메뉴 건너뛰기




Volumn 8, Issue 1, 2015, Pages

Primary cilia modulate balance of canonical and non-canonical Wnt signaling responses in the injured kidney

Author keywords

Cilia; Epithelial; Fibrosis

Indexed keywords

UNCLASSIFIED DRUG; WNT PROTEIN; WNT1 PROTEIN; WNT10A PROTEIN; WNT11 PROTEIN; WNT2B PROTEIN; WNT3A PROTEIN; WNT4 PROTEIN; WNT5A PROTEIN; WNT6 PROTEIN; WNT7A PROTEIN; WNT7B PROTEIN; WNT9B PROTEIN;

EID: 84949128536     PISSN: None     EISSN: 17551536     Source Type: Journal    
DOI: 10.1186/s13069-015-0024-y     Document Type: Article
Times cited : (24)

References (52)
  • 2
    • 84863333338 scopus 로고    scopus 로고
    • Reprogramming the kidney: a novel approach for regeneration
    • Hendry CE, Little MH. Reprogramming the kidney: a novel approach for regeneration. Kidney Int. 2012;82(2):138-46.
    • (2012) Kidney Int , vol.82 , Issue.2 , pp. 138-146
    • Hendry, C.E.1    Little, M.H.2
  • 3
    • 84920778336 scopus 로고    scopus 로고
    • The role of complement in the pathogenesis of renal ischemia-reperfusion injury and fibrosis
    • Danobeitia JS, Djamali A, Fernandez LA. The role of complement in the pathogenesis of renal ischemia-reperfusion injury and fibrosis. Fibrogenesis Tissue Repair. 2014;7:16.
    • (2014) Fibrogenesis Tissue Repair , vol.7 , pp. 16
    • Danobeitia, J.S.1    Djamali, A.2    Fernandez, L.A.3
  • 4
    • 77952174830 scopus 로고    scopus 로고
    • Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury
    • Yang L, Besschetnova TY, Brooks CR, Shah JV, Bonventre JV. Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury. Nat Med. 2010;16(5):535-43. 1p following 143.
    • (2010) Nat Med , vol.16 , Issue.5 , pp. 535-543
    • Yang, L.1    Besschetnova, T.Y.2    Brooks, C.R.3    Shah, J.V.4    Bonventre, J.V.5
  • 6
    • 78149298226 scopus 로고    scopus 로고
    • Mechanisms of tubulointerstitial fibrosis
    • Zeisberg M, Neilson EG. Mechanisms of tubulointerstitial fibrosis. J Am Soc Nephrol. 2010;21(11):1819-34.
    • (2010) J Am Soc Nephrol , vol.21 , Issue.11 , pp. 1819-1834
    • Zeisberg, M.1    Neilson, E.G.2
  • 7
    • 84899155968 scopus 로고    scopus 로고
    • The extracellular matrix in the kidney: a source of novel non-invasive biomarkers of kidney fibrosis?
    • Genovese F, Manresa AA, Leeming DJ, Karsdal MA, Boor P. The extracellular matrix in the kidney: a source of novel non-invasive biomarkers of kidney fibrosis? Fibrogenesis Tissue Repair. 2014;7(1):4.
    • (2014) Fibrogenesis Tissue Repair , vol.7 , Issue.1 , pp. 4
    • Genovese, F.1    Manresa, A.A.2    Leeming, D.J.3    Karsdal, M.A.4    Boor, P.5
  • 9
    • 84897107588 scopus 로고    scopus 로고
    • Potential approaches to reverse or repair renal fibrosis
    • Tampe D, Zeisberg M. Potential approaches to reverse or repair renal fibrosis. Nat Rev Nephrol. 2014;10(4):226-37.
    • (2014) Nat Rev Nephrol , vol.10 , Issue.4 , pp. 226-237
    • Tampe, D.1    Zeisberg, M.2
  • 10
    • 84870252814 scopus 로고    scopus 로고
    • The complex world of WNT receptor signalling
    • Niehrs C. The complex world of WNT receptor signalling. Nat Rev Mol Cell Biol. 2012;13(12):767-79.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , Issue.12 , pp. 767-779
    • Niehrs, C.1
  • 11
    • 42549164807 scopus 로고    scopus 로고
    • Wnt signalling and its impact on development and cancer
    • Klaus A, Birchmeier W. Wnt signalling and its impact on development and cancer. Nat Rev Cancer. 2008;8(5):387-98.
