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Volumn 9783642299742, Issue , 2013, Pages 395-411

Use of metabolomics and transcriptomics to gain insights into the regulation and biosynthesis of medicinal compounds: Hypericum as a model

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; GENES; MEDICINE; METABOLITES;

EID: 84949176213     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-3-642-29974-2_17     Document Type: Chapter
Times cited : (5)

References (75)
  • 1
    • 0037057564 scopus 로고    scopus 로고
    • Biosynthesis of Hyperforin in Hypericum perforatum
    • Adam P, Arigoni D, Bacher A, Eisenreich W (2002) Biosynthesis of Hyperforin in Hypericum perforatum. J Med Chem 45:4786-4793
    • (2002) J Med Chem , vol.45 , pp. 4786-4793
    • Adam, P.1    Arigoni, D.2    Bacher, A.3    Eisenreich, W.4
  • 4
    • 0042858113 scopus 로고    scopus 로고
    • Molecular and biochemical characterization of an enzyme responsible for the formation of hypericin in St. John's Wort (Hypericum perforatum L)
    • Bais HP, Vepachedu R, Lawrence CB, Stermitz FR, Vivanco JM (2003) Molecular and biochemical characterization of an enzyme responsible for the formation of hypericin in St. John's Wort (Hypericum perforatum L). J Biol Chem 278(34):32413-32422
    • (2003) J Biol Chem , vol.278 , Issue.34 , pp. 32413-32422
    • Bais, H.P.1    Vepachedu, R.2    Lawrence, C.B.3    Stermitz, F.R.4    Vivanco, J.M.5
  • 5
    • 80052394237 scopus 로고    scopus 로고
    • Predator data station: A fast data acquisition system for advanced FT-ICR MS experiments
    • Blakney GT, Hendrickson CL, Marshall AG (2011) Predator data station: a fast data acquisition system for advanced FT-ICR MS experiments. Int J Mass Spectrom 306:246-252
    • (2011) Int J Mass Spectrom , vol.306 , pp. 246-252
    • Blakney, G.T.1    Hendrickson, C.L.2    Marshall, A.G.3
  • 7
    • 79955439351 scopus 로고    scopus 로고
    • Effects of UV-B on secondary metabolites of St. John's Wort (Hypericum perforatum L) grown in controlled environments
    • Brechner ML, Albright LD, Weston LA (2011) Effects of UV-B on secondary metabolites of St. John's Wort (Hypericum perforatum L) grown in controlled environments. Photochem Photobiol 87:680-684
    • (2011) Photochem Photobiol , vol.87 , pp. 680-684
    • Brechner, M.L.1    Albright, L.D.2    Weston, L.A.3
  • 8
    • 0034124646 scopus 로고    scopus 로고
    • Comparison of an extract of Hypericum (LI 160) and sertraline in the treatment of depression: A double-blind, randomized pilot study
    • Brenner R, Azbel V, Madhusoodanan S, Pawlowska M (2000) Comparison of an extract of Hypericum (LI 160) and sertraline in the treatment of depression: a double-blind, randomized pilot study. Clin Ther 22(4):411-419
    • (2000) Clin Ther , vol.22 , Issue.4 , pp. 411-419
    • Brenner, R.1    Azbel, V.2    Madhusoodanan, S.3    Pawlowska, M.4
  • 9
    • 0037311116 scopus 로고    scopus 로고
    • Variation of glucosinolate accumulation among different organs and developmental stages of Arabidopsis thaliana
    • Brown PD, Tokuhisa JG, Reichelt M, Gershenzon J (2003) Variation of glucosinolate accumulation among different organs and developmental stages of Arabidopsis thaliana. Phytochemistry 62(3):471-481
