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Volumn 63, Issue 9, 2015, Pages 1553-1567

Inhibition of connexin43 improves functional recovery after ischemic brain injury in neonatal rats

Author keywords

Astrocyte; Caspase 3; Connexin43; Glutamate; Ischemic brain injury

Indexed keywords

CASPASE 3; CONNEXIN 43; GLUTAMIC ACID; SERINE; CONNEXIN 43 PROTEIN, RAT; GAP 26 PEPTIDE; GAP 27 PEPTIDE; GAP JUNCTION PROTEIN; GLUCOSE; NEUROPROTECTIVE AGENT; PEPTIDE;

EID: 84949109724     PISSN: 08941491     EISSN: 10981136     Source Type: Journal    
DOI: 10.1002/glia.22826     Document Type: Article
Times cited : (82)

References (64)
  • 1
    • 0033779559 scopus 로고    scopus 로고
    • Astrocyte glutamate transport: Review of properties, regulation, and physiological functions
    • Anderson CM, Swanson RA. 2000. Astrocyte glutamate transport: Review of properties, regulation, and physiological functions. Glia 32:1-14.
    • (2000) Glia , vol.32 , pp. 1-14
    • Anderson, C.M.1    Swanson, R.A.2
  • 2
    • 34247644332 scopus 로고    scopus 로고
    • Change in permeant size selectivity by phosphorylation of connexin 43 gap-junctional hemichannels by PKC
    • Bao X, Lee SC, Reuss L, Altenberg GA. 2007. Change in permeant size selectivity by phosphorylation of connexin 43 gap-junctional hemichannels by PKC. Proc Natl Acad Sci USA 104:4919-4924.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 4919-4924
    • Bao, X.1    Lee, S.C.2    Reuss, L.3    Altenberg, G.A.4
  • 3
    • 84891403754 scopus 로고    scopus 로고
    • 14-3-3theta facilitates plasma membrane delivery and function of mechanosensitive connexin 43 hemichannels
    • Batra N, Riquelme MA, Burra S, Jiang JX. 2014. 14-3-3theta facilitates plasma membrane delivery and function of mechanosensitive connexin 43 hemichannels. J Cell Sci 127:137-146.
    • (2014) J Cell Sci , vol.127 , pp. 137-146
    • Batra, N.1    Riquelme, M.A.2    Burra, S.3    Jiang, J.X.4
  • 4
    • 0242380340 scopus 로고    scopus 로고
    • Pharmacological sensitivity of ATP release triggered by photoliberation of inositol-1,4,5-trisphosphate and zero extracellular calcium in brain endothelial cells
    • Braet K, Aspeslagh S, Vandamme W, Willecke K, Martin PE, Evans WH, Leybaert L. 2003. Pharmacological sensitivity of ATP release triggered by photoliberation of inositol-1, 4, 5-trisphosphate and zero extracellular calcium in brain endothelial cells. J Cell Physiol 197:205-213.
    • (2003) J Cell Physiol , vol.197 , pp. 205-213
    • Braet, K.1    Aspeslagh, S.2    Vandamme, W.3    Willecke, K.4    Martin, P.E.5    Evans, W.H.6    Leybaert, L.7
  • 5
    • 84905025755 scopus 로고    scopus 로고
    • Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice
    • Chen G, Park CK, Xie RG, Berta T, Nedergaard M, Ji RR. 2014. Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice. Brain 137:2193-2209.
    • (2014) Brain , vol.137 , pp. 2193-2209
    • Chen, G.1    Park, C.K.2    Xie, R.G.3    Berta, T.4    Nedergaard, M.5    Ji, R.R.6
  • 6
    • 84906257686 scopus 로고    scopus 로고
    • Astroglial connexin43 hemichannels tune basal excitatory synaptic transmission
    • Chever O, Lee CY, Rouach N. 2014. Astroglial connexin43 hemichannels tune basal excitatory synaptic transmission. J Neurosci 34:11228-11232.
