Anti-inflammatory effects and antioxidant activity of dihydroasparagusic acid in lipopolysaccharide-activated microglial cells

Brain Research Bulletin

Volumn 120, Issue , 2016, Pages 151-158

  Salemme, Adele ^a   Togna, Anna Rita ^a   Mastrofrancesco, Arianna ^b   Cammisotto, Vittoria ^a   Ottaviani, Monica ^b   Bianco, Armandodoriano ^a   Venditti, Alessandro ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b SAN GALLICANO DERMATOLOGICAL INSTITUTE   (Italy)

Author keywords

Dihydroasparagusic acid; Inflammation; Lipopolysaccharide; Microglia; Neurodegenerative disease; Oxidative stress

Indexed keywords

CYCLOOXYGENASE 2; DIHYDROASPARAGUSIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; LIPOXYGENASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NATURAL PRODUCT; NEUROPROTECTIVE AGENT; NITRIC OXIDE; PROSTAGLANDIN E2; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; THIOPHENE DERIVATIVE;

ALZHEIMER DISEASE; ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; DRUG EFFICACY; ENZYME ACTIVITY; IN VITRO STUDY; MEDIATOR RELEASE; MICROGLIA; MICROGLIAL CELL CULTURE; MULTIPLE SCLEROSIS; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; ANIMAL; BRAIN CORTEX; CELL CULTURE; CELL SURVIVAL; DRUG EFFECTS; IMMUNOLOGY; IMMUNOMODULATION; INFLAMMATION; METABOLISM; PHYSIOLOGY; PRECLINICAL STUDY; WISTAR RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; DRUG EVALUATION, PRECLINICAL; INFLAMMATION; LIPOPOLYSACCHARIDES; MICROGLIA; NEUROIMMUNOMODULATION; NF-KAPPA B; NITRIC OXIDE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS, WISTAR; REACTIVE OXYGEN SPECIES; THIOPHENES;

EID: 84949526046     PISSN: 03619230     EISSN: 18732747     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2015.11.014     Document Type: Article

References (39)

