RAID3 - An interleukin-6 receptor-binding aptamer with post-selective modification-resistant affinity

RNA Biology

Volumn 12, Issue 9, 2015, Pages 1043-1053

  Mittelberger, Florian ^a   Meyer, Cindy ^b   Waetzig, Georg H ^c   Zacharias, Martin ^d   Valentini, Erica ^a,e   Svergun, Dmitri I ^e   Berg, Katharina ^a   Lorenzen, Inken ^f   Grötzinger, Joachim ^f   Rose John, Stefan ^f   Hahn, Ulrich ^a  

^a UNIVERSITY OF HAMBURG   (Germany)

^b ROCKEFELLER UNIVERSITY   (United States)

^c CONARIS Research Institute AG ^*  (Germany)

^d TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^e EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^f UNIVERSITY OF KIEL   (Germany)

Author keywords

Aptamers; Cell biology; Cytokine signaling; Interleukin 6 receptor; Internalization; Molecular modelling; Post selective modification; Protein RNA interactions; SAXS

Indexed keywords

APTAMER; INTERLEUKIN 6 RECEPTOR; NUCLEOTIDE; OLIGOMER; PROTEIN; PYRIMIDINE DERIVATIVE; RAID3 PROTEIN; UNCLASSIFIED DRUG; INTERLEUKIN 6; PROTEIN BINDING;

ARTICLE; BINDING AFFINITY; BIOTINYLATION; CIRCULAR DICHROISM; CONTROLLED STUDY; HUMAN; HUMAN CELL; MOLECULAR MODEL; PROTEIN DOMAIN; PROTEIN MODIFICATION; PROTEIN MOTIF; PROTEIN STRUCTURE; RNA STABILITY; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY; ANIMAL; BINDING SITE; CELL LINE; CHEMISTRY; CONFORMATION; METABOLISM; MOUSE; NUCLEOTIDE MOTIF; SYSTEMATIC EVOLUTION OF LIGANDS BY EXPONENTIAL ENRICHMENT APTAMER TECHNIQUE;

ANIMALS; APTAMERS, NUCLEOTIDE; BINDING SITES; CELL LINE; HUMANS; INTERLEUKIN-6; MICE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NUCLEIC ACID CONFORMATION; NUCLEOTIDE MOTIFS; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; RECEPTORS, INTERLEUKIN-6; SELEX APTAMER TECHNIQUE;

EID: 84949804112     PISSN: 15476286     EISSN: 15558584     Source Type: Journal    
DOI: 10.1080/15476286.2015.1079681     Document Type: Article

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