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Volumn 9781461416890, Issue , 2012, Pages 233-254

Mapping metabolomic quantitative trait loci (mQTL): A link between metabolome-wide association studies and systems biology

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EID: 84949175280     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4614-1689-0_14     Document Type: Chapter
Times cited : (4)

References (55)
  • 1
    • 33645671556 scopus 로고    scopus 로고
    • Assessment of analytical reproducibility of 1 H NMR spectroscopy based metabonomics for large-scale epidemiological research: The INTERMAP Study
    • Dumas ME, Maibaum EC, Teague C et al (2006) Assessment of analytical reproducibility of 1 H NMR spectroscopy based metabonomics for large-scale epidemiological research: the INTERMAP Study. Anal Chem 78(7):2199-2208
    • (2006) Anal Chem , vol.78 , Issue.7 , pp. 2199-2208
    • Dumas, M.E.1    Maibaum, E.C.2    Teague, C.3
  • 2
    • 43749087841 scopus 로고    scopus 로고
    • Human metabolic phenotype diversity and its association with diet and blood pressure
    • Holmes E, Loo RL, Stamler J et al (2008) Human metabolic phenotype diversity and its association with diet and blood pressure. Nature 453(7193):396-400
    • (2008) Nature , vol.453 , Issue.7193 , pp. 396-400
    • Holmes, E.1    Loo, R.L.2    Stamler, J.3
  • 3
    • 0035400051 scopus 로고    scopus 로고
    • Genetical genomics: The added value from segregation
    • Jansen RC, Nap JP (2001) Genetical genomics: the added value from segregation. Trends Genet 17(7):388-391
    • (2001) Trends Genet , vol.17 , Issue.7 , pp. 388-391
    • Jansen, R.C.1    Nap, J.P.2
  • 4
    • 34548805282 scopus 로고    scopus 로고
    • A genome-wide association study of global gene expression
    • Dixon AL, Liang L, Moffatt MF et al (2007) A genome-wide association study of global gene expression. Nat Genet 39(10):1202-1207
    • (2007) Nat Genet , vol.39 , Issue.10 , pp. 1202-1207
    • Dixon, A.L.1    Liang, L.2    Moffatt, M.F.3
  • 5
    • 0037456823 scopus 로고    scopus 로고
    • Genetics of gene expression surveyed in maize, mouse and man
    • Schadt EE, Monks SA, Drake TA et al (2003) Genetics of gene expression surveyed in maize, mouse and man. Nature 422(6929):297-302
    • (2003) Nature , vol.422 , Issue.6929 , pp. 297-302
    • Schadt, E.E.1    Monks, S.A.2    Drake, T.A.3
  • 6
    • 18544382234 scopus 로고    scopus 로고
    • Genetic analysis of the mouse brain proteome
    • Klose J, Nock C, Herrmann M et al (2002) Genetic analysis of the mouse brain proteome. Nat Genet 30(4):385-393
    • (2002) Nat Genet , vol.30 , Issue.4 , pp. 385-393
    • Klose, J.1    Nock, C.2    Herrmann, M.3
  • 7
    • 33645746673 scopus 로고    scopus 로고
    • Comprehensive metabolic profiling and phenotyping of interspecific introgression lines for tomato improvement
    • Schauer N, Semel Y, Roessner U et al (2006) Comprehensive metabolic profiling and phenotyping of interspecific introgression lines for tomato improvement. Nat Biotechnol 24(4):447-454
    • (2006) Nat Biotechnol , vol.24 , Issue.4 , pp. 447-454
    • Schauer, N.1    Semel, Y.2    Roessner, U.3
  • 8
    • 33745580270 scopus 로고    scopus 로고
    • The genetics of plant metabolism
    • Keurentjes JJ, Fu J, de Vos CH et al (2006) The genetics of plant metabolism. Nat Genet 38(7):842-849
    • (2006) Nat Genet , vol.38 , Issue.7 , pp. 842-849
    • Keurentjes, J.J.1    Fu, J.2    De Vos, C.H.3
  • 9
    • 34247560771 scopus 로고    scopus 로고
    • Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models
    • Dumas ME, Wilder SP, Bihoreau MT et al (2007) Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models. Nat Genet 39(5):666-672
    • (2007) Nat Genet , vol.39 , Issue.5 , pp. 666-672
