Ondansetron does not block paracetamol-induced analgesia in a mouse model of fracture pain

British Journal of Anaesthesia

Volumn 106, Issue 1, 2011, Pages 112-118

  Minville, V ^a,b   Fourcade, O ^a   Mazoit, J X ^c   Girolami, J P ^b   Tack, I ^b  

^a TOULOUSE UNIVERSITY HOSPITAL   (France)

^b CHU RANGUEIL   (France)

^c UNIVERSITÉ PARIS SACLAY   (France)

Author keywords

fracture; ondansetron; pain; paracetamol; serotonin

Indexed keywords

ANALGESIC AGENT; ANTIEMETIC AGENT; ONDANSETRON; PARACETAMOL; SEROTONIN ANTAGONIST;

ANIMAL; ARTICLE; C57BL MOUSE; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; DRUG INTERACTION; HYPERALGESIA; MALE; METHODOLOGY; MOUSE; PAIN ASSESSMENT; PAIN THRESHOLD; PATHOPHYSIOLOGY; REACTION TIME; TIBIA FRACTURE;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; ANTIEMETICS; DISEASE MODELS, ANIMAL; DRUG INTERACTIONS; HYPERALGESIA; MALE; MICE; MICE, INBRED C57BL; ONDANSETRON; PAIN MEASUREMENT; PAIN THRESHOLD; REACTION TIME; SEROTONIN ANTAGONISTS; TIBIAL FRACTURES;

MLCS; MLOWN;

EID: 79952198242     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aeq277     Document Type: Article

References (44)

