Structure of human Bloom's syndrome helicase in complex with ADP and duplex DNA

Acta Crystallographica Section D: Biological Crystallography

Volumn 70, Issue 5, 2014, Pages 1465-1475

  Swan, Michael K ^a   Legris, Valerie ^a   Tanner, Adam ^a   Reaper, Philip M ^a   Vial, Sarah ^a   Bordas, Rebecca ^a   Pollard, John R ^a   Charlton, Peter A ^a   Golec, Julian M C ^a   Bertrand, Jay A ^a  

^a VERTEX PHARMACEUTICALS   (United States)

Author keywords

BLM; Bloom's syndrome; DNA helicases

Indexed keywords

ADENOSINE DIPHOSPHATE; BLOOM SYNDROME HELICASE; HETERODUPLEX; RECQ HELICASE;

BLOOM SYNDROME; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVE SITE; GENETICS; HUMAN; HYDROLYSIS; METABOLISM; MUTATION; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

ADENOSINE DIPHOSPHATE; BLOOM SYNDROME; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; HUMANS; HYDROLYSIS; MODELS, MOLECULAR; MUTATION; NUCLEIC ACID HETERODUPLEXES; PROTEIN CONFORMATION; RECQ HELICASES;

EID: 84900459777     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S139900471400501X     Document Type: Article

References (42)

