Microarray analysis of nemorosone-induced cytotoxic effects on pancreatic cancer cells reveals activation of the unfolded protein response (UPR)

British Journal of Pharmacology

Volumn 162, Issue 5, 2011, Pages 1045-1059

  Holtrup, Frank ^a,b   Bauer, Andrea ^a   Fellenberg, Kurt ^c   Hilger, Ralf A ^d   Wink, Michael ^b   Hoheisel, Jörg D ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

endoplasmic reticulum stress; mitochondrial membrane potential; nemorosone; pancreatic cancer; polycyclic polyprenylated acylphloroglucinols; unfolded protein response

Indexed keywords

ANTINEOPLASTIC AGENT; CALCIUM; CASPASE; CYTOCHROME C; NEMOROSONE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CANCER CELL; CANCER INHIBITION; CELL ASSAY; CELL PROLIFERATION; CONTROLLED STUDY; CYTOSOL; DNA DAMAGE; DRUG CYTOTOXICITY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME ASSAY; ENZYME RELEASE; FIBROBLAST; GENE EXPRESSION PROFILING; GENE SILENCING; HUMAN; HUMAN CELL; MICROARRAY ANALYSIS; MITOCHONDRIAL MEMBRANE POTENTIAL; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN FOLDING; RNA ISOLATION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BASE SEQUENCE; BENZOPHENONES; CALCIUM; CASPASES; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CYTOCHROMES C; DRUG SCREENING ASSAYS, ANTITUMOR; ENDOPLASMIC RETICULUM; GENE EXPRESSION PROFILING; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PANCREATIC NEOPLASMS; RNA INTERFERENCE; RNA, SMALL INTERFERING; STRESS, PHYSIOLOGICAL; TRANSCRIPTION FACTOR CHOP; UNFOLDED PROTEIN RESPONSE;

EID: 79551491523     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.01125.x     Document Type: Article

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