The retinoid anticancer signal: Mechanisms of target gene regulation

British Journal of Cancer

Volumn 93, Issue 3, 2005, Pages 310-318

  Liu, T ^a   Bohlken, A ^a   Kuljaca, S ^a   Lee, M ^a   Nguyen, T ^a   Smith, S ^a   Cheung, B ^a   Morris, M D ^a   Haber, M ^a   Holloway, A J ^b   Bowtell, D D L ^b   Marshall, G M ^a,c  

^a CHILDREN S CANCER INSTITUTE AUSTRALIA FOR MEDICAL RESEARCH   (Australia)

^b PETER MACCALLUM CANCER CENTRE   (Australia)

^c SYDNEY CHILDREN'S HOSPITAL   (Australia)

Author keywords

Gene expression profiling; Neuroblastoma; Retinoid; Retinoid signalling

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ANTINEOPLASTIC AGENT; COMPLEMENTARY DNA; CYTOCHROME P450; CYTOCHROME P450 26A1; EARLY GROWTH RESPONSE FACTOR 1; HISTONE; HISTONE DEACETYLASE INHIBITOR; ISOTRETINOIN; MITOGEN ACTIVATED PROTEIN KINASE; RAR BETA2 PROTEIN; RETINOIC ACID; RETINOID; TRICHOSTATIN A; UNCLASSIFIED DRUG; PRIMER DNA; SMALL INTERFERING RNA;

ACETYLATION; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL LINE; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA METHYLATION; DNA MICROARRAY; GENE CONTROL; GENE EXPRESSION; GENE EXPRESSION PROFILING; GROWTH INHIBITION; HUMAN; HUMAN CELL; LUNG CANCER; MOUSE; NEUROBLASTOMA; NEUROBLASTOMA CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; ANIMAL; COMPARATIVE STUDY; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; IMMUNOBLOTTING; NEOPLASM; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; DNA PRIMERS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOBLOTTING; MICE; MICE, TRANSGENIC; NEOPLASMS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RETINOIDS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 25144469506     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6602700     Document Type: Article

References (31)

