Age-induced alterations in biological clock: Therapeutic effects of melatonin

Brain Aging and Therapeutic Interventions

Volumn , Issue , 2012, Pages 111-129

  Wadhwa, Renu ^a  

^a UNIVERSITY OF HYDERABAD   (India)

Author keywords

Aging; Antioxidant; Circadian rhythms; Melatonin; Suprachiasmatic nucleus

Indexed keywords

EID: 84948975578     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-94-007-5237-5_8     Document Type: Chapter

References (81)

1. Agostino PV, Ferreyra GA, Murad AD, Watanabe Y, Golombek DA (2004) Diurnal, circadian and photic regulation of calcium/calmodulin-dependent kinase II and neuronal nitric oxide synthase in the hamster suprachiasmatic nuclei. Neurochem Int 44:617-625
2. Antoch MP, Gorbacheva VY, Vykhovanets O, Toshkov IA, Kondratov RV, Kondratova AA (2008) Disruption of the circadian clock due to the Clock mutation has discrete effects on aging and carcinogenesis. Cell Cycle 7:1197-1204
3. Arivazhagan P, Thilakavathy T, Panneerselvam C (2000) Antioxidant lipoate and tissue antioxidants in aged rats. J Nutr Biochem 11:122-127
4. Asai M, Yoshinobu Y, Kaneko S, Mori A, Nikaido T, Moriya T, Akiyama M, Shibata S (2001) Circadian profile of per Gene mRNA expression in the Suprachiasmatic Nucleus, Paraventricular Nucleus, and Pineal Body of aged rats. J Neurosci Res 66:1133-1139
5. Aujard F, Dkhissi-Benyahya O, Fournier I, claustrat B, Schilling A, Cooper HM, Perret M (2001) Artificially accelerated aging by shortened photoperiod alters early gene expression fos in the suprachiasmatic nucleus and sulfatoxymelatonin excretion in a small primate, microcebus murinus. Neuroscience 105:403-412
6. Baeza I, Fdez-Tresguerres J, Ariznavarreta C, De la Fuente M (2010) Effects of growth hormone, melatonin, oestrogens and phytoestrogens on the oxidized glutathione (GSSG)/reduced glutathione (GSH) ratio and lipid peroxidation in aged ovariectomized rats. Biogerontology 11:687-701
7. Baydas G, Gursu MF, Yilmaz S, Canpolat S, Yasar A, Cikim G, Canatan H (2002) Daily rhythm of glutathione peroxidase activity, lipid peroxidation and glutathione levels in tissues of pinealec-tomized rats. Neurosci Lett 323:195-198
8. Bellet MM, Sassone-Corsi PP (2010) Mammalian circadian clock and metabolism—the epigenetic link. Cell Sci 23:3837-3848
9. Benloucifa S, Greena K, L’Hermite-Baleriaux M, Weintraub S, Wolfed LF, Zee PC (2006) Responsiveness of the aging circadian clock to light. Neurobiol Aging 27:1870-1879
10. Billiard M (2009) REM sleep behavior disorder and narcolepsy. CNS Neurol Disord Drug Targets 8:264-270
11. Buscemi N, Vandermeer B, Hooton N, Pandya R, Tjosvold L, Hartling L, Vohra S, Klassen TP, Baker G (2006) Efficacy and safety of exogenous melatonin for secondary sleep disorders and sleep disorders accompanying sleep restriction: meta-analysis. BMJ 332:385-393
12. Cardinali DP, Esquifino AI, Srinivasan V, Seithikurippu R, Pandi-Perumal (2008) Melatonin and the immune system in aging. Neuroimmunomodulation 15:272-278
13. Cardinali DP, Pagano ES, Scacchi Bernasconi PA, Reynoso R, Scacchi P (2011) Disrupted chrono-biology of sleep and cytoprotection in obesity: possible therapeutic value of melatonin. Neuro Endocrinol Lett 32:588-606
14. Chen SJ, Kao CL, Chang YL, Yen CJ, Shui JW, Chien CS, Chen IL, Tsai TH, Ku HH, Chiou SH (2007) Antidepressant administration modulates neural stem cell survival and serotoninergic differentiation through bcl-2. Curr Neurovasc Res 4:19-29
15. Davidson AJ, Yamazaki S, Arble DM, Menaker M, Block GD (2008) Resetting of central and peripheral circadian oscillators in aged rats. Neurobiol Aging 29:471-477
16. Dibner C, Schibler U, Albrecht U (2010) The mammalian circadian timing system: organization and coordination of central and peripheral clocks. Annu Rev Physiol 72:517-549
