메뉴 건너뛰기




Volumn 5, Issue 11-12, 2014, Pages 420-435

RGS16, a novel p53 and prb cross-talk candidate inhibits migration and invasion of pancreatic cancer cells

Author keywords

EGF; Migration; P53; Pancreatic cancer; PRb; RGS16

Indexed keywords

ADENOVIRUS VECTOR; BCL2L11 PROTEIN; BTG 2 PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR; INTERLEUKIN 6; MESSENGER RNA; PROTEIN P53; RETINOBLASTOMA PROTEIN; STAT4 PROTEIN; TUMOR PROTEIN; UNCLASSIFIED DRUG;

EID: 84949508564     PISSN: 19476019     EISSN: 19476027     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (17)

References (90)
  • 1
    • 0030893707 scopus 로고    scopus 로고
    • Cooperative effects of p53 and pRB alterations in primary superficial bladder tumors
    • Cordon-Cardo, C., et al., Cooperative effects of p53 and pRB alterations in primary superficial bladder tumors. Cancer Res, 1997. 57(7): p. 1217-21.
    • (1997) Cancer Res , vol.57 , Issue.7 , pp. 1217-1221
    • Cordon-Cardo, C.1
  • 2
    • 0022506980 scopus 로고
    • A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma
    • Friend, S.H., et al., A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature, 1986. 323(6089): p. 643-6.
    • (1986) Nature , vol.323 , Issue.6089 , pp. 643-646
    • Friend, S.H.1
  • 3
    • 70149121143 scopus 로고    scopus 로고
    • Molecular genetics of sarcomas: Applications to diagnoses and therapy
    • Toguchida, J. and T. Nakayama, Molecular genetics of sarcomas: applications to diagnoses and therapy. Cancer Sci, 2009. 100(9): p. 1573-80.
    • (2009) Cancer Sci , vol.100 , Issue.9 , pp. 1573-1580
    • Toguchida, J.1    Nakayama, T.2
  • 4
    • 0028673104 scopus 로고
    • Tumorigenic and developmental effects of combined germ-line mutations in Rb and p53
    • Williams, B.O., et al., Tumorigenic and developmental effects of combined germ-line mutations in Rb and p53. Cold Spring Harb Symp Quant Biol, 1994. 59: p. 449-57.
    • (1994) Cold Spring Harb Symp Quant Biol , vol.59 , pp. 449-457
    • Williams, B.O.1
  • 5
    • 0036205872 scopus 로고    scopus 로고
    • Alterations in p53 and pRb pathways and their prognostic significance in oesophageal cancer
    • Mathew, R., et al., Alterations in p53 and pRb pathways and their prognostic significance in oesophageal cancer. Eur J Cancer, 2002. 38(6): p. 832-41.
    • (2002) Eur J Cancer , vol.38 , Issue.6 , pp. 832-841
    • Mathew, R.1
  • 6
    • 0026334753 scopus 로고
    • Abnormalities of the p53 tumour suppressor gene in human pancreatic cancer
    • Barton, C.M., et al., Abnormalities of the p53 tumour suppressor gene in human pancreatic cancer. Br J Cancer, 1991. 64(6): p. 1076-82.
    • (1991) Br J Cancer , vol.64 , Issue.6 , pp. 1076-1082
    • Barton, C.M.1
  • 7
    • 0028059330 scopus 로고
    • Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma
    • Caldas, C., et al., Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma. Nat Genet, 1994. 8(1): p. 27-32.
    • (1994) Nat Genet , vol.8 , Issue.1 , pp. 27-32
    • Caldas, C.1
  • 8
    • 33750590095 scopus 로고    scopus 로고
    • Inactivation of the p53 pathway in retinoblastoma
    • Laurie, N.A., et al., Inactivation of the p53 pathway in retinoblastoma. Nature, 2006. 444(7115): p. 61-6.
    • (2006) Nature , vol.444 , Issue.7115 , pp. 61-66
    • Laurie, N.A.1
  • 9
    • 0033552627 scopus 로고    scopus 로고
    • Mdm2: A bridge over the two tumour suppressors, p53 and Rb
    • Yap D.B., et al., mdm2: a bridge over the two tumour suppressors, p53 and Rb. Oncogene, 1999. 18(53): p. 7681-9.
    • (1999) Oncogene , vol.18 , Issue.53 , pp. 7681-7689
    • Yap, D.B.1
  • 10
    • 0030865615 scopus 로고    scopus 로고
    • Reduced expression of retinoblastoma gene product (PRB) and high expression of p53 are associated with poor prognosis in ovarian cancer
    • Dong, Y., et al., Reduced expression of retinoblastoma gene product (pRB) and high expression of p53 are associated with poor prognosis in ovarian cancer. Int J Cancer, 1997. 74(4): p. 407-15.
    • (1997) Int J Cancer , vol.74 , Issue.4 , pp. 407-415
    • Dong, Y.1
  • 11
    • 33748078111 scopus 로고    scopus 로고
    • Synergy of p53 and Rb deficiency in a conditional mouse model for metastatic prostate cancer
    • Zhou, Z., et al., Synergy of p53 and Rb deficiency in a conditional mouse model for metastatic prostate cancer. Cancer Res, 2006. 66(16): p. 7889-98.