    • (2003) Phytochemistry , vol.62 , Issue.3 , pp. 471-481
    • Brown, P.D.1    Tokuhisa, J.G.2    Reichelt, M.3    Gershenzon, J.4
  • 10
    • 0036399975 scopus 로고    scopus 로고
    • Ontogenetic variation regarding hypericin and hyperforin levels in four accessions of Hypericum perforatum L
    • &3
    • Bt' lter KB, Bt' lter B. 2002) Ontogenetic variation regarding hypericin and hyperforin levels in four accessions of Hypericum perforatum L. J Herbs Spices Med Plants 9(2&3 95-100
    • (2002) J Herbs Spices Med Plants , vol.9 , Issue.2 , pp. 95-100
    • Btlter, K.B.1    Btlter, B.2
  • 11
    • 34548442151 scopus 로고    scopus 로고
    • St John's Wort: Role of active compounds for its mechanism of action and efficacy
    • Butterweck V, Schmidt M (2007) St John's Wort: role of active compounds for its mechanism of action and efficacy. Wien Med Wochenschr 157:356-361
    • (2007) Wien Med Wochenschr , vol.157 , pp. 356-361
    • Butterweck, V.1    Schmidt, M.2
  • 12
    • 1642423554 scopus 로고    scopus 로고
    • Composition and antifungal activity of essential oils isolated from Hypericum hyssopifolium and Hypericum heterophyllum
    • Cakir A, Kordali S, Zengin H, Izumi S, Hirata T (2004) Composition and antifungal activity of essential oils isolated from Hypericum hyssopifolium and Hypericum heterophyllum. Flavour Frag J 19:62-68
    • (2004) Flavour Frag J , vol.19 , pp. 62-68
    • Cakir, A.1    Kordali, S.2    Zengin, H.3    Izumi, S.4    Hirata, T.5
  • 13
    • 55249122149 scopus 로고    scopus 로고
    • Direct profiling and imagining of plant metabolites in intact tissues by using colloidal graphiteassisted laser desorption ionization mass spectrometry
    • Cha S, Zhang H, Ilarslan HI, Wurtele ES, Libuse B, Nikolau BJ, Yeung ES (2008) Direct profiling and imagining of plant metabolites in intact tissues by using colloidal graphiteassisted laser desorption ionization mass spectrometry. Plant J 55:348-360
    • (2008) Plant J , vol.55 , pp. 348-360
    • Cha, S.1    Zhang, H.2    Ilarslan, H.I.3    Wurtele, E.S.4    Libuse, B.5    Nikolau, B.J.6    Yeung, E.S.7
  • 14
    • 0034932011 scopus 로고    scopus 로고
    • The "black nodules" of Hypericum perforatum L. subsp. perforatum: Morphological, anatomical, and histochemical studies during the course of ontogenesis
    • Ciccarelli D, Andreucci AC, Pagni AM (2001) The "black nodules" of Hypericum perforatum L. subsp. perforatum: morphological, anatomical, and histochemical studies during the course of ontogenesis. Israel J Plant Sci 49:33-40
    • (2001) Israel J Plant Sci , vol.49 , pp. 33-40
    • Ciccarelli, D.1    Andreucci, A.C.2    Pagni, A.M.3
  • 18
    • 0033850714 scopus 로고    scopus 로고
    • Current lead natural products for the chemotherapy of human immunodeficiency virus (HIV) infection
    • De Clercq E (2000) Current lead natural products for the chemotherapy of human immunodeficiency virus (HIV) infection. Med Res Rev 20:323-349
    • (2000) Med Res Rev , vol.20 , pp. 323-349
    • De Clercq, E.1
  • 21
    • 0032508952 scopus 로고    scopus 로고
    • Trends in alternative medicine use in the United States, 1990-1997: Results of a follow-up national survey