1. Aguirre E., Lòpez-Bernardo E., Cadenas S. Functional evidence for nitric oxide production by skeletal-muscle mitochondria from lipopolysaccharide-treated mice. Mitochondrion 2012, 12:126-131.
2. Allan S.M. The role of pro- and anti-inflammatory cytokines in neurodegeneration. Ann. N.Y. Acad. Sci. 2000, 917:84-93.
3. Amor S., Puentes F., Baker D., van der Valk P. Inflammation in neurodegenerative diseases. Immunology 2010, 129:154-169.
4. Bianco A., Bottari E., Festa M.R., Gentile L., Serrilli A.M., Venditti A. Properties of DHAA and its use as an antidote against mercury(II) poisoning. Monatsh. Chem. 2013, 144:1767-1773.
5. Block M.L., Zecca L., Hong J.S. Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat. Rev. Neurosci. 2007, 8:57-69.
6. Chu J., Praticò D. The 5-lipoxygenase as a common pathway for pathological brain and vascular aging. Cardiovasc. Psychiatry Neurol. 2009, 10.1155/2009/174657.
7. Doherty G.H. Nitric oxide in neurodegeneration: potential benefits of non steroidal anti-inflammatories. Neurosci. Bull. 2011, 27:366-382.
8. Han L., Yin K., Zhang S., Wu Z., Wang C., Zhang Q., Pan J., Chen B., Li J., Tan R., et al. Dalesconols B inhibits lipopolysaccharide induced inflammation and suppresses NF-κB and p38/JNK activation in microglial cells. Neurochem. Int. 2013, 62:913-921.
9. Hirsch E.C., Vyas S., Hunot S. Neuroinflammation in Parkinson's disease. Parkinsonism Relat. Disord. 2012, 18(Suppl. (1)):S210-S212.
10. Hou X., Zhang J., Ahmad H., Zhang H., Hu Z., Wang T. Evaluation of antioxidant activities of ampelopsin and its protective effect in lipopolysaccharide-induced oxidative stress piglets. PloS One 2014, 9:e108314.
11. Hu Z., Yu F., Gong Y., Qiu W., Xhou Y., Cui J., Li J., Chen H. Subneurotoxic copper(II)-induced NF-kappaB-dependent microglial activation is associated with mitochondrial ROS. Toxicol. Appl. Pharmacol. 2014, 276:95-103.
12. Jansen E.F. The isolation and identification of 2,2'-dithiolisobutyric acid from asparagus. J. Biol. Chem. 1948, 176:657-664.
13. 2. J. Immunol. 2012, 18:21-28.
14. Kim E.A., Han A.R., Choi J., Ahn J.Y., Choi S.Y., Cho S.W. Anti-inflammatory mechanisms of N-adamantyl-4-methylthiazol-2-amine in lipopolysaccharide-stimulated BV-2 microglial cells. Int. Immunopharmacol. 2014, 22:73-83.
15. Kim J.H., Na H.J., Kim C.K., Kim J.Y., Ha K.S., Lee H., Chung H.T., Kwon H.J., Kwon Y.G., Kim Y.M. The non-provitamin A carotenoid, lutein, inhibits NF-kappaB-dependent gene expression through redox-based regulation of the phosphatidylinositol 3-kinase/PTEN/Akt and NF-kappaB-inducing kinase pathways: role of H(2)O(2) in NF-kappaB activation. Free Radic. Biol. Med. 2008, 45:885-896.
16. Lim H.-W., Park J.-I., More S.-V., Park J.-Y., Kim B.-W., Jeon S.-B., Yun Y., Park E.-J., Yoon S.-H., Choi D.-K. Anti-neuroinflammatory effects of DPTP, a novel synthetic clovamide derivative in in vitro and in vivo model of neuroinflammation. Brain Res. Bull. 2015, 112:25-34.
17. Maccioni R.B., Rojo L.E., Fernandez J.A., Kuljis R.O. The role of neuroimmunomodulation in Alzheimer's disease. Ann. N.Y. Acad. Sci. 2009, 1153:240-246.
18. Mirshafiey A., Jadidi-Niaragh F. Prostaglandins in pathogenesis and treatment of multiple sclerosis. Immunopharmacol. Immunotoxicol. 2010, 32:543-554.
19. Nakajima K., Kohsaka S. Microglia: activation and their significance in the central nervous system. J. Biochem. 2001, 130:169-175.
20. Palomba L., Persichini T., Mazzone V., Colasanti M., Cantoni O. Inhibition of nitric-oxide synthase-I (NOS-I)-dependent nitric oxide production by lipopolysaccharide plus interferon-gamma is mediated by arachidonic acid: effects on NF-κB activation and late- inducible NOS expression. J. Biol. Chem. 2004, 279:29895-29901.
21. Palumbo S., Bosetti F. Alterations of brain eicosanoid synthetic pathway in multiple sclerosis and in animal models of demyelination: role of cyclooxygenase-2. Prostaglandins Leukot. Essent. Fatty Acids 2013, 89:273-278.
