Hypericum perforatum treatment: Effect on behaviour and neurogenesis in a chronic stress model in mice

BMC Complementary and Alternative Medicine

Volumn 11, Issue , 2011, Pages

  Crupi, Rosalia ^a   Mazzon, Emanuela ^b   Marino, Angela ^c   La Spada, Giuseppina ^c   Bramanti, Placido ^b   Battaglia, Fortunato ^d   Cuzzocrea, Salvatore ^a,b   Spina, Edoardo ^a,b  

^a UNIVERSITY OF MESSINA   (Italy)

^b IRCCS CENTRO NEUROLESI BONINO PULEJO   (Italy)

^c UNIVERSITY OF MESSINA   (Italy)

^d NewYork Presbyterian Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; CORTICOSTERONE; DOUBLECORTIN; HYPERICUM PERFORATUM EXTRACT; PLANT EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY DISORDER; ARTICLE; BEHAVIOR; BEHAVIOR CHANGE; CELL LABELING; CELL PROLIFERATION; CHRONIC STRESS; CONTROLLED STUDY; DENDRITIC SPINE; DENTATE GYRUS; DEPRESSION; FEEDING; FORCED SWIMMING TEST; GOLGI COMPLEX; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NONHUMAN; OPEN FIELD BEHAVIOR; STEREOMETRY; TREATMENT DURATION; ANIMAL; ANIMAL BEHAVIOR; ANXIETY; CHEMICALLY INDUCED DISORDER; DENDRITE; DISEASE MODEL; DRUG EFFECT; HYPERICUM; MOUSE STRAIN; PHYSIOLOGICAL STRESS; PHYTOTHERAPY; STEM CELL;

ANIMALS; ANXIETY; BEHAVIOR, ANIMAL; CELL PROLIFERATION; CORTICOSTERONE; DENDRITES; DEPRESSION; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; HYPERICUM; MALE; MICE; MICE, INBRED STRAINS; NEUROGENESIS; PHYTOTHERAPY; PLANT EXTRACTS; STEM CELLS; STRESS, PHYSIOLOGICAL;

EID: 79251553447     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-11-7     Document Type: Article

References (57)