1. Kehlet, H, Dahl, JB, Anaesthesia, surgery, and challenges in postoperative recovery. Lancet 362 (2003), 1921–1928 doi:10.1016/S0140-6736(03)14966-5.
2. Kehlet, H, Jensen, TS, Woolf, CJ, Persistent postsurgical pain: risk factors and prevention. Lancet 367 (2006), 1618–1625 doi:10.1016/S0140-6736(06)68700-X.
3. Bonnet, F, Marret, E, Influence of anaesthetic and analgesic techniques on outcome after surgery. Br J Anaesth 95 (2005), 52–58 doi:10.1093/bja/aei038.
4. Minville, V, Laffosse, JM, Fourcade, O, Girolami, JP, Tack, I, Mouse model of fracture pain. Anesthesiology 108 (2008), 467–472 doi:10.1097/ALN.0b013e3181649333.
5. Houghton, AK, Hewitt, E, Westlund, KN, Enhanced withdrawal responses to mechanical and thermal stimuli after bone injury. Pain 73 (1997), 325–337 doi:10.1016/S0304-3959(97)00087-0.
6. Houghton, AK, Valdez, JG, Westlund, KN, Peripheral morphine administration blocks the development of hyperalgesia and allodynia after bone damage in the rat. Anesthesiology 89 (1998), 120–190 doi:10.1097/00000542-199807000-00026.
7. Viallon, A, Marjollet, O, Guyomarch, P, et al. Analgesic efficacy of orodispersible paracetamol in patients admitted to the emergency department with an osteoarticular injury. Eur J Emerg Med 14 (2007), 337–342 doi:10.1097/MEJ.0b013e3282703606.
8. Sandby-Thomas, M, Sullivan, G, Hall, JE, A national survey into the peri-operative anaesthetic management of patients presenting for surgical correction of a fractured neck of femur. Anaesthesia 63 (2008), 250–258 doi:10.1111/j.1365-2044.2007.05328.x.
9. Hyllested, M, Jones, S, Pedersen, JL, Kehlet, H, Comparative effect of paracetamol, NSAIDs or their combination in postoperative pain management: a qualitative review. Br J Anaesth 88 (2002), 199–214 doi:10.1093/bja/88.2.199.
10. Flower, RJ, Vane, JR, Inhibition of prostaglandin synthetase in brain explains the anti-pyretic activity of paracetamol (4-acetamidophenol). Nature 240 (1972), 410–411 doi:10.1038/240410a0.
11. Zygmunt, PM, Chuang, H, Movahed, P, et al. The anandamide transport inhibitor AM404 activates vanilloid receptors. Eur J Pharmacol 396 (2000), 39–42 doi:10.1016/S0014-2999(00)00207-7.
12. Ottani, A, Leone, S, Sandrini, M, et al. The analgesic activity of paracetamol is prevented by the blockade of cannabinoid CB1 receptors. Eur J Pharmacol 531 (2006), 280–281 doi:10.1016/j.ejphar.2005.12.015.
13. Bonnefont, J, Courade, JP, Alloui, A, Eschalier, A, Antinociceptive mechanism of action of paracetamol. Drugs 63 (2003), 1–4 doi:10.2165/00003495-200363992-00002.
14. Courade, JP, Chassaing, C, Bardin, L, Alloui, A, Eschalier, A, 5-HT receptor subtypes involved in the spinal antinociceptive effect of acetaminophen in rats. Eur J Pharmacol 432 (2001), 1–7 doi:10.1016/S0014-2999(01)01464-9.
15. Roca-Vinardell, A, Ortega-Alvaro, A, Gibert-Rahola, J, Micó, JA, The role of 5-HT1A/B autoreceptors in the antinociceptive effect of systemic administration of acetaminophen. Anesthesiology 98 (2003), 741–747 doi:10.1097/00000542-200303000-00025.
16. Bertolini, A, Ferrari, A, Ottani, A, Guerzoni, S, Tacchi, R, Leone, S, Paracetamol: new vistas of an old drug. CNS Drug Rev 12 (2006), 250–275 doi:10.1111/j.1527-3458.2006.00250.x.
17. Pickering, G, Loriot, MA, Libert, F, Eschalier, A, Beaune, P, Dubray, C, Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism. Clin Pharmacol Ther 79 (2006), 371–378 doi:10.1016/j.clpt.2005.12.307.
18. Rosow, CE, Haspel, KL, Smith, SE, Grecu, L, Bittner, EA, Haloperidol versus ondansetron for prophylaxis of postoperative nausea and vomiting. Anesth Analg 106 (2008), 1407–1409 doi:10.1213/ane.0b013e3181609022.
19. Diemunsch, P, Conseiller, C, Clyti, N, Mamet, JP, The French Ondansetron Study, Ondansetron compared with metoclopramide in the treatment of established postoperative nausea and vomiting. Br J Anaesth, 79, 1997, 322.
20. Diemunsch, P, Gan, TJ, Philip, BK, et al. Single-dose aprepitant vs ondansetron for the prevention of postoperative nausea and vomiting: a randomized, double-blind Phase III trial in patients undergoing open abdominal surgery. Br J Anaesth 99 (2007), 202–211 doi:10.1093/bja/aem133.
21. Kogan, A, Eidelman, LA, Raanani, E, Orlov, B, Shenkin, O, Vidne, BA, Nausea and vomiting after fast-track cardiac anaesthesia. Br J Anaesth 91 (2003), 214–217 doi:10.1093/bja/aeg166.
22. Bugedo, G, Gonzalez, J, Asenjo, C, et al. Ondansetron and droperidol in the prevention of postoperative nausea and vomiting. Br J Anaesth 83 (1999), 813–814.
