-
1
-
-
79952127438
-
Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress
-
Aggarwal, M., Sommers, J. A., Shoemaker, R. H., and Brosh, R. M. Jr. (2011). Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress. Proc. Natl. Acad. Sci. U.S.A. 108, 1525-1530. doi: 10.1073/pnas.1006423108
-
(2011)
Proc. Natl. Acad. Sci. U. S. A.
, vol.108
, pp. 1525-1530
-
-
Aggarwal, M.1
Sommers, J.A.2
Shoemaker, R.H.3
Brosh, R.M.4
-
2
-
-
79959903572
-
RECQL1 and WRN proteins are potential therapeutic targets in head and neck squamous cell carcinoma
-
Arai, A., Chano, T., Futami, K., Furuichi, Y., Ikebuchi, K., Inui, T.,et al. (2011). RECQL1 and WRN proteins are potential therapeutic targets in head and neck squamous cell carcinoma. Cancer Res. 71, 4598-4607. doi: 10.1158/0008-5472.CAN-11-0320
-
(2011)
Cancer Res
, vol.71
-
-
Arai, A.1
Chano, T.2
Futami, K.3
Furuichi, Y.4
Ikebuchi, K.5
Inui, T.6
-
3
-
-
23444440610
-
Conferring substrate specificity to DNA helicases: role of the RecQ HRDC domain
-
Bernstein, D. A., and Keck, J. L. (2005). Conferring substrate specificity to DNA helicases: role of the RecQ HRDC domain. Structure 13, 1173-1182. doi: 10.1016/j.str.2005.04.018
-
(2005)
Structure
, vol.13
, pp. 1173-1182
-
-
Bernstein, D.A.1
Keck, J.L.2
-
4
-
-
0141865522
-
High-resolution structure of the E. coli RecQ helicase catalytic core
-
Bernstein, D. A., Zittel, M. C., and Keck, J. L. (2003). High-resolution structure of the E. coli RecQ helicase catalytic core. EMBO J. 22, 4910-4921. doi: 10.1093/emboj/cdg500
-
(2003)
EMBO J
, vol.22
, pp. 4910-4921
-
-
Bernstein, D.A.1
Zittel, M.C.2
Keck, J.L.3
-
5
-
-
84881145018
-
DNA helicases involved in DNA repair and their roles in cancer
-
Brosh, R. M. Jr. (2013). DNA helicases involved in DNA repair and their roles in cancer. Nat. Rev. Cancer 13, 542-558. doi: 10.1038/nrc3560
-
(2013)
Nat. Rev. Cancer
, vol.13
, pp. 542-558
-
-
Brosh, R.M.1
-
6
-
-
34447132375
-
Structural basis for DNA duplex separation by a superfamily-2 helicase
-
Buttner, K., Nehring, S., and Hopfner, K. P. (2007). Structural basis for DNA duplex separation by a superfamily-2 helicase. Nat. Struct. Mol. Biol. 14, 647-652. doi: 10.1038/nsmb1246
-
(2007)
Nat. Struct. Mol. Biol.
, vol.14
, pp. 647-652
-
-
Buttner, K.1
Nehring, S.2
Hopfner, K.P.3
-
7
-
-
34547192058
-
BLM is required for faithful chromosome segregation and its localization defines a class of ultrafine anaphase bridges
-
Chan, K. L., North, P. S., and Hickson, I. D. (2007). BLM is required for faithful chromosome segregation and its localization defines a class of ultrafine anaphase bridges. EMBO J. 26, 3397-3409. doi: 10.1038/sj.emboj.7601777
-
(2007)
EMBO J
, vol.26
, pp. 3397-3409
-
-
Chan, K.L.1
North, P.S.2
Hickson, I.D.3
-
8
-
-
34248143468
-
Probing the roles of active site residues in the 3'-5' exonuclease of the Werner syndrome protein
-
Choi, J. M., Kang, S. Y., Bae, W. J., Jin, K. S., Ree, M., and Cho, Y. (2007). Probing the roles of active site residues in the 3′-5′ exonuclease of the Werner syndrome protein. J. Biol. Chem. 282, 9941-9951. doi: 10.1074/jbc.M609657200
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 9941-9951
-
-
Choi, J.M.1
Kang, S.Y.2
Bae, W.J.3
Jin, K.S.4
Ree, M.5
Cho, Y.6
-
9
-
-
54049147388
-
The Werner syndrome protein binds replication fork and Holliday junction DNAs as an oligomer
-
Compton, S. A., Tolun, G., Kamath-Loeb, A. S., Loeb, L. A., and Griffith, J. D. (2008). The Werner syndrome protein binds replication fork and Holliday junction DNAs as an oligomer. J. Biol. Chem. 283, 24478-24483. doi: 10.1074/jbc.M803370200
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 24478-24483
-
-
Compton, S.A.1
Tolun, G.2
Kamath-Loeb, A.S.3
Loeb, L.A.4
Griffith, J.D.5
-
10
-
-
0034231844
-
Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest
-
Constantinou, A., Tarsounas, M., Karow, J. K., Brosh, R. M., Bohr, V. A., Hickson, I. D.,et al. (2000). Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest. EMBO Rep. 1, 80-84. doi: 10.1093/embo-reports/kvd004
-
(2000)
EMBO Rep
, vol.1
, pp. 80-84
-
-
Constantinou, A.1
Tarsounas, M.2
Karow, J.K.3
Brosh, R.M.4
Bohr, V.A.5
Hickson, I.D.6
-
11
-
-
84902187810
-
Human RecQ helicases in DNA repair, recombination, and replication
-
Croteau, D. L., Popuri, V., Opresko, P. L., and Bohr, V. A. (2014). Human RecQ helicases in DNA repair, recombination, and replication. Annu. Rev. Biochem. 83, 519-552. doi: 10.1146/annurev-biochem-060713-035428
-
(2014)
Annu. Rev. Biochem.