1. Miller AL. St. John's Wort (Hypericum perforatum): clinical effects on depression and other conditions. Altern Med Rev 1998, 3:18-26.
2. Shelton RC. St John's wort (Hypericum perforatum) in major depression. J Clin Psychiatry 2009, 5:23-7.
3. Kasper S, Gastpar M, Müller WE, Volz HP, Dienel A, Kieser M, Möller HJ. Efficacy of St. John's wort extract WS 5570 in acute treatment of mild depression: a reanalysis of data from controlled clinical trials. Eur Arch Psychiatry Clin Neurosci 2008, 258:59-63. 10.1007/s00406-007-0779-2, 18084790.
4. Langosch JM, Zhou XY, Heinen M, Kupferschmid S, Chatterjee SS, Noldner M, Walden J. St John's wort (Hypericum perforatum) modulates evoked potentials in guinea pig hippocampal slices via AMPA and GABA receptors. Eur Neuropsychopharmacol 2002, 12:209-16. 10.1016/S0924-977X(02)00022-6, 12007672.
5. Di Paola R, Mazzon E, Muià C, Crisafulli C, Genovese T, Di Bella P, Esposito E, Menegazzi M, Meli R, Suzuki H, Cuzzocrea S. Protective effect of Hypericum perforatum in zymosan-induced multiple organ dysfunction syndrome: relationship to its inhibitory effect on nitric oxide production and its peroxynitrite scavenging activity. Nitric Oxide 2007, 16:118-30. 10.1016/j.niox.2006.05.006, 16889996.
6. Butterweck V, Schmidt M. St. John's wort: role of active compounds for its mechanism of action and efficacy. Wien Med Wochenschr 2007, 157:356-61. 10.1007/s10354-007-0440-8, 17704987.
7. Muller WE, Rolli M, Schafer C, Hafner U. Effects of hypericum extract (LI 160) in biochemical models of antidepressant activity. Pharmacopsychiatry 1997, 30:102-7. 10.1055/s-2007-979528, 9342769.
8. Wonnemann M, Singer A, Muller WE. Inhibition of synaptosomal uptake of 3H-l-glutamate and 3H-GABA by hyperforin, a major constituent of St. John's wort: the role of amiloride sensitive sodium conductive pathways. Neuropsychopharmacol 2000, 23:188-97.
9. Masood A, Banerjee B, Vijayan VK, Ray A. Modulation of stress-induced neurobehavioral changes by nitric oxide in rats. Eur J Pharmacol 2003, 458:135-9. 10.1016/S0014-2999(02)02688-2, 12498917.
10. Masood A, Banerji B, Vijayan VK, Ray A. Pharmacological and biochemical studies on the possible role of nitric oxide in stress adaptation in rats. Eur J Pharmacol 2004, 493:111-5. 10.1016/j.ejphar.2004.04.018, 15189771.
11. Kendler KS, Karkowski LM, Prescott CA. Causal relationship between stressful life events and the onset of major depression. Am J Psychiatry 1999, 156:837-41.
12. Duman RS. Pathophysiology of depression: the concept of synaptic plasticity. Eur Psychiatry 2002, 3:306-10.
13. Sapolsky RM. Stress and plasticity in the limbic system. Neuroch Res 2003, 28:1735-42.
14. Mirescu C, Gould E. Stress and adult neurogenesis. Hippocampus 2006, 16:233-8. 10.1002/hipo.20155, 16411244.
15. Gage F. Mammalian neural stem cells. Science 2000, 287:1433-8. 10.1126/science.287.5457.1433, 10688783.
16. Gould E, Panapat P, Rydel T, Hastings N. Regulation of hippocampal neurogenesis in adulthood. Biol Psychiatry 2000, 48:715-20. 10.1016/S0006-3223(00)01021-0, 11063968.
17. Gould E, McEwen BS, Tanapat P, Galea LA, Fuchs E. Neurogenesis in the dentate gyrus of the adult tree shrew is regulated by psychosocial stress and NMDA receptor activation. J Neurosci 1997, 17:2492-8.
18. Coe CL, Kramer M, Czéh B, Gould E, Reeves AJ, Kirschbaum C, Fuchs E. Prenatal stress diminishes neurogenesis in the dentate gyrus of juvenile rhesus monkeys. Biol Psychiatry 2003, 54:1025-34. 10.1016/S0006-3223(03)00698-X, 14625144.
19. Malberg JE, Duman RS. Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment. Neuropsychopharmacol 2003, 28:1562-71.
20. David DJ, Samuels BA, Rainer Q, Wang JW, Marsteller D, Mendez I, Drew M, Craig DA, Guiard BP, Guilloux JP, Artymyshyn RP, Gardier AM, Gerald C, Antonijevic IA, Leonardo ED, Hen R. Neurogenesis-dependent and independent effects of fluoxetine in an animal model of anxiety/depression. Neuron 2009, 62:479-93. 10.1016/j.neuron.2009.04.017, 2759281, 19477151.
