Selection strategy to generate aptamer pairs that bind to distinct sites on protein targets

Analytical Chemistry

Volumn 84, Issue 12, 2012, Pages 5365-5371

  Gong, Qiang ^a   Wang, Jinpeng ^b   Ahmad, Kareem M ^a   Csordas, Andrew T ^b   Zhou, Jiehua ^c   Nie, Jeff ^d,e   Stewart, Ron ^d,e   Thomson, James A ^d,e   Rossi, John J ^c   Soh, H Tom ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b University of California   (United States)

^c CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^d MORGRIDGE INSTITUTE FOR RESEARCH   (United States)

^e UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AFFINITY REAGENTS; ANALYTICAL TECHNIQUES; APTAMERS; CHEMICAL SYNTHESIS; COMPLEX MIXTURE; CROSS-REACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; INTEGRINS; NANOMOLAR AFFINITY; PRODUCTION COST; PROTEIN TARGETS; SELECTION METHODS; SYSTEMATIC EVOLUTION OF LIGANDS BY EXPONENTIAL ENRICHMENTS;

RNA;

BINDING SITES;

APTAMER; LIGAND; VITRONECTIN RECEPTOR;

ANIMAL; ARTICLE; BINDING SITE; CATTLE; CHEMISTRY; COMBINATORIAL CHEMISTRY; ENZYME SPECIFICITY; METABOLISM; METHODOLOGY; PROTEIN SUBUNIT; SEQUENCE HOMOLOGY;

ANIMALS; APTAMERS, NUCLEOTIDE; BINDING SITES; CATTLE; INTEGRIN ALPHAVBETA3; LIGANDS; PROTEIN SUBUNITS; SELEX APTAMER TECHNIQUE; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

EID: 84862583911     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac300873p     Document Type: Article

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