    • (2014) J Neurosci , vol.34 , pp. 11228-11232
    • Chever, O.1    Lee, C.Y.2    Rouach, N.3
  • 9
    • 0034888287 scopus 로고    scopus 로고
    • Applications of the morris water maze in the study of learning and memory
    • D'Hooge R, De Deyn PP. 2001. Applications of the morris water maze in the study of learning and memory. Brain Res Brain Res Rev 36:60-90.
    • (2001) Brain Res Brain Res Rev , vol.36 , pp. 60-90
    • D'Hooge, R.1    De Deyn, P.P.2
  • 11
    • 0037281030 scopus 로고    scopus 로고
    • The carboxy-tail of connexin-43 localizes to the nucleus and inhibits cell growth
    • Dang X, Doble BW, Kardami E. 2003. The carboxy-tail of connexin-43 localizes to the nucleus and inhibits cell growth. Mol Cell Biochem 242:35-38.
    • (2003) Mol Cell Biochem , vol.242 , pp. 35-38
    • Dang, X.1    Doble, B.W.2    Kardami, E.3
  • 12
    • 33748316458 scopus 로고    scopus 로고
    • Regulation of connexin-43-mediated growth inhibition by a phosphorylatable amino-acid is independent of gap junction-forming ability
    • Dang X, Jeyaraman M, Kardami E. 2006. Regulation of connexin-43-mediated growth inhibition by a phosphorylatable amino-acid is independent of gap junction-forming ability. Mol Cell Biochem 289:201-207.
    • (2006) Mol Cell Biochem , vol.289 , pp. 201-207
    • Dang, X.1    Jeyaraman, M.2    Kardami, E.3
  • 16
    • 84892502745 scopus 로고    scopus 로고
    • Injury-triggered akt phosphorylation of cx43: A ZO-1-driven molecular switch that regulates gap junction size
    • Dunn CA, Lampe PD. 2014. Injury-triggered akt phosphorylation of cx43: A ZO-1-driven molecular switch that regulates gap junction size. J Cell Sci 127:455-464.
    • (2014) J Cell Sci , vol.127 , pp. 455-464
    • Dunn, C.A.1    Lampe, P.D.2
  • 17
    • 33745528139 scopus 로고    scopus 로고
    • The gap junction cellular internet: Connexin hemichannels enter the signalling limelight
    • Evans WH, De Vuyst E, Leybaert L. 2006. The gap junction cellular internet: Connexin hemichannels enter the signalling limelight. Biochem J 397:1-14.
    • (2006) Biochem J , vol.397 , pp. 1-14
    • Evans, W.H.1    De Vuyst, E.2    Leybaert, L.3
  • 20
    • 0037382614 scopus 로고    scopus 로고
    • Beyond the gap: Functions of unpaired connexon channels
    • Goodenough DA, Paul DL. 2003. Beyond the gap: Functions of unpaired connexon channels. Nat Rev Mol Cell Biol 4:285-294.
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 285-294
    • Goodenough, D.A.1    Paul, D.L.2
  • 21
    • 34247377375 scopus 로고    scopus 로고
    • Up-regulation of connexin43 in the glial scar following photothrombotic ischemic injury
    • Haupt C, Witte OW, Frahm C. 2007. Up-regulation of connexin43 in the glial scar following photothrombotic ischemic injury. Mol Cell Neurosci 35:89-99.
    • (2007) Mol Cell Neurosci , vol.35 , pp. 89-99
    • Haupt, C.1    Witte, O.W.2    Frahm, C.3
  • 22
    • 84865568181 scopus 로고    scopus 로고
    • Single intravenous low-dose injections of connexin 43 mimetic peptides protect ischemic heart in vivo against myocardial infarction
    • Hawat G, Helie P, Baroudi G. 2012. Single intravenous low-dose injections of connexin 43 mimetic peptides protect ischemic heart in vivo against myocardial infarction. J Mol Cell Cardiol 53:559-566.
