Subneurotoxic copper(II)-induced NF-κB-dependent microglial activation is associated with mitochondrial ROS

Toxicology and Applied Pharmacology

Volumn 276, Issue 2, 2014, Pages 95-103

  Hu, Zhuqin ^a   Yu, Fengxiang ^a   Gong, Ping ^a   Qiu, Yu ^a   Zhou, Wei ^a   Cui, Yongyao ^a   Li, Juan ^a   Chen, Hongzhuan ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Copper(II); Microglia; Nitric oxide; Nuclear factor k cyrillic B (NF k cyrillic B); Reactive oxygen species; Tumor necrosis factor (TNF )

Indexed keywords

3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; ACETYLCYSTEINE; CUPRIC ION; HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL VIABILITY ASSAY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUOROMETRY; HIPPOCAMPAL NEURONAL CULTURE; MICROGLIA; MICROGLIAL CELL CULTURE; MOUSE; NERVOUS SYSTEM INFLAMMATION; NEUROTOXICITY; NONHUMAN; OPTICAL DENSITY; OXIDATION;

MURINAE; RATTUS;

COPPER(II); MICROGLIA; NITRIC OXIDE; NUCLEAR FACTOR-KB (NF-KB); REACTIVE OXYGEN SPECIES; TUMOR NECROSIS FACTOR-Α (TNF-Α);

ANIMALS; CELLS, CULTURED; COPPER; HUMANS; MICE; MICROGLIA; MITOCHONDRIA; NADPH OXIDASE; NF-KAPPA B; NITRIC OXIDE; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SUPEROXIDES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84898056697     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2014.01.020     Document Type: Article

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