21. Lucassen PJ, Heine VM, Muller MB, van der Beek EM, Wiegant VM, De Kloet ER, Joels M, Fuchs E, Swaab DF, Czeh B. Stress, depression and hippocampal apoptosis. CNS Neurol Disord Drug Targets 2006, 5:531-46. 10.2174/187152706778559273, 17073656.
22. Woolley CS, Gould E, Frankfurt M, McEwen BS. Naturally occurring fluctuation in dendritic spine density on adult hippocampal pyramidal neurons. J Neurosci 1990, 10:4035-9.
23. Watanabe Y, Gould E, Cameron HA, Daniels DC, McEwen BS. Phenytoin prevents stress- and corticosterone-induced atrophy of CA3 pyramidal neurons. Hippocampus 1992, 2:431-5. 10.1002/hipo.450020410, 1308199.
24. Magariños AM, McEwen BS, Flügge G, Fuchs E. Chronic psychosocial stress causes apical dendritic atrophy of hippocampal CA3 pyramidal neurons in subordinate tree shrews. J Neurosci 1996, 16:3534-40.
25. Magariños AM, Orchinik M, McEwen BS. Morphological changes in the hippocampal CA3 region induced by non-invasive glucocorticoid administration: a paradox. Brain Res 1998, 809:314-8.
26. Sousa N, Lukoyanov NV, Madeira MD, Almeida OF, Paula-Barbosa MM. Reorganization of the morphology of hippocampal neurites and synapses after stress-induced damage correlates with behavioral improvement. Neuroscience 2000, 97:253-66. 10.1016/S0306-4522(00)00050-6, 10799757.
27. Czéh B, Michaelis T, Watanabe T, Frahm J, de Biurrun G, van Kampen M, Bartolomucci A, Fuchs E. Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine. Proc Natl Acad Sci USA 2001, 98:12320-2. 60045, 11675480.
28. Holderbach R, Clark K, Moreau JL, Bischofberger J, Normann C. Enhanced long-term synaptic depression in an animal model of depression. Biol Psychiatry 2007, 62:92-100. 10.1016/j.biopsych.2006.07.007, 17141742.
29. Pittenger C, Duman RS. Stress, depression, and neuroplasticity: a convergence of mechanisms. Neuropsychopharmacol 2008, 33:88-109.
30. Griebel G, Simiand J, Serradeil-Le Gal C, Wagnon J, Pascal M, Scatton B, Maffrand JP, Soubrie P. Anxiolytic-and antidepressant-like effects of the non-peptide vasopressin V1b receptor antagonist, SSR149415, suggest an innovative approach for the treatment of stress-related disorders. Proc Natl Acad Sci USA 2002, 99:6370-5. 10.1073/pnas.092012099, 122955, 11959912.
31. Santarelli L, Saxe M, Gross C, Surget A, Battaglia F, Dulawa S, Weisstaub N, Lee J, Duman R, Arancio O, Belzung C, Hen R. Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 2003, 301:805-9. 10.1126/science.1083328, 12907793.
32. Porsolt RD, Bertin A, Blavet N, Deniel M, Jalfre M. Immobility induced by forced swimming in rats: effects of agents which modify central catecholamine and serotonin activity. Eur J Pharmacol 1979, 57:201-10. 10.1016/0014-2999(79)90366-2, 488159.
33. Jiang F, Zhen Y, Ferreira A, Tomizawa K, Liauw JA, Zhuo M, Allen, Allen PB, Ouimet CC, Greengrad P. Spinophilin regulates the formation and function of dendritic spines. Proc Natl Acad Sci USA 2000, 97:9287-92. 10.1073/pnas.97.16.9287, 16860, 10922077.
34. Kumar A, Singh A. Protective effect of St. John's wort (Hypericum perforatum) extract on 72-hour sleep deprivation-induced anxiety-like behavior and oxidative damage in mice. Planta Med 2007, 73:1358-64. 10.1055/s-2007-990234, 17918039.
35. Kumar A, Garg R, Prakash AK. Effect of St. John's Wort (Hypericum perforatum) treatment on restraint stress-induced behavioral and biochemical alteration in mice. BMC Complement Altern Med 2010, 10:18-23. 10.1186/1472-6882-10-18, 2882899, 20459658.
36. Flausino OA, Zangrossi H, Salgado JV, Viana MB. Effects of acute and chronic treatment with Hypericum perforatum L. (LI 160) on different anxiety-related responses in rats. Pharmacology, Biochemistry, and Behavior 2002, 71:251-7. 10.1016/S0091-3057(01)00665-7, 11812530.
37. Singewald N, Sinner C, Hetzenauer A, Sartori SB, Murck H. Magnesium-deficient diet alters depression-and anxiety-related behavior in mice-influence of desipramine and Hypericum perforatum extract. Neuropsychopharmacol 2004, 47:1189-97.