    • (2006) Cancer Res , vol.66 , Issue.16 , pp. 7889-7898
    • Zhou, Z.1
  • 12
    • 0032940947 scopus 로고    scopus 로고
    • Differential regulation of p21 by p53 and Rb in cellular response to oxidative stress
    • Yin, Y., et al., Differential regulation of p21 by p53 and Rb in cellular response to oxidative stress. Mol Carcinog, 1999. 24(1): p. 15-24.
    • (1999) Mol Carcinog , vol.24 , Issue.1 , pp. 15-24
    • Yin, Y.1
  • 13
    • 0001510491 scopus 로고    scopus 로고
    • The RB and p53 pathways in cancer
    • Sherr, C.J. and F. McCormick, The RB and p53 pathways in cancer. Cancer Cell, 2002. 2(2): p. 103-12.
    • (2002) Cancer Cell , vol.2 , Issue.2 , pp. 103-112
    • Sherr, C.J.1    McCormick, F.2
  • 14
    • 70349437076 scopus 로고    scopus 로고
    • Ginsberg, p53 and E2f: Partners in life and death
    • Polager, S. and D. Ginsberg, p53 and E2f: partners in life and death. Nat Rev Cancer, 2009. 9(10): p. 738-48.
    • (2009) Nat Rev Cancer , vol.9 , Issue.10 , pp. 738-748
    • Polager, S.1
  • 15
    • 12644313243 scopus 로고    scopus 로고
    • The p53 tumor suppressor targets a novel regulator of G protein signaling
    • Buckbinder, L., et al., The p53 tumor suppressor targets a novel regulator of G protein signaling. Proc Natl Acad Sci U S A, 1997. 94(15): p. 7868-72.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , Issue.15 , pp. 7868-7872
    • Buckbinder, L.1
  • 16
    • 0034128414 scopus 로고    scopus 로고
    • The regulator of G protein signaling family
    • De Vries, L., et al., The regulator of G protein signaling family. Annu Rev Pharmacol Toxicol, 2000. 40: p. 235-71.
    • (2000) Annu Rev Pharmacol Toxicol , vol.40 , pp. 235-271
    • De Vries, L.1
  • 17
    • 27644503703 scopus 로고    scopus 로고
    • RGS16 is a negative regulator of SDF-1-CXCR4 signaling in megakaryocytes
    • Berthebaud, M., et al., RGS16 is a negative regulator of SDF-1-CXCR4 signaling in megakaryocytes. Blood, 2005. 106(9): p. 2962-8.
    • (2005) Blood , vol.106 , Issue.9 , pp. 2962-2968
    • Berthebaud, M.1
  • 18
    • 0345099293 scopus 로고    scopus 로고
    • RGS16 inhibits signalling through the G alpha 13-Rho axis
    • Johnson, E.N., et al., RGS16 inhibits signalling through the G alpha 13-Rho axis. Nat Cell Biol, 2003. 5(12): p. 1095-103.
    • (2003) Nat Cell Biol , vol.5 , Issue.12 , pp. 1095-1103
    • Johnson, E.N.1
  • 19
    • 69249124530 scopus 로고    scopus 로고
    • RGS16 inhibits breast cancer cell growth by mitigating phosphatidylinositol 3- kinase signaling
    • Liang, G., et al., RGS16 inhibits breast cancer cell growth by mitigating phosphatidylinositol 3- kinase signaling. J Biol Chem, 2009. 284(32): p. 21719-27.
    • (2009) J Biol Chem , vol.284 , Issue.32 , pp. 21719-21727
    • Liang, G.1
  • 20
    • 77953090345 scopus 로고    scopus 로고
    • CXCL12 (SDF-1)/CXCR4 pathway in cancer
    • Teicher, B.A. and S.P. Fricker, CXCL12 (SDF-1)/CXCR4 pathway in cancer. Clin Cancer Res, 2010. 16(11): p. 2927-31.
    • (2010) Clin Cancer Res , vol.16 , Issue.11 , pp. 2927-2931
    • Teicher, B.A.1    Fricker, S.P.2
  • 21
    • 8544223594 scopus 로고    scopus 로고
    • Increased survival, proliferation, and migration in metastatic human pancreatic tumor cells expressing functional CXCR4
    • Marchesi, F., et al., Increased survival, proliferation, and migration in metastatic human pancreatic tumor cells expressing functional CXCR4. Cancer Res, 2004. 64(22): p. 8420-7.
    • (2004) Cancer Res , vol.64 , Issue.22 , pp. 8420-8427
    • Marchesi, F.1
  • 22
    • 0034307305 scopus 로고    scopus 로고
    • Inhibition of phosphatidylinositide 3-kinase enhances gemcitabine-induced apoptosis in human pancreatic cancer cells
    • Ng, S.S.W., et al., Inhibition of phosphatidylinositide 3-kinase enhances gemcitabine-induced apoptosis in human pancreatic cancer cells. Cancer Res, 2000. 60(19): p. 5451-5.
    • (2000) Cancer Res , vol.60 , Issue.19 , pp. 5451-5455
    • Ng, S.1
  • 23
    • 0348049845 scopus 로고    scopus 로고
    • Incidence, mechanism and prognostic value of activated AKT in pancreas cancer
    • Schlieman, M.G., et al., Incidence, mechanism and prognostic value of activated AKT in pancreas cancer. Br J Cancer, 2003. 89(11): p. 2110-5.