    • Eisenberg DM, Davis RB, Ettner SL (1998) Trends in alternative medicine use in the United States, 1990-1997: results of a follow-up national survey. J Am Med Assoc 280:1569-1575
    • (1998) J Am Med Assoc , vol.280 , pp. 1569-1575
    • Eisenberg, D.M.1    Davis, R.B.2    Ettner, S.L.3
  • 24
    • 0000115393 scopus 로고
    • The spectral properties of Hypericum perforatum leaves: The implications for its photoactivated defences
    • Fields P, Arnason J, Fucher R (1990) The spectral properties of Hypericum perforatum leaves: the implications for its photoactivated defences. Can J Bot 68:1166-1170
    • (1990) Can J Bot , vol.68 , pp. 1166-1170
    • Fields, P.1    Arnason, J.2    Fucher, R.3
  • 25
    • 0034912383 scopus 로고    scopus 로고
    • Plasma pharmacokinetics and cerebrospinal fluid penetration of hypericin in nonhuman primates
    • Fox E, Murphy RF, McCully CL, Adamson PC (2001) Plasma pharmacokinetics and cerebrospinal fluid penetration of hypericin in nonhuman primates. Cancer Chemother 47(1):41-44
    • (2001) Cancer Chemother , vol.47 , Issue.1 , pp. 41-44
    • Fox, E.1    Murphy, R.F.2    McCully, C.L.3    Adamson, P.C.4
  • 26
    • 84863225155 scopus 로고    scopus 로고
    • Xanthone biosynthesis in Hypericum perforatum cells provides antioxidant and antimicrobial protection upon biotic stress
    • Franklin G, Conceição LFR, Kombrink E, Dias ACP (2009) Xanthone biosynthesis in Hypericum perforatum cells provides antioxidant and antimicrobial protection upon biotic stress. Phytochemistry 70:60-68
    • (2009) Phytochemistry , vol.70 , pp. 60-68
    • Franklin, G.1    Conceição, L.F.R.2    Kombrink, E.3    Acp, D.4
  • 27
    • 46849117067 scopus 로고    scopus 로고
    • Antiinflammatory and antioxidant activity of Hypericum rumeliacum Boiss Subsp apollinis (Boiss & Heldr) Robson & Strid methanol extract
    • Galati EM, Contartese G, Miceli N, Taviano MF, Sdrafkakis V, Couladis M, Tzakou O, Lanuzza F (2008) Antiinflammatory and antioxidant activity of Hypericum rumeliacum Boiss. Subsp. apollinis (Boiss. & Heldr) Robson & Strid methanol extract. Phytother Res 22(6):766-771
    • (2008) Phytother Res , vol.22 , Issue.6 , pp. 766-771
    • Galati, E.M.1    Contartese, G.2    Miceli, N.3    Taviano, M.F.4    Sdrafkakis, V.5    Couladis, M.6    Tzakou, O.7    Lanuzza, F.8
  • 28
    • 0036278084 scopus 로고    scopus 로고
    • Hypericum perforatum-chemical profiling and quantitative results of St. John's Wort products by an improved high-performance liquid chromatography method
    • Ganzera M, Zhao J, Khan IA (2002) Hypericum perforatum-chemical profiling and quantitative results of St. John's Wort products by an improved high-performance liquid chromatography method. J Pharm Sci 91(3):623-630
    • (2002) J Pharm Sci , vol.91 , Issue.3 , pp. 623-630
    • Ganzera, M.1    Zhao, J.2    Khan, I.A.3
  • 29
    • 77951628507 scopus 로고    scopus 로고
    • Flavonoid, tannin, and hypericin concentrations in the leaves of St. John's Wort (Hypericum perforatum L) are affected by UV-B radiation levels
    • Germ M, Stibilj V, Kreft S, Gaberšc?ik A, Kreft I (2010) Flavonoid, tannin, and hypericin concentrations in the leaves of St. John's Wort (Hypericum perforatum L) are affected by UV-B radiation levels. Food Chem 122:471-474