    • (2008) Nat Rev Cancer , vol.8 , Issue.5 , pp. 387-398
    • Klaus, A.1    Birchmeier, W.2
  • 12
    • 84896694895 scopus 로고    scopus 로고
    • Coordination of kidney organogenesis by Wnt signaling
    • Halt K, Vainio S. Coordination of kidney organogenesis by Wnt signaling. Pediatr Nephrol. 2014;29(4):737-44.
    • (2014) Pediatr Nephrol , vol.29 , Issue.4 , pp. 737-744
    • Halt, K.1    Vainio, S.2
  • 13
    • 65249134946 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling promotes renal interstitial fibrosis
    • He W, Dai C, Li Y, Zeng G, Monga SP, Liu Y. Wnt/beta-catenin signaling promotes renal interstitial fibrosis. J Am Soc Nephrol. 2009;20(4):765-76.
    • (2009) J Am Soc Nephrol , vol.20 , Issue.4 , pp. 765-776
    • He, W.1    Dai, C.2    Li, Y.3    Zeng, G.4    Monga, S.P.5    Liu, Y.6
  • 15
    • 84871093351 scopus 로고    scopus 로고
    • Wnt signalling in kidney diseases: dual roles in renal injury and repair
    • Kawakami T, Ren S, Duffield JS. Wnt signalling in kidney diseases: dual roles in renal injury and repair. J Pathol. 2013;229(2):221-31.
    • (2013) J Pathol , vol.229 , Issue.2 , pp. 221-231
    • Kawakami, T.1    Ren, S.2    Duffield, J.S.3
  • 16
    • 84865261784 scopus 로고    scopus 로고
    • Tubule-specific ablation of endogenous beta-catenin aggravates acute kidney injury in mice
    • Zhou D, Li Y, Lin L, Zhou L, Igarashi P, Liu Y. Tubule-specific ablation of endogenous beta-catenin aggravates acute kidney injury in mice. Kidney Int. 2012;82(5):537-47.
    • (2012) Kidney Int , vol.82 , Issue.5 , pp. 537-547
    • Zhou, D.1    Li, Y.2    Lin, L.3    Zhou, L.4    Igarashi, P.5    Liu, Y.6
  • 18
    • 78651384347 scopus 로고    scopus 로고
    • Blockade of Wnt/beta-catenin signaling by paricalcitol ameliorates proteinuria and kidney injury
    • He W, Kang YS, Dai C, Liu Y. Blockade of Wnt/beta-catenin signaling by paricalcitol ameliorates proteinuria and kidney injury. J Am Soc Nephrol. 2011;22(1):90-103.
    • (2011) J Am Soc Nephrol , vol.22 , Issue.1 , pp. 90-103
    • He, W.1    Kang, Y.S.2    Dai, C.3    Liu, Y.4
  • 19
    • 84877090354 scopus 로고    scopus 로고
    • Loss of Klotho contributes to kidney injury by derepression of Wnt/beta-catenin signaling
    • Zhou L, Li Y, Zhou D, Tan RJ, Liu Y. Loss of Klotho contributes to kidney injury by derepression of Wnt/beta-catenin signaling. J Am Soc Nephrol. 2013;24(5):771-85.
    • (2013) J Am Soc Nephrol , vol.24 , Issue.5 , pp. 771-785
    • Zhou, L.1    Li, Y.2    Zhou, D.3    Tan, R.J.4    Liu, Y.5
  • 21
    • 79960132726 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition predicts cyclosporine nephrotoxicity in renal transplant recipients
    • Hazzan M, Hertig A, Buob D, Copin MC, Noel C, Rondeau E, et al. Epithelial-to-mesenchymal transition predicts cyclosporine nephrotoxicity in renal transplant recipients. J Am Soc Nephrol. 2011;22(7):1375-81.