1. Altucci L, Gronemeyer H (2001) The promise of retinoids to fight against cancer. Nat Rev Cancer 1: 181-193
2. Balmer JE, Blomhoff R (2002) Gene expression regulation by retinoic acid. J Lipid Res 43: 1773-1808
3. Becker EW (2004) Relevance of the kinetic equilibrium of forces to the control of the cell cycle by Ras proteins. Biol Chem 385: 41-47
4. Bordow SB, Norris MD, Haber PS, Marshall GM, Haber M (1998) Prognostic significance of MYCN oncogene expression in childhood neuroblastoma. J Clin Oncol 16: 3286-3294
5. Boussioutas A, Li H, Liu J, Waring P, Lade S, Holloway AJ, Taupin D, Gorringe K, Haviv I, Desmond PV, Bowtell DD (2003) Distinctive patterns of gene expression in premalignant gastric mucosa and gastric cancer. Cancer Res 63: 2569-2577
6. Buckbinder L, Velasco-Miguel S, Chen Y, Xu N, Talbott R, Gelbert L, Gao J, Seizinger BR, Gutkind JS, Kley N (1997) The p53 tumor suppressor targets a novel regulator of G protein signaling. Proc Natl Acad Sci USA 94: 7868-7872
7. Burkhart CA, Cheng AJ, Madafiglio J, Kavallaris M, Mili M, Marshall GM, Weiss WA, Khachigian LM, Morris MD, Haber M (2003) Effects of MYCN antisense oligonucleotide administration on tumorigenesis in a murine model of neuroblastoma. J Natl Cancer Inst 95: 1394-1403
8. Chambon P (1996) A decade of molecular biology of retinoic acid receptors. FASEB J 10: 940-954
9. Chen C, Wang H, Pong CW, Lin SC (2001) Multiple phosphorylation sites in RGS16 differentially modulate its GAP activity. FEBS Lett 504: 16-22
10. Cheung B, Hocker JE, Smith SA, Norris MD, Haber M, Marshall GM (1998) Favorable prognostic significance of high-level retinoic acid receptor beta expression in neuroblastoma mediated by effects on cell cycle regulation. Oncogene 17: 751-759
11. Cheung B, Yan J, Smith SA, Nguyen T, Lee M, Kavallaris M, Norris MD, Haber M, Marshall GM (2003) Growth inhibitory retinoid effects after recruitment of retinoid X receptor beta to the retinoic acid receptor beta promoter. Int J Cancer 105: 856-867
12. Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T (2001) Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411: 494-498
13. Evans TR, Kaye SB (1999) Retinoids: present role and future potential. Br J Cancer 80: 1-8
14. Freeman WM, Walker SJ, Vrana KE (1999) Quantitative RT-PCR: pitfalls and potential. Biotechniques 26: 112-122
15. Freemantle SJ, Spinella MJ, Dmitrovsky E (2003) Retinoids in cancer therapy and chemoprevention: promise meets resistance. Oncogene 22: 7305-7315
16. Furukawa T, Horii A (2004) Molecular pathology of pancreatic cancer: in quest of tumor suppressor genes. Pancreas 28: 253-256
17. Furukawa T, Sunamura M, Motoi F, Matsuno S, Horii A (2003) Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer. Am J Pathol 162: 1807-1815
18. Groom LA, Sneddon AA, Alessi DR, Dowd S, Keyse SM (1996) Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase. EMBO J 15: 3621-3632
19. Houle B, Rochette-Egly C, Bradley WE (1993) Tumor-suppressive effect of the retinoic acid receptor beta in human epidermoid lung cancer cells. Proc Natl Acad Sci USA 90: 985-989
20. Hunter T (1995) Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. Cell 80: 225-236
21. Matthay KK, Villablanca JG, Seeger RC, Stram DO, Harris RE, Ramsay NK, Swift P, Shimada H, Black CT, Brodeur GM, Gerbing RB, Reynolds CP (1999) Treatment of high-risk neuroblastoma with intensive chemo-therapy, radiotherapy, autologous bone marrow transplantation, and 13-cis-retinoic acid. Children's Cancer Group. N Engl J Med 341: 1165-1173
22. Nakagawa S, Fujii T, Yokoyama G, Kazanietz MG, Yamana H, Shirouzu K (2003) Cell growth inhibition by all-trans retinoic acid in SKBR-3 breast cancer cells: involvement of protein kinase C alpha and extracellular signal-regulated kinase mitogen-activated protein kinase. Mol Carcinog 38: 106-116
23. Nguyen T, Hocker JE, Thomas W, Smith SA, Norris MD, Haber M, Cheung B, Marshall GM (2003) Combined RAR alpha- and RXR-specific ligands overcome N-myc-associated retinoid resistance in neuroblastoma cells. Biochem Biophys Res Commun 302: 462-468
24. Norris MD, Bordow SB, Marshall GM, Haber PS, Cohn SL, Haber M (1996) Expression of the gene for multidrug-resistance-associated protein and outcome in patients with neuroblastoma. N Engl J Med 334: 231-238
25. Sah JF, Eckert RL, Chandraratna RA, Rorke EA (2002) Retinoids suppress epidermal growth factor-associated cell proliferation by inhibiting epidermal growth factor receptor-dependent ERK1/2 activation. J Biol Chem 277: 9728-9735
26. Sebolt-Leopold JS, Herrera R (2004) Targeting the mitogen-activated protein kinase cascade to treat cancer. Nat Rev Cancer 4: 937-947
27. Sirchia SM, Ren M, Pili R, Sironi E, Somenzi G, Ghidoni R, Toma S, Nicolo G, Sacchi N (2002) Endogenous reactivation of the RARbeta2 tumor suppressor gene epigenetically silenced in breast cancer. Cancer Res 62: 2455-2461
28. Sonneveld E, van den Brink CE, van der Leede BM, Schulkes RK, Petkovich M, van der Burg B, van der Saag PT (1998) Human retinoic acid (RA) 4-hydroxylase (CYP26) is highly specific for all-trans-RA and can be induced through RA receptors in human breast and colon carcinoma cells. Cell Growth Differ 9: 629-637
29. Suh YA, Lee HY, Virmani A, Wong J, Mann KK, Miller Jr WH, Gazdar A, Kurie JM (2002) Loss of retinoic acid receptor beta gene expression is linked to aberrant histone H3 acetylation in lung cancer cell lines. Cancer Res 62: 3945-3949
30. Sun SY, Lotan R (2002) Retinoids and their receptors in cancer development and chemoprevention. Crit Rev Oncol Hematol 41: 41-55
31. Weiss WA, Aldape K, Mohapatra G, Feuerstein BG, Bishop JM (1997) Targeted expression of MYCN causes neuroblastoma in transgenic mice. EMBO J 16: 2985-2995