    • Dumas, M.E.1    Wilder, S.P.2    Bihoreau, M.T.3
  • 10
    • 57149114936 scopus 로고    scopus 로고
    • Genetics meets metabolomics: A genome-wide association study of metabolite profiles in human serum
    • Gieger C, Geistlinger L, Altmaier E et al (2008) Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum. PLoS Genet 4(11):e1000282
    • (2008) PLoS Genet , vol.4 , Issue.11
    • Gieger, C.1    Geistlinger, L.2    Altmaier, E.3
  • 11
    • 75749134031 scopus 로고    scopus 로고
    • A genome-wide perspective of genetic variation in human metabolism
    • Illig T, Gieger C, Zhai G et al (2010) A genome-wide perspective of genetic variation in human metabolism. Nat Genet 42(2):137-141
    • (2010) Nat Genet , vol.42 , Issue.2 , pp. 137-141
    • Illig, T.1    Gieger, C.2    Zhai, G.3
  • 12
    • 79957604338 scopus 로고    scopus 로고
    • A genome-wide association study of metabolic traits in human urine
    • Suhre K, Wallaschofski H, Raffler J et al (2011) A genome-wide association study of metabolic traits in human urine. Nat Genet 43:565-569
    • (2011) Nat Genet , vol.43 , pp. 565-569
    • Suhre, K.1    Wallaschofski, H.2    Raffler, J.3
  • 14
    • 34548292504 scopus 로고    scopus 로고
    • PLINK: A tool set for whole-genome association and population-based linkage analyses
    • Purcell S, Neale B, Todd-Brown K et al (2007) PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81(3):559-575
    • (2007) Am J Hum Genet , vol.81 , Issue.3 , pp. 559-575
    • Purcell, S.1    Neale, B.2    Todd-Brown, K.3
  • 15
    • 0024576268 scopus 로고
    • A genetic polymorphism in the renin gene of Dahl rats cosegregates with blood pressure
    • Rapp JP, Wang SM, Dene H (1989) A genetic polymorphism in the renin gene of Dahl rats cosegregates with blood pressure. Science 243(4890):542-544
    • (1989) Science , vol.243 , Issue.4890 , pp. 542-544
    • Rapp, J.P.1    Wang, S.M.2    Dene, H.3
  • 16
    • 9044247460 scopus 로고    scopus 로고
    • Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat
    • Gauguier D, Froguel P, Parent V et al (1996) Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat. Nat Genet 12(1):38-43
    • (1996) Nat Genet , vol.12 , Issue.1 , pp. 38-43
    • Gauguier, D.1    Froguel, P.2    Parent, V.3
  • 17
    • 61449224751 scopus 로고    scopus 로고
    • A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: The NIH heterogeneous stock
    • Johannesson M, Lopez-Aumatell R, Stridh P et al (2009) A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: the NIH heterogeneous stock. Genome Res 19(1):150-158
    • (2009) Genome Res , vol.19 , Issue.1 , pp. 150-158
    • Johannesson, M.1    Lopez-Aumatell, R.2    Stridh, P.3
  • 18
    • 33746540478 scopus 로고    scopus 로고
    • Genome-wide genetic association of complex traits in heterogeneous stock mice
    • Valdar W, Solberg LC, Gauguier D et al (2006) Genome-wide genetic association of complex traits in heterogeneous stock mice. Nat Genet 38(8):879-887
    • (2006) Nat Genet , vol.38 , Issue.8 , pp. 879-887
    • Valdar, W.1    Solberg, L.C.2    Gauguier, D.3
  • 19
    • 33745225182 scopus 로고    scopus 로고
    • Mapping diabetes QTL in an intercross derived from a congenic strain of the Brown Norway and Goto-Kakizaki rats
    • Collins SC, Wallis RH, Wilder SP et al (2006) Mapping diabetes QTL in an intercross derived from a congenic strain of the Brown Norway and Goto-Kakizaki rats. Mamm Genome 17(6):538-547
    • (2006) Mamm Genome , vol.17 , Issue.6 , pp. 538-547
    • Collins, S.C.1    Wallis, R.H.2    Wilder, S.P.3
  • 20
    • 77956597651 scopus 로고    scopus 로고
    • High-resolution magic-angle-spinning NMR spectroscopy for metabolic profiling of intact tissues