, vol.83
, pp. 519-552
-
-
Croteau, D.L.1
Popuri, V.2
Opresko, P.L.3
Bohr, V.A.4
-
12
-
-
84859699244
-
BLM helicase ortholog Sgs1 is a central regulator of meiotic recombination intermediate metabolism
-
De Muyt, A., Jessop, L., Kolar, E., Sourirajan, A., Chen, J., Dayani, Y.,et al. (2012). BLM helicase ortholog Sgs1 is a central regulator of meiotic recombination intermediate metabolism. Mol. Cell 46, 43-53. doi: 10.1016/j.molcel.2012.02.020
-
(2012)
Mol. Cell
, vol.46
, pp. 43-53
-
-
De Muyt, A.1
Jessop, L.2
Kolar, E.3
Sourirajan, A.4
Chen, J.5
Dayani, Y.6
-
13
-
-
0034635961
-
The Holliday junction in an inverted repeat DNA sequence: sequence effects on the structure of four-way junctions
-
Eichman, B. F., Vargason, J. M., Mooers, B. H., and Ho, P. S. (2000). The Holliday junction in an inverted repeat DNA sequence: sequence effects on the structure of four-way junctions. Proc. Natl. Acad. Sci. U.S.A. 97, 3971-3976. doi: 10.1073/pnas.97.8.3971
-
(2000)
Proc. Natl. Acad. Sci. U. S. A.
, vol.97
, pp. 3971-3976
-
-
Eichman, B.F.1
Vargason, J.M.2
Mooers, B.H.3
Ho, P.S.4
-
14
-
-
77949535720
-
Features and development of Coot
-
Emsley, P., Lohkamp, B., Scott, W. G., and Cowtan, K. (2010). Features and development of Coot. Acta Crystallogr. D Biol. Crystallogr. 66, 486-501. doi: 10.1107/S0907444910007493
-
(2010)
Acta Crystallogr. D Biol. Crystallogr.
, vol.66
, pp. 486-501
-
-
Emsley, P.1
Lohkamp, B.2
Scott, W.G.3
Cowtan, K.4
-
15
-
-
35348935500
-
Increased chemotherapeutic activity of camptothecin in cancer cells by siRNA-induced silencing of WRN helicase
-
Futami, K., Takagi, M., Shimamoto, A., Sugimoto, M., and Furuichi, Y. (2007). Increased chemotherapeutic activity of camptothecin in cancer cells by siRNA-induced silencing of WRN helicase. Biol. Pharm. Bull. 30, 1958-1961. doi: 10.1248/bpb.30.1958
-
(2007)
Biol. Pharm. Bull.
, vol.30
, pp. 1958-1961
-
-
Futami, K.1
Takagi, M.2
Shimamoto, A.3
Sugimoto, M.4
Furuichi, Y.5
-
17
-
-
0034708205
-
Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding
-
Gajiwala, K. S., Chen, H., Cornille, F., Roques, B. P., Reith, W., Mach, B.,et al. (2000). Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding. Nature 403, 916-921. doi: 10.1038/35002634
-
(2000)
Nature
, vol.403
, pp. 916-921
-
-
Gajiwala, K.S.1
Chen, H.2
Cornille, F.3
Roques, B.P.4
Reith, W.5
Mach, B.6
-
18
-
-
0033652180
-
Werner's syndrome: from clinics to genetics
-
Goto, M. (2000). Werner's syndrome: from clinics to genetics. Clin. Exp. Rheumatol. 18, 760-766.
-
(2000)
Clin. Exp. Rheumatol.
, vol.18
, pp. 760-766
-
-
Goto, M.1
-
19
-
-
84875947376
-
Werner syndrome: a changing pattern of clinical manifestations in Japan (1917-2008)
-
Goto, M., Ishikawa, Y., Sugimoto, M., and Furuichi, Y. (2013). Werner syndrome: a changing pattern of clinical manifestations in Japan (1917-2008). Biosci. Trends 7, 13-22. doi: 10.5582/bst.2013.v7.1.13
-
(2013)
Biosci. Trends
, vol.7
, pp. 13-22
-
-
Goto, M.1
Ishikawa, Y.2
Sugimoto, M.3
Furuichi, Y.4
-
20
-
-
84890475344
-
Visualization of human Bloom's syndrome helicase molecules bound to homologous recombination intermediates
-
Gyimesi, M., Pires, R. H., Billington, N., Sarlos, K., Kocsis, Z. S., Modos, K.,et al. (2013). Visualization of human Bloom's syndrome helicase molecules bound to homologous recombination intermediates. FASEB J. 27, 4954-4964. doi: 10.1096/fj.13-234088
-
(2013)
FASEB J
, vol.27
, pp. 4954-4964
-
-
Gyimesi, M.1
Pires, R.H.2
Billington, N.3
Sarlos, K.4
Kocsis, Z.S.5
Modos, K.6
-
21
-
-
84879424236
-
From keys to bulldozers: expanding roles for winged helix domains in nucleic-acid-binding proteins
-
Harami, G. M., Gyimesi, M., and Kovacs, M. (2013). From keys to bulldozers: expanding roles for winged helix domains in nucleic-acid-binding proteins. Trends Biochem. Sci. 38, 364-371. doi: 10.1016/j.tibs.2013.04.006
-
(2013)
Trends Biochem. Sci.