    • (2012) J Mol Cell Cardiol , vol.53 , pp. 559-566
    • Hawat, G.1    Helie, P.2    Baroudi, G.3
  • 23
    • 0342879924 scopus 로고    scopus 로고
    • Use of antibodies in the analysis of connexin 43 turnover and phosphorylation
    • Hertzberg EL, Saez JC, Corpina RA, Roy C, Kessler JA. 2000. Use of antibodies in the analysis of connexin 43 turnover and phosphorylation. Methods 20:129-139.
    • (2000) Methods , vol.20 , pp. 129-139
    • Hertzberg, E.L.1    Saez, J.C.2    Corpina, R.A.3    Roy, C.4    Kessler, J.A.5
  • 24
    • 28644434657 scopus 로고    scopus 로고
    • Zonula occludens-1 alters connexin43 gap junction size and organization by influencing channel accretion
    • Hunter AW, Barker RJ, Zhu C, Gourdie RG. 2005. Zonula occludens-1 alters connexin43 gap junction size and organization by influencing channel accretion. Mol Biol Cell 16:5686-5698.
    • (2005) Mol Biol Cell , vol.16 , pp. 5686-5698
    • Hunter, A.W.1    Barker, R.J.2    Zhu, C.3    Gourdie, R.G.4
  • 25
    • 84887991440 scopus 로고    scopus 로고
    • Connexin-43 hemichannels contribute to the propagation of mu-calpain-mediated neuronal death in a cortical ablation injury model
    • Ishii Y, Shintani-Ishida K, Yoshida KI. 2013. Connexin-43 hemichannels contribute to the propagation of mu-calpain-mediated neuronal death in a cortical ablation injury model. Biochem Biophys Res Commun 441:457-462.
    • (2013) Biochem Biophys Res Commun , vol.441 , pp. 457-462
    • Ishii, Y.1    Shintani-Ishida, K.2    Yoshida, K.I.3
  • 27
    • 0034788643 scopus 로고    scopus 로고
    • Pathways of neuron-astrocyte interactions and their possible role in neuroprotection
    • Kirchhoff F, Dringen R, Giaume C. 2001. Pathways of neuron-astrocyte interactions and their possible role in neuroprotection. Eur Arch Psychiatry Clin Neurosci 251:159-169.
    • (2001) Eur Arch Psychiatry Clin Neurosci , vol.251 , pp. 159-169
    • Kirchhoff, F.1    Dringen, R.2    Giaume, C.3
  • 28
    • 0033745550 scopus 로고    scopus 로고
    • Metabolic inhibition activates a non-selective current through connexin hemichannels in isolated ventricular myocytes
    • Kondo RP, Wang SY, John SA, Weiss JN, Goldhaber JI. 2000. Metabolic inhibition activates a non-selective current through connexin hemichannels in isolated ventricular myocytes. J Mol Cell Cardiol 32:1859-1872.
    • (2000) J Mol Cell Cardiol , vol.32 , pp. 1859-1872
    • Kondo, R.P.1    Wang, S.Y.2    John, S.A.3    Weiss, J.N.4    Goldhaber, J.I.5
  • 29
    • 0030028301 scopus 로고    scopus 로고
    • The gap junction communication channel
    • Kumar NM, Gilula NB. 1996. The gap junction communication channel. Cell 84:381-388.
    • (1996) Cell , vol.84 , pp. 381-388
    • Kumar, N.M.1    Gilula, N.B.2
  • 30
    • 0032103769 scopus 로고    scopus 로고
    • Proteolysis of connexin43-containing gap junctions in normal and heat-stressed cardiac myocytes
    • Laing JG, Tadros PN, Green K, Saffitz JE, Beyer EC. 1998. Proteolysis of connexin43-containing gap junctions in normal and heat-stressed cardiac myocytes. Cardiovasc Res 38:711-718.