    • Beckonert O, Coen M, Keun HC et al (2010) High-resolution magic-angle-spinning NMR spectroscopy for metabolic profiling of intact tissues. Nat Protoc 5(6):1019-1032
    • (2010) Nat Protoc , vol.5 , Issue.6 , pp. 1019-1032
    • Beckonert, O.1    Coen, M.2    Keun, H.C.3
  • 21
    • 39149126712 scopus 로고    scopus 로고
    • Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts
    • Beckonert O, Keun HC, Ebbels TM et al (2007) Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts. Nat Protoc 2(11):2692-2703
    • (2007) Nat Protoc , vol.2 , Issue.11 , pp. 2692-2703
    • Beckonert, O.1    Keun, H.C.2    Ebbels, T.M.3
  • 22
    • 77952205557 scopus 로고    scopus 로고
    • Global metabolic profiling procedures for urine using UPLC-MS
    • Want EJ, Wilson ID, Gika H et al (2010) Global metabolic profiling procedures for urine using UPLC-MS. Nat Protoc 5(6):1005-1018
    • (2010) Nat Protoc , vol.5 , Issue.6 , pp. 1005-1018
    • Want, E.J.1    Wilson, I.D.2    Gika, H.3
  • 23
    • 38049150496 scopus 로고    scopus 로고
    • Metabotyping of Caenorhabditis elegans reveals latent phenotypes
    • Blaise BJ, Giacomotto J, Elena B et al (2007) Metabotyping of Caenorhabditis elegans reveals latent phenotypes. Proc Natl Acad Sci USA 104(50):19808-19812
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.50 , pp. 19808-19812
    • Blaise, B.J.1    Giacomotto, J.2    Elena, B.3
  • 24
    • 66749085607 scopus 로고    scopus 로고
    • Metabolic profiling strategy of Caenorhabditis elegans by whole-organism nuclear magnetic resonance
    • Blaise BJ, Giacomotto J, Triba MN et al (2009) Metabolic profiling strategy of Caenorhabditis elegans by whole-organism nuclear magnetic resonance. J Proteome Res 8(5):2542-2550
    • (2009) J Proteome Res , vol.8 , Issue.5 , pp. 2542-2550
    • Blaise, B.J.1    Giacomotto, J.2    Triba, M.N.3
  • 25
    • 32444446805 scopus 로고    scopus 로고
    • XCMS: Processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification
    • Smith CA, Want EJ, O'Maille G, Abagyan R, Siuzdak G (2006) XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification. Anal Chem 78(3):779-787
    • (2006) Anal Chem , vol.78 , Issue.3 , pp. 779-787
    • Smith, C.A.1    Want, E.J.2    O'Maille, G.3    Abagyan, R.4    Siuzdak, G.5
  • 26
    • 12244293657 scopus 로고    scopus 로고
    • Evaluation of the orthogonal projection on latent structure model limitations caused by chemical shift variability and improved visualization of biomarker changes in 1 H NMR spectroscopic metabonomic studies
    • Cloarec O, Dumas ME, Trygg J et al (2005) Evaluation of the orthogonal projection on latent structure model limitations caused by chemical shift variability and improved visualization of biomarker changes in 1 H NMR spectroscopic metabonomic studies. Anal Chem 77(2): 517-526
    • (2005) Anal Chem , vol.77 , Issue.2 , pp. 517-526
    • Cloarec, O.1    Dumas, M.E.2    Trygg, J.3
  • 27
    • 58149477904 scopus 로고    scopus 로고
    • Recursive segment-wise peak alignment of biological (1)h NMR spectra for improved metabolic biomarker recovery
    • Veselkov KA, Lindon JC, Ebbels TM et al (2009) Recursive segment-wise peak alignment of biological (1)h NMR spectra for improved metabolic biomarker recovery. Anal Chem 81(1):56-66
    • (2009) Anal Chem , vol.81 , Issue.1 , pp. 56-66
    • Veselkov, K.A.1    Lindon, J.C.2    Ebbels, T.M.3
  • 28
    • 68049111557 scopus 로고    scopus 로고
    • Statistical recoupling prior to significance testing in nuclear magnetic resonance based metabonomics
    • Blaise BJ, Shintu L, Elena B, Emsley L, Dumas ME, Toulhoat P (2009) Statistical recoupling prior to significance testing in nuclear magnetic resonance based metabonomics. Anal Chem 81(15):6242-6251
    • (2009) Anal Chem , vol.81 , Issue.15 , pp. 6242-6251
