Gene expression profile of mouse white adipose tissue during inflammatory stress: Age-dependent upregulation of major procoagulant factors

Aging Cell

Volumn 12, Issue 2, 2013, Pages 194-206

  Starr, Marlene E ^a,b,d   Hu, Yanling ^c   Stromberg, Arnold J ^c   Carmical, Joseph R ^d   Wood, Thomas G ^d   Evers, B Mark ^a,b,d   Saito, Hiroshi ^a,b,d  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

^d University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Adipose tissue; Aging; Coagulation; Lipopolysaccharide; Microarray; Systemic inflammation

Indexed keywords

BETA 3 ADRENERGIC RECEPTOR; BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 13A; BLOOD CLOTTING FACTOR 5; BLOOD CLOTTING FACTOR 7; CARBONATE DEHYDRATASE III; COLLAGENASE 3; CXCL3 CHEMOKINE; ENDOTOXIN; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; FORMYLPEPTIDE RECEPTOR; INTERLEUKIN 1; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 6; LECTIN; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PROCOAGULANT; SERUM AMYLOID A; THROMBOSPONDIN 1; TUMOR NECROSIS FACTOR ALPHA; ZINC FINGER PROTEIN;

AGED; ARTICLE; BODY TEMPERATURE; CONTROLLED STUDY; DISEASE SEVERITY; EPIDIDYMIS FAT; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE PROBE; HYPOTHERMIA; INFLAMMATION; MOUSE; NONHUMAN; PHYSIOLOGICAL STRESS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STRESS; UPREGULATION; WHITE ADIPOSE TISSUE;

ADIPOCYTES; ADIPOSE TISSUE, WHITE; AGING; ANIMALS; BLOOD COAGULATION FACTORS; CYTOKINES; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; INFLAMMATION; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED C57BL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; STRESS, PHYSIOLOGICAL; STROMAL CELLS; THROMBOSIS;

MUS;

EID: 84878943672     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12040     Document Type: Article

References (35)

1. Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR (2001) Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit. Care Med. 29, 1303-1310.
2. Cartwright MJ, Schlauch K, Lenburg ME, Tchkonia T, Pirtskhalava T, Cartwright A, Thomou T, Kirkland JL (2010) Aging, depot origin, and preadipocyte gene expression. J. Gerontol. A Biol. Sci. Med. Sci. 65, 242-251.
3. Chorinchath BB, Kong LY, Mao L, McCallum RE (1996) Age-associated differences in TNF-alpha and nitric oxide production in endotoxic mice. J. Immunol. 156, 1525-1530.
4. Chung S, Lapoint K, Martinez K, Kennedy A, Boysen Sandberg M, McIntosh MK (2006) Preadipocytes mediate lipopolysaccharide-induced inflammation and insulin resistance in primary cultures of newly differentiated human adipocytes. Endocrinology 147, 5340-5351.
5. Dahlquist KD, Salomonis N, Vranizan K, Lawlor SC, Conklin BR (2002) GenMAPP, a new tool for viewing and analyzing microarray data on biological pathways. Nat. Genet. 31, 19-20.
6. Doniger SW, Salomonis N, Dahlquist KD, Vranizan K, Lawlor SC, Conklin BR (2003) MAPPFinder: using Gene Ontology and GenMAPP to create a global geneexpression profile from microarray data. Genome Biol. 4, R7.
7. Ellis MP, French JJ, Charnley RM (2009) Acute pancreatitis and the influence of socioeconomic deprivation. Br. J. Surg. 96, 74-80.
8. Gomez CR, Goral J, Ramirez L, Kopf M, Kovacs EJ (2006) Aberrant acutephase response in aged interleukin-6 knockout mice. Shock 25, 581- 585.
9. Gordon S, Taylor PR (2005) Monocyte and macrophage heterogeneity. Nat. Rev. Immunol. 5, 953-964.
10. Gustafson B, Gogg S, Hedjazifar S, Jenndahl L, Hammarstedt A, Smith U (2009) Inflammation and impaired adipogenesis in hypertrophic obesity in man. Am. J. Physiol. Endocrinol. Metab. 297, E999-E1003.
11. Hemmeryckx B, Loeckx D, Dresselaers T, Himmelreich U, Hoylaerts MF, Lijnen HR (2010) Age-associated adaptations in murine adipose tissues. Endocr. J. 57, 925-930.
12. Kanneganti TD, Dixit VD (2012) Immunological complications of obesity. Nat. Immunol. 13, 707-712.
13. Lumeng CN, Liu J, Geletka L, Delaney C, Delproposto J, Desai A, Oatmen K, Martinez-Santibanez G, Julius A, Garg S, Yung RL (2011) Aging is associated with an increase in T cells and inflammatory macrophages in visceral adipose tissue. J. Immunol. 187, 6208-6216.
14. Marik PE (2006) Management of the critically ill geriatric patient. Crit. Care Med. 34, S176-S182.
15. Martin GS, Mannino DM, Moss M (2006) The effect of age on the development and outcome of adult sepsis. Crit. Care Med. 34, 15-21.
16. Park SK, Kim K, Page GP, Allison DB, Weindruch R, Prolla TA (2009) Gene expression profiling of aging in multiple mouse strains: identification of aging biomarkers and impact of dietary antioxidants. Aging Cell 8, 484-495.
17. Pisani MA (2009) Considerations in caring for the critically ill older patient. J. Intensive Care Med. 24, 83-95.
18. Saito H, Sherwood ER, Varma TK, Evers BM (2003) Effects of aging on mortality, hypothermia, and cytokine induction in mice with endotoxemia or sepsis. Mech. Ageing Dev. 124, 1047-1058.
19. Salomonis N, Hanspers K, Zambon AC, Vranizan K, Lawlor SC, Dahlquist KD, Doniger SW, Stuart J, Conklin BR, Pico AR (2007) GenMAPP 2: new features and resources for pathway analysis. BMC Bioinformat. 8, 217.
20. Sebastian C, Lloberas J, Celada A (2009) Molecular and cellular aspects of macrophage aging. In Handbook on Immunosenescence (Fulop T, Franceschi C, Hirokawa K, Pawelec G, eds). Dordrecht: Springer Science+Business Media B.V., pp. 919-945.
21. Starr ME, Evers BM, Saito H (2009) Age-associated increase in cytokine production during systemic inflammation: adipose tissue as a major source of IL-6. J. Gerontol. A Biol. Sci. Med. Sci. 64, 723-730.
22. Starr ME, Ueda J, Takahashi H, Weiler H, Esmon CT, Evers BM, Saito H (2010) Agedependent vulnerability to endotoxemia is associated with reduction of anti-coagulant factors activated protein C and thrombomodulin. Blood 115, 4886-4893.
23. Tateda K, Matsumoto T, Miyazaki S, Yamaguchi K (1996) Lipopolysaccharideinduced lethality and cytokine production in aged mice. Infect. Immun. 64, 769-774.
24. Tchkonia T, Pirtskhalava T, Thomou T, Cartwright MJ, Wise B, Karagiannides I, Shpilman A, Lash TL, Becherer JD, Kirkland JL (2007) Increased TNFalpha and CCAAT/enhancer-binding protein homologous protein with aging predispose preadipocytes to resist adipogenesis. Am. J. Physiol. Endocrinol. Metab. 293, E1810-E1819.
25. Tchkonia T, Morbeck DE, Von Zglinicki T, Van Deursen J, Lustgarten J, Scrable H, Khosla S, Jensen MD, Kirkland JL (2010) Fat tissue, aging, and cellular senescence. Aging Cell 9, 667-684.
26. Tsuchihashi H, Yamamoto H, Maeda K, Ugi S, Mori T, Shimizu T, Endo Y, Hanasawa K, Tani T (2006) Circulating concentrations of adiponectin, an endogenous lipopolysaccharide neutralizing protein, decrease in rats with polymicrobial sepsis. J. Surg. Res. 134, 348-353.
27. Ueda J, Starr ME, Takahashi H, Du J, Chang LY, Crapo JD, Evers BM, Saito H (2008) Decreased pulmonary extracellular superoxide dismutase during systemic inflammation. Free Radic. Biol. Med. 45, 897-904.
28. Wallenius V, Wallenius K, Ahren B, Rudling M, Carlsten H, Dickson SL, Ohlsson C, Jansson JO (2002) Interleukin-6-deficient mice develop mature-onset obesity. Nat. Med. 8, 75-79.
29. Weichenhan D, Kunze B, Winking H, van Geel M, Osoegawa K, de Jong PJ, Traut W (2001) Source and component genes of a 6-200 Mb gene cluster in the house mouse. Mamm. Genome 12, 590-594.
30. Wu D, Ren Z, Pae M, Guo W, Cui X, Merrill AH, Meydani SN (2007) Aging up-regulates expression of inflammatory mediators in mouse adipose tissue. J. Immunol. 179, 4829-4839.
31. Xin MJ, Chen H, Luo B, Sun JB (2008) Severe acute pancreatitis in the elderly: etiology and clinical characteristics. World J. Gastroenterol. 14, 2517-2521.
32. Yamamoto K, Shimokawa T, Yi H, Isobe K, Kojima T, Loskutoff DJ, Saito H (2002) Aging accelerates endotoxin-induced thrombosis: increased responses of plasminogen activator inhibitor-1 and lipopolysaccharide signaling with aging. Am. J. Pathol. 161, 1805-1814.
33. Yamamoto K, Takeshita K, Kojima T, Takamatsu J, Saito H (2005) Aging and plasminogen activator inhibitor-1 (PAI-1) regulation: implication in the pathogenesis of thrombotic disorders in the elderly. Cardiovasc. Res. 66, 276-285.
34. Yang H, Youm YH, Vandanmagsar B, Ravussin A, Gimble JM, Greenway F, Stephens JM, Mynatt RL, Dixit VD (2010) Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: implications for systemic inflammation and insulin resistance. J. Immunol. 185, 1836-1845.
35. Zeyda M, Gollinger K, Kriehuber E, Kiefer FW, Neuhofer A, Stulnig TM (2010) Newly identified adipose tissue macrophage populations in obesity with distinct chemokine and chemokine receptor expression. Int. J. Obes. (Lond) 34, 1684- 1694.