23. Minville, V, Fourcade, O, Girolami, JP, Tack, I, Opioid-induced hyperalgesia in a mice model of orthopaedic pain: preventive effect of ketamine. Br J Anaesth 104 (2010), 231–238 doi:10.1093/bja/aep363.
24. Zimmermann, M, Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16 (1983), 109–110 doi:10.1016/0304-3959(83)90201-4.
25. Umathe, SN, Bhutada, PS, Raut, VS, Jain, NS, Mundhada, YR, The 5-HT3 receptor antagonist, ondansetron, blocks the development and expression of ethanol-induced locomotor sensitization in mice. Behav Pharmacol 20 (2009), 78–83 doi:10.1097/FBP.0b013e3283242ff4.
26. Ramamoorthy, R, Radhakrishnan, M, Borah, M, Antidepressant-like effects of serotonin type-3 antagonist, ondansetron: an investigation in behaviour-based rodent models. Behav Pharmacol 19 (2008), 29–40 doi:10.1097/FBP.0b013e3282f3cfd4.
27. Attal, N, Jazat, F, Kayser, V, Guilbaud, G, Further evidence for ‘pain-related’ behaviours in a model of unilateral peripheral mononeuropathy. Pain 41 (1990), 235–251 doi:10.1016/0304-3959(90)90022-6.
28. Lee, KC, Wilder, RT, Smith, RL, Berde, CB, Thermal hyperalgesia accelerates and MK-801 prevents the development of tachyphylaxis to rat sciatic nerve blockade. Anesthesiology 81 (1994), 1284–1293 doi:10.1097/00000542-199411000-00024.
29. Sheiner, LB, Beal, SL, Boeckmann, AJ, NONMEM Project Group, University of California at San Francisco, San Francisco, CA http://www.globomax.net/products/nonmem.cfm, 1990 (accessed October 23, 2008).
30. Miranda, HF, Prieto, JC, Puig, MM, Pinardi, G, Isobolographic analysis of multimodal analgesia in an animal model of visceral acute pain. Pharmacol Biochem Behav 88 (2008), 481–486 doi:10.1016/j.pbb.2007.10.005.
31. Miranda, HF, Puig, MM, Prieto, JC, Pinardi, G, Synergism between paracetamol and nonsteroidal anti-inflammatory drugs in experimental acute pain. Pain 121 (2006), 22–28 doi:10.1016/j.pain.2005.11.012.
32. Qiu, HX, Liu, J, Kong, H, Liu, Y, Mei, XG, Isobolographic analysis of the antinociceptive interactions between ketoprofen and paracetamol. Eur J Pharmacol 557 (2007), 141–146 doi:10.1016/j.ejphar.2006.11.017.
33. Remy, C, Marret, E, Bonnet, F, State of the art of paracetamol in acute pain therapy. Curr Opin Anaesthesiol 19 (2006), 562–565 doi:10.1097/01.aco.0000245285.30282.70.
34. Remy, C, Marret, E, Bonnet, F, Effects of acetaminophen on morphine side-effects and consumption after major surgery: meta-analysis of randomized controlled trials. Br J Anaesth 94 (2005), 505–513 doi:10.1093/bja/aei085.
35. Girard, P, Pansart, Y, Coppé, MC, Niedergang, B, Gillardin, JM, Modulation of paracetamol and nefopam antinociception by serotonin 5-HT(3) receptor antagonists in mice. Pharmacology 83 (2009), 243–246 doi:10.1159/000207448.
36. Bardin, L, Jourdan, D, Alloui, A, Lavarenne, J, Eschalier, A, Differential influence of two serotonin 5-HT3 receptor antagonists on spinal serotonin-induced analgesia in rats. Brain Res 765 (1997), 267–272 doi:10.1016/S0006-8993(97)00566-0.
37. Graham, GG, Scott, KF, Mechanism of action of paracetamol. Am J Ther 12 (2005), 46–55 doi:10.1097/00045391-200501000-00008.
38. Sandrini, M, Pini, LA, Vitale, G, Differential involvement of central 5-HT1B and 5-HT3 receptor subtypes in the antinociceptive effect of paracetamol. Inflamm Res 52 (2003), 347–352 doi:10.1007/s00011-003-1185-5.
39. Libert, F, Bonnefont, J, Bourinet, E, et al. Acetaminophen: a central analgesic drug that involves a spinal tropisetron-sensitive, non-5-HT(3) receptor-mediated effect. Mol Pharmacol 66 (2004), 728–734.
40. Scott, JA, Wood, M, Flood, P, The pronociceptive effect of ondansetron in the setting of P-glycoprotein inhibition. Anesth Analg 103 (2006), 742–746 doi:10.1213/01.ane.0000228861.80314.22.
41. Oatway, MA, Chen, Y, Weaver, LC, The 5-HT3 receptor facilitates at-level mechanical allodynia following spinal cord injury. Pain 110 (2004), 259–268 doi:10.1016/j.pain.2004.03.040.
42. McCleane, GJ, Suzuki, R, Dickenson, AH, Does a single intravenous injection of the 5HT3 receptor antagonist ondansetron have an analgesic effect in neuropathic pain? A double-blinded, placebo-controlled cross-over study. Anesth Analg 97 (2003), 1474–1478 doi:10.1213/01.ANE.0000085640.69855.51.
43. Dürsteler, C, Mases, A, Fernandez, V, Pol, O, Puig, MM, Interaction between tramadol and two anti-emetics on nociception and gastrointestinal transit in mice. Eur J Pain 10 (2006), 629–638 doi:10.1016/j.ejpain.2005.10.002.
44. Kim, SI, Kim, SC, Baek, YH, et al. Comparison of ramosetron with ondansetron for prevention of postoperative nausea and vomiting in patients undergoing gynaecological surgery. Br J Anaesth 103 (2009), 549–553 doi:10.1093/bja/aep209.