    • Blaise, B.J.1    Shintu, L.2    Elena, B.3    Emsley, L.4    Dumas, M.E.5    Toulhoat, P.6
  • 29
    • 0037108962 scopus 로고    scopus 로고
    • Analyzing the physiological signature of anabolic steroids in cattle urine using pyrolysis/metastable atom bombardment mass spectrometry and pattern recognition
    • Dumas ME, Debrauwer L, Beyet L et al (2002) Analyzing the physiological signature of anabolic steroids in cattle urine using pyrolysis/metastable atom bombardment mass spectrometry and pattern recognition. Anal Chem 74(20):5393-5404
    • (2002) Anal Chem , vol.74 , Issue.20 , pp. 5393-5404
    • Dumas, M.E.1    Debrauwer, L.2    Beyet, L.3
  • 30
    • 78650666244 scopus 로고    scopus 로고
    • The evolution of partial least squares models and related chemometric approaches in metabonomics and metabolic phenotyping
    • Fonville JM, Richards SE, Barton RH et al (2010) The evolution of partial least squares models and related chemometric approaches in metabonomics and metabolic phenotyping. J Chemom 24(11-12):636-649
    • (2010) J Chemom , vol.24 , Issue.11-12 , pp. 636-649
    • Fonville, J.M.1    Richards, S.E.2    Barton, R.H.3
  • 31
    • 20044366919 scopus 로고    scopus 로고
    • Statistical total correlation spectroscopy: An exploratory approach for latent biomarker identification from metabolic 1 H NMR data sets
    • Cloarec O, Dumas ME, Craig A et al (2005) Statistical total correlation spectroscopy: an exploratory approach for latent biomarker identification from metabolic 1 H NMR data sets. Anal Chem 77(5):1282-1289
    • (2005) Anal Chem , vol.77 , Issue.5 , pp. 1282-1289
    • Cloarec, O.1    Dumas, M.E.2    Craig, A.3
  • 32
    • 26844461471 scopus 로고    scopus 로고
    • Selection of biomarkers by a multivariate statistical processing of composite metabonomic data sets using multiple factor analysis
    • Dumas ME, Canlet C, Debrauwer L, Martin P, Paris A (2005) Selection of biomarkers by a multivariate statistical processing of composite metabonomic data sets using multiple factor analysis. J Proteome Res 4(5):1485-1492
    • (2005) J Proteome Res , vol.4 , Issue.5 , pp. 1485-1492
    • Dumas, M.E.1    Canlet, C.2    Debrauwer, L.3    Martin, P.4    Paris, A.5
  • 33
    • 30744443014 scopus 로고    scopus 로고
    • Statistical heterospectroscopy, an approach to the integrated analysis of NMR and UPLC-MS data sets: Application in metabonomic toxicology studies
    • Crockford DJ, Holmes E, Lindon JC et al (2006) Statistical heterospectroscopy, an approach to the integrated analysis of NMR and UPLC-MS data sets: application in metabonomic toxicology studies. Anal Chem 78(2):363-371
    • (2006) Anal Chem , vol.78 , Issue.2 , pp. 363-371
    • Crockford, D.J.1    Holmes, E.2    Lindon, J.C.3
  • 34
    • 33745700438 scopus 로고    scopus 로고
    • Targeted profiling: Quantitative analysis of 1H NMR metabolomics data
    • Weljie AM, Newton J, Mercier P, Carlson E, Slupsky CM (2006) Targeted profiling: quantitative analysis of 1H NMR metabolomics data. Anal Chem 78(13):4430-4442
    • (2006) Anal Chem , vol.78 , Issue.13 , pp. 4430-4442
    • Weljie, A.M.1    Newton, J.2    Mercier, P.3    Carlson, E.4    Slupsky, C.M.5
  • 35
    • 0037092881 scopus 로고    scopus 로고
    • Metabonomic assessment of physiological disruptions using 1 H-13C HMBC-NMR spectroscopy combined with pattern recognition procedures performed onfiltered variables
    • Dumas ME, Canlet C, Andre F, Vercauteren J, Paris A (2002) Metabonomic assessment of physiological disruptions using 1 H-13C HMBC-NMR spectroscopy combined with pattern recognition procedures performed onfiltered variables. Anal Chem 74(10):2261-2273
    • (2002) Anal Chem , vol.74 , Issue.10 , pp. 2261-2273