, vol.38
, pp. 364-371
-
-
Harami, G.M.1
Gyimesi, M.2
Kovacs, M.3
-
22
-
-
75849146289
-
Werner helicase wings DNA binding
-
Hoadley, K. A., and Keck, J. L. (2010). Werner helicase wings DNA binding. Structure 18, 149-151. doi: 10.1016/j.str.2010.01.007
-
(2010)
Structure
, vol.18
, pp. 149-151
-
-
Hoadley, K.A.1
Keck, J.L.2
-
23
-
-
29444432958
-
Solution structure of a multifunctional DNA- and protein-binding motif of human Werner syndrome protein
-
Hu, J. S., Feng, H., Zeng, W., Lin, G. X., and Xi, X. G. (2005). Solution structure of a multifunctional DNA- and protein-binding motif of human Werner syndrome protein. Proc. Natl. Acad. Sci. U.S.A. 102, 18379-18384. doi: 10.1073/pnas.0509380102
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.102
-
-
Hu, J.S.1
Feng, H.2
Zeng, W.3
Lin, G.X.4
Xi, X.G.5
-
24
-
-
33646100776
-
A conserved G4 DNA binding domain in RecQ family helicases
-
Huber, M. D., Duquette, M. L., Shiels, J. C., and Maizels, N. (2006). A conserved G4 DNA binding domain in RecQ family helicases. J. Mol. Biol. 358, 1071-1080. doi: 10.1016/j.jmb.2006.01.077
-
(2006)
J. Mol. Biol.
, vol.358
, pp. 1071-1080
-
-
Huber, M.D.1
Duquette, M.L.2
Shiels, J.C.3
Maizels, N.4
-
25
-
-
0034669196
-
The acidic pin of RuvA modulates Holliday junction binding and processing by the RuvABC resolvasome
-
Ingleston, S. M., Sharples, G. J., and Lloyd, R. G. (2000). The acidic pin of RuvA modulates Holliday junction binding and processing by the RuvABC resolvasome. EMBO J. 19, 6266-6274. doi: 10.1093/emboj/19.22.6266
-
(2000)
EMBO J
, vol.19
, pp. 6266-6274
-
-
Ingleston, S.M.1
Sharples, G.J.2
Lloyd, R.G.3
-
26
-
-
0038004735
-
Characterization and mutational analysis of the RecQ core of the Bloom syndrome protein
-
Janscak, P., Garcia, P. L., Hamburger, F., Makuta, Y., Shiraishi, K., Imai, Y.,et al. (2003). Characterization and mutational analysis of the RecQ core of the Bloom syndrome protein. J. Mol. Biol. 330, 29-42. doi: 10.1016/S0022-2836(03)00534-5
-
(2003)
J. Mol. Biol.
, vol.330
, pp. 29-42
-
-
Janscak, P.1
Garcia, P.L.2
Hamburger, F.3
Makuta, Y.4
Shiraishi, K.5
Imai, Y.6
-
27
-
-
77950353700
-
Altered gene expression in the Werner and Bloom syndromes is associated with sequences having G-quadruplex forming potential
-
Johnson, J. E., Cao, K., Ryvkin, P., Wang, L. S., and Johnson, F. B. (2010). Altered gene expression in the Werner and Bloom syndromes is associated with sequences having G-quadruplex forming potential. Nucleic Acids Res. 38, 1114-1122. doi: 10.1093/nar/gkp1103
-
(2010)
Nucleic Acids Res
, vol.38
, pp. 1114-1122
-
-
Johnson, J.E.1
Cao, K.2
Ryvkin, P.3
Wang, L.S.4
Johnson, F.B.5
-
28
-
-
84855829770
-
The Werner syndrome protein is distinguished from the Bloom syndrome protein by its capacity to tightly bind diverse DNA structures
-
Kamath-Loeb, A., Loeb, L. A., and Fry, M. (2012). The Werner syndrome protein is distinguished from the Bloom syndrome protein by its capacity to tightly bind diverse DNA structures. PLoS ONE 7:e30189. doi: 10.1371/journal.pone.0030189
-
(2012)
PLoS ONE
, vol.7
-
-
Kamath-Loeb, A.1
Loeb, L.A.2
Fry, M.3
-
29
-
-
0031576552
-
BLM (the causative gene of Bloom syndrome) protein translocation into the nucleus by a nuclear localization signal
-
Kaneko, H., Orii, K. O., Matsui, E., Shimozawa, N., Fukao, T., Matsumoto, T.,et al. (1997). BLM (the causative gene of Bloom syndrome) protein translocation into the nucleus by a nuclear localization signal. Biochem. Biophys. Res. Commun. 240, 348-353. doi: 10.1006/bbrc.1997.7648
-
(1997)
Biochem. Biophys. Res. Commun
, vol.240
, pp. 348-353
-
-
Kaneko, H.1
Orii, K.O.2
Matsui, E.3
Shimozawa, N.4
Fukao, T.5
Matsumoto, T.6
-
30
-
-
0034612333
-
The Bloom's syndrome gene product promotes branch migration of Holliday junctions
-
Karow, J. K., Constantinou, A., Li, J. L., West, S. C., and Hickson, I. D. (2000). The Bloom's syndrome gene product promotes branch migration of Holliday junctions. Proc. Natl. Acad. Sci. U.S.A. 97, 6504-6508. doi: 10.1073/pnas.100448097
-
(2000)
Proc. Natl. Acad. Sci. U. S. A.
