Tissue acidosis induces neuronal necroptosis via ASIC1a channel independent of its ionic conduction

eLife

Volumn 4, Issue NOVEMBER2015, 2015, Pages

  Wang, Yi Zhi ^a   Wang, Jing Jing ^a   Huang, Yu ^a   Liu, Fan ^a   Zeng, Wei Zheng ^a   Li, Ying ^a   Xiong, Zhi Gang ^b   Zhu, Michael X ^c   Xu, Tian Le ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b MOREHOUSE SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACID SENSING ION CHANNEL; ACID SENSING ION CHANNEL 1A; CASPASE 3; CASPASE 7; CASPASE 8; CYTOSOLIC PHOSPHOLIPASE A2; GLUTAMATE RECEPTOR; LACTATE DEHYDROGENASE; MEMBRANE PROTEIN; REACTIVE OXYGEN METABOLITE; RECEPTOR INTERACTION PROTEIN 1; SHORT HAIRPIN RNA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL; VOLTAGE GATED SODIUM CHANNEL; ACCN2 PROTEIN, MOUSE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; PROTEIN BINDING; RALBP1 PROTEIN, MOUSE;

ACIDOSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD FLOW; BRAIN CELL; BRAIN DAMAGE; BRAIN ISCHEMIA; CELL LABELING; CELL VIABILITY; CHO CELL LINE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; ENZYME ACTIVITY; FLUORESCENCE MICROSCOPY; GENETIC TRANSFECTION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NECROPTOSIS; NONHUMAN; PROTEIN PHOSPHORYLATION; TISSUE ACIDOSIS; WESTERN BLOTTING; WHOLE CELL PATCH CLAMP; ANIMAL; BRAIN; DISEASE MODEL; DRUG EFFECTS; ISCHEMIA; METABOLISM; NECROSIS; NERVE CELL; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN PROCESSING;

ACID SENSING ION CHANNELS; ACIDOSIS; ANIMALS; BRAIN; DISEASE MODELS, ANIMAL; GTPASE-ACTIVATING PROTEINS; ISCHEMIA; MICE; NECROSIS; NEURONS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL;

EID: 84949976386     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.05682     Document Type: Article

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