    • Dumas, M.E.1    Canlet, C.2    Andre, F.3    Vercauteren, J.4    Paris, A.5
  • 36
    • 0036052338 scopus 로고    scopus 로고
    • Approaches to the analysis of complex quantitative phenotypes and marker map construction based on the analysis of rat models of hypertension
    • Gauguier D, Samani N (2002) Approaches to the analysis of complex quantitative phenotypes and marker map construction based on the analysis of rat models of hypertension. Methods Mol Biol 195:225-251
    • (2002) Methods Mol Biol , vol.195 , pp. 225-251
    • Gauguier, D.1    Samani, N.2
  • 37
    • 33646942472 scopus 로고
    • A simple regression method for mapping quantitative trait loci in line crosses using flanking markers
    • Haley CS, Knott SA (1992) A simple regression method for mapping quantitative trait loci in line crosses using flanking markers. Heredity 69(4):315-324
    • (1992) Heredity , vol.69 , Issue.4 , pp. 315-324
    • Haley, C.S.1    Knott, S.A.2
  • 38
    • 0036245475 scopus 로고    scopus 로고
    • Understanding quantitative genetic variation
    • Barton NH, Keightley PD (2002) Understanding quantitative genetic variation. Nat Rev Genet 3(1):11-21
    • (2002) Nat Rev Genet , vol.3 , Issue.1 , pp. 11-21
    • Barton, N.H.1    Keightley, P.D.2
  • 39
    • 0036245218 scopus 로고    scopus 로고
    • Mapping and analysis of quantitative trait loci in experimental populations
    • Doerge RW (2002) Mapping and analysis of quantitative trait loci in experimental populations. Nat Rev Genet 3(1):43-52
    • (2002) Nat Rev Genet , vol.3 , Issue.1 , pp. 43-52
    • Doerge, R.W.1
  • 40
    • 67651108806 scopus 로고    scopus 로고
    • The genetics of quantitative traits: Challenges and prospects
    • Mackay TF, Stone EA, Ayroles JF (2009) The genetics of quantitative traits: challenges and prospects. Nat Rev Genet 10(8):565-577
    • (2009) Nat Rev Genet , vol.10 , Issue.8 , pp. 565-577
    • Mackay, T.F.1    Stone, E.A.2    Ayroles, J.F.3
  • 41
    • 0030052609 scopus 로고    scopus 로고
    • Permutation tests for multiple loci affecting a quantitative character
    • Doerge RW, Churchill GA (1996) Permutation tests for multiple loci affecting a quantitative character. Genetics 142(1):285-294
    • (1996) Genetics , vol.142 , Issue.1 , pp. 285-294
    • Doerge, R.W.1    Churchill, G.A.2
  • 42
    • 0742305866 scopus 로고    scopus 로고
    • Network biology: Understanding the cell's functional organization
    • Barabasi AL, Oltvai ZN (2004) Network biology: understanding the cell's functional organization. Nat Rev Genet 5(2):101-113
    • (2004) Nat Rev Genet , vol.5 , Issue.2 , pp. 101-113
    • Barabasi, A.L.1    Oltvai, Z.N.2
  • 43
    • 0033764169 scopus 로고    scopus 로고
    • The small world of metabolism
    • Fell DA, Wagner A (2000) The small world of metabolism. Nat Biotechnol 18(11): 1121-1122
    • (2000) Nat Biotechnol , vol.18 , Issue.11 , pp. 1121-1122
    • Fell, D.A.1    Wagner, A.2
  • 44
    • 34548024598 scopus 로고    scopus 로고
    • Integrating physical and genetic maps: From genomes to interaction networks
    • Beyer A, Bandyopadhyay S, Ideker T (2007) Integrating physical and genetic maps: from genomes to interaction networks. Nat Rev Genet 8(9):699-710
    • (2007) Nat Rev Genet , vol.8 , Issue.9 , pp. 699-710
    • Beyer, A.1    Bandyopadhyay, S.2    Ideker, T.3
  • 45
    • 0033982936 scopus 로고    scopus 로고
    • KEGG: Kyoto encyclopedia of genes and genomes
    • Kanehisa M, Goto S (2000) KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res 28(1):27-30
    • (2000) Nucleic Acids Res , vol.28 , Issue.1 , pp. 27-30
    • Kanehisa, M.1    Goto, S.2
  • 46
    • 79953687426 scopus 로고    scopus 로고
    • Broad-ranging natural metabotype variation drives physiological plasticity in healthy control inbred rat strains