17. Doi M, Ishida A, Miyake A, Sato M, Komatsu R, Yamazaki F, Kimura I, Tsuchiya S, Kori H, Seo K, Yamaguchi Y, Matsuo M, Fustin JM, Tanaka R, Santo Y, Yamada H, Takahashi Y, Araki M, Nakao K, Aizawa S, Kobayashi M, Obrietan K, Tsujimoto G, Okamura H (2011) Circadian regulation of intracellular G-protein signalling mediates intercellular synchrony and rhythmic-ity in the suprachiasmatic nucleus. Nat Commun 2:327-336
18. Dowling GA, Mastick J, Colling E, Carter JH, Singer CM, Aminoff MJ (2005) Melatonin for sleep disturbances in Parkinson’s disease. Sleep Med 6:459-466
19. Dubocovich ML, Rivera-Bermudez MA, Gerdin MJ, Masana MI (2003) Molecular pharmacology, regulation and function of mammalian melatonin receptors. Front Biosci 1:1093-1098
20. Gibson MV, Fritz J, Kachur V (2009) Practical strategies for management of hypertension in the elderly. Geriatrics 64:10-19
21. Hardeland R, Cardinali DP, Srinivasan V, Spence DW, Brown GM, Pandi-Perumal SR (2011) Melatonin—a pleiotropic, orchestrating regulator molecule. Prog Neurobiol 93:350-384
22. Hardeland R, Madrid JA, Tan DX, Reiter RJ (2012) Melatonin, the circadian multioscillator system and health: the need for detailed analyses of peripheral melatonin signaling. J Pineal Res 52:139-166
23. Harper DG, Volicer L, Stopa EG, Mckee AC, Nitta M, Satlin A (2005) Disturbance of endogenous circadian rhythm in aging and Alzheimer disease. Am J Geriatr Psychiatry 13:359-368
24. Hill V, Dunn L, Dunning K, Page SJ (2011) A pilot study of rhythm and timing training as a supplement to occupational therapy in stroke rehabilitation. Top Stroke Rehabil 18:728-737
25. Hofman MA, Swaab DF (2006) Living by the clock: the circadian pacemaker in older people. Aging Res Rev 5:33-51
26. Hussain AM, Mitra AK (2000) Effect of aging on tryptophan hydroxylase in rat brain: implications on serotonin level. Drug Metab Dispos 28:1038-1042
27. Jagota A (2005) Aging and Sleep Disorders. I J Gerontol 19:415-424
28. Jagota A (2006) Suprachiasmatic nucleus: the center for circadian timing system in mammals. Proc Indian Natl Sci Acad B71:275-288
29. Jagota A, Kalyani D (2008) Daily serotonin rhythms in rat brain during postnatal development and aging. Biogerontology 9:229-234
30. Jagota A, Kalyani D (2010) Effect of melatonin on age induced changes in daily serotonin rhythms in suprachiasmatic nucleus of male wistar rat. Biogerontology 11:299-308
31. Jagota A, Reddy MY (2007) The effect of curcumin on ethanol induced changes in suprachias-matic nucleus (SCN) and pineal. Cell Mol Neurobiol 27:997-1006
32. Jagota A, de la Iglesia HO, Schwartz WJ (2000) Morning and evening circadian oscillations in the suprachiasmatic nucleus in vitro. Nat Neurosci 3:372-376
33. Judge S, Jang YM, Smith A, Hagen T, Leeuwenburgh C (2005) Age-associated increases in oxidative stress and antioxidant enzyme activities in cardiac interfibrillar mitochondria: implications for the mitochondrial theory of aging. FASEB J 19:419-421
34. Jung-Hynes B, Reiter RJ, Ahmad N (2010) Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer. J Pineal Res. 48:9-19
35. Kakiuchi T, Ohba H, Nishiyama S, Sato K, Harada N, Nakanishi S, Tsukada H (2001) Age-related changes in muscarinic cholinergic receptors in the living brain: a PET study using N-[11C] methyl-4-piperidyl benzilate combined with cerebral blood flow measurement in conscious monkeys. Brain Res 916:22-31
36. Kirkwood TB (2005) Time of our lives. What controls the length of life? EMBO Rep Spec:S4-8
37. Kondratov RV, Kondratova AA, Gorbacheva VY, Vykhovanets OV, Antoch MP (2006) Early aging and age-related pathologies in mice deficient in BMAL1, the core componentof the circadian clock. Genes Dev 20:1868-1873
38. Kunieda T, Minamino T, Katsuno T, Tateno K, Nishi J, Miyauchi H, Orimo M, Okada S, Komuro I (2006) Cellular senescence impairs circadian expression of clock genes in vitro and in vivo. Circ Res 98:532-539
