Progesterone treatment reduces neuroinflammation, oxidative stress and brain damage and improves long-term outcomes in a rat model of repeated mild traumatic brain injury

Journal of Neuroinflammation

Volumn 12, Issue 1, 2015, Pages

  Webster, Kyria M ^a   Wright, David K ^a,b   Sun, Mujun ^a   Semple, Bridgette D ^a   Ozturk, Ezgi ^a   Stein, Donald G ^c   O'Brien, Terence J ^a   Shultz, Sandy R ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Animal model; Astrogliosis; Chronic traumatic encephalopathy; Concussion; DTI; Lipid peroxidation; Macrophages; Microglia; MRI; Treatment

Indexed keywords

PROGESTERONE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; ARTICLE; BRAIN DAMAGE; COGNITIVE DEFECT; CONTROLLED STUDY; DEPRESSION; DISEASE MARKER; DISEASE MODEL; DRUG EFFICACY; FUNCTIONAL ASSESSMENT; GRAY MATTER; HISTOPATHOLOGY; LONG EVANS RAT; MALE; MOTOR PERFORMANCE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OUTCOME ASSESSMENT; OXIDATIVE STRESS; RAT; SENSORIMOTOR NEUROPATHY; SHAM PROCEDURE; TRAUMATIC BRAIN INJURY; TREATMENT DURATION; TREATMENT RESPONSE; WHITE MATTER; ANIMAL; BRAIN CONCUSSION; BRAIN INJURIES; DRUG EFFECTS; INFLAMMATION; METABOLISM; PATHOLOGY; PHYSIOLOGY; TIME FACTOR; TREATMENT OUTCOME;

ANIMALS; BRAIN CONCUSSION; BRAIN INJURIES; DISEASE MODELS, ANIMAL; INFLAMMATION; MALE; MOTOR SKILLS; OXIDATIVE STRESS; PROGESTERONE; RATS; RATS, LONG-EVANS; TIME FACTORS; TREATMENT OUTCOME;

EID: 84949811099     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/s12974-015-0457-7     Document Type: Article

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