Acetaminophen hepatotoxicity in mice: Effect of age, frailty and exposure type

Experimental Gerontology

Volumn 73, Issue , 2016, Pages 95-106

  Kane, Alice E ^a,b,c   Mitchell, Sarah J ^d   Mach, John ^a,b,c   Huizer Pajkos, Aniko ^a,b   McKenzie, Catriona ^e   Jones, Brett ^a,b,c   Cogger, Victoria ^c,f   Le Couteur, David G ^c,f   de Cabo, Rafael ^d   Hilmer, Sarah N ^a,b,c  

^a UNIVERSITY OF SYDNEY   (Australia)

^b ROYAL NORTH SHORE HOSPITAL   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

^d NATIONAL INSTITUTE ON AGING   (United States)

^e ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^f ANZAC RESEARCH INSTITUTE   (Australia)

Author keywords

Acetaminophen; Ageing; Frailty; Hepatotoxicity; Liver; Mice; Paracetamol

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; CASPASE 3; CYTOCHROME P450 2E1; GLUTATHIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; MESSENGER RNA; N ACETYL 1,4 BENZOQUINONE IMINE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE QUINONE 1; PARACETAMOL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1BETA; PROTEIN BAX; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANALGESIC AGENT; AUTACOID;

ACUTE DRUG ADMINISTRATION; AGE; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DRUG MEGADOSE; FRAIL ELDERLY; GENE EXPRESSION; JUVENILE ANIMAL; LIVER NECROSIS; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; AGING; ANIMAL; APOPTOSIS; C57BL MOUSE; CHEMICAL AND DRUG INDUCED LIVER INJURY; DRUG ADMINISTRATION; GENE EXPRESSION REGULATION; GENETICS; LIVER MITOCHONDRION; METABOLISM; PATHOLOGY; PHYSIOLOGY;

ACETAMINOPHEN; AGING; ANALGESICS, NON-NARCOTIC; ANIMALS; APOPTOSIS; CHEMICAL AND DRUG INDUCED LIVER INJURY; DRUG ADMINISTRATION SCHEDULE; GENE EXPRESSION REGULATION; INFLAMMATION MEDIATORS; MALE; MICE, INBRED C57BL; MITOCHONDRIA, LIVER; RNA, MESSENGER;

EID: 84949663581     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2015.11.013     Document Type: Article

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