    • (2003) Br J Cancer , vol.89 , Issue.11 , pp. 2110-2115
    • Schlieman, M.G.1
  • 24
    • 13844273087 scopus 로고    scopus 로고
    • PI3K-Akt pathway: Its functions and alterations in human cancer
    • Osaki, M., M. Oshimura, and H. Ito, PI3K-Akt pathway: its functions and alterations in human cancer. Apoptosis, 2004. 9(6): p. 667-76.
    • (2004) Apoptosis , vol.9 , Issue.6 , pp. 667-676
    • Osaki, M.1    Oshimura, M.2    Ito, H.3
  • 25
    • 48249112654 scopus 로고    scopus 로고
    • A fragile site within the HPC1 region at 1q25.3 affecting RGS16, RGSL1, and RGSL2 in human breast carcinomas
    • Wiechec, E., J. Overgaard, and L.L. Hansen, A fragile site within the HPC1 region at 1q25.3 affecting RGS16, RGSL1, and RGSL2 in human breast carcinomas. Genes Chromosomes Cancer, 2008. 47(9): p. 766-80.
    • (2008) Genes Chromosomes Cancer , vol.47 , Issue.9 , pp. 766-780
    • Wiechec, E.1    Overgaard, J.2    Hansen, L.L.3
  • 26
    • 78049505737 scopus 로고    scopus 로고
    • RGS16 and FosB underexpressed in pancreatic cancer with lymph node metastasis promote tumor progression
    • Kim, J.H., et al., RGS16 and FosB underexpressed in pancreatic cancer with lymph node metastasis promote tumor progression. Tumour Biol, 2010. 31(5): p. 541-8.
    • (2010) Tumour Biol , vol.31 , Issue.5 , pp. 541-548
    • Kim, J.H.1
  • 27
    • 84901271728 scopus 로고    scopus 로고
    • Management options in locally advanced pancreatic cancer
    • Mian, O.Y., et al., Management options in locally advanced pancreatic cancer. Curr Oncol Rep, 2014. 16(6): p. 388.
    • (2014) Curr Oncol Rep , vol.16 , Issue.6 , pp. 388
    • Mian, O.Y.1
  • 28
    • 77951755278 scopus 로고    scopus 로고
    • Pancreatic cancer
    • Hidalgo, M., Pancreatic cancer. N Engl J Med, 2010. 362(17): p. 1605-17.
    • (2010) N Engl J Med , vol.362 , Issue.17 , pp. 1605-1617
    • Hidalgo, M.1
  • 29
    • 55349124957 scopus 로고    scopus 로고
    • Biology and management of pancreatic cancer
    • Ghaneh, P., E. Costello, and J.P. Neoptolemos, Biology and management of pancreatic cancer. Postgrad Med J, 2008. 84(995): p. 478-97.
    • (2008) Postgrad Med J , vol.84 , Issue.995 , pp. 478-497
    • Ghaneh, P.1    Costello, E.2    Neoptolemos, J.P.3
  • 30
    • 0037124024 scopus 로고    scopus 로고
    • A role for p53 in maintaining and establishing the quiescence growth arrest in human cells
    • Itahana, K., et al., A role for p53 in maintaining and establishing the quiescence growth arrest in human cells. J Biol Chem, 2002. 277(20): p. 18206-14.
    • (2002) J Biol Chem , vol.277 , Issue.20 , pp. 18206-18214
    • Itahana, K.1
  • 31
    • 2942532249 scopus 로고    scopus 로고
    • Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells
    • Marchesini, N., et al., Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells. J Biol Chem, 2004. 279(24): p. 25101-11.
    • (2004) J Biol Chem , vol.279 , Issue.24 , pp. 25101-25111
    • Marchesini, N.1
  • 32
    • 77956642350 scopus 로고    scopus 로고
    • Expression of oncogenic K-ras and loss of Smad4 cooperate to induce the expression of EGFR and to promote invasion of immortalized human pancreas ductal cells
    • Zhao, S., et al., Expression of oncogenic K-ras and loss of Smad4 cooperate to induce the expression of EGFR and to promote invasion of immortalized human pancreas ductal cells. Int J Cancer, 2010. 127(9): p. 2076-87.
    • (2010) Int J Cancer , vol.127 , Issue.9 , pp. 2076-2087
    • Zhao, S.1
  • 33
    • 0027293748 scopus 로고
    • Coexpression of epidermal growth factor receptor and ligands in human pancreatic cancer is associated with enhanced tumor aggressiveness
    • Yamanaka, Y., et al., Coexpression of epidermal growth factor receptor and ligands in human pancreatic cancer is associated with enhanced tumor aggressiveness. Anticancer Res, 1993. 13(3): p. 565-9.
    • (1993) Anticancer Res , vol.13 , Issue.3 , pp. 565-569
    • Yamanaka, Y.1
  • 34
    • 84866007085 scopus 로고    scopus 로고
    • EGF receptor is required for KRASinduced pancreatic tumorigenesis
    • Ardito, C.M., et al., EGF receptor is required for KRASinduced pancreatic tumorigenesis. Cancer Cell, 2012. 22(3): p. 304-17.
    • (2012) Cancer Cell , vol.22 , Issue.3 , pp. 304-317
    • Ardito, C.M.1
  • 35
    • 0033778289 scopus 로고    scopus 로고
    • Retinoblastoma protein-initiated cellular growth arrest overcomes the ability of cotransfected wild-type p53 to induce apoptosis
    • Shinohara, H., et al., Retinoblastoma protein-initiated cellular growth arrest overcomes the ability of cotransfected wild-type p53 to induce apoptosis. Br J Cancer, 2000. 83(8): p. 1039-46.
