Synthetic microRNA cassette dosing: Pharmacokinetics, tissue distribution and bioactivity

Molecular Pharmaceutics

Volumn 9, Issue 6, 2012, Pages 1638-1644

  Wang, Hongyan ^a,b   Chiu, Ming ^a   Xie, Zhiliang ^a   Chiu, Michael ^a   Liu, Zhongfa ^a,b   Chen, Ping ^a   Liu, Shujun ^b   Byrd, John C ^a,b   Muthusamy, Natarajan ^a,b   Garzon, Ramiro ^a,b   Croce, Carlo M ^b   Marcucci, Guido ^a,b   Chan, Kenneth K ^a,b,c  

^a OHIO STATE UNIVERSITY   (United States)

^b THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

2 MeOPSmiRs; cassette dosing; pharmacodynamic; pharmacokinetics; tissue distribution

Indexed keywords

2 METHOXYPHOSPHOROTHIOATE MIRS; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; MESSENGER RNA; MICRORNA; OLIGONUCLEOTIDE; PROTEIN BCL 2; PROTEIN MCL 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE MARROW; BRAIN TISSUE; DOWN REGULATION; DRUG CLEARANCE; DRUG HALF LIFE; DRUG TISSUE LEVEL; LIVER; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN;

ANIMALS; BLOTTING, WESTERN; BRAIN; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; ENZYME-LINKED IMMUNOSORBENT ASSAY; LUNG; MALE; MICE; MICE, INBRED C57BL; MICRORNAS; PROTO-ONCOGENE PROTEINS C-BCL-2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84862004156     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp2006483     Document Type: Article

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