, vol.97
, pp. 6504-6508
-
-
Karow, J.K.1
Constantinou, A.2
Li, J.L.3
West, S.C.4
Hickson, I.D.5
-
31
-
-
33749132155
-
Sit down, relax and unwind: structural insights into RecQ helicase mechanisms
-
Killoran, M. P., and Keck, J. L. (2006). Sit down, relax and unwind: structural insights into RecQ helicase mechanisms. Nucleic Acids Res. 34, 4098-4105. doi: 10.1093/nar/gkl538
-
(2006)
Nucleic Acids Res
, vol.34
, pp. 4098-4105
-
-
Killoran, M.P.1
Keck, J.L.2
-
32
-
-
44349121787
-
Structure and function of the regulatory C-terminal HRDC domain from Deinococcus radiodurans RecQ
-
Killoran, M. P., and Keck, J. L. (2008). Structure and function of the regulatory C-terminal HRDC domain from Deinococcus radiodurans RecQ. Nucleic Acids Res. 36, 3139-3149. doi: 10.1093/nar/gkn143
-
(2008)
Nucleic Acids Res
, vol.36
, pp. 3139-3149
-
-
Killoran, M.P.1
Keck, J.L.2
-
33
-
-
84888218379
-
Structure of the RecQ C-terminal domain of human Bloom syndrome protein
-
Kim, S. Y., Hakoshima, T., and Kitano, K. (2013). Structure of the RecQ C-terminal domain of human Bloom syndrome protein. Sci. Rep. 3, 3294. doi: 10.1038/srep03294
-
(2013)
Sci. Rep.
, vol.3
, pp. 3294
-
-
Kim, S.Y.1
Hakoshima, T.2
Kitano, K.3
-
34
-
-
78649877700
-
Structure and function of the regulatory HRDC domain from human Bloom syndrome protein
-
Kim, Y. M., and Choi, B. S. (2010). Structure and function of the regulatory HRDC domain from human Bloom syndrome protein. Nucleic Acids Res. 38, 7764-7777. doi: 10.1093/nar/gkq586
-
(2010)
Nucleic Acids Res
, vol.38
, pp. 7764-7777
-
-
Kim, Y.M.1
Choi, B.S.2
-
35
-
-
75849122854
-
Structural basis for DNA strand separation by the unconventional winged-helix domain of RecQ helicase WRN
-
Kitano, K., Kim, S. Y., and Hakoshima, T. (2010). Structural basis for DNA strand separation by the unconventional winged-helix domain of RecQ helicase WRN. Structure 18, 177-187. doi: 10.1016/j.str.2009.12.011
-
(2010)
Structure
, vol.18
, pp. 177-187
-
-
Kitano, K.1
Kim, S.Y.2
Hakoshima, T.3
-
36
-
-
34047267832
-
Crystal structure of the HRDC domain of human Werner syndrome protein
-
Kitano, K., Yoshihara, N., and Hakoshima, T. (2007). Crystal structure of the HRDC domain of human Werner syndrome protein, WRN. J. Biol. Chem. 282, 2717-2728. doi: 10.1074/jbc.M610142200
-
(2007)
WRN. J. Biol. Chem.
, vol.282
, pp. 2717-2728
-
-
Kitano, K.1
Yoshihara, N.2
Hakoshima, T.3
-
37
-
-
0029670530
-
A new pattern for helix-turn-helix recognition revealed by the PU 1 ETS-domain-DNA complex
-
Kodandapani, R., Pio, F., Ni, C. Z., Piccialli, G., Klemsz, M., Mckercher, S.,et al. (1996). A new pattern for helix-turn-helix recognition revealed by the PU.1 ETS-domain-DNA complex. Nature 380, 456-460. doi: 10.1038/380456a0
-
(1996)
Nature
, vol.380
, pp. 456-460
-
-
Kodandapani, R.1
Pio, F.2
Ni, C.Z.3
Piccialli, G.4
Klemsz, M.5
Mckercher, S.6
-
38
-
-
0030740262
-
Major domain swiveling revealed by the crystal structures of complexes of E. coli Rep helicase bound to single-stranded DNA and ADP
-
Korolev, S., Hsieh, J., Gauss, G. H., Lohman, T. M., and Waksman, G. (1997). Major domain swiveling revealed by the crystal structures of complexes of E. coli Rep helicase bound to single-stranded DNA and ADP. Cell 90, 635-647. doi: 10.1016/S0092-8674(00)80525-5
-
(1997)
Cell
, vol.90
, pp. 635-647
-
-
Korolev, S.1
Hsieh, J.2
Gauss, G.H.3
Lohman, T.M.4
Waksman, G.5
-
39
-
-
27144551710
-
Accumulation of Werner protein at DNA double-strand breaks in human cells
-
Lan, L., Nakajima, S., Komatsu, K., Nussenzweig, A., Shimamoto, A., Oshima, J.,et al. (2005). Accumulation of Werner protein at DNA double-strand breaks in human cells. J. Cell Sci. 118, 4153-4162. doi: 10.1242/jcs.02544
-
(2005)