    • (2011) J Am Soc Nephrol , vol.22 , Issue.7 , pp. 1375-1381
    • Hazzan, M.1    Hertig, A.2    Buob, D.3    Copin, M.C.4    Noel, C.5    Rondeau, E.6
  • 22
    • 84855460847 scopus 로고    scopus 로고
    • Cilia in vertebrate development and disease
    • Oh EC, Katsanis N. Cilia in vertebrate development and disease. Development. 2012;139(3):443-8.
    • (2012) Development , vol.139 , Issue.3 , pp. 443-448
    • Oh, E.C.1    Katsanis, N.2
  • 23
    • 79954617321 scopus 로고    scopus 로고
    • The emerging face of primary cilia
    • Zaghloul NA, Brugmann SA. The emerging face of primary cilia. Genesis. 2011;49(4):231-46.
    • (2011) Genesis , vol.49 , Issue.4 , pp. 231-246
    • Zaghloul, N.A.1    Brugmann, S.A.2
  • 24
    • 84859768493 scopus 로고    scopus 로고
    • Carcinogens induce loss of the primary cilium in human renal proximal tubular epithelial cells independently of effects on the cell cycle
    • Radford R, Slattery C, Jennings P, Blacque O, Pfaller W, Gmuender H, et al. Carcinogens induce loss of the primary cilium in human renal proximal tubular epithelial cells independently of effects on the cell cycle. Am J Physiol Renal Physiol. 2012;302(8):F905-16.
    • (2012) Am J Physiol Renal Physiol , vol.302 , Issue.8 , pp. F905-F916
    • Radford, R.1    Slattery, C.2    Jennings, P.3    Blacque, O.4    Pfaller, W.5    Gmuender, H.6
  • 25
    • 0032808256 scopus 로고    scopus 로고
    • Molecular and cellular pathophysiology of obstructive nephropathy
    • Chevalier RL. Molecular and cellular pathophysiology of obstructive nephropathy. Pediatr Nephrol. 1999;13(7):612-9.
    • (1999) Pediatr Nephrol , vol.13 , Issue.7 , pp. 612-619
    • Chevalier, R.L.1
  • 26
    • 0033029428 scopus 로고    scopus 로고
    • Recovery following relief of unilateral ureteral obstruction in the neonatal rat
    • Chevalier RL, Kim A, Thornhill BA, Wolstenholme JT. Recovery following relief of unilateral ureteral obstruction in the neonatal rat. Kidney Int. 1999;55(3):793-807.
    • (1999) Kidney Int , vol.55 , Issue.3 , pp. 793-807
    • Chevalier, R.L.1    Kim, A.2    Thornhill, B.A.3    Wolstenholme, J.T.4
  • 28
    • 79954581525 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition as a biomarker in renal fibrosis: are we ready for the bedside?
    • Galichon P, Hertig A. Epithelial to mesenchymal transition as a biomarker in renal fibrosis: are we ready for the bedside? Fibrogenesis Tissue Repair. 2011;4:11.
    • (2011) Fibrogenesis Tissue Repair , vol.4 , pp. 11
    • Galichon, P.1    Hertig, A.2
  • 29
    • 0029781509 scopus 로고    scopus 로고
    • Functional interaction of beta-catenin with the transcription factor LEF-1
    • Behrens J, von Kries JP, Kuhl M, Bruhn L, Wedlich D, Grosschedl R, et al. Functional interaction of beta-catenin with the transcription factor LEF-1. Nature. 1996;382(6592):638-42.
    • (1996) Nature , vol.382 , Issue.6592 , pp. 638-642
    • Behrens, J.1    Kries, J.P.2    Kuhl, M.3    Bruhn, L.4    Wedlich, D.5    Grosschedl, R.6
  • 30
    • 0032473355 scopus 로고    scopus 로고
    • Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin
    • Ikeda S, Kishida S, Yamamoto H, Murai H, Koyama S, Kikuchi A. Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin. EMBO J. 1998;17(5):1371-84.