    • (2010) Food Chem , vol.122 , pp. 471-474
    • Germ, M.1    Stibilj, V.2    Kreft, S.3    Gaberšcik, A.4    Kreft, I.5
  • 30
    • 34848845498 scopus 로고    scopus 로고
    • Inhibition of prostaglandin E2 production by anti-inflammatory Hypericum perforatum extracts and constituents in RAW264.7 mouse macrophage cells
    • Hammer KDP, Hillwig ML, Solco AKS, Dixon PM, Delate K, Murphy PA, Wurtele ES, Birt DF (2007) Inhibition of prostaglandin E2 production by anti-inflammatory Hypericum perforatum extracts and constituents in RAW264.7 mouse macrophage cells. J Agric Food Chem 55:7323-7331
    • (2007) J Agric Food Chem , vol.55 , pp. 7323-7331
    • Hammer, K.D.P.1    Hillwig, M.L.2    Solco, A.K.S.3    Dixon, P.M.4    Delate, K.5    Murphy, P.A.6    Wurtele, E.S.7    Birt, D.F.8
  • 31
    • 77950226499 scopus 로고    scopus 로고
    • Identification of JAK-STAT pathways as important for the anti-inflammatory activity of a Hypericum perforatum fraction and bioactive constituents in RAW 264.7 mouse macrophages
    • Hammer KDP, Yum M, Dixon PM, Birt DF (2010) Identification of JAK-STAT pathways as important for the anti-inflammatory activity of a Hypericum perforatum fraction and bioactive constituents in RAW 264.7 mouse macrophages. Phytochemistry 71:716-725
    • (2010) Phytochemistry , vol.71 , pp. 716-725
    • Hammer, K.D.P.1    Yum, M.2    Dixon, P.M.3    Birt, D.F.4
  • 32
    • 47349130585 scopus 로고    scopus 로고
    • Characterizing the metabolite fingerprint and anti-inflammatory activity of Hypericum gentianoides
    • HillwigML, Hammer KD, Birt DF, Wurtele ES (2008) Characterizing the metabolite fingerprint and anti-inflammatory activity of Hypericum gentianoides. J Agric Food Chem 56(12):4359-4366
    • (2008) J Agric Food Chem , vol.56 , Issue.12 , pp. 4359-4366
    • Hillwigml Hammer, K.D.1    Birt, D.F.2    Wurtele, E.S.3
  • 33
    • 79551491523 scopus 로고    scopus 로고
    • Microarray analysis of nemorosone-induced cytotoxic effects on pancreatic cancer cells reveals activation of the unfolding protein response (UPR)
    • Holtrup F, Bauer A, Fellenberg K, Hilger RA, Wink M, Hoheisel J (2011) Microarray analysis of nemorosone-induced cytotoxic effects on pancreatic cancer cells reveals activation of the unfolding protein response (UPR). Br J Pharmacol 162(5):1045-1059
    • (2011) Br J Pharmacol , vol.162 , Issue.5 , pp. 1045-1059
    • Holtrup, F.1    Bauer, A.2    Fellenberg, K.3    Hilger, R.A.4    Wink, M.5    Hoheisel, J.6
  • 34
    • 0023626547 scopus 로고
    • Saroaspidin A, B, and C: Additional antibiotic compounds from Hypericum japonicum
    • Ishiguro K, Yamaki M, Kashihara M, Takagi S (1987) Saroaspidin A, B, and C: additional antibiotic compounds from Hypericum japonicum. Planta Med 53(5):415-417
    • (1987) Planta Med , vol.53 , Issue.5 , pp. 415-417
    • Ishiguro, K.1    Yamaki, M.2    Kashihara, M.3    Takagi, S.4
  • 35
    • 64549119707 scopus 로고    scopus 로고
    • Statistical inferences for isoform expression in RNA-Seq
    • Jiang H, Wong WH (2009) Statistical inferences for isoform expression in RNA-Seq. Bioinformatics 25(8):1026-1032
    • (2009) Bioinformatics , vol.25 , Issue.8 , pp. 1026-1032
