Synthetic and natural small molecule TLR4 antagonists inhibit motoneuron death in cultures from ALS mouse model

Pharmacological Research

Volumn 103, Issue , 2016, Pages 180-187

  De Paola, Massimiliano ^a   Sestito, Stefania E ^b   Mariani, Alessandro ^a   Memo, Christian ^a   Fanelli, Roberto ^a   Freschi, Mattia ^a   Bendotti, Caterina ^a   Calabrese, Valentina ^b   Peri, Francesco ^b  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b UNIVERSITY OF MILANO BICOCCA   (Italy)

Author keywords

Amyotrophic lateral sclerosis (ALS); Extra virgin olive oil; Inflammation; Microgliaa; Motoneuron; TLR4

Indexed keywords

CD14 ANTIGEN; COPPER ZINC SUPEROXIDE DISMUTASE; GLYCOLIPID; HIGH MOBILITY GROUP B1 PROTEIN; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; NITRIC OXIDE; OLIVE OIL; TOLL LIKE RECEPTOR 4; PHENOL DERIVATIVE; SUPEROXIDE DISMUTASE;

ADAPTIVE IMMUNITY; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COCULTURE; CONTROLLED STUDY; DISEASE COURSE; GLIA; INFLAMMATION; INNATE IMMUNITY; LETHALITY; MICROGLIA; MOTONEURON; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SPINAL CORD CELL CULTURE; WILD TYPE; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL DEATH; DISEASE MODEL; DRUG EFFECTS; GENETICS; HEK293 CELL LINE; HUMAN; METABOLISM; SPINAL CORD; TRANSGENIC MOUSE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CELL DEATH; COCULTURE TECHNIQUES; DISEASE MODELS, ANIMAL; HEK293 CELLS; HUMANS; LIPOPOLYSACCHARIDES; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROGLIA; MOTOR NEURONS; NITRIC OXIDE; OLIVE OIL; PHENOLS; SPINAL CORD; SUPEROXIDE DISMUTASE; TOLL-LIKE RECEPTOR 4;

EID: 84949595598     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2015.11.020     Document Type: Article

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