    • (1998) Cardiovasc Res , vol.38 , pp. 711-718
    • Laing, J.G.1    Tadros, P.N.2    Green, K.3    Saffitz, J.E.4    Beyer, E.C.5
  • 31
    • 10344233669 scopus 로고    scopus 로고
    • Extracellular proteolytic pathophysiology in the neurovascular unit after stroke
    • Lee SR, Wang X, Tsuji K, Lo EH. 2004. Extracellular proteolytic pathophysiology in the neurovascular unit after stroke. Neurol Res 26:854-861.
    • (2004) Neurol Res , vol.26 , pp. 854-861
    • Lee, S.R.1    Wang, X.2    Tsuji, K.3    Lo, E.H.4
  • 32
    • 1842426943 scopus 로고    scopus 로고
    • Epidermal growth factor regulates ubiquitination, internalization and proteasome-dependent degradation of connexin43
    • Leithe E, Rivedal E. 2004. Epidermal growth factor regulates ubiquitination, internalization and proteasome-dependent degradation of connexin43. J Cell Sci 117:1211-1220.
    • (2004) J Cell Sci , vol.117 , pp. 1211-1220
    • Leithe, E.1    Rivedal, E.2
  • 34
    • 84884708157 scopus 로고    scopus 로고
    • PKCvarepsilon mediates serine phosphorylation of connexin43 induced by lysophosphatidylcholine in neonatal rat cardiomyocytes
    • Liao CK, Cheng HH, Wang SD, Yeih DF, Wang SM. 2013. PKCvarepsilon mediates serine phosphorylation of connexin43 induced by lysophosphatidylcholine in neonatal rat cardiomyocytes. Toxicology 314:11-21.
    • (2013) Toxicology , vol.314 , pp. 11-21
    • Liao, C.K.1    Cheng, H.H.2    Wang, S.D.3    Yeih, D.F.4    Wang, S.M.5
  • 35
    • 36849085955 scopus 로고    scopus 로고
    • Mechanisms of glutamate release from astrocytes
    • Malarkey EB, Parpura V. 2008. Mechanisms of glutamate release from astrocytes. Neurochem Int 52:142-154.
    • (2008) Neurochem Int , vol.52 , pp. 142-154
    • Malarkey, E.B.1    Parpura, V.2
  • 36
    • 15944401408 scopus 로고    scopus 로고
    • Effects of connexin-mimetic peptides on gap junction functionality and connexin expression in cultured vascular cells
    • Martin PE, Wall C, Griffith TM. 2005. Effects of connexin-mimetic peptides on gap junction functionality and connexin expression in cultured vascular cells. Br J Pharmacol 144:617-627.
    • (2005) Br J Pharmacol , vol.144 , pp. 617-627
    • Martin, P.E.1    Wall, C.2    Griffith, T.M.3
  • 37
    • 0034067910 scopus 로고    scopus 로고
    • Connexins and gap junctions of astrocytes and oligodendrocytes in the CNS
    • Nagy JI, Rash JE. 2000. Connexins and gap junctions of astrocytes and oligodendrocytes in the CNS. Brain Res Brain Res Rev 32:29-44.
    • (2000) Brain Res Brain Res Rev , vol.32 , pp. 29-44
    • Nagy, J.I.1    Rash, J.E.2
  • 38
    • 0042122377 scopus 로고    scopus 로고
    • Astrocytic gap junctions composed of connexin 43 reduce apoptotic neuronal damage in cerebral ischemia
    • Nakase T, Fushiki S, Naus CC. 2003. Astrocytic gap junctions composed of connexin 43 reduce apoptotic neuronal damage in cerebral ischemia. Stroke 34:1987-1993.