    • Jiang, H.1    Wong, W.H.2
  • 36
    • 45849140534 scopus 로고    scopus 로고
    • Protein quantification by selective isolation and fragmentation of isotopic pairs using FT-ICR M.S
    • Johnson H, Wong SCC, Simpson DM, Beynon RJ, Gaskell SJ (2008) Protein quantification by selective isolation and fragmentation of isotopic pairs using FT-ICR MS. J Am Soc Mass Spectrom 19:973-977
    • (2008) J Am Soc Mass Spectrom , vol.19 , pp. 973-977
    • Johnson, H.1    Wong, S.C.C.2    Simpson, D.M.3    Beynon, R.J.4    Gaskell, S.J.5
  • 37
    • 79952485718 scopus 로고    scopus 로고
    • Profiling of hypothalamic and hippocampal gene expression in chronically stressed rats treated with St. John's Wort extract (STW 3-VI) and fluoxetine
    • Jungke P, Ostrow G, Li JL, Norton S, Nieber K, Kelber O, Butterweck V (2011) Profiling of hypothalamic and hippocampal gene expression in chronically stressed rats treated with St. John's Wort extract (STW 3-VI) and fluoxetine. Psychopharmacology 213(4):757-772
    • (2011) Psychopharmacology , vol.213 , Issue.4 , pp. 757-772
    • Jungke, P.1    Ostrow, G.2    Li, J.L.3    Norton, S.4    Nieber, K.5    Kelber, O.6    Butterweck, V.7
  • 39
    • 49349090382 scopus 로고    scopus 로고
    • Octaketide-producing type III polyketide synthase from Hypericum perforatum is expressed in dark glands accumulating hypericins
    • Karppinen K, Hokkanen J, Mattila S, Neubauer P, Hohtola A (2008) Octaketide-producing type III polyketide synthase from Hypericum perforatum is expressed in dark glands accumulating hypericins. FEBS J 275(17):4329-4342
    • (2008) FEBS J , vol.275 , Issue.17 , pp. 4329-4342
    • Karppinen, K.1    Hokkanen, J.2    Mattila, S.3    Neubauer, P.4    Hohtola, A.5
  • 40
    • 52949111480 scopus 로고    scopus 로고
    • Continuation and long-term maintenance treatment with hypericum extract WS5570 after recovery from an acute episode of moderate depression-A double-blind, randomized, placebo controlled long-term trial
    • Kasper S, Volz HP, Moller HJ, Dienel A, Kieser M (2008) Continuation and long-term maintenance treatment with hypericum extract WS5570 after recovery from an acute episode of moderate depression-A double-blind, randomized, placebo controlled long-term trial. Eur Neuropsychopharmacol 18:803-813
    • (2008) Eur Neuropsychopharmacol , vol.18 , pp. 803-813
    • Kasper, S.1    Volz, H.P.2    Moller, H.J.3    Dienel, A.4    Kieser, M.5
  • 41
    • 1042265023 scopus 로고    scopus 로고
    • The production of hypericins and hyperforin by in vitro cultures of St. John's Wort (Hypericum perforatum)
    • Kirakosyan A, Sirvent TM, Gibson DM, Kaufman PB (2004) The production of hypericins and hyperforin by in vitro cultures of St. John's Wort (Hypericum perforatum). Biotechnol Appl Biochem 39:71-81
    • (2004) Biotechnol Appl Biochem , vol.39 , pp. 71-81
    • Kirakosyan, A.1    Sirvent, T.M.2    Gibson, D.M.3    Kaufman, P.B.4
  • 44
    • 34548533345 scopus 로고    scopus 로고
    • Regulation of metabolite production by precursors and elicitors in liquid cultures of Hypericum perforatum
    • Liu XN, Zhang XQ, Zhang SX, Sun JS (2007a) Regulation of metabolite production by precursors and elicitors in liquid cultures of Hypericum perforatum. Plant Cell Tissue Organ Cult 91:1-7
