The use of MMP2 antibody-conjugated cationic microbubble to target the ischemic myocardium, enhance Timp3 gene transfection and improve cardiac function

Biomaterials

Volumn 35, Issue 3, 2014, Pages 1063-1073

  Yan, Ping ^a,b,c   Chen, Ko Jie ^d   Wu, Jun ^b,c   Sun, Lu ^b,c   Sung, Hsing Wen ^d   Weisel, Richard D ^b,c   Xie, Jun ^a   Li, Ren Ke ^b,c  

^a SHANXI MEDICAL UNIVERSITY   (China)

^b UNIVERSITY HEALTH NETWORK   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d NATIONAL TSING HUA UNIVERSITY   (Taiwan)

Author keywords

Gene transfection; Ischemic myocardium; Matrix modulation; MMP; Targeted microbubble; TIMP

Indexed keywords

GENE TRANSFECTION; ISCHEMIC MYOCARDIUM; MATRIX MODULATION; MICRO-BUBBLE; MMP; TIMP;

ANTIBODIES;

GENES;

ANTIBODY CONJUGATE; GELATINASE A; GELATINASE B;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; GENE TARGETING; GENETIC ENHANCEMENT; GENETIC TRANSFECTION; HEART FUNCTION; HEART MUSCLE ISCHEMIA; HEART VENTRICLE FUNCTION; MICROBUBBLE; NONHUMAN; PLASMID; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; RODENT; SCAR;

RATTUS; RODENTIA;

GENE TRANSFECTION; ISCHEMIC MYOCARDIUM; MATRIX MODULATION; MMP; TARGETED MICROBUBBLE; TIMP;

ANIMALS; IMMUNOCONJUGATES; MALE; MATRIX METALLOPROTEINASE 2; MICROBUBBLES; MYOCARDIAL ISCHEMIA; MYOCARDIUM; PHOSPHATIDYLETHANOLAMINES; PLASMIDS; POLYETHYLENE GLYCOLS; RATS; RATS, SPRAGUE-DAWLEY; TISSUE INHIBITOR OF METALLOPROTEINASE-3; TRANSFECTION;

EID: 84887625242     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.10.043     Document Type: Article

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