Repeated acetaminophen dosing in rats: Adaptation of hepatic antioxidant system

Human and Experimental Toxicology

Volumn 19, Issue 5, 2000, Pages 277-283

  O'Brien, P J ^a   Slaughter, M R ^a   Swain, A ^a   Birmingham, J M ^a   Greenhill, R W ^a   Elcock, F ^a   Bugelski, P J ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Acetaminophen; Antioxidant system; Glucose 6 phosphate dehydrogenase; Paracetamol; Rat liver

Indexed keywords

ALANINE AMINOTRANSFERASE; CATALASE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; MALONALDEHYDE; PARACETAMOL; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ADAPTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EXPOSURE; DRUG SENSITIVITY; ENZYME ACTIVITY; FEEDING; LIVER; LIVER CELL DAMAGE; LIVER TOXICITY; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTECTION; RAT; REGULATORY MECHANISM;

ANIMALIA; FELIS CATUS;

EID: 0033866362     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1191/096032700678815918     Document Type: Article

References (4)

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3. Ellouk-Achard S et al. Ex vivo and in vitro models in acetaminophen hepatotoxicity studies. Relationships between glutathione depletion, oxidative stress and disturbances in calcium homeostasis and energy metabolism. Archives of Toxicology, Supplement 1995; 17: 209-214.
4. Buttar HS, Nera EA, Downie RH. Serum enzyme activities and hepatic triglyceride levels in acute and subacute acetaminophen-treated rats. Toxicology 1976; 6: 9-20.