    • (2000) Br J Cancer , vol.83 , Issue.8 , pp. 1039-1046
    • Shinohara, H.1
  • 36
    • 0035204005 scopus 로고    scopus 로고
    • PRb-expressing adenovirus Ad5-Rb attenuates the p53-induced apoptosis in cervical cancer cell lines
    • Ip S.M., et al., pRb-expressing adenovirus Ad5-Rb attenuates the p53-induced apoptosis in cervical cancer cell lines. Eur J Cancer, 2001. 37(18): p. 2475-83.
    • (2001) Eur J Cancer , vol.37 , Issue.18 , pp. 2475-2483
    • Ip, S.M.1
  • 37
    • 70350440143 scopus 로고    scopus 로고
    • The p53-mediated sensitivity of cancer cells to chemotherapeutic agents is conditioned by the status of the retinoblastoma protein
    • Derenzini, M., et al., The p53-mediated sensitivity of cancer cells to chemotherapeutic agents is conditioned by the status of the retinoblastoma protein. J Pathol, 2009. 219(3): p. 373-82.
    • (2009) J Pathol , vol.219 , Issue.3 , pp. 373-382
    • Derenzini, M.1
  • 38
    • 33748752327 scopus 로고    scopus 로고
    • Identification of cell cycle regulatory genes as principal targets of p53-mediated transcriptional repression
    • Spurgers, K.B., et al., Identification of cell cycle regulatory genes as principal targets of p53-mediated transcriptional repression. J Biol Chem, 2006. 281(35): p. 25134-42.
    • (2006) J Biol Chem , vol.281 , Issue.35 , pp. 25134-25142
    • Spurgers, K.B.1
  • 39
    • 0038751837 scopus 로고    scopus 로고
    • Transcriptional repression mediated by the p53 tumour suppressor
    • Ho, J. and S. Benchimol, Transcriptional repression mediated by the p53 tumour suppressor. Cell Death Differ, 2003. 10(4): p. 404-8.
    • (2003) Cell Death Differ , vol.10 , Issue.4 , pp. 404-408
    • Ho, J.1    Benchimol, S.2
  • 40
    • 0034656243 scopus 로고    scopus 로고
    • Analysis of p53-regulated gene expression patterns using oligonucleotide arrays
    • Zhao, R., et al., Analysis of p53-regulated gene expression patterns using oligonucleotide arrays. Genes Dev, 2000. 14(8): p. 981-93.
    • (2000) Genes Dev , vol.14 , Issue.8 , pp. 981-993
    • Zhao, R.1
  • 41
    • 33646229339 scopus 로고    scopus 로고
    • Genome-wide analysis of p53 under hypoxic conditions
    • Hammond, E.M., et al., Genome-wide analysis of p53 under hypoxic conditions. Mol Cell Biol, 2006. 26(9): p. 3492-504.
    • (2006) Mol Cell Biol , vol.26 , Issue.9 , pp. 3492-3504
    • Hammond, E.M.1
  • 42
    • 0035953394 scopus 로고    scopus 로고
    • DNA microarrays identification of primary and secondary target genes regulated by p53
    • Kannan, K., et al., DNA microarrays identification of primary and secondary target genes regulated by p53. Oncogene, 2001. 20(18): p. 2225-34.
    • (2001) Oncogene , vol.20 , Issue.18 , pp. 2225-2234
    • Kannan, K.1
  • 43
    • 84884795813 scopus 로고    scopus 로고
    • T antigen transformation reveals Tp53/RB-dependent route to PLAC1 transcription activation in primary fibroblasts
    • Chen, Y., D. Schlessinger, and R. Nagaraja, T antigen transformation reveals Tp53/RB-dependent route to PLAC1 transcription activation in primary fibroblasts. Oncogenesis, 2013. 2: p. e67.
    • (2013) Oncogenesis , vol.2
    • Chen, Y.1    Schlessinger, D.2    Nagaraja, R.3
  • 44
    • 70350518233 scopus 로고    scopus 로고
    • Emerging roles of E2Fs in cancer: An exit from cell cycle control
    • Chen, H.Z., S.Y. Tsai, and G. Leone, Emerging roles of E2Fs in cancer: an exit from cell cycle control. Nat Rev Cancer, 2009. 9(11): p. 785-97.
    • (2009) Nat Rev Cancer , vol.9 , Issue.11 , pp. 785-797
    • Chen, H.Z.1    Tsai, S.Y.2    Leone, G.3
  • 45
    • 0036037189 scopus 로고    scopus 로고
    • The retinoblastoma family: Twins or distant cousins?
    • Claudio, P.P., T. Tonini, and A. Giordano, The retinoblastoma family: twins or distant cousins? Genome Biol, 2002. 3(9): p. reviews 3012.
    • (2002) Genome Biol , vol.3 , Issue.9 , pp. 3012
    • Claudio, P.P.1    Tonini, T.2    Giordano, A.3
  • 46
    • 33748028804 scopus 로고    scopus 로고
    • Cell cycle control and beyond: Emerging roles for the retinoblastoma gene family
    • Genovese, C., et al., Cell cycle control and beyond: emerging roles for the retinoblastoma gene family. Oncogene, 2006. 25(38): p. 5201-9.