38. Chatterjee SS, Nöldner M, Koch E, Erdelmeier C. Antidepressant activity of Hypericum perforatum and hyperforin: the neglected possibility. Pharmacopsychiatry 1998, 1:7-15.
39. Di Carlo G, Borrelli F, Ernst E, Izzo AA. St John's wort: Prozac from the plant kingdom. Trends Pharmacol Sci 2001, 22:292-7. 10.1016/S0165-6147(00)01716-8, 11395157.
40. Butterweck V, Nahrstedt A, Evans J, Hufeisen S, Rauser L, Savage J, Popadak B, Ernsberger P, Roth BL. In vitro receptor screening of pure constituents of St. John's wort reveals novel interactions with a number of GPCRs. Psychopharmacol (Ber) 2002, 162:193-202.
41. Roz N, Mazur Y, Hirshfeld A, Rehavi M. Inhibition of vesicular uptake of monoamines by hyperforin. Life Sci 2002, 71:2227-37. 10.1016/S0024-3205(02)01995-1, 12215370.
42. Butterweck V, Böckers T, Korte B, Wittkowski W, Winterhoff H. Long-term effects of St. John's wort and hypericin on monoamine levels in rat hypothalamus and hippocampus. Brain Res 2002, 930:21-9. 10.1016/S0006-8993(01)03394-7, 11879791.
43. Suzuki O, Katsumata Y, Oya M, Bladt S, Wagner H. Inhibition of monoamine oxidase by hypericin. Planta Medica 1984, 50:272-4. 10.1055/s-2007-969700, 6484033.
44. Langosch JM, Zhou XY, Frick A, Grunze H, Walden J. Effects of lamotrigine on field potentials and long-term potentiation in guinea pig hippocampal slices. Epilepsia 2000, 41:1102-6. 10.1111/j.1528-1157.2000.tb00314.x, 10999548.
45. Sapolsky RM. Is impaired neurogenesis relevant to the affective symptoms of depression?. Biol Psychiatry 2004, 56:137-9. 10.1016/j.biopsych.2004.04.012, 15271580.
46. Surget A, Saxe M, Leman S, Ibarguen-Vargas Y, Chalon S, Griebel G, Hen R, Belzung C. Drug-dependent requirement of hippocampal neurogenesis in a model of depression and of antidepressant reversal. Biol Psychiatry 2008, 64:293-301. 10.1016/j.biopsych.2008.02.022, 18406399.
47. McEwen BS, Seeman T. Protective and damaging effects of mediators of stress. Elaborating and testing the concepts of allostasis and allostatic load. Ann N Y Acad Sci 1999, 896:30-47. 10.1111/j.1749-6632.1999.tb08103.x, 10681886.
48. Sapolsky RM. Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. Arch Gen Psychiatry 2000, 57:925-35. 10.1001/archpsyc.57.10.925, 11015810.
49. Lucassen PJ, Meerlo P, Naylor AS, van Dam AM, Dayer AG, Fuchs E, Oomen CA, Czéh B. Regulation of adult neurogenesis by stress, sleep disruption, exercise and inflammation: Implications for depression and antidepressant action. Eur Neuropsychopharmacol 2010, 20:1-17. 10.1016/j.euroneuro.2009.08.003, 19748235.
50. Segal M. Dendritic spines and long-term plasticity. Nat Rev Neurosci 2005, 6:277-84. 10.1038/nrn1649, 15803159.
51. Koester HJ, Sakmann B. Calcium dynamics in single spines during coincident pre- and postsynaptic activity depend on relative timing of back-propagating action potentials and subthreshold excitatory postsynaptic potentials. Proc Natl Acad Sci USA 1998, 95:9596-601. 10.1073/pnas.95.16.9596, 21384, 9689126.
52. Yuste R, Bonhoeffer T. Genesis of dendritic spines: insights from ultrastructural and imaging studies. Nat Rev Neurosci 2004, 5:24-34. 10.1038/nrn1300, 14708001.
53. Calabrese B, Halpain S. Essential role for the PKC target MARCKS in maintaining dendritic spine morphology. Neuron 2005, 48:77-90. 10.1016/j.neuron.2005.08.027, 16202710.
54. Yuste R, Bonhoeffer T. Morphological changes in dendritic spines associated with long-term synaptic plasticity. Ann Rev Neurosci 2001, 24:1071-89. 10.1146/annurev.neuro.24.1.1071, 11520928.
55. Brunson KL, Kramár E, Lin B, Chen Y, Colgin LL, Yanagihara TK, Lynch G, Baram TZ. Mechanisms of late-onset cognitive decline after early-life stress. J Neurosci 2005, 25:9328-38. 10.1523/JNEUROSCI.2281-05.2005, 16221841.
56. Holtmaat A, Svoboda K. Experience-dependent structural synaptic plasticity in the mammalian brain. Nat Rev Neurosci 2009, 10:647-58. 10.1038/nrn2699, 19693029.
57. Zafir A, Banu N. Antioxidant potential of fluoxetine in comparison to Curcuma longa in restraint-stressed rats. Eur J Pharmacol 2007, 572:23-31. 10.1016/j.ejphar.2007.05.062, 17610875.