Topical treatment of atopic dermatitis with St. John's wort cream - A randomized, placebo controlled, double blind half-side comparison

Phytomedicine

Volumn 10, Issue SUPPL. 4, 2003, Pages 31-37

  Schempp, Christoph M ^a   Windeck, Timo ^b   Hezel, Svea ^a   Simon, Jan C ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b Lichtwer Pharma AG   (Germany)

Author keywords

Half side comparison; Hyperforin; Randomised clinical trial; Severity Scoring of Atopic Dermatitis; St. John's wort

Indexed keywords

BUFEXAMAC; CALENDULA EXTRACT; CHAMOMILE; CORTICOSTEROID; DIFLUCORTOLONE VALERATE; GLUCOCORTICOID; HAMAMELIS EXTRACT; HYPERFORIN; HYPERICUM PERFORATUM EXTRACT; PLACEBO; PLANT EXTRACT; SOLANUM DULCAMARA EXTRACT; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ANTIBACTERIAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ATOPIC DERMATITIS; BACTERIAL COLONIZATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTACT DERMATITIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CREAM; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG FORMULATION; FEMALE; HUMAN; HYPERICUM PERFORATUM; MALE; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STAPHYLOCOCCUS AUREUS;

ANTHEMIS; BACTERIA (MICROORGANISMS); CALENDULA; HAMAMELIS; HYPERICUM; HYPERICUM PERFORATUM; SOLANUM; SOLANUM DULCAMARA; STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS;

EID: 0037911532     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1078/1433-187X-00306     Document Type: Article

References (19)

1. Aertgeerts P, Albring M, Klaschka F, Nasemann T, Patzelt-Wenczler, Rauhhut K, Weigl B (1985) Vergleichende Prüfung von Kamillosan-Creme gegenüber steroidalen (0,25% Hydrocortison, 0,75% Fluocortinbutylester) und nichtsteroidalen (5% Bufexamac) Externa in der Erhaltungstherapie von Ekzemerkrankungen. Z Hautkr 60: 270-277
2. European Task force on Atopic Dermatitis (1993) Severity Scoring of Atopic Dermatitis: The SCORAD Index. Consensus Report of the European Task force on Atopic Dermatitis. Dermatology 186: 23-31
3. Gniazdowska B, Rueff F, Przybilla B (1999) Delayed contact hypersensitivity to non-steroidal anti-inflammatory drugs. Contact Dermatitis 40: 63-65
4. Gurevich AI, Dobrynin VN, Kolosov MN, Popravko SA, Riabova ID (1971) Hyperforin, an antibiotic from Hypericum perforatum L. Antibiotiki 16: 510-513
5. Kaul R (2000) Johanniskraut. Botanik, Inhaltsstoffe, Qualitätskontrolle, Pharmakologie, Toxikologie und Klinik. Wiss. Verlagsges. Stuttgart
6. Korting HC, Schafer-Korting M, Klovekorn W, Klovekorn G, Martin C, Laux P (1995) Comparative efficacy of hamamelis distillate and hydrocortisone cream in atopic eczema. Eur J Clin Pharm 48: 461-465
7. Maisenbacher P, Kovar KA (1992) Analysis and stability of Hyperici oleum. Planta Med 58: 351-354
8. Mezger J (1991) Gesichtete homöopathische Arzneimittellehre: Hypericum perforatum. Haug Verlag, Heidelberg, pp 761-765
9. Niedner R (1996) Solanum dulcamara L. - a "plant cortisone"? Med Monatsschr Pharm 19: 339-340
10. Patzelt-Wenczler R, Ponce-Poschl E (2000) Proof of efficacy of Kamillosan(R) cream in atopic eczema. Eur J Med Res 19: 171-175
11. Roth L (1990) Hypericum - Hypericin. Botanik, Inhaltsstoffe, Wirkungen. Ecomed Arzneipflanzen-Monographie. Ecomed, Landsberg/Lech
12. Schempp CM, Pelz K, Wittmer A, Schöpf E, Simon JC (1999) Antibacterial activity of hyperforin from St John's wort, against multiresistant Staphylokokkus aureus and gram-positive bacteria. Lancet 353: 2129
13. Schempp CM, Winghofer B, Lüdtke R, Simon-Haarhaus, Schöpf E, Simon JC (2000a) Effect of topical application of Hypericum perforatum extract (St. John's wort) on skin sensitivity to solar simulated radiation. Photodermatol Photoimmunol Photomed 16: 125-128
14. Schempp CM, Winghofer B, Lüdtke R, Simon-Haarhaus, Schöpf E, Simon JC (2000b) Topical application of St. John's wort (Hypericum perforatum L.) and of its metabolite hyperforin inhibits the allostimulatory capacity of epidermal cells. Br J Dermatol 142: 979-984
15. Schempp CM, Müller KA, Winghofer B, Schöpf E, Simon JC (2002a) Johanniskraut (Hypericum perforatum L.) - eine Pflanze mit Relevanz für die Dermatologie. Hautarzt 53: 316-321
16. Schempp CM, Schöpf E, Simon JC (2002b) Durch Pflanzen ausgelöste toxische und allergische Dermatitis (Phytodermatitis). Hautarzt 53: 93-97
17. Sears HW, Bailer JW, Yeadon A (1997) Efficacy and Safety of Hydrocortisone Buteprate 0,1% Cream in Patients with Atopic Dermatitis. Clin Ther 19: 710-719
18. Swoboda M, Meurer J (1991) Therapie von Neurodermitis durch Hamamelis virginiana-Extrakt in Salbenform. Z Phytother 12: 114-117
19. Thumm EJ, Stoss M, Bayerl C, Schürholz T (2000) Überprüfung der Wirksamkeit einer 20%igen und 10%igen Sanddornkernölcreme bei Patienten mit leichter bis mittelgradiger atopischer Dermatitis. Akt Dermatol 26: 285-290