Repeated and targeted transfer of angiogenic plasmids into the infarcted rat heart via ultrasound targeted microbubble destruction enhances cardiac repair

European Heart Journal

Volumn 32, Issue 16, 2011, Pages 2075-2084

  Fujii, Hiroko ^a,b   Li, Shu Hong ^a,b   Wu, Jun ^a,b   Miyagi, Yasuo ^a,b   Yau, Terrence M ^a,b   Rakowski, Harry ^b   Egashira, Kensuke ^c   Guo, Jian ^a   Weisel, Richard D ^a   Li, Ren Ke ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY HEALTH NETWORK   (Canada)

^c KYUSHU UNIVERSITY   (Japan)

Author keywords

Angiogenesis; Echocardiography; Gene therapy; Heart failure; Myocardial infarction

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; MESSENGER RNA; STEM CELL FACTOR; STROMAL CELL DERIVED FACTOR 1ALPHA;

ANGIOGENIC GENE THERAPY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIAC REPAIR; CHEMICAL ANALYSIS; CONTROLLED STUDY; CORONARY ARTERY LIGATION; ECHOCARDIOGRAPHY; GENE DELIVERY SYSTEM; HEART INFARCTION; HEART INFARCTION SIZE; HEART MUSCLE PERFUSION; HEART VENTRICLE FUNCTION; HISTOPATHOLOGY; MICROBUBBLE; MYOCARDIAL PERFUSION IMAGING; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TISSUE REPAIR; ULTRASOUND TARGETED MICROBUBBLE DESTRUCTION;

ANIMALS; CHEMOKINE CXCL12; COLLATERAL CIRCULATION; ECHOCARDIOGRAPHY; GENE THERAPY; GENE TRANSFER TECHNIQUES; MICROBUBBLES; MYOCARDIAL INFARCTION; MYOCARDIAL REVASCULARIZATION; MYOFIBROBLASTS; NEOVASCULARIZATION, PHYSIOLOGIC; PLASMIDS; PROTO-ONCOGENE PROTEINS C-KIT; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CXCR4; STEM CELL TRANSPLANTATION; STROKE VOLUME; TRANSFECTION; TROPONIN I; ULTRASONIC THERAPY; VENTRICULAR FUNCTION, LEFT;

EID: 79960443644     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehq475     Document Type: Article

References (27)