    • (1998) EMBO J , vol.17 , Issue.5 , pp. 1371-1384
    • Ikeda, S.1    Kishida, S.2    Yamamoto, H.3    Murai, H.4    Koyama, S.5    Kikuchi, A.6
  • 31
    • 84876840190 scopus 로고    scopus 로고
    • Components of the canonical and non-canonical Wnt pathways are not mis-expressed in pituitary tumors
    • Colli LM, Saggioro F, Serafini LN, Camargo RC, Machado HR, Moreira AC, et al. Components of the canonical and non-canonical Wnt pathways are not mis-expressed in pituitary tumors. PLoS One. 2013;8(4):e62424.
    • (2013) PLoS One , vol.8 , Issue.4 , pp. e62424
    • Colli, L.M.1    Saggioro, F.2    Serafini, L.N.3    Camargo, R.C.4    Machado, H.R.5    Moreira, A.C.6
  • 32
    • 70450228519 scopus 로고    scopus 로고
    • Canonical Wnt signaling is antagonized by noncanonical Wnt5a in hepatocellular carcinoma cells
    • Yuzugullu H, Benhaj K, Ozturk N, Senturk S, Celik E, Toylu A, et al. Canonical Wnt signaling is antagonized by noncanonical Wnt5a in hepatocellular carcinoma cells. Mol Cancer. 2009;8:90.
    • (2009) Mol Cancer , vol.8 , pp. 90
    • Yuzugullu, H.1    Benhaj, K.2    Ozturk, N.3    Senturk, S.4    Celik, E.5    Toylu, A.6
  • 33
    • 33745496759 scopus 로고    scopus 로고
    • The emerging complexity of the vertebrate cilium: new functional roles for an ancient organelle
    • Davis EE, Brueckner M, Katsanis N. The emerging complexity of the vertebrate cilium: new functional roles for an ancient organelle. Dev Cell. 2006;11(1):9-19.
    • (2006) Dev Cell , vol.11 , Issue.1 , pp. 9-19
    • Davis, E.E.1    Brueckner, M.2    Katsanis, N.3
  • 34
    • 20944435539 scopus 로고    scopus 로고
    • Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways
    • Simons M, Gloy J, Ganner A, Bullerkotte A, Bashkurov M, Kronig C, et al. Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways. Nat Genet. 2005;37(5):537-43.
    • (2005) Nat Genet , vol.37 , Issue.5 , pp. 537-543
    • Simons, M.1    Gloy, J.2    Ganner, A.3    Bullerkotte, A.4    Bashkurov, M.5    Kronig, C.6
  • 35
    • 33746891890 scopus 로고    scopus 로고
    • The primary cilium as the cell's antenna: signaling at a sensory organelle
    • Singla V, Reiter JF. The primary cilium as the cell's antenna: signaling at a sensory organelle. Science. 2006;313(5787):629-33.
    • (2006) Science , vol.313 , Issue.5787 , pp. 629-633
    • Singla, V.1    Reiter, J.F.2
  • 36
    • 42449110394 scopus 로고    scopus 로고
    • Renal cilia display length alterations following tubular injury and are present early in epithelial repair
    • Verghese E, Weidenfeld R, Bertram JF, Ricardo SD, Deane JA. Renal cilia display length alterations following tubular injury and are present early in epithelial repair. Nephrol Dial Transplant. 2008;23(3):834-41.
    • (2008) Nephrol Dial Transplant , vol.23 , Issue.3 , pp. 834-841
    • Verghese, E.1    Weidenfeld, R.2    Bertram, J.F.3    Ricardo, S.D.4    Deane, J.A.5
  • 37
    • 48449092858 scopus 로고    scopus 로고
    • Alterations in renal cilium length during transient complete ureteral obstruction in the mouse
    • Wang L, Weidenfeld R, Verghese E, Ricardo SD, Deane JA. Alterations in renal cilium length during transient complete ureteral obstruction in the mouse. J Anat. 2008;213(2):79-85.
    • (2008) J Anat , vol.213 , Issue.2 , pp. 79-85
    • Wang, L.1    Weidenfeld, R.2    Verghese, E.3    Ricardo, S.D.4    Deane, J.A.5
  • 38
    • 77958495473 scopus 로고    scopus 로고
    • Cell shape and contractility regulate ciliogenesis in cell cycle-arrested cells
    • Pitaval A, Tseng Q, Bornens M, Thery M. Cell shape and contractility regulate ciliogenesis in cell cycle-arrested cells. J Cell Biol. 2010;191(2):303-12.