    • (2006) Oncogene , vol.25 , Issue.38 , pp. 5201-5209
    • Genovese, C.1
  • 47
    • 79551675502 scopus 로고    scopus 로고
    • E2f binding-deficient Rb1 protein suppresses prostate tumor progression in vivo
    • Sun, H., et al., E2f binding-deficient Rb1 protein suppresses prostate tumor progression in vivo. Proc Natl Acad Sci U S A, 2011. 108(2): p. 704-9.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , Issue.2 , pp. 704-709
    • Sun, H.1
  • 48
    • 0031930466 scopus 로고    scopus 로고
    • Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth
    • Sellers, W.R., et al., Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth. Genes Dev, 1998. 12(1): p. 95-106.
    • (1998) Genes Dev , vol.12 , Issue.1 , pp. 95-106
    • Sellers, W.R.1
  • 49
    • 21244446214 scopus 로고    scopus 로고
    • Rb enhances p160/SRC coactivatordependent activity of nuclear receptors and hormone responsiveness
    • Batsche, E., et al., Rb enhances p160/SRC coactivatordependent activity of nuclear receptors and hormone responsiveness. J Biol Chem, 2005. 280(20): p. 19746-56.
    • (2005) J Biol Chem , vol.280 , Issue.20 , pp. 19746-19756
    • Batsche, E.1
  • 50
    • 33846849372 scopus 로고    scopus 로고
    • A p53-type response element in the GDF15 promoter confers high specificity for p53 activation
    • Osada, M., et al., A p53-type response element in the GDF15 promoter confers high specificity for p53 activation. Biochem Biophys Res Commun, 2007. 354(4): p. 913-8.
    • (2007) Biochem Biophys Res Commun , vol.354 , Issue.4 , pp. 913-918
    • Osada, M.1
  • 51
    • 16144362452 scopus 로고    scopus 로고
    • Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway
    • Rouault, J.P., et al., Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway. Nat Genet, 1996. 14(4): p. 482-6.
    • (1996) Nat Genet , vol.14 , Issue.4 , pp. 482-486
    • Rouault, J.P.1
  • 52
    • 84892599654 scopus 로고    scopus 로고
    • Induction of amphiregulin by p53 promotes apoptosis via control of microRNA biogenesis in response to DNA damage
    • Taira, N., et al., Induction of amphiregulin by p53 promotes apoptosis via control of microRNA biogenesis in response to DNA damage. Proc Natl Acad Sci U S A, 2014. 111(2): p. 717-22.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , Issue.2 , pp. 717-722
    • Taira, N.1
  • 53
    • 0037180503 scopus 로고    scopus 로고
    • Gene expression profiling of isogenic cells with different TP53 gene dosage reveals numerous genes that are affected by TP53 dosage and identifies CSPG2 as a direct target of p53
    • Yoon, H., et al., Gene expression profiling of isogenic cells with different TP53 gene dosage reveals numerous genes that are affected by TP53 dosage and identifies CSPG2 as a direct target of p53. Proc Natl Acad Sci U S A, 2002. 99(24): p. 15632-7.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.24 , pp. 15632-15637
    • Yoon, H.1
  • 54
    • 84877139062 scopus 로고    scopus 로고
    • Folate stress induces apoptosis via p53-dependent de novo ceramide synthe sis and upregulation of ceramide synthase 6
    • Hoeferlin, L.A., et al., Folate stress induces apoptosis via p53-dependent de novo ceramide synthe sis and upregulation of ceramide synthase 6. J Biol Chem, 2013. 288(18): p. 12880-90.
    • (2013) J Biol Chem , vol.288 , Issue.18 , pp. 12880-12890
    • Hoeferlin, L.A.1
  • 55
    • 77952301694 scopus 로고    scopus 로고
    • Differential levels of transcription of p53-regulated genes by the arginine/proline polymorphism: P53 with arginine at codon 72 favors apoptosis
    • Jeong, B.S., et al., Differential levels of transcription of p53-regulated genes by the arginine/proline polymorphism: p53 with arginine at codon 72 favors apoptosis. FASEB J, 2010. 24(5): p. 1347-53.
    • (2010) FASEB J , vol.24 , Issue.5 , pp. 1347-1353
    • Jeong, B.S.1
  • 56
    • 0033566163 scopus 로고    scopus 로고
    • The antiapoptotic decoy receptor TRID/ TRAIL-R3 is a p53-regulated DNA damage-inducible gene that is overexpressed in primary tumors of the gastrointestinal tract
    • Sheikh, M.S., et al., The antiapoptotic decoy receptor TRID/ TRAIL-R3 is a p53-regulated DNA damage-inducible gene that is overexpressed in primary tumors of the gastrointestinal tract. Oncogene, 1999. 18(28): p. 4153-9.
    • (1999) Oncogene , vol.18 , Issue.28 , pp. 4153-4159
    • Sheikh, M.S.1
  • 57
    • 84891368496 scopus 로고    scopus 로고
    • AKR1B10, a transcriptional target of p53, is downregulated in colorectal cancers associated with poor prognosis
    • Ohashi, T., et al., AKR1B10, a transcriptional target of p53, is downregulated in colorectal cancers associated with poor prognosis. Mol Cancer Res, 2013. 11(12): p. 1554-63.