1. St John SM, Pfeffer MA, Moye L, Plappert T, Rouleau JL, Lamas G, Rouleau J, Parker JO, Arnold MO, Sussex B, Braunwald E. Cardiovascular death and left ventricular remodeling two years after myocardial infarction: baseline predictors and impact of long-term use of captopril: information from the Survival and Ventricular Enlargement (SAVE) trial. Circulation 1997;96:3294-3299. (Pubitemid 27513397)
2. Sutton MG, Sharpe N. Left ventricular remodeling after myocardial infarction: pathophysiology and therapy. Circulation 2000;101:2981-2988. (Pubitemid 30415891)
3. Jayasankar V, Woo YJ, Bish LT, Pirolli TJ, Chatterjee S, Berry MF, Burdick J, Gardner TJ, Sweeney HL. Gene transfer of hepatocyte growth factor attenuates postinfarction heart failure. Circulation 2003;108(Suppl. 1):II230-II236. (Pubitemid 37099960)
4. Yau TM, Fung K, Weisel RD, Fujii T, Mickle DA, Li RK. Enhanced myocardial angiogenesis by gene transfer with transplanted cells. Circulation 2001;104: I218-I222. (Pubitemid 32884806)
5. Bekeredjian R, Grayburn PA, Shohet RV. Use of ultrasound contrast agents for gene or drug delivery in cardiovascular medicine. J Am Coll Cardiol 2005;45: 329-335. (Pubitemid 40186780)
6. Chen S, Shohet RV, Bekeredjian R, Frenkel P, Grayburn PA. Optimization of ultrasound parameters for cardiac gene delivery of adenoviral or plasmid deoxyribonucleic acid by ultrasound-targeted microbubble destruction. J Am Coll Cardiol 2003;42:301-308. (Pubitemid 36851422)
7. Fujii H, Sun Z, Li SH, Wu J, Fazel S, Weisel RD, Rakowski H, Lindner J, Li RK. Ultrasound-targeted gene delivery induces angiogenesis after a myocardial infarction in mice. JACC Cardiovasc Imaging 2009;2:869-879.
8. Villanueva FS. Ultrasound mediated destruction of DNA-loaded microbubbles for enhancement of cell-based therapies: new promise amidst a confluence of uncertainties? JACC Cardiovasc Imaging 2009;2:880-882.
9. Dimmeler S, Zeiher AM, Schneider MD. Unchain my heart: the scientific foundations of cardiac repair. J Clin Invest 2005;115:572-583. (Pubitemid 40322227)
10. Fazel S, Cimini M, Chen L, Li S, Angoulvant D, Fedak P, Verma S, Weisel RD, Keating A, Li RK. Cardioprotective c-kit+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines. J Clin Invest 2006;116: 1865-1877. (Pubitemid 44033311)
11. van Der Wouw PA, Brauns AC, Bailey SE, Powers JE, Wilde AA. Premature ventricular contractions during triggered imaging with ultrasound contrast. J Am Soc Echocardiogr 2000;13:288-294. (Pubitemid 30215253)
12. Korpanty G, Chen S, Shohet RV, Ding J, Yang B, Frenkel PA, Grayburn PA. Targeting of VEGF-mediated angiogenesis to rat myocardium using ultrasonic destruction of microbubbles. Gene Ther 2005;12:1305-1312. (Pubitemid 43084486)
13. Chen S, Kroll MH, Shohet RV, Frenkel P, Mayer SA, Grayburn PA. Bioeffects of myocardial contrast microbubble destruction by echocardiography. Echocardiography 2002;19:495-500. (Pubitemid 35026183)
14. Porter TR, Xie F. Myocardial perfusion imaging with contrast ultrasound. JACC Cardiovasc Imaging 2010;3:176-187.
15. Fujii H, Tomita S, Nakatani T, Fukuhara S, Hanatani A, Ohtsu Y, Ishida M, Yutani C, Miyatake K, Kitamura S. A novel application of myocardial contrast echocardiography to evaluate angiogenesis by autologous bone marrow cell transplantation in chronic ischemic pig model. J Am Coll Cardiol 2004;43:1299-1305. (Pubitemid 38452610)
16. Cimini M, Fazel S, Zhuo S, Xaymardan M, Fujii H, Weisel RD, Li RK. c-kit dysfunction impairs myocardial healing after infarction. Circulation 2007;116:I77-I82. (Pubitemid 47480773)
17. Bonig H, Priestley GV, Papayannopoulou T. Hierarchy of molecular-pathway usage in bone marrow homing and its shift by cytokines. Blood 2006;107:79-86. (Pubitemid 43053527)
18. De FE, Porcelli D, Torella AR, Straino S, Iachininoto MG, Orlandi A, Truffa S, Biglioli P, Napolitano M, Capogrossi MC, Pesce M. SDF-1 involvement in endothelial phenotype and ischemia-induced recruitment of bone marrow progenitor cells. Blood 2004;104:3472-3482. (Pubitemid 39564415)
19. Hiasa K, Ishibashi M, Ohtani K, Inoue S, Zhao Q, Kitamoto S, Sata M, Ichiki T, Takeshita A, Egashira K. Gene transfer of stromal cell-derived factor-1alpha enhances ischemic vasculogenesis and angiogenesis via vascular endothelial growth factor/endothelial nitric oxide synthase-related pathway: next-generation chemokine therapy for therapeutic neovascularization. Circulation 2004;109: 2454-2461. (Pubitemid 38679567)
20. Pandit SA, Bostick D, Berkowitz ML. Molecular dynamics simulation of a dipalmitoylphosphatidylcholine bilayer with NaCl. Biophys J 2003;84:3743-3750. (Pubitemid 36644146)
21. Koltover I, Salditt T, Safinya CR. Phase diagram, stability, and overcharging of lamellar cationic lipid-DNA self-assembled complexes. Biophys J 1999;77: 915-924. (Pubitemid 29362462)
22. Skyba DM, Price RJ, Linka AZ, Skalak TC, Kaul S. Direct in vivo visualization of intravascular destruction of microbubbles by ultrasound and its local effects on tissue. Circulation 1998;98:290-293. (Pubitemid 28348049)
23. Christiansen JP, French BA, Klibanov AL, Kaul S, Lindner JR. Targeted tissue transfection with ultrasound destruction of plasmid-bearing cationic microbubbles. Ultrasound Med Biol 2003;29:1759-1767. (Pubitemid 38091725)
24. Amyot R, Yu E, Honos G, Choy J, Schnell G, Leong-Poi H. Contrast echocardiography: putting things into perspective-a Canadian Cardiovascular Society/Canadian Society of Echocardiography joint commentary. Can J Cardiol 2008;24: 835-837.
25. Ansari A. Anatomy and clinical significance of ventricular Thebesian veins. Clin Anat 2001;14:102-110. (Pubitemid 32183128)
26. Fuchs S, Kornowski R, Mehran R, Lansky AJ, Satler LF, Pichard AD, Kent KM, Clark CE, Stone GW, Leon MB. Prognostic value of cardiac troponin-I levels following catheter-based coronary interventions. Am J Cardiol 2000;85: 1077-1082. (Pubitemid 30214252)
27. Heeschen C, Hamm CW, Bruemmer J, Simoons ML. Predictive value of Creactive protein and troponin T in patients with unstable angina: a comparative analysis. CAPTURE Investigators. Chimeric c7E3 AntiPlatelet Therapy in Unstable angina REfractory to standard treatment trial. J Am Coll Cardiol 2000;35: 1535-1542.