    • (2010) J Cell Biol , vol.191 , Issue.2 , pp. 303-312
    • Pitaval, A.1    Tseng, Q.2    Bornens, M.3    Thery, M.4
  • 39
    • 84888021623 scopus 로고    scopus 로고
    • A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing
    • Florian MC, Nattamai KJ, Dorr K, Marka G, Uberle B, Vas V, et al. A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing. Nature. 2013;503(7476):392-6.
    • (2013) Nature , vol.503 , Issue.7476 , pp. 392-396
    • Florian, M.C.1    Nattamai, K.J.2    Dorr, K.3    Marka, G.4    Uberle, B.5    Vas, V.6
  • 40
    • 35648985644 scopus 로고    scopus 로고
    • Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response
    • Gerdes JM, Liu Y, Zaghloul NA, Leitch CC, Lawson SS, Kato M, et al. Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response. Nat Genet. 2007;39(11):1350-60.
    • (2007) Nat Genet , vol.39 , Issue.11 , pp. 1350-1360
    • Gerdes, J.M.1    Liu, Y.2    Zaghloul, N.A.3    Leitch, C.C.4    Lawson, S.S.5    Kato, M.6
  • 41
    • 77950835647 scopus 로고    scopus 로고
    • Chronic kidney disease induced in mice by reversible unilateral ureteral obstruction is dependent on genetic background
    • Puri TS, Shakaib MI, Chang A, Mathew L, Olayinka O, Minto AW, et al. Chronic kidney disease induced in mice by reversible unilateral ureteral obstruction is dependent on genetic background. Am J Physiol Renal Physiol. 2010;298(4):F1024-32.
    • (2010) Am J Physiol Renal Physiol , vol.298 , Issue.4 , pp. F1024-F1032
    • Puri, T.S.1    Shakaib, M.I.2    Chang, A.3    Mathew, L.4    Olayinka, O.5    Minto, A.W.6
  • 43
    • 0035991607 scopus 로고    scopus 로고
    • Direct evidence for a role of beta-catenin/LEF-1 signaling pathway in induction of EMT
    • Kim K, Lu Z, Hay ED. Direct evidence for a role of beta-catenin/LEF-1 signaling pathway in induction of EMT. Cell Biol Int. 2002;26(5):463-76.
    • (2002) Cell Biol Int , vol.26 , Issue.5 , pp. 463-476
    • Kim, K.1    Lu, Z.2    Hay, E.D.3
  • 44
    • 0029553183 scopus 로고
    • An overview of epithelio-mesenchymal transformation
    • Hay ED. An overview of epithelio-mesenchymal transformation. Acta Anat. 1995;154(1):8-20.
    • (1995) Acta Anat , vol.154 , Issue.1 , pp. 8-20
    • Hay, E.D.1
  • 45
    • 61749102618 scopus 로고    scopus 로고
    • Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis
    • Kim KK, Wei Y, Szekeres C, Kugler MC, Wolters PJ, Hill ML, et al. Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis. J Clin Invest. 2009;119(1):213-24.
    • (2009) J Clin Invest , vol.119 , Issue.1 , pp. 213-224
    • Kim, K.K.1    Wei, Y.2    Szekeres, C.3    Kugler, M.C.4    Wolters, P.J.5    Hill, M.L.6
  • 46
    • 50649103964 scopus 로고    scopus 로고
    • Snail promotes Wnt target gene expression and interacts with beta-catenin
    • Stemmer V, de Craene B, Berx G, Behrens J. Snail promotes Wnt target gene expression and interacts with beta-catenin. Oncogene. 2008;27(37):5075-80.