    • Pontoizeau C, Fearnside JF, Navratil V et al (2011) Broad-ranging natural metabotype variation drives physiological plasticity in healthy control inbred rat strains. J Proteome Res 10(4):1675-1689
    • (2011) J Proteome Res , vol.10 , Issue.4 , pp. 1675-1689
    • Pontoizeau, C.1    Fearnside, J.F.2    Navratil, V.3
  • 47
    • 77954256613 scopus 로고    scopus 로고
    • MSEA: A web-based tool to identify biologically meaningful patterns in quantitative metabolomic data
    • Xia J, Wishart DS (2010) MSEA: a web-based tool to identify biologically meaningful patterns in quantitative metabolomic data. Nucleic Acids Res 38:W71-W77
    • (2010) Nucleic Acids Res , vol.38 , pp. W71-W77
    • Xia, J.1    Wishart, D.S.2
  • 48
    • 79951999565 scopus 로고    scopus 로고
    • MBRole: Enrichment analysis of metabolomic data
    • Chagoyen M, Pazos F (2011) MBRole: enrichment analysis of metabolomic data. Bioinformatics 27(5):730-731
    • (2011) Bioinformatics , vol.27 , Issue.5 , pp. 730-731
    • Chagoyen, M.1    Pazos, F.2
  • 49
    • 27344435774 scopus 로고    scopus 로고
    • Gene set enrichment analysis: A knowledge- based approach for interpreting genome-wide expression profiles
    • Subramanian A, Tamayo P, Mootha VK et al (2005) Gene set enrichment analysis: a knowledge- based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 102(43):15545-15550
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.43 , pp. 15545-15550
    • Subramanian, A.1    Tamayo, P.2    Mootha, V.K.3
  • 50
    • 1242319556 scopus 로고    scopus 로고
    • The metabolic world of Escherichia coli is not small
    • Arita M (2004) The metabolic world of Escherichia coli is not small. Proc Natl Acad Sci USA 101(6):1543-1547
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.6 , pp. 1543-1547
    • Arita, M.1
  • 51
    • 77956334971 scopus 로고    scopus 로고
    • Two-dimensional statistical recoupling for the identification of perturbed metabolic networks from NMR spectroscopy
    • Blaise BJ, Navratil V, Domange C et al (2010) Two-dimensional statistical recoupling for the identification of perturbed metabolic networks from NMR spectroscopy. J Proteome Res 9(9):4513-4520
    • (2010) J Proteome Res , vol.9 , Issue.9 , pp. 4513-4520
    • Blaise, B.J.1    Navratil, V.2    Domange, C.3
  • 52
    • 0034628508 scopus 로고    scopus 로고
    • A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae
    • Uetz P, Giot L, Cagney G et al (2000) A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae. Nature 403(6770):623-627
    • (2000) Nature , vol.403 , Issue.6770 , pp. 623-627
    • Uetz, P.1    Giot, L.2    Cagney, G.3
  • 53
    • 83055168319 scopus 로고    scopus 로고
    • A metabolomic and systems biology perspective on the brain of the fragile X syndrome mouse model
    • Davidovic L, Navratil V, Bonaccorso CM et al (2011) A metabolomic and systems biology perspective on the brain of the fragile X syndrome mouse model. Genome Res 21:2190-2202
    • (2011) Genome Res , vol.21 , pp. 2190-2202
    • Davidovic, L.1    Navratil, V.2    Bonaccorso, C.M.3
  • 54
    • 84865730611 scopus 로고
    • A set of measures of centrality based on betweenness
    • Freeman LC
    • Freeman LC (1977) A set of measures of centrality based on betweenness. Sociometry 40:35-41
    • (1977) Sociometry , vol.40 , pp. 35-41
  • 55
    • 33747618036 scopus 로고    scopus 로고
    • Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice
    • Dumas ME, Barton RH, Toye A et al (2006) Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice. Proc Natl Acad Sci USA 103(33):12511-12516
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.33 , pp. 12511-12516
    • Dumas, M.E.1    Barton, R.H.2    Toye, A.3


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