Synthesis and in vitro sodium channel blocking activity evaluation of novel homochiral mexiletine analogs

Chirality

Volumn 22, Issue 3, 2010, Pages 299-307

  Carocci, Alessia ^a   Catalano, Alessia ^a   Bruno, Claudio ^a   Lentini, Giovanni ^a   Franchini, Carlo ^a   De Bellis, Michela ^a   De Luca, Annamaria ^a   Camerino, Diana Conte ^a  

^a UNIVERSITY OF BARI   (Italy)

Author keywords

Enantiomeric excess; Mexiletine; Myotonia; Use dependent block; Voltage gated sodium channels

Indexed keywords

3 (2,6 DIMETHYLPHENOXY)BUTAN 1 AMINE; MEXILETINE; R 3 (2,6 DIMETHYLPHENOXY)1 PHENYLPROPAN 1 AMINE; S 3 (2,6 DIMETHYLPHENOXY)1 PHENYLPROPAN 1 AMINE; SODIUM CHANNEL BLOCKING AGENT; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL;

ANIMAL EXPERIMENT; ARTICLE; CHIRALITY; DRUG POTENCY; DRUG SYNTHESIS; ENANTIOSELECTIVITY; FROG; NONHUMAN; PRIORITY JOURNAL; SKELETAL MUSCLE;

ANIMALS; MEXILETINE; MUSCLES; MYOTONIA; SODIUM CHANNEL BLOCKERS;

EID: 75849128495     PISSN: 08990042     EISSN: 1520636X     Source Type: Journal    
DOI: 10.1002/chir.20741     Document Type: Article

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