    • (2013) Mol Cancer Res , vol.11 , Issue.12 , pp. 1554-1563
    • Ohashi, T.1
  • 58
    • 77956881990 scopus 로고    scopus 로고
    • D4S234E, a novel p53-responsive gene, induces apoptosis in response to DNA damage
    • Kudoh, T., et al., D4S234E, a novel p53-responsive gene, induces apoptosis in response to DNA damage. Exp Cell Res, 2010. 316(17): p. 2849-58.
    • (2010) Exp Cell Res , vol.316 , Issue.17 , pp. 2849-2858
    • Kudoh, T.1
  • 59
    • 0034632671 scopus 로고    scopus 로고
    • PRB and p107 have distinct effects when expressed in pRB-deficient tumor cells at physiologically relevant levels
    • Jiang H., et al., pRB and p107 have distinct effects when expressed in pRB-deficient tumor cells at physiologically relevant levels. Oncogene, 2000. 19(34): p. 3878-87.
    • (2000) Oncogene , vol.19 , Issue.34 , pp. 3878-3887
    • Jiang, H.1
  • 60
    • 0242495787 scopus 로고    scopus 로고
    • Identification of target genes of the p16INK4A-pRB-E2F pathway
    • Vernell, R., K. Helin, and H. Muller, Identification of target genes of the p16INK4A-pRB-E2F pathway. J Biol Chem, 2003. 278(46): p. 46124-37.
    • (2003) J Biol Chem , vol.278 , Issue.46 , pp. 46124-46137
    • Vernell, R.1    Helin, K.2    Muller, H.3
  • 61
    • 80051748549 scopus 로고    scopus 로고
    • RB restricts DNA damage-initiated tumorigenesis through an LXCXE- dependent mechanism of transcriptional control
    • Bourgo, R.J., et al., RB restricts DNA damage-initiated tumorigenesis through an LXCXE- dependent mechanism of transcriptional control. Mol Cell, 2011. 43(4): p. 663-72.
    • (2011) Mol Cell , vol.43 , Issue.4 , pp. 663-672
    • Bourgo, R.J.1
  • 62
    • 0038615915 scopus 로고    scopus 로고
    • Impact of p53 knockout and topotecan treatment on gene expression profiles in human colon carcinoma cells: A pharmacogenomic study
    • Daoud, S.S., et al., Impact of p53 knockout and topotecan treatment on gene expression profiles in human colon carcinoma cells: a pharmacogenomic study. Cancer Res, 2003. 63(11): p. 2782-93.
    • (2003) Cancer Res , vol.63 , Issue.11 , pp. 2782-2793
    • Daoud, S.S.1
  • 63
    • 33846474121 scopus 로고    scopus 로고
    • G-protein-coupled receptors and cancer
    • Dorsam, R.T. and J.S. Gutkind, G-protein-coupled receptors and cancer. Nat Rev Cancer, 2007. 7(2): p. 79-94.
    • (2007) Nat Rev Cancer , vol.7 , Issue.2 , pp. 79-94
    • Dorsam, R.T.1    Gutkind, J.S.2
  • 64
    • 84890899629 scopus 로고    scopus 로고
    • Treatment of BRAF-mutant melanoma: The role of vemurafenib and other therapies
    • Jang, S. and M.B. Atkins, Treatment of BRAF-mutant melanoma: the role of vemurafenib and other therapies. Clin Pharmacol Ther, 2014. 95(1): p. 24-31.
    • (2014) Clin Pharmacol Ther , vol.95 , Issue.1 , pp. 24-31
    • Jang, S.1    Atkins, M.B.2
  • 65
    • 34548427346 scopus 로고    scopus 로고
    • Tiling resolution array comparative genomic hybridization, expression and methylation analyses of dup(1q) in Burkitt lymphomas and pediatric high hyperdiploid acute lymphoblastic leukemias reveal clustered near-centromeric breakpoints and overexpression of genes in 1q22-32.3
    • Davidsson, J., et al., Tiling resolution array comparative genomic hybridization, expression and methylation analyses of dup(1q) in Burkitt lymphomas and pediatric high hyperdiploid acute lymphoblastic leukemias reveal clustered near-centromeric breakpoints and overexpression of genes in 1q22-32.3. Hum Mol Genet, 2007. 16(18): p. 2215-25.
    • (2007) Hum Mol Genet , vol.16 , Issue.18 , pp. 2215-2225
    • Davidsson, J.1
  • 66
    • 71549128693 scopus 로고    scopus 로고
    • RGS16 is a marker for prognosis in colorectal cancer
    • Miyoshi, N., et al., RGS16 is a marker for prognosis in colorectal cancer. Ann Surg Oncol, 2009. 16(12): p. 3507-14.
    • (2009) Ann Surg Oncol , vol.16 , Issue.12 , pp. 3507-3514
    • Miyoshi, N.1
  • 67
    • 25144469506 scopus 로고    scopus 로고
    • The retinoid anticancer signal: Mechanisms of target gene regulation
    • Liu, T., et al., The retinoid anticancer signal: mechanisms of target gene regulation. Br J Cancer, 2005. 93(3): p. 310-8.
    • (2005) Br J Cancer , vol.93 , Issue.3 , pp. 310-318
    • Liu, T.1
  • 68
    • 84878964098 scopus 로고    scopus 로고
    • Crosstalk between lysine-specific demethylase 1 (LSD1) and histone deacetylases mediates antineoplastic efficacy of HDAC inhibitors in human breast cancer cells
    • Vasilatos, S.N., et al., Crosstalk between lysine-specific demethylase 1 (LSD1) and histone deacetylases mediates antineoplastic efficacy of HDAC inhibitors in human breast cancer cells. Carcinogenesis, 2013. 34(6): p. 1196-207.