    • (2003) Stroke , vol.34 , pp. 1987-1993
    • Nakase, T.1    Fushiki, S.2    Naus, C.C.3
  • 39
    • 33748864085 scopus 로고    scopus 로고
    • Enhanced connexin 43 immunoreactivity in penumbral areas in the human brain following ischemia
    • Nakase T, Yoshida Y, Nagata K. 2006. Enhanced connexin 43 immunoreactivity in penumbral areas in the human brain following ischemia. Glia 54:369-375.
    • (2006) Glia , vol.54 , pp. 369-375
    • Nakase, T.1    Yoshida, Y.2    Nagata, K.3
  • 40
    • 0035876476 scopus 로고    scopus 로고
    • Glutamate release and neuronal damage in ischemia
    • Nishizawa Y. 2001. Glutamate release and neuronal damage in ischemia. Life Sci 69:369-381.
    • (2001) Life Sci , vol.69 , pp. 369-381
    • Nishizawa, Y.1
  • 41
    • 84875956067 scopus 로고    scopus 로고
    • Connexin43 mimetic peptide is neuroprotective and improves function following spinal cord injury
    • O'Carroll SJ, Gorrie CA, Velamoor S, Green CR, Nicholson LF. 2013. Connexin43 mimetic peptide is neuroprotective and improves function following spinal cord injury. Neurosci Res 75:256-267.
    • (2013) Neurosci Res , vol.75 , pp. 256-267
    • O'Carroll, S.J.1    Gorrie, C.A.2    Velamoor, S.3    Green, C.R.4    Nicholson, L.F.5
  • 42
    • 79953059185 scopus 로고    scopus 로고
    • A peptide mimetic of the connexin43 carboxyl terminus reduces gap junction remodeling and induced arrhythmia following ventricular injury
    • O'Quinn MP, Palatinus JA, Harris BS, Hewett KW, Gourdie RG. 2011. A peptide mimetic of the connexin43 carboxyl terminus reduces gap junction remodeling and induced arrhythmia following ventricular injury. Circ Res 108:704-715.
    • (2011) Circ Res , vol.108 , pp. 704-715
    • O'Quinn, M.P.1    Palatinus, J.A.2    Harris, B.S.3    Hewett, K.W.4    Gourdie, R.G.5
  • 43
    • 75849165091 scopus 로고    scopus 로고
    • Hypoxia in high glucose followed by reoxygenation in normal glucose reduces the viability of cortical astrocytes through increased permeability of connexin 43 hemichannels
    • Orellana JA, Hernandez DE, Ezan P, Velarde V, Bennett MV, Giaume C, Saez JC. 2010. Hypoxia in high glucose followed by reoxygenation in normal glucose reduces the viability of cortical astrocytes through increased permeability of connexin 43 hemichannels. Glia 58:329-343.
    • (2010) Glia , vol.58 , pp. 329-343
    • Orellana, J.A.1    Hernandez, D.E.2    Ezan, P.3    Velarde, V.4    Bennett, M.V.5    Giaume, C.6    Saez, J.C.7
  • 45
    • 33749368927 scopus 로고    scopus 로고
    • Molecular dynamics and in vitro analysis of connexin43: A new 14-3-3 mode-1 interacting protein
    • Park DJ, Freitas TA, Wallick CJ, Guyette CV, Warn-Cramer BJ. 2006. Molecular dynamics and in vitro analysis of connexin43: A new 14-3-3 mode-1 interacting protein. Protein Sci 15:2344-2355.
    • (2006) Protein Sci , vol.15 , pp. 2344-2355
    • Park, D.J.1    Freitas, T.A.2    Wallick, C.J.3    Guyette, C.V.4    Warn-Cramer, B.J.5
  • 48
    • 0037040922 scopus 로고    scopus 로고
    • Transduction of cell survival signals by connexin-43 hemichannels
    • Plotkin LI, Manolagas SC, Bellido T. 2002. Transduction of cell survival signals by connexin-43 hemichannels. J Biol Chem 277:8648-8657.