    • (2007) Plant Cell Tissue Organ Cult , vol.91 , pp. 1-7
    • Liu, X.N.1    Zhang, X.Q.2    Zhang, S.X.3    Sun, J.S.4
  • 45
    • 35448934884 scopus 로고    scopus 로고
    • Effects of cytokinins and elicitors on the production of hypericins and hyperforin metabolites in Hypericum sampsonii and Hypericum perforatum
    • Liu XN, Zhang XQ, Sun JS (2007b) Effects of cytokinins and elicitors on the production of hypericins and hyperforin metabolites in Hypericum sampsonii and Hypericum perforatum. Plant Growth Regul 53:207-214
    • (2007) Plant Growth Regul , vol.53 , pp. 207-214
    • Liu, X.N.1    Zhang, X.Q.2    Sun, J.S.3
  • 46
    • 52949096084 scopus 로고    scopus 로고
    • Next-generation DNA sequencing methods
    • Mardis ER (2008) Next-generation DNA sequencing methods. Annu Rev Genomics Human Genet 9:387-402
    • (2008) Annu Rev Genomics Human Genet , vol.9 , pp. 387-402
    • Mardis, E.R.1
  • 47
    • 2542465858 scopus 로고    scopus 로고
    • Hypericum perforatum methanolic extract inhibits growth of human prostatic carcinoma cell line orthotopically implanted in nude mice
    • Martarelli D, Martarelli B, Pediconi D, Nabissi MI, Perfumi M, Pompei P (2004) Hypericum perforatum methanolic extract inhibits growth of human prostatic carcinoma cell line orthotopically implanted in nude mice. Cancer Lett 210(1):27-33
    • (2004) Cancer Lett , vol.210 , Issue.1 , pp. 27-33
    • Martarelli, D.1    Martarelli, B.2    Pediconi, D.3    Nabissi, M.I.4    Perfumi, M.5    Pompei, P.6
  • 48
    • 2942682962 scopus 로고    scopus 로고
    • The antidepressant mechanism of Hypericum perforatum
    • Mennini T, Gobbi M (2004) The antidepressant mechanism of Hypericum perforatum. Life Sci 75:1021-1027
    • (2004) Life Sci , vol.75 , pp. 1021-1027
    • Mennini, T.1    Gobbi, M.2
  • 49
    • 0040805180 scopus 로고
    • Therapeutic agents with dramatic antiretroviral activity and little toxicity at effective doses: Aromatic polycyclic diones hypericin and pseudohypericin
    • Meruelo D, Lavie G, Lavie D (1988) Therapeutic agents with dramatic antiretroviral activity and little toxicity at effective doses: aromatic polycyclic diones hypericin and pseudohypericin. Proc Natl Acad Sci USA 85(14):5230-5234
    • (1988) Proc Natl Acad Sci USA , vol.85 , Issue.14 , pp. 5230-5234
    • Meruelo, D.1    Lavie, G.2    Lavie, D.3
  • 50
    • 72849144434 scopus 로고    scopus 로고
    • Sequencing technologies-The next generation
    • Metzker ML (2010) Sequencing technologies-the next generation. Nat Rev Genet 11(1):31-46
    • (2010) Nat Rev Genet , vol.11 , Issue.1 , pp. 31-46
    • Metzker, M.L.1
  • 53
    • 48249155450 scopus 로고    scopus 로고
    • The leaf epidermome of Catharanthus roseus reveals its biochemical specialization
    • Murata J, Roepke J, Gordon H, De Luca V (2008) The leaf epidermome of Catharanthus roseus reveals its biochemical specialization. Plant Cell 20:524-542
    • (2008) Plant Cell , vol.20 , pp. 524-542
    • Murata, J.1    Roepke, J.2    Gordon, H.3    De Luca, V.4
  • 54
    • 2542624510 scopus 로고    scopus 로고
    • In vitro propagation of some important Chinese medicinal plants and their sustainable usage