J. Cell Sci.
, vol.118
, pp. 4153-4162
-
-
Lan, L.1
Nakajima, S.2
Komatsu, K.3
Nussenzweig, A.4
Shimamoto, A.5
Oshima, J.6
-
40
-
-
84873667075
-
RecQ helicases: conserved guardians of genomic integrity
-
Larsen, N. B., and Hickson, I. D. (2013). RecQ helicases: conserved guardians of genomic integrity. Adv. Exp. Med. Biol. 767, 161-184. doi: 10.1007/978-1-4614-5037-5_8
-
(2013)
Adv. Exp. Med. Biol.
, vol.767
, pp. 161-184
-
-
Larsen, N.B.1
Hickson, I.D.2
-
41
-
-
28244488655
-
Modulation of Werner syndrome protein function by a single mutation in the conserved RecQ domain
-
Lee, J. W., Kusumoto, R., Doherty, K. M., Lin, G. X., Zeng, W., Cheng, W. H.,et al. (2005). Modulation of Werner syndrome protein function by a single mutation in the conserved RecQ domain. J. Biol. Chem. 280, 39627-39636. doi: 10.1074/jbc.M506112200
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 39627-39636
-
-
Lee, J.W.1
Kusumoto, R.2
Doherty, K.M.3
Lin, G.X.4
Zeng, W.5
Cheng, W.H.6
-
42
-
-
33845657428
-
UvrD helicase unwinds DNA one base pair at a time by a two-part power stroke
-
Lee, J. Y., and Yang, W. (2006). UvrD helicase unwinds DNA one base pair at a time by a two-part power stroke. Cell 127, 1349-1360. doi: 10.1016/j.cell.2006.10.049
-
(2006)
Cell
, vol.127
, pp. 1349-1360
-
-
Lee, J.Y.1
Yang, W.2
-
43
-
-
84881476152
-
NMR structure of the N-terminal-most HRDC1 domain of RecQ helicase from Deinococcus radiodurans
-
Liu, S., Zhang, W., Gao, Z., Ming, Q., Hou, H., Lan, W.,et al. (2013). NMR structure of the N-terminal-most HRDC1 domain of RecQ helicase from Deinococcus radiodurans. FEBS Lett. 587, 2635-2642. doi: 10.1016/j.febslet.2013.06.048
-
(2013)
FEBS Lett
, vol.587
, pp. 2635-2642
-
-
Liu, S.1
Zhang, W.2
Gao, Z.3
Ming, Q.4
Hou, H.5
Lan, W.6
-
44
-
-
8444248943
-
Happy Hollidays: 40th anniversary of the Holliday junction
-
Liu, Y., and West, S. C. (2004). Happy Hollidays: 40th anniversary of the Holliday junction. Nat. Rev. Mol. Cell Biol. 5, 937-944. doi: 10.1038/nrm1502
-
(2004)
Nat. Rev. Mol. Cell Biol.
, vol.5
, pp. 937-944
-
-
Liu, Y.1
West, S.C.2
-
45
-
-
0033573075
-
The three-dimensional structure of the HRDC domain and implications for the Werner and Bloom syndrome proteins
-
Liu, Z., Macias, M. J., Bottomley, M. J., Stier, G., Linge, J. P., Nilges, M.,et al. (1999). The three-dimensional structure of the HRDC domain and implications for the Werner and Bloom syndrome proteins. Structure 7, 1557-1566. doi: 10.1016/S0969-2126(00)88346-X
-
(1999)
Structure
, vol.7
, pp. 1557-1566
-
-
Liu, Z.1
Macias, M.J.2
Bottomley, M.J.3
Stier, G.4
Linge, J.P.5
Nilges, M.6
-
46
-
-
84887045621
-
The BLM dissolvasome in DNA replication and repair
-
Manthei, K. A., and Keck, J. L. (2013). The BLM dissolvasome in DNA replication and repair. Cell. Mol. Life Sci. 70, 4067-4084. doi: 10.1007/s00018-013-1325-1
-
(2013)
Cell. Mol. Life Sci.
, vol.70
, pp. 4067-4084
-
-
Manthei, K.A.1
Keck, J.L.2
-
47
-
-
0031204917
-
Impaired nuclear localization of defective DNA helicases in Werner's syndrome
-
Matsumoto, T., Shimamoto, A., Goto, M., and Furuichi, Y. (1997). Impaired nuclear localization of defective DNA helicases in Werner's syndrome. Nat. Genet. 16, 335-336. doi: 10.1038/ng0897-335
-
(1997)
Nat. Genet.
, vol.16
, pp. 335-336
-
-
Matsumoto, T.1
Shimamoto, A.2
Goto, M.3
Furuichi, Y.4
-
48
-
-
84869840130
-
Non-Bloom syndrome-associated partial and total loss-of-function variants of BLM helicase
-
Mirzaei, H., and Schmidt, K. H. (2012). Non-Bloom syndrome-associated partial and total loss-of-function variants of BLM helicase. Proc. Natl. Acad. Sci. U.S.A. 109, 19357-19362. doi: 10.1073/pnas.1210304109
-
(2012)
Proc. Natl. Acad. Sci. U. S. A.
