Mapping and analysis of quantitative trait loci in experimental populations

Nature Reviews Genetics

Volumn 3, Issue 1, 2002, Pages 43-52

  Doerge, Rebecca W ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANALYSIS OF VARIANCE; DNA MICROARRAY; GENE MAPPING; GENETIC MODEL; HUMAN; NONHUMAN; POPULATION GENETICS; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; REVIEW; STATISTICAL MODEL;

ALGORITHMS; ANIMALS; CHROMOSOME MAPPING; GENE EXPRESSION PROFILING; GENETIC MARKERS; GENOTYPE; HUMANS; LINEAR MODELS; MICE; MODELS, GENETIC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENOTYPE; QUANTITATIVE TRAIT, HERITABLE; VARIATION (GENETICS);

EID: 0036245218     PISSN: 14710056     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrg703     Document Type: Review

References (99)

1. The association of size difference with seed-coat pattern and pigmentation in Phaseolus vulgaris
2. Location of polygenes
3. A structure for deoxyribose nucleic acid
4. Detection of specific sequences among DNA fragments separated by gel electrophoresis
5. DNA sequencing with chain-terminating inhibitors
6. Enzymatic amplification of β-globin genomic sequences and restriction site analysis for diagnosis of sickle-cell anemia
7. Identification of the cystic fibrosis gene: Genetic analysis
8. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosome
9. Localization of the gene of familial dysautomia on chromosome 9 and definition of DNA markers for genetic diagnosis
10. Microsatellite mapping of a gene affecting horn development in Bos taurus
11. RFLP mapping in soybean: Association between marker loci and variation in quantitative traits
12. Molecular-marker-facilitated investigations of quantitative-trait loci in maize. I. Numbers, genomic distribution and types of gene action
13. Detection of linkage between marker loci and loci affecting quantitative traits in crosses between segregating populations
14. Maximum likelihood estimation of linkage between a marker gene and a quantitative trait locus
15. Mapping Mendelian factors underlying quantitative traits using RFLP linkage maps
16. Mapping quantitative trait loci using molecular marker linkage maps
17. Interval mapping in the analysis of nonadditive quantitative trait loci
18. A general mixture model for mapping quantitative trait loci by using molecular markers
19. Aspects of maximum likelihood methods for the mapping of quantitative trait loci in line crosses
20. On the use of the moments method of estimation to obtain approximate maximum likelihood estimates of linkage between a genetic marker and a quantitative locus
21. Theoretical basis of precision mapping of quantitative trait loci
22. Relationships among analytical methods used to study genotypic variation and genotype-by-environmental interaction in plant breeding multi-environment experiments
23. QTL analysis: A simple 'marker-regression' approach
24. Precision mapping of quantitative trait loci
25. Mixed model analysis of quantitative trait loci
26. Interval mapping of multiple quantitative trait loci
27. High resolution of quantitative traits into multiple loci via interval mapping
28. Multiple trait analysis of genetic mapping for quantitative trait loci
29. Multiple interval mapping for quantitative trait loci
30. Linkage between loci of quantitative traits and marker loci: Multi-trait analysis with a single marker
31. Interval mapping of quantitative trait loci employing correlated trait complexes
32. Multi-interval mapping of correlated trait complexes
33. A quantitative trait locus key to the evolution of tomato fruit size
34. The chipping forecast
35. Large-scale statistical analyses of rice ESTs reveal correlated patterns of gene expression
36. A gene expression map for Caenorhabditis elegans
37. The transcriptional program in the response of human fibrolasts to serum
38. Distinctive gene expression patterns in human mammary epithelial cells and breast cancers
39. Global analysis of protein activities using proteome chips
40. Proteomics for genetic and physiological studies in plants
41. Mapping polygenes
42. Statistical issues in the search for genes affecting quantitative traits in experimental populations
43. Computational analysis of microarray data
44. Enhancing candidate gene detection via experimental genome annotation and treating transcript abundance as quantitative traits
45. Genetical genomics: The added value from segregation
46. Model selection for quantitative trait locus analysis in polyploids
47. Mapping quantitative trait loci in tetraploid populations
48. Quantitative trait loci in Drosophila
49. Large upward bias in estimation of locus-specific effects from genomew ide scans
50. Linkage between RFLP markers and genes affecting kernel hardness in wheat
51. Linkage mapping of quantitative trait loci controlling seed weight in pea (Pisum sativum L.)
52. Identification of eight chromosomes and a microsatellite marker on 1AS associated with QTL for grain weight in bread wheat
53. Construction of multilocus genetic linkage maps in humans
54. Construction of integrated genetic linkage maps by means of a new computer package: Join map
55. On the power of experimental designs for the detection of linkage between marker loci and quantitative loci in crosses between inbred lines
56. The expected distribution of marker-linked quantitative effects in crosses between inbred lines
57. Estimating the locations and the size of the effects of quantitative trait loci using flanking markers
58. Empirical threshold values for quantitative trait mapping
59. Marker pair selection for mapping quantitative trait loci
60. Detection of closely linked multiple quantitative trait loci using a genetic algorithm
61. A statistical framework for quantitative trait mapping
62. Reversible jump Markov chain Monte Carlo computation and Bayesian model determination
63. The use of a genetic algorithm for simultaneous mapping of multiple interacting quantitative trait loci
64. Evolutionary computation
65. On the asymptotic performance of the log likelihood ratio statistic for the mixture model and related results
66. A failure of likelihood asymptotics for normal distributions
67. Asymptotic properties of maximum likelihood estimators and likelihood ratio tests under nonstandard conditions
68. Approximate thresholds of interval mapping tests for QTL detection
69. Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results
70. A quick method for computing approximate thresholds for quantitative trait loci detection
71. Hypothesis testing when a nuisance parameter is present only under the alternative
72. Hypothesis testing when a nuisance parameter is present only under the alternative
73. LOD significance thresholds for QTL analysis in experimental populations of diploid species
74. Significance thresholds for QTL mapping tests
75. Quantitative trait loci analysis of powdery mildew disease resistance in the Arabidopsis thaliana accession Kashmir-1
76. Statistical design and the analysis of gene expression microarrays
77. Analysis of variance for gene expression microarray data
78. On differential variability of expression ratios: Improving statistical inference about gene expression changes from microarray data
79. Cluster analysis of genome-wide expression patterns
80. Fundamental patterns underlying gene expression profiles: Simplicity from complexity
81. Genetic analysis of disease subtype and sexual dimorphism in mouse EAE: Relapsing-remitting and monophasic remitting/non-relapsing EAE are immunogenetically distinct