22. Park J., Min J.S., Kim B., Chaea U.B., Won Yunb J., Choic M.S., Kongd I.K., Change K.T., Leea D.S. Mitochondrial ROS govern the LPS-induced pro-inflammatory response in microglia cells by regulating MAPK and NF-κB pathways. Neurosci. Lett. 2015, 584:191-196.
23. Pawate S., Shen Q., Fan F., Bhat N.R. Redox regulation of glial inflammatory response to lipopolysaccharide and interferongamma. J. Neurosci. Res. 2004, 77:540-551.
24. Pontiki E., Kontogiorgis C., Xu Y., Hadjipavlou-Litina D., Luob Y. New lipoxygenase inhibitors of reactive oxygen species production in cellular models of amyloid (A2) toxicities. J. Alzheimers Dis. 2012, 34:215-230.
25. Song X.Y., Hu J.F., Sun M.N., Li Z.P., Zhu Z.X., Song L.K., Yuan Y.H., Liu G., Chen N.H. IMM-H004, a novel coumarin derivative compound, attenuates the production of inflammatory mediatory mediators in lipopolysaccharide-activated BV2 microglia. Brain Res. Bull. 2014, 106:30-38.
26. Su P., Zhanga J., Zhaoa F., Aschnerb M., Chena J., Luoa W. The interaction between microglia and neural stem/precursor cells. Brain Res. Bull. 2014, 109:32-38.
27. Takasugi M., Yachida Y., Anetai M., Masamune T., Kegasawa K. Identification of asparagusic acid as a nematicide occurring naturally in the roots of asparagus. Chem. Lett. 1975, 4:43-44.
28. Tao L., Zhang F., Hao L., Wu J., Jia J., Liu J.Y., Zeng L.T., Zhen X. 1-O-tigloyl-1-O-deacetyl-nimbolinin B inhibits LPS-stimulated inflammatory responses by suppressing NF-κB and JNK activation in microglia cells. J. Pharmacol. Sci. 2014, 125:364-374.
29. Togna A.R., Latina V., Trefiletti G., Guiso M., Moschini S., Togna G.I. 1-Phenyl-6,7-dihydroxy-isochroman inhibits inflammatory activation of microglia. Brain Res. Bull. 2013, 95:33-39.
30. Venditti A., Mandrone M., Serrilli A.M., Bianco A., Iannello C., Poli F., Antognoni F. Dihydroasparagusic acid: antioxidant and tyrosinase inhibitory activities and improved synthesis. J. Agric. Food Chem. 2013, 61:6848-6855.
31. Volkers P.I., Rauchfuss T.B., Wilson S.R. Coordination chemistry of 3-mercapto-e-(mercaptomethyl) propanoic acid (dihydroasparagusic acid) with iron and nickel. Eur. J. Inorg. Chem 2006, 23:4793-4799.
32. 2 in microglia. J. Neurochem. 2004, 88:939-947.
33. Wong W.T. Microglia aging in the healthy of CNS: phenotypes, drivers and rejuvenation. Front. Cell. Neurosci. 2013, 7(22).
34. Xu J., Zhang Y., Xiao Y.S., Liu Q., Dang S., Jin M., Shi Y., Wan B., Zhang Y. Inhibition of 12/15-lipoxygenase by baicalein induces microglia PPARβ/(δ: a potential therapeutic role for CNS autoimmune disease. Cell Death Dis. 2013, 4:e569. 10.1038/cddis.2013.86.
35. Yanagawa Y., Kato T., Kitahara Y. Asparagusic acid, dihidroasparagusic acid and S-acetuldihydroasparagusic acid, a new plant growth inhibitor in etiolated young asparagus shoots. Tetrahedron Lett. 1972, 25:2549-2552.
36. Yanagawa H., Kato T., Kitahara Y., Yakahashi N. Stimulation of growth and pyruvate oxidation in Streptococcus faecalis by asparagusic acid and its derivatives. Plant Cell Physiol. 1973, 14:791-795.
37. Yanagawa H., Kato T., Kitahara Y. Stimulation of pyruvate oxidation in asparagus mitochondria by asparagusic acid. Plant Cell Physiol. 1973, 14:1213-1216.
38. Yang C., Yu L., Kong L., Ma R., Zhang J., Zhu Q., Zhu J., Hao D. Pyrroloquinoline quinone (PQQ) inhibits lipopolysaccharide induced inflammation in part via downregulated NF-(κB and p38/JNK activation in microglial and attenuates microglia activation in lipopolysaccharide treatment mice. PLoS One 2014, 14(10):e109502. 9. 10.1371/journal.pone.0109502.
39. Zhu M.D., Zhao L.X., Wang X.T., Gao Y.J., Zhang Z.J. Ligustilide inhibits microglia-mediated proinflammatory cytokines production and inflammatory pain. Brain Res. Bull. 2014, 109:54-60.