Ultrasound and microbubble-targeted delivery of macromolecules is regulated by induction of endocytosis and pore formation

Circulation Research

Volumn 104, Issue 5, 2009, Pages 679-687

  Meijering, Bernadet D M ^a,d   Juffermans, Lynda J M ^b,d   Van Wamel, Annemieke ^c,d   Henning, Rob H ^a   Zuhorn, Inge S ^a   Emmer, Marcia ^c   Versteilen, Amanda M G ^a,b   Paulus, Walter J ^b   Van Gilst, Wiek H ^a,d   Kooiman, Klazina ^c   De Jong, Nico ^c,d   Musters, René J P ^b   Deelman, Leo E ^a,d   Kamp, Otto ^b,d  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d ROYAL NETHERLANDS ACADEMY OF ARTS AND SCIENCES   (Netherlands)

Author keywords

Cell membrane pore; Dextran; Endocytosis; Endothelial cells; Ultrasound microbubble targeted delivery

Indexed keywords

ADENOSINE TRIPHOSPHATE; CAVEOLIN 1; CLATHRIN; DEXTRAN; ANDROSTANE DERIVATIVE; CHLORPROMAZINE; CONTRAST AGENT BR1; CONTRAST MEDIUM; FILIPIN; FLUORESCENT DYE; PHOSPHOLIPID; SULFUR HEXAFLUORIDE; WORTMANNIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CELLULAR DISTRIBUTION; CHANNEL GATING; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG UPTAKE; ENDOCYTOSIS; IN VIVO STUDY; MACROMOLECULE; MALE; MICROBUBBLE; NONHUMAN; PINOCYTOSIS; PRIORITY JOURNAL; RAT; ULTRASOUND; ANIMAL; CATTLE; CAVEOLA; CELL CULTURE; CHEMISTRY; CYTOSOL; DRUG EFFECT; ENDOTHELIUM CELL; FEMORAL ARTERY; FLUORESCENCE MICROSCOPY; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; MOLECULAR WEIGHT; PRESSURE; THREE DIMENSIONAL IMAGING; TIME; TRANSPORT AT THE CELLULAR LEVEL; TRANSPORT VESICLE; WISTAR RAT;

ADENOSINE TRIPHOSPHATE; ANDROSTADIENES; ANIMALS; BIOLOGICAL TRANSPORT; CATTLE; CAVEOLAE; CAVEOLIN 1; CELLS, CULTURED; CHLORPROMAZINE; CLATHRIN; CONTRAST MEDIA; CYTOSOL; DEXTRANS; DRUG DELIVERY SYSTEMS; ENDOCYTOSIS; ENDOTHELIAL CELLS; FEMORAL ARTERY; FILIPIN; FLUORESCENT DYES; IMAGING, THREE-DIMENSIONAL; INFUSIONS, INTRAVENOUS; MICROBUBBLES; MICROSCOPY, FLUORESCENCE; MOLECULAR WEIGHT; PHOSPHOLIPIDS; PINOCYTOSIS; PRESSURE; RATS; RATS, WISTAR; SULFUR HEXAFLUORIDE; TIME FACTORS; TRANSPORT VESICLES; ULTRASONICS;

EID: 63649084601     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.108.183806     Document Type: Article

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