    • (2002) J Biol Chem , vol.277 , pp. 8648-8657
    • Plotkin, L.I.1    Manolagas, S.C.2    Bellido, T.3
  • 49
    • 0034611012 scopus 로고    scopus 로고
    • Physiological role of gap-junctional hemichannels. Extracellular calcium-dependent isosmotic volume regulation
    • Quist AP, Rhee SK, Lin H, Lal R. 2000. Physiological role of gap-junctional hemichannels. Extracellular calcium-dependent isosmotic volume regulation. J Cell Biol 148:1063-1074.
    • (2000) J Cell Biol , vol.148 , pp. 1063-1074
    • Quist, A.P.1    Rhee, S.K.2    Lin, H.3    Lal, R.4
  • 50
    • 79955501784 scopus 로고    scopus 로고
    • Connexin 43 connexon to gap junction transition is regulated by zonula occludens-1
    • Rhett JM, Jourdan J, Gourdie RG. 2011. Connexin 43 connexon to gap junction transition is regulated by zonula occludens-1. Mol Biol Cell 22:1516-1528.
    • (2011) Mol Biol Cell , vol.22 , pp. 1516-1528
    • Rhett, J.M.1    Jourdan, J.2    Gourdie, R.G.3
  • 51
    • 84901200175 scopus 로고    scopus 로고
    • Mutation of human connexin43 amino acids s279/s282 increases protein stability upon treatment with epidermal growth factor
    • Schmitt M, Leykauf K, Reinz E, Cheng H, Alonso A, Schenkel J. 2014. Mutation of human connexin43 amino acids s279/s282 increases protein stability upon treatment with epidermal growth factor. Cell Biochem Biophys 69:379-384.
    • (2014) Cell Biochem Biophys , vol.69 , pp. 379-384
    • Schmitt, M.1    Leykauf, K.2    Reinz, E.3    Cheng, H.4    Alonso, A.5    Schenkel, J.6
  • 53
    • 14844295525 scopus 로고    scopus 로고
    • Expression and functions of neuronal gap junctions
    • Sohl G, Maxeiner S, Willecke K. 2005. Expression and functions of neuronal gap junctions. Nat Rev Neurosci 6:191-200.
    • (2005) Nat Rev Neurosci , vol.6 , pp. 191-200
    • Sohl, G.1    Maxeiner, S.2    Willecke, K.3
  • 54
    • 33750300467 scopus 로고    scopus 로고
    • Functional connexin "hemichannels": A critical appraisal
    • Spray DC, Ye ZC, Ransom BR. 2006. Functional connexin "hemichannels": A critical appraisal. Glia 54:758-773.
    • (2006) Glia , vol.54 , pp. 758-773
    • Spray, D.C.1    Ye, Z.C.2    Ransom, B.R.3
  • 56
    • 0034757195 scopus 로고    scopus 로고
    • Transient upregulation of the glial glutamate transporter GLAST in response to fibroblast growth factor, insulin-like growth factor and epidermal growth factor in cultured astrocytes
    • Suzuki K, Ikegaya Y, Matsuura S, Kanai Y, Endou H, Matsuki N. 2001. Transient upregulation of the glial glutamate transporter GLAST in response to fibroblast growth factor, insulin-like growth factor and epidermal growth factor in cultured astrocytes. J Cell Sci 114:3717-3725.
    • (2001) J Cell Sci , vol.114 , pp. 3717-3725
    • Suzuki, K.1    Ikegaya, Y.2    Matsuura, S.3    Kanai, Y.4    Endou, H.5    Matsuki, N.6
  • 58
    • 0042833252 scopus 로고    scopus 로고
    • Do connexin 43 gap-junctional hemichannels activate and cause cell damage during ATP depletion of renal-tubule cells?
    • Vergara L, Bao X, Bello-Reuss E, Reuss L. 2003. Do connexin 43 gap-junctional hemichannels activate and cause cell damage during ATP depletion of renal-tubule cells? Acta Physiol Scand 179:33-38.