, vol.109
, pp. 19357-19362
-
-
Mirzaei, H.1
Schmidt, K.H.2
-
49
-
-
0030697336
-
A putative nucleic acid-binding domain in Bloom's and Werner's syndrome helicases
-
Morozov, V., Mushegian, A. R., Koonin, E. V., and Bork, P. (1997). A putative nucleic acid-binding domain in Bloom's and Werner's syndrome helicases. Trends Biochem. Sci. 22, 417-418. doi: 10.1016/S0968-0004(97)01128-6
-
(1997)
Trends Biochem. Sci.
, vol.22
, pp. 417-418
-
-
Morozov, V.1
Mushegian, A.R.2
Koonin, E.V.3
Bork, P.4
-
50
-
-
84858865110
-
MYC-driven tumorigenesis is inhibited by WRN syndrome gene deficiency
-
Moser, R., Toyoshima, M., Robinson, K., Gurley, K. E., Howie, H. L., Davison, J.,et al. (2012). MYC-driven tumorigenesis is inhibited by WRN syndrome gene deficiency. Mol. Cancer Res. 10, 535-545. doi: 10.1158/1541-7786.MCR-11-0508
-
(2012)
Mol. Cancer Res.
, vol.10
, pp. 535-545
-
-
Moser, R.1
Toyoshima, M.2
Robinson, K.3
Gurley, K.E.4
Howie, H.L.5
Davison, J.6
-
51
-
-
84872966436
-
A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells
-
Nguyen, G. H., Dexheimer, T. S., Rosenthal, A. S., Chu, W. K., Singh, D. K., Mosedale, G., et al. (2013). A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells. Chem. Biol. 20, 55-62. doi: 10.1016/j.chembiol.2012.10.016
-
(2013)
Chem. Biol.
, vol.20
, pp. 55-62
-
-
Nguyen, G.H.1
Dexheimer, T.S.2
Rosenthal, A.S.3
Chu, W.K.4
Singh, D.K.5
Mosedale, G.6
-
52
-
-
84903973907
-
Regulation of gene expression by the BLM helicase correlates with the presence of G-quadruplex DNA motifs
-
Nguyen, G. H., Tang, W., Robles, A. I., Beyer, R. P., Gray, L. T., Welsh, J. A.,et al. (2014). Regulation of gene expression by the BLM helicase correlates with the presence of G-quadruplex DNA motifs. Proc. Natl. Acad. Sci. U.S.A. 111, 9905-9910. doi: 10.1073/pnas.1404807111
-
(2014)
Proc. Natl. Acad. Sci. U. S. A.
, vol.111
, pp. 9905-9910
-
-
Nguyen, G.H.1
Tang, W.2
Robles, A.I.3
Beyer, R.P.4
Gray, L.T.5
Welsh, J.A.6
-
53
-
-
34547670683
-
Role for the Werner syndrome protein in the promotion of tumor cell growth
-
Opresko, P. L., Calvo, J. P., and Von Kobbe, C. (2007). Role for the Werner syndrome protein in the promotion of tumor cell growth. Mech. Ageing Dev. 128, 423-436. doi: 10.1016/j.mad.2007.05.009
-
(2007)
Mech. Ageing Dev.
, vol.128
, pp. 423-436
-
-
Opresko, P.L.1
Calvo, J.P.2
Von Kobbe, C.3
-
54
-
-
2942637828
-
The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2
-
Opresko, P. L., Otterlei, M., Graakjaer, J., Bruheim, P., Dawut, L., Kolvraa, S.,et al. (2004). The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2. Mol. Cell 14, 763-774. doi: 10.1016/j.molcel.2004.05.023
-
(2004)
Mol. Cell
, vol.14
, pp. 763-774
-
-
Opresko, P.L.1
Otterlei, M.2
Graakjaer, J.3
Bruheim, P.4
Dawut, L.5
Kolvraa, S.6
-
55
-
-
0032883842
-
Crystal structure of a DNA Holliday junction
-
Ortiz-Lombardia, M., Gonzalez, A., Eritja, R., Aymami, J., Azorin, F., and Coll, M. (1999). Crystal structure of a DNA Holliday junction. Nat. Struct. Biol. 6, 913-917. doi: 10.1038/13277
-
(1999)
Nat. Struct. Biol.
, vol.6
, pp. 913-917
-
-
Ortiz-Lombardia, M.1
Gonzalez, A.2
Eritja, R.3
Aymami, J.4
Azorin, F.5
Coll, M.6
-
56
-
-
84882753887
-
Chapter 18 - the biological basis of aging: implications for medical genetics
-
eds D. L. Rimoin, R. E. Pyeritz, and B. Korf (Philadelphia, PA: Elsevier)
-
Oshima, J., Martin, G. M., and Hisama, F. M. (2013). "Chapter 18 - the biological basis of aging: implications for medical genetics," in Emery and Rimoin's Principles and Practice of Medical Genetics, eds D. L. Rimoin, R. E. Pyeritz, and B. Korf (Philadelphia, PA: Elsevier), 1-19. doi: 10.1016/B978-0-12-383834-6.00022-7
-
(2013)
Emery and Rimoin's Principles and Practice of Medical Genetics
, pp. 119
-
-
Oshima, J.1
Martin, G.M.2
Hisama, F.M.3
-
57
-
-
33745084835
-
WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing
-
Perry, J. J., Yannone, S. M., Holden, L. G., Hitomi, C., Asaithamby, A., Han, S.,et al. (2006). WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing. Nat. Struct. Mol. Biol. 13, 414-422. doi: 10.1038/nsmb1088
-
(2006)
Nat. Struct. Mol. Biol.