    • Nalawade SM, Tsay HS (2004) In vitro propagation of some important Chinese medicinal plants and their sustainable usage. In Vitro Cell Dev Biol Plant 40(2):143-154
    • (2004) Vitro Cell Dev Biol Plant , vol.40 , Issue.2 , pp. 143-154
    • Nalawade, S.M.1    Tsay, H.S.2
  • 56
    • 78751570979 scopus 로고    scopus 로고
    • RNA sequencing: Advances, challenges and opportunities
    • Ozsolak F, Milos PM (2011) RNA sequencing: advances, challenges and opportunities. Nat Rev Genet 12(2):87-98
    • (2011) Nat Rev Genet , vol.12 , Issue.2 , pp. 87-98
    • Ozsolak, F.1    Milos, P.M.2
  • 57
    • 85193194347 scopus 로고    scopus 로고
    • Formulations of St
    • John's Wort oil ointment and evaluation of its antibacterial effect Accessed 15 June 2011
    • Peeva-Naumovska V, Panovski N, Grdanovska T, Fredro-Kumbaradzi E (2010) Formulations of St. John's Wort oil ointment and evaluation of its antibacterial effect. AMAPSEEC. www.amapseec.org/cmapseec.1/Papers/papp067.htm. Accessed 15 June 2011
    • (2010) AMAPSEEC
    • Peeva-Naumovska, V.1    Panovski, N.2    Grdanovska, T.3    Fredro-Kumbaradzi, E.4
  • 58
    • 0031055425 scopus 로고    scopus 로고
    • Alkamide levels in Echinacea purpurea: A rapid analytical method revealing differences among roots, rhizomes, stems, leaves and flowers
    • Perry NB, Van Klink JW, Burgess EJ, Parmenter GA (1997) Alkamide levels in Echinacea purpurea: a rapid analytical method revealing differences among roots, rhizomes, stems, leaves and flowers. Planta Med 63(1):58-62
    • (1997) Planta Med , vol.63 , Issue.1 , pp. 58-62
    • Perry, N.B.1    Van Klink, J.W.2    Burgess, E.J.3    Parmenter, G.A.4
  • 60
    • 0025802148 scopus 로고
    • Antiviral therapy of HIV infection
    • Richman DD (1991) Antiviral therapy of HIV infection. Annu Rev Med 42:69-90
    • (1991) Annu Rev Med , vol.42 , pp. 69-90
    • Richman, D.D.1
  • 61
    • 77956651667 scopus 로고    scopus 로고
    • A review of the antibacterial activity of Hypericum perforatum L
    • Saddiqe Z, Naeem I, Maimoona A (2010) A review of the antibacterial activity of Hypericum perforatum L. J Ethnopharmacol 131:511-521
    • (2010) J Ethnopharmacol , vol.131 , pp. 511-521
    • Saddiqe, Z.1    Naeem, I.2    Maimoona, A.3
  • 63
    • 0036176775 scopus 로고    scopus 로고
    • Phototoxic and apoptosis-inducing capacity of pseudohypericin
    • Schempp CM, Simon-Haarhaus B, Simon JC (2002b) Phototoxic and apoptosis-inducing capacity of pseudohypericin. Planta Med 68(2):171-173
    • (2002) Planta Med , vol.68 , Issue.2 , pp. 171-173
    • Schempp, C.M.1    Simon-Haarhaus, B.2    Simon, J.C.3
  • 64
    • 0037911532 scopus 로고    scopus 로고
    • Topical treatment of atopic dermatitis with St. John's Wort cream-A randomized, placebo controlled, double blind half-side comparison
    • Schempp CM, Windeck T, Hezel S, Simon JC (2003) Topical treatment of atopic dermatitis with St. John's Wort cream-A randomized, placebo controlled, double blind half-side comparison. Phytomed Suppl 4:31-37
    • (2003) Phytomed Suppl , vol.4 , pp. 31-37
    • Schempp, C.M.1    Windeck, T.2    Hezel, S.3    Simon, J.C.4
  • 65
    • 33646509647 scopus 로고    scopus 로고
