PROTON PUMP INHIBITOR; RYANODINE RECEPTOR; SODIUM ION; SULFONYLUREA DERIVATIVE; TOLBUTAMIDE; TWO PORE CHANNEL 1; TWO PORE CHANNEL 2; UNCLASSIFIED DRUG; VACUOLAR PROTON PUMP INHIBITOR; VOLTAGE DEPENDENT CALCIUM CHANNEL; CALCIUM; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TPCN1 PROTEIN, MOUSE; TPCN2 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM CURRENT; CALCIUM SIGNALING; CALCIUM TRANSPORT; CELL MEMBRANE POTENTIAL; CELL STIMULATION; CELLULAR DISTRIBUTION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENDOLYSOSOME; ENDOPLASMIC RETICULUM; GENE EXPRESSION; GENE INACTIVATION; HUMAN; HUMAN CELL; INSULIN RELEASE; INTRACELLULAR SIGNALING; LYSOSOME; MALE; MEMBRANE CURRENT; MEMBRANE ELECTROPHYSIOLOGY; MEMBRANE EXCITABILITY; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; POTASSIUM CURRENT; PRIORITY JOURNAL; STIMULUS SECRETION COUPLING; ANALOGS AND DERIVATIVES; ANIMAL; CELL CULTURE; CYTOLOGY; ENDOSOME; GENETICS; KNOCKOUT MOUSE; MEMBRANE POTENTIAL; METABOLISM;

ANIMALS; CALCIUM; CALCIUM CHANNELS; CELLS, CULTURED; ENDOSOMES; GLUCOSE; INSULIN; INSULIN-SECRETING CELLS; MALE; MEMBRANE POTENTIALS; MICE; MICE, KNOCKOUT; NADP;

EID: 84940553934     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.671248     Document Type: Article

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