, vol.13
, pp. 414-422
-
-
Perry, J.J.1
Yannone, S.M.2
Holden, L.G.3
Hitomi, C.4
Asaithamby, A.5
Han, S.6
-
58
-
-
59049103795
-
Structure of the human RECQ1 helicase reveals a putative strand-separation pin
-
Pike, A. C., Shrestha, B., Popuri, V., Burgess-Brown, N., Muzzolini, L., Costantini, S.,et al. (2009). Structure of the human RECQ1 helicase reveals a putative strand-separation pin. Proc. Natl. Acad. Sci. U.S.A. 106, 1039-1044. doi: 10.1073/pnas.0806908106
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 1039-1044
-
-
Pike, A.C.1
Shrestha, B.2
Popuri, V.3
Burgess-Brown, N.4
Muzzolini, L.5
Costantini, S.6
-
59
-
-
33746600628
-
Topoisomerase IIIa and Bloom's helicase can resolve a mobile double Holliday junction substrate through convergent branch migration
-
Plank, J. L., Wu, J., and Hsieh, T. S. (2006). Topoisomerase IIIα and Bloom's helicase can resolve a mobile double Holliday junction substrate through convergent branch migration. Proc. Natl. Acad. Sci. U.S.A. 103, 11118-11123. doi: 10.1073/pnas.0604873103
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 11118-11123
-
-
Plank, J.L.1
Wu, J.2
Hsieh, T.S.3
-
60
-
-
77958026729
-
Solution structure of the HRDC domain of human Bloom syndrome protein BLM
-
Sato, A., Mishima, M., Nagai, A., Kim, S. Y., Ito, Y., Hakoshima, T.,et al. (2010). Solution structure of the HRDC domain of human Bloom syndrome protein BLM. J. Biochem. 148, 517-525. doi: 10.1093/jb/mvq097
-
(2010)
J. Biochem.
, vol.148
, pp. 517-525
-
-
Sato, A.1
Mishima, M.2
Nagai, A.3
Kim, S.Y.4
Ito, Y.5
Hakoshima, T.6
-
61
-
-
33746966063
-
Bloom helicase and DNA topoisomerase IIIa are involved in the dissolution of sister chromatids
-
Seki, M., Nakagawa, T., Seki, T., Kato, G., Tada, S., Takahashi, Y.,et al. (2006). Bloom helicase and DNA topoisomerase IIIα are involved in the dissolution of sister chromatids. Mol. Cell. Biol. 26, 6299-6307. doi: 10.1128/MCB.00702-06
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 6299-6307
-
-
Seki, M.1
Nakagawa, T.2
Seki, T.3
Kato, G.4
Tada, S.5
Takahashi, Y.6
-
62
-
-
34548638261
-
Structure and mechanism of helicases and nucleic acid translocases
-
Singleton, M. R., Dillingham, M. S., and Wigley, D. B. (2007). Structure and mechanism of helicases and nucleic acid translocases. Annu. Rev. Biochem. 76, 23-50. doi: 10.1146/annurev.biochem.76.052305.115300
-
(2007)
Annu. Rev. Biochem.
, vol.76
, pp. 23-50
-
-
Singleton, M.R.1
Dillingham, M.S.2
Wigley, D.B.3
-
63
-
-
0029856618
-
Crystal structure of a DExx box DNA helicase
-
Subramanya, H. S., Bird, L. E., Brannigan, J. A., and Wigley, D. B. (1996). Crystal structure of a DExx box DNA helicase. Nature 384, 379-383. doi: 10.1038/384379a0
-
(1996)
Nature
, vol.384
, pp. 379-383
-
-
Subramanya, H.S.1
Bird, L.E.2
Brannigan, J.A.3
Wigley, D.B.4
-
64
-
-
84900459777
-
Structure of human Bloom's syndrome helicase in complex with ADP and duplex DNA
-
Swan, M. K., Legris, V., Tanner, A., Reaper, P. M., Vial, S., Bordas, R.,et al. (2014). Structure of human Bloom's syndrome helicase in complex with ADP and duplex DNA. Acta Crystallogr. D Biol. Crystallogr. 70, 1465-1475. doi: 10.1107/S139900471400501X
-
(2014)
Acta Crystallogr. D Biol. Crystallogr.
, vol.70
, pp. 1465-1475
-
-
Swan, M.K.1
Legris, V.2
Tanner, A.3
Reaper, P.M.4
Vial, S.5
Bordas, R.6
-
65
-
-
84864974044
-
DNA binding residues in the RQC domain of Werner protein are critical for its catalytic activities
-
Tadokoro, T., Kulikowicz, T., Dawut, L., Croteau, D. L., and Bohr, V. A. (2012). DNA binding residues in the RQC domain of Werner protein are critical for its catalytic activities. Aging (Albany, N.Y.) 4, 417-430.