    • (2013) Carcinogenesis , vol.34 , Issue.6 , pp. 1196-1207
    • Vasilatos, S.N.1
  • 69
    • 0041845007 scopus 로고    scopus 로고
    • Role of regulator of G protein signaling 16 in inflammation-induced T lymphocyte migration and activation
    • Lippert, E., et al., Role of regulator of G protein signaling 16 in inflammation-induced T lymphocyte migration and activation. J Immunol, 2003. 171(3): p. 1542-55.
    • (2003) J Immunol , vol.171 , Issue.3 , pp. 1542-1555
    • Lippert, E.1
  • 70
    • 84862613676 scopus 로고    scopus 로고
    • RGS16 attenuates pulmonary Th2/Th17 inflammatory responses
    • Shankar, S.P., et al., RGS16 attenuates pulmonary Th2/Th17 inflammatory responses. J Immunol, 2012. 188(12): p. 6347-56.
    • (2012) J Immunol , vol.188 , Issue.12 , pp. 6347-6356
    • Shankar, S.P.1
  • 71
    • 0035874879 scopus 로고    scopus 로고
    • Inhibition of epidermal growth factorinduced RhoA translocation and invasion of human pancreatic cancer cells by 3-hydroxy-3-methylglutarylcoenzyme a reductase inhibitors
    • Kusama, T., et al., Inhibition of epidermal growth factorinduced RhoA translocation and invasion of human pancreatic cancer cells by 3-hydroxy-3-methylglutarylcoenzyme a reductase inhibitors. Cancer Res, 2001. 61(12): p. 4885-91.
    • (2001) Cancer Res , vol.61 , Issue.12 , pp. 4885-4891
    • Kusama, T.1
  • 72
    • 33644758292 scopus 로고    scopus 로고
    • Control of cell migration: A tumour suppressor function for p53?
    • Roger, L., G. Gadea, and P. Roux, Control of cell migration: a tumour suppressor function for p53? Biol Cell, 2006. 98(3): p. 141-52.
    • (2006) Biol Cell , vol.98 , Issue.3 , pp. 141-152
    • Roger, L.1    Gadea, G.2    Roux, P.3
  • 73
    • 33845325491 scopus 로고    scopus 로고
    • Wild-type p53 inhibits nuclear factor-kappaBinduced matrix metalloproteinase-9 promoter activation: Implications for soft tissue sarcoma growth and metastasis
    • Liu, J., et al., Wild-type p53 inhibits nuclear factor-kappaBinduced matrix metalloproteinase-9 promoter activation: implications for soft tissue sarcoma growth and metastasis. Mol Cancer Res, 2006. 4(11): p. 803-10.
    • (2006) Mol Cancer Res , vol.4 , Issue.11 , pp. 803-810
    • Liu, J.1
  • 74
    • 0032815816 scopus 로고    scopus 로고
    • Human metalloproteinase-1 (Collagenase-1) is a tumor suppressor protein p53 target gene
    • Sun, Y., et al., Human metalloproteinase-1 (collagenase-1) is a tumor suppressor protein p53 target gene. Ann N Y Acad Sci, 1999. 878: p. 638-41.
    • (1999) Ann N Y Acad Sci , vol.878 , pp. 638-641
    • Sun, Y.1
  • 75
    • 0033597213 scopus 로고    scopus 로고
    • P53 down-regulates human matrix metalloproteinase-1 (Collagenase-1) gene expression
    • Sun Y., et al., p53 down-regulates human matrix metalloproteinase-1 (Collagenase-1) gene expression. J Biol Chem, 1999. 274(17): p. 11535-40.
    • (1999) J Biol Chem , vol.274 , Issue.17 , pp. 11535-11540
    • Sun, Y.1
  • 76
    • 73249152867 scopus 로고    scopus 로고
    • A role for p53 in the regulation of extracellular matrix metalloproteinase inducer in human cancer cells
    • Zhu, H., et al., A role for p53 in the regulation of extracellular matrix metalloproteinase inducer in human cancer cells. Cancer Biol Ther, 2009. 8(18): p. 1722-8.
    • (2009) Cancer Biol Ther , vol.8 , Issue.18 , pp. 1722-1728
    • Zhu, H.1
  • 77
    • 78751481791 scopus 로고    scopus 로고
    • Rb/E2F regulates expression of neogenin during neuronal migration
    • Andrusiak, M.G., et al., Rb/E2F regulates expression of neogenin during neuronal migration. Mol Cell Biol, 2011. 31(2): p. 238-47.
    • (2011) Mol Cell Biol , vol.31 , Issue.2 , pp. 238-247
    • Andrusiak, M.G.1
  • 78
    • 84891868134 scopus 로고    scopus 로고
    • Rb suppresses collective invasion, circulation and metastasis of breast cancer cells in CD44-dependent manner
    • Kim, K.J., et al., Rb suppresses collective invasion, circulation and metastasis of breast cancer cells in CD44-dependent manner. PLoS One, 2013. 8(12): p. e80590.