    • (2003) Acta Physiol Scand , vol.179 , pp. 33-38
    • Vergara, L.1    Bao, X.2    Bello-Reuss, E.3    Reuss, L.4
  • 59
    • 84890433663 scopus 로고    scopus 로고
    • Connexin targeting peptides as inhibitors of voltage- and intracellular Ca2+-triggered cx43 hemichannel opening
    • Wang N, De Bock M, Decrock E, Bol M, Gadicherla A, Bultynck G, Leybaert L. 2013a. Connexin targeting peptides as inhibitors of voltage- and intracellular Ca2+-triggered cx43 hemichannel opening. Neuropharmacology 75:506-516.
    • (2013) Neuropharmacology , vol.75 , pp. 506-516
    • Wang, N.1    De Bock, M.2    Decrock, E.3    Bol, M.4    Gadicherla, A.5    Bultynck, G.6    Leybaert, L.7
  • 60
    • 84876672134 scopus 로고    scopus 로고
    • The role of connexin 43 and hemichannels correlated with the astrocytic death following ischemia/reperfusion insult
    • Wang X, Ma A, Zhu W, Zhu L, Zhao Y, Xi J, Zhang X, Zhao B. 2013b. The role of connexin 43 and hemichannels correlated with the astrocytic death following ischemia/reperfusion insult. Cell Mol Neurobiol 33:401-410.
    • (2013) Cell Mol Neurobiol , vol.33 , pp. 401-410
    • Wang, X.1    Ma, A.2    Zhu, W.3    Zhu, L.4    Zhao, Y.5    Xi, J.6    Zhang, X.7    Zhao, B.8
  • 61
    • 36248933743 scopus 로고    scopus 로고
    • Necrostatin-1 protects against glutamate-induced glutathione depletion and caspase-independent cell death in HT-22 cells
    • Xu X, Chua CC, Kong J, Kostrzewa RM, Kumaraguru U, Hamdy RC, Chua BH. 2007. Necrostatin-1 protects against glutamate-induced glutathione depletion and caspase-independent cell death in HT-22 cells. J Neurochem 103:2004-2014.
    • (2007) J Neurochem , vol.103 , pp. 2004-2014
    • Xu, X.1    Chua, C.C.2    Kong, J.3    Kostrzewa, R.M.4    Kumaraguru, U.5    Hamdy, R.C.6    Chua, B.H.7
  • 62
    • 0037531231 scopus 로고    scopus 로고
    • Functional hemichannels in astrocytes: A novel mechanism of glutamate release
    • Ye ZC, Wyeth MS, Baltan-Tekkok S, Ransom BR. 2003. Functional hemichannels in astrocytes: A novel mechanism of glutamate release. J Neurosci 23:3588-3596.
    • (2003) J Neurosci , vol.23 , pp. 3588-3596
    • Ye, Z.C.1    Wyeth, M.S.2    Baltan-Tekkok, S.3    Ransom, B.R.4
  • 63
    • 78650176658 scopus 로고    scopus 로고
    • Dose-dependent protective effect of connexin43 mimetic peptide against neurodegeneration in an ex vivo model of epileptiform lesion
    • Yoon JJ, Green CR, O'Carroll SJ, Nicholson LF. 2010. Dose-dependent protective effect of connexin43 mimetic peptide against neurodegeneration in an ex vivo model of epileptiform lesion. Epilepsy Res 92:153-162.
    • (2010) Epilepsy Res , vol.92 , pp. 153-162
    • Yoon, J.J.1    Green, C.R.2    O'Carroll, S.J.3    Nicholson, L.F.4
  • 64
    • 77957076579 scopus 로고    scopus 로고
    • Targeting astrocytes for stroke therapy
    • Zhao Y, Rempe DA. 2010. Targeting astrocytes for stroke therapy. Neurotherapeutics 7:439-451.
    • (2010) Neurotherapeutics , vol.7 , pp. 439-451
    • Zhao, Y.1    Rempe, D.A.2


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