    • (2008) Oncogene , vol.27 , Issue.37 , pp. 5075-5080
    • Stemmer, V.1    Craene, B.2    Berx, G.3    Behrens, J.4
  • 47
    • 22144497081 scopus 로고    scopus 로고
    • Invasion and metastasis in colorectal cancer: epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and beta-catenin
    • Brabletz T, Hlubek F, Spaderna S, Schmalhofer O, Hiendlmeyer E, Jung A, et al. Invasion and metastasis in colorectal cancer: epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and beta-catenin. Cells Tissues Organs. 2005;179(1-2):56-65.
    • (2005) Cells Tissues Organs , vol.179 , Issue.1-2 , pp. 56-65
    • Brabletz, T.1    Hlubek, F.2    Spaderna, S.3    Schmalhofer, O.4    Hiendlmeyer, E.5    Jung, A.6
  • 48
    • 38349078213 scopus 로고    scopus 로고
    • Tumor escape in a Wnt1-dependent mouse breast cancer model is enabled by p19ARF/p53 pathway lesions but not p16 Ink4a loss
    • Debies MT, Gestl SA, Mathers JL, Mikse OR, Leonard TL, Moody SE, et al. Tumor escape in a Wnt1-dependent mouse breast cancer model is enabled by p19ARF/p53 pathway lesions but not p16 Ink4a loss. J Clin Invest. 2008;118(1):51-63.
    • (2008) J Clin Invest , vol.118 , Issue.1 , pp. 51-63
    • Debies, M.T.1    Gestl, S.A.2    Mathers, J.L.3    Mikse, O.R.4    Leonard, T.L.5    Moody, S.E.6
  • 49
    • 79952283482 scopus 로고    scopus 로고
    • p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs
    • Chang CJ, Chao CH, Xia W, Yang JY, Xiong Y, Li CW, et al. p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs. Nat Cell Biol. 2011;13(3):317-23.
    • (2011) Nat Cell Biol , vol.13 , Issue.3 , pp. 317-323
    • Chang, C.J.1    Chao, C.H.2    Xia, W.3    Yang, J.Y.4    Xiong, Y.5    Li, C.W.6
  • 50
    • 58149496651 scopus 로고    scopus 로고
    • Increased expression of secreted frizzled-related protein 4 in polycystic kidneys
    • Romaker D, Puetz M, Teschner S, Donauer J, Geyer M, Gerke P, et al. Increased expression of secreted frizzled-related protein 4 in polycystic kidneys. J Am Soc Nephrol. 2009;20(1):48-56.
    • (2009) J Am Soc Nephrol , vol.20 , Issue.1 , pp. 48-56
    • Romaker, D.1    Puetz, M.2    Teschner, S.3    Donauer, J.4    Geyer, M.5    Gerke, P.6
  • 51
    • 84864076896 scopus 로고    scopus 로고
    • The ciliary protein nephrocystin-4 translocates the canonical Wnt regulator Jade-1 to the nucleus to negatively regulate beta-catenin signaling
    • Borgal L, Habbig S, Hatzold J, Liebau MC, Dafinger C, Sacarea I, et al. The ciliary protein nephrocystin-4 translocates the canonical Wnt regulator Jade-1 to the nucleus to negatively regulate beta-catenin signaling. J Biol Chem. 2012;287(30):25370-80.
    • (2012) J Biol Chem , vol.287 , Issue.30 , pp. 25370-25380
    • Borgal, L.1    Habbig, S.2    Hatzold, J.3    Liebau, M.C.4    Dafinger, C.5    Sacarea, I.6
  • 52
    • 84906547871 scopus 로고    scopus 로고
    • Tet3-mediated hydroxymethylation of epigenetically silenced genes contributes to bone morphogenic protein 7-induced reversal of kidney fibrosis
    • Tampe B, Tampe D, Muller CA, Sugimoto H, Lebleu V, Xu X, et al. Tet3-mediated hydroxymethylation of epigenetically silenced genes contributes to bone morphogenic protein 7-induced reversal of kidney fibrosis. J Am Soc Nephrol. 2014;25(5):905-12. doi: 10.1681/ASN.2013070723.
    • (2014) J Am Soc Nephrol , vol.25 , Issue.5 , pp. 905-912
    • Tampe, B.1    Tampe, D.2    Muller, C.A.3    Sugimoto, H.4    Lebleu, V.5    Xu, X.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.