    • Evaluation of the light-sensitive cytotoxicity of Hypericum perforatum extracts, fractions, and pure compounds
    • Schmitt LA, Liu Y, Murphy PA, Birt DF (2006) Evaluation of the light-sensitive cytotoxicity of Hypericum perforatum extracts, fractions, and pure compounds. J Agric Food Chem 54: 2681-2890
    • (2006) J Agric Food Chem , vol.54 , pp. 2681-2890
    • Schmitt, L.A.1    Liu, Y.2    Murphy, P.A.3    Birt, D.F.4
  • 67
    • 37749031255 scopus 로고    scopus 로고
    • Next-generation sequencing transforms today's biology
    • Schuster SC (2008) Next-generation sequencing transforms today's biology. Nat Methods 5(1):16-18
    • (2008) Nat Methods , vol.5 , Issue.1 , pp. 16-18
    • Schuster, S.C.1
  • 68
    • 75249084792 scopus 로고    scopus 로고
    • Use of herbal products and potential interactions in patients with cardiovascular diseases
    • Tachjian A, Maria V, Jahangir A (2010) Use of herbal products and potential interactions in patients with cardiovascular diseases. J Am Coll Cordiol 55(6):515-525
    • (2010) J Am Coll Cordiol , vol.55 , Issue.6 , pp. 515-525
    • Tachjian, A.1    Maria, V.2    Jahangir, A.3
  • 70
    • 65449136284 scopus 로고    scopus 로고
    • TopHat: Discovering splice junctions with RNA-Seq
    • Trapnell C, Pachter L, Salzberg SL (2009) TopHat: discovering splice junctions with RNA-Seq. Bioinformatics 25(9):1105-1111
    • (2009) Bioinformatics , vol.25 , Issue.9 , pp. 1105-1111
    • Trapnell, C.1    Pachter, L.2    Salzberg, S.L.3
  • 72
    • 23044443597 scopus 로고    scopus 로고
    • Photogenotoxicity of hypericin in HaCaT keratinocytes: Implications for St. John's Wort supplements and high dose UVA-1 therapy
    • Traynor NJ, Beattie PE, Ibbotson SH, Moseley H, Ferguson J, Woods JA (2005) Photogenotoxicity of hypericin in HaCaT keratinocytes: implications for St. John's Wort supplements and high dose UVA-1 therapy. Toxicol Lett 158:220-224
    • (2005) Toxicol Lett , vol.158 , pp. 220-224
    • Traynor, N.J.1    Beattie, P.E.2    Ibbotson, S.H.3    Moseley, H.4    Ferguson, J.5    Woods, J.A.6
  • 74
    • 79957921486 scopus 로고    scopus 로고
    • Improvement of tropane alkaloids production in hairy root cultures of Atropa belladonna by overexpressing pmt and h6h genes
    • Yang C, Chen M, Zeng L, Zhang L, Liu X, Lan X, Tang K, Liao Z (2011) Improvement of tropane alkaloids production in hairy root cultures of Atropa belladonna by overexpressing pmt and h6h genes. Plant Omics 4(1):29-33
    • (2011) Plant Omics , vol.4 , Issue.1 , pp. 29-33
    • Yang, C.1    Chen, M.2    Zeng, L.3    Zhang, L.4    Liu, X.5    Lan, X.6    Tang, K.7    Liao, Z.8
  • 75
    • 79958853083 scopus 로고    scopus 로고
    • Hypericum lanceolatum (Hypericaceae) as a potential source of new anti-malarial agents: A bioassayguided fractionation of the stem bark
    • Zofou D, Kowa TK, Wabo HK, Ngemenya MN, Tane P, Titanji VPK (2011) Hypericum lanceolatum (Hypericaceae) as a potential source of new anti-malarial agents: a bioassayguided fractionation of the stem bark. Malar J 10:167
    • (2011) Malar J , vol.10 , pp. 167
    • Zofou, D.1    Kowa, T.K.2    Wabo, H.K.3    Ngemenya, M.N.4    Tane, P.5    Vpk, T.6


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