1. Abrahams, J. P. & Leslie, A. G. W. (1996). Acta Cryst. D52, 30-42.
2. Bachrati, C. Z., Borts, R. H. & Hickson, I. D. (2006). Nucleic Acids Res. 34, 2269-2279.
3. Bennett, R. J. & Keck, J. L. (2004). Crit. Rev. Biochem. Mol. Biol. 39, 79-97.
4. Bernstein, D. A. & Keck, J. L. (2003). Nucleic Acids Res. 31, 2778-2785.
5. Bernstein, D. A., Zittel, M. C. & Keck, J. L. (2003). EMBO J. 22, 4910-4921.
6. Chaganti, R. S., Schonberg, S. & German, J. (1974). Proc. Natl Acad. Sci. USA, 71, 4508-4512.
7. Chan, K. L., North, P. S. & Hickson, I. D. (2007). EMBO J. 26, 3397-3409.
8. Chen, V. B., Arendall, W. B., Headd, J. J., Keedy, D. A., Immormino, R. M., Kapral, G. J., Murray, L. W., Richardson, J. S. & Richardson, D. C. (2010). Acta Cryst. D66, 12-21.
9. Chu, W. K. & Hickson, I. D. (2009). Nature Rev. Cancer, 9, 644-654.
10. Davies, S. L., North, P. S. & Hickson, I. D. (2007). Nature Struct. Mol. Biol. 14, 677-679.
11. Durant, S. T. (2012). J. Cancer, 3, 67-82.
12. Ellis, N. A., Groden, J., Ye, T.-Z., Straughen, J., Lennon, D. J., Ciocci, S., Proytcheva, M. & German, J. (1995). Cell, 83, 655-666.
13. Emsley, P., Lohkamp, B., Scott, W. G. & Cowtan, K. (2010). Acta Cryst. D66, 486-501.
14. Foucault, F., Vaury, C., Barakat, A., Thibout, D., Planchon, P., Jaulin, C., Praz, F. & Amor-Gué ret, M. (1997). Hum. Mol. Genet. 6, 1427-1434.
15. German, J. (1997). Cancer Genet. Cytogenet. 93, 100-106.
16. German, J., Archibald, R. & Bloom, D. (1965). Science, 148, 506-507.
17. German, J., Sanz, M. M., Ciocci, S., Ye, T.-Z. & Ellis, N. A. (2007). Hum. Mutat. 28, 743-753.
18. Guo, R.-B., Rigolet, P., Ren, H., Zhang, B., Zhang, X. D., Dou, S.-X., Wang, P.-Y., Amor-Gueret, M. & Xi, X.-G. (2007). Nucleic Acids Res. 35, 6297-6310.
19. Guo, R.-B., Rigolet, P., Zargarian, L., Fermandjian, S. & Xi, X.-G. (2005). Nucleic Acids Res. 33, 3109-3124.
20. Huber, M. D., Duquette, M. L., Shiels, J. C. & Maizels, N. (2006). J. Mol. Biol. 358, 1071-1080.
21. Imamura, O., Fujita, K., Shimamoto, A., Tanabe, H., Takeda, S., Furuichi, Y. & Matsumoto, T. (2001). Oncogene, 20, 1143-1151.
22. Janscak, P., Garcia, P. L., Hamburger, F., Makuta, Y., Shiraishi, K., Imai, Y., Ikeda, H. & Bickle, T. A. (2003). J. Mol. Biol. 330, 29-42.
23. Karow, J. K., Chakraverty, R. K. & Hickson, I. D. (1997). J. Biol. Chem. 272, 30611-30614.
24. Karow, J. K., Constantinou, A., Li, J.-L., West, S. C. & Hickson, I. D. (2000). Proc. Natl Acad. Sci. USA, 97, 6504-6508.
25. Kim, S.-Y., Hakoshima, T. & Kitano, K. (2013). Sci. Rep. 3, 3294.
26. Kim, Y. M. & Choi, B.-S. (2010). Nucleic Acids Res. 38, 7764-7777.
27. Kitano, K., Kim, S.-Y. & Hakoshima, T. (2010). Structure, 18, 177-187.
28. Mirzaei, H. & Schmidt, K. H. (2012). Proc. Natl Acad. Sci. USA, 109, 19357-19362.
29. Mohaghegh, P., Karow, J. K. Jr, Brosh, R. M., Bohr, V. A. & Hickson, I. D. (2001). Nucleic Acids Res. 29, 2843-2849.
30. Morozov, V., Mushegian, A. R., Koonin, E. V. & Bork, P. (1997). Trends Biochem. Sci. 22, 417-418.
31. Muyldermans, S. (2001). Rev. Mol. Biotechnol. 74, 277-302.
32. Neff, N. F., Ellis, N. A., Ye, T.-Z., Noonan, J., Huang, K., Sanz, M. & Proytcheva, M. (1999). Mol. Biol. Cell, 10, 665-676.
33. Nguyen, G. H. et al. (2013). Chem. Biol. 20, 55-62.
34. Pike, A. C.W., Shrestha, B., Popuri, V., Burgess-Brown, N., Muzzolini, L., Costantini, S., Vindigni, A. & Gileadi, O. (2009). Proc. Natl Acad. Sci. USA, 106, 1039-1044.
35. Ren, H., Dou, S.-X., Rigolet, P., Yang, Y., Wang, P.-Y., Amor-Gueret, M. & Xi, X. G. (2007). Nucleic Acids Res. 35, 6029-6041.
36. Rezazadeh, S. (2013). Mol. Biol. Rep. 40, 3049-3064.
37. Rosenthal, A. S., Dexheimer, T. S., Gileadi, O., Nguyen, G. H., Chu, W. K., Hickson, I. D., Jadhav, A., Simeonov, A. & Maloney, D. J. (2013). Bioorg. Med. Chem. Lett. 23, 5660-5666.
38. Sato, A., Mishima, M., Nagai, A., Kim, S.-Y., Ito, Y., Hakoshima, T., Jee, J.-G. & Kitano, K. (2010). J. Biochem. 148, 517-525.
39. Sun, H., Karow, J. K., Hickson, I. D. & Maizels, N. (1998). J. Biol. Chem. 273, 27587-27592.
40. Vonrhein, C., Blanc, E., Roversi, P. & Bricogne, G. (2007). Methods Mol. Biol. 364, 215-230.
41. Wu, L., Chan, K. L., Ralf, C., Bernstein, D. A., Garcia, P. L., Bohr, V. A., Vindigni, A., Janscak, P., Keck, J. L. & Hickson, I. D. (2005). EMBO J. 24, 2679-2687.
42. Wu, L. & Hickson, I. D. (2003). Nature (London), 426, 870-874.