    • (2013) Plos One , vol.8 , Issue.12
    • Kim, K.J.1
  • 79
    • 84862907531 scopus 로고    scopus 로고
    • Regulation of matrix metalloproteinase genes by E2F transcription factors: Rb-Raf-1 interaction as a novel target for metastatic disease
    • Johnson, J.L., et al., Regulation of matrix metalloproteinase genes by E2F transcription factors: Rb-Raf-1 interaction as a novel target for metastatic disease. Cancer Res, 2012. 72(2): p. 516-26.
    • (2012) Cancer Res , vol.72 , Issue.2 , pp. 516-526
    • Johnson, J.L.1
  • 80
    • 77953708565 scopus 로고    scopus 로고
    • Non-canonical functions of RGS proteins
    • Sethakorn, N., D.M. Yau, and N.O. Dulin, Non-canonical functions of RGS proteins. Cell Signal, 2010. 22(9): p. 1274-81.
    • (2010) Cell Signal , vol.22 , Issue.9 , pp. 1274-1281
    • Sethakorn, N.1    Yau, D.M.2    Dulin, N.O.3
  • 81
    • 0032564357 scopus 로고    scopus 로고
    • The cancer growth suppressor gene mda-7 selectively induces apoptosis in human breast cancer cells and inhibits tumor growth in nude mice
    • Su, Z.Z., et al., The cancer growth suppressor gene mda-7 selectively induces apoptosis in human breast cancer cells and inhibits tumor growth in nude mice. Proc Natl Acad Sci U S A, 1998. 95(24): p. 14400-5.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , Issue.24 , pp. 14400-14405
    • Su, Z.Z.1
  • 82
    • 76349119006 scopus 로고    scopus 로고
    • Eradication of therapy-resistant human prostate tumors using an ultrasound- guided site-specific cancer terminator virus delivery approach
    • Greco, A., et al., Eradication of therapy-resistant human prostate tumors using an ultrasound- guided site-specific cancer terminator virus delivery approach. Mol Ther, 2010. 18(2): p. 295-306.
    • (2010) Mol Ther , vol.18 , Issue.2 , pp. 295-306
    • Greco, A.1
  • 83
    • 84861636293 scopus 로고    scopus 로고
    • Targeting a newly established spontaneous feline fibrosarcoma cell line by gene transfer
    • Nande, R., et al., Targeting a newly established spontaneous feline fibrosarcoma cell line by gene transfer. PLoS One, 2012. 7(5): p. e37743.
    • (2012) Plos One , vol.7 , Issue.5
    • Nande, R.1
  • 84
    • 0035942271 scopus 로고    scopus 로고
    • Significance analysis of microarrays applied to the ionizing radiation response
    • Tusher, V.G., R. Tibshirani, and G. Chu, Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci U S A, 2001. 98(9): p. 5116-21.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , Issue.9 , pp. 5116-5121
    • Tusher, V.G.1    Tibshirani, R.2    Chu, G.3
  • 85
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak, K.J. and T.D. Schmittgen, Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods, 2001. 25(4): p. 402-8.
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 86
    • 35148832569 scopus 로고    scopus 로고
    • Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up- regulation of TWIST gene expression
    • Lo, H.W., et al., Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up- regulation of TWIST gene expression. Cancer Res, 2007. 67(19): p. 9066-76.
    • (2007) Cancer Res , vol.67 , Issue.19 , pp. 9066-9076
    • Lo, H.W.1
  • 87
    • 0036832606 scopus 로고    scopus 로고
    • Induction of cancer cell migration by epidermal growth factor is initiated by specific phosphorylation of tyrosine 1248 of c-erbB-2 receptor via EGFR
    • Dittmar, T., et al., Induction of cancer cell migration by epidermal growth factor is initiated by specific phosphorylation of tyrosine 1248 of c-erbB-2 receptor via EGFR. FASEB J, 2002. 16(13): p. 1823-5.
    • (2002) FASEB J , vol.16 , Issue.13 , pp. 1823-1825
    • Dittmar, T.1
  • 88
    • 0034621967 scopus 로고    scopus 로고
    • Growth factor-dependent activation of the Ras-Raf-MEK-MAPK pathway in the human pancreatic carcinoma cell line PANC-1 carrying activated K-ras: Implications for cell proliferation and cell migration
    • Giehl, K., et al., Growth factor-dependent activation of the Ras-Raf-MEK-MAPK pathway in the human pancreatic carcinoma cell line PANC-1 carrying activated K-ras: implications for cell proliferation and cell migration. Oncogene, 2000. 19(25): p. 2930-42.
    • (2000) Oncogene , vol.19 , Issue.25 , pp. 2930-2942
    • Giehl, K.1
  • 89
    • 77951710240 scopus 로고    scopus 로고
    • Phenotype and genotype of pancreatic cancer cell lines
    • Deer, E.L., et al., Phenotype and genotype of pancreatic cancer cell lines. Pancreas, 2010. 39(4): p. 425-35.
    • (2010) Pancreas , vol.39 , Issue.4 , pp. 425-435
    • Deer, E.L.1
  • 90
    • 30344439138 scopus 로고    scopus 로고
    • Simultaneous targeting of the epidermal growth factor receptor and cyclooxygenase-2 pathways for pancreatic cancer therapy
    • Ali, S., et al., Simultaneous targeting of the epidermal growth factor receptor and cyclooxygenase-2 pathways for pancreatic cancer therapy. Mol Cancer Ther, 2005. 4(12): p. 1943-51.
    • (2005) Mol Cancer Ther , vol.4 , Issue.12 , pp. 1943-1951
    • Ali, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.