-
(2012)
Aging (Albany, N. Y. )
, vol.4
, pp. 417-430
-
-
Tadokoro, T.1
Kulikowicz, T.2
Dawut, L.3
Croteau, D.L.4
Bohr, V.A.5
-
66
-
-
0033515425
-
Crystal structures of complexes of PcrA DNA helicase with a DNA substrate indicate an inchworm mechanism
-
Velankar, S. S., Soultanas, P., Dillingham, M. S., Subramanya, H. S., and Wigley, D. B. (1999). Crystal structures of complexes of PcrA DNA helicase with a DNA substrate indicate an inchworm mechanism. Cell 97, 75-84. doi: 10.1016/S0092-8674(00)80716-3
-
(1999)
Cell
, vol.97
, pp. 75-84
-
-
Velankar, S.S.1
Soultanas, P.2
Dillingham, M.S.3
Subramanya, H.S.4
Wigley, D.B.5
-
67
-
-
77953024275
-
Probing the structural basis of RecQ helicase function
-
Vindigni, A., Marino, F., and Gileadi, O. (2010). Probing the structural basis of RecQ helicase function. Biophys. Chem. 149, 67-77. doi: 10.1016/j.bpc.2010.03.012
-
(2010)
Biophys. Chem.
, vol.149
, pp. 67-77
-
-
Vindigni, A.1
Marino, F.2
Gileadi, O.3
-
68
-
-
0347362703
-
Werner syndrome protein contains three structure-specific DNA binding domains
-
Von Kobbe, C., Thoma, N. H., Czyzewski, B. K., Pavletich, N. P., and Bohr, V. A. (2003). Werner syndrome protein contains three structure-specific DNA binding domains. J. Biol. Chem. 278, 52997-53006. doi: 10.1074/jbc.M308338200
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 52997-53006
-
-
Von Kobbe, C.1
Thoma, N.H.2
Czyzewski, B.K.3
Pavletich, N.P.4
Bohr, V.A.5
-
69
-
-
23044449199
-
The HRDC domain of BLM is required for the dissolution of double Holliday junctions
-
Wu, L., Chan, K. L., Ralf, C., Bernstein, D. A., Garcia, P. L., Bohr, V. A.,et al. (2005). The HRDC domain of BLM is required for the dissolution of double Holliday junctions. EMBO J. 24, 2679-2687. doi: 10.1038/sj.emboj.7600740
-
(2005)
EMBO J
, vol.24
, pp. 2679-2687
-
-
Wu, L.1
Chan, K.L.2
Ralf, C.3
Bernstein, D.A.4
Garcia, P.L.5
Bohr, V.A.6
-
70
-
-
0347987856
-
The Bloom's syndrome helicase suppresses crossing over during homologous recombination
-
Wu, L., and Hickson, I. D. (2003). The Bloom's syndrome helicase suppresses crossing over during homologous recombination. Nature 426, 870-874. doi: 10.1038/nature02253
-
(2003)
Nature
, vol.426
, pp. 870-874
-
-
Wu, L.1
Hickson, I.D.2
-
71
-
-
1842861596
-
Three-dimensional structural views of branch migration and resolution in DNA homologous recombination
-
Yamada, K., Ariyoshi, M., and Morikawa, K. (2004). Three-dimensional structural views of branch migration and resolution in DNA homologous recombination. Curr. Opin. Struct. Biol. 14, 130-137. doi: 10.1016/j.sbi.2004.03.005
-
(2004)
Curr. Opin. Struct. Biol.
, vol.14
, pp. 130-137
-
-
Yamada, K.1
Ariyoshi, M.2
Morikawa, K.3
-
72
-
-
27544459564
-
Analysis of the Xenopus Werner syndrome protein in DNA double-strand break repair
-
Yan, H., Mccane, J., Toczylowski, T., and Chen, C. (2005). Analysis of the Xenopus Werner syndrome protein in DNA double-strand break repair. J. Cell Biol. 171, 217-227. doi: 10.1083/jcb.200502077
-
(2005)
J. Cell Biol.
, vol.171
, pp. 217-227
-
-
Yan, H.1
Mccane, J.2
Toczylowski, T.3
Chen, C.4
-
73
-
-
84859714621
-
Delineation of joint molecule resolution pathways in meiosis identifies a crossover-specific resolvase
-
Zakharyevich, K., Tang, S., Ma, Y., and Hunter, N. (2012). Delineation of joint molecule resolution pathways in meiosis identifies a crossover-specific resolvase. Cell 149, 334-347. doi: 10.1016/j.cell.2012.03.023
-
(2012)
Cell
, vol.149
, pp. 334-347
-
-
Zakharyevich, K.1
Tang, S.2
Ma, Y.3
Hunter, N.4
-
74
-
-
21744450431
-
Crystal structure of Escherichia coli RNase D, an exoribonuclease involved in structured RNA processing
-
Zuo, Y., Wang, Y., and Malhotra, A. (2005). Crystal structure of Escherichia coli RNase D, an exoribonuclease involved in structured RNA processing. Structure 13, 973-984. doi: 10.1016/j.str.2005.04.015
-
(2005)
Structure
, vol.13
, pp. 973-984
-
-
Zuo, Y.1
Wang, Y.2
Malhotra, A.3
|