39. Lee CC (2005) The circadian clock and tumor suppression by mammalian period genes. Methods Enzymol 393:852-861
40. Martin J, Marler M, Shochat TAncoli-Israe S (2000) Circadian rhythms of agitation in institutionalized patients with Alzheimer’s Disease. Chronobiol Internat. 17:405-418
41. Mauriz JL, Molpeceres V, Garcia-Mediavilla MV, Gonzalez P, Barrio JP, Gonzalez-Gallego J (2007) Melatonin prevents oxidative stress and changes in antioxidant enzyme expression and activity in the liver of aging rats. J Pineal Res 42:222-230
42. Maurizi CP (2001) Alzheimer’s disease: roles for mitochondrial damage, the hydroxyl radical, and cerebrospinal fluid deficiency of melatonin. Med Hypotheses 57:156-160
43. Miller JP, Mcauley JD, Pang KCH (2005) Spontaneous fos expression in the Suprachiasmatic nucleus of young and old mice. Neurobiol Aging 26:1107-1115
44. Mishima K, Okawa M, Shimizu T, Hishikawa Y (2001) Diminished melatonin secretion in the elderly caused by insufficient environmental illumination. J Clin Endocrinol Metab 8:129-134
45. Mitsui S, Yamaguchi S, Matsuo T, Ishida Y, Okamura H (2001) Antagonistic role of E4BP4 and PAR proteins in the circadian oscillatory mechanism. Genes Dev 15:995-1006
46. Nachiyar RK, Subramanian KP, Manivasagam TT (2011) Influence of aging on the circadian patterns of thiobarbituric acid reactive substances and antioxidants in Wistar rats. Biol Rhythm Res 42:147-154
47. Nishida S, Sato R, Murai I, Nakagawa S (2003) Effect of pinealectomy on plasma levels of insulin and leptin and on hepatic lipids in type 2 diabetic rats. J Pineal Res 35:251-256
48. Nunes DM, Mota RM, Machado MO, Pereira ED, Bruin VM, Bruin PF (2008) Effect of melatonin administration on subjective sleep quality in chronic obstructive pulmonary disease. Braz J Med Biol Res 41:926-931
49. Pandi-Perumal SR, Zisapel N, Srinivasan V, Cardanali DP (2005) Melatonin and sleep in aging population. Exp Gerontol 40:911-925
50. Perreau-Lenz S, Kalsbeek A, Van Der Vliet J, P’evet P, Buijs RM (2005) In vivo evidence for a controlled offset of melatonin synthesis at dawn by the suprachiasmatic nucleus in the rat. Neuroscience 130:797-803
51. Poeggeler B (2005) Melatonin, aging, and age-related diseases: perspectives for prevention, intervention, and therapy. Endocrine 27:201-212
52. Rebrin I, Zicker S, Wedekind KJ, Paetau-Robinson I, Packer L, Sohal RS (2005) Effect of antioxidant-enriched diets on glutathione redox status in tissue homogenates and mitochondria of the senescence-accelerated mouse. Free Radic Biol Med 39:549-557
53. Rehman H, Masson E (2001) Neuroendocrinology of aging. Age Aging 30:279-287
54. Reiter RJ, Tan DX, Fuentes-Broto L (2010) Melatonin: a multitasking molecule. Prog Brain Res181:127-151
55. Revell VL, Burgess HJ, Gazda CJ, Smith MR, Fogg L, Eastman CI (2006) Advancing human circadian rhythms with afternoon melatonin and morning intermittent bright light. J Clin Endocrinol Metab 91:54-59
56. Rollo CD (2009) Dopamine and aging: intersecting facets. Neurochem Res 34:601-629
57. Simonneaux V, Ribelayga C (2003) Generation of the melatonin endocrine message in mammals: a review of the complex regulation of melatonin synthesis by norepinephrine, peptides, and other pineal transmitters. Pharmacol Rev 55:325-395
58. Smith CP, Walton A, Loveland AD, Umberger GH, Kryscio RJ, Gash DM (2005). Memories that last in old age: motor skill learning and memory presentation. Neurobiol Aging 26:883-890
59. Sohal RS (2002) Role of oxidative stress and protein oxidation in the aging process. Free Radic Biol Med 33:37-44
60. Spadoni G, Bedini A, Rivara S, Mor M (2011) Melatonin receptor agonists: new options for insomnia and depression treatment. CNS Neurosci Ther 17:733-741
61. Srinivasan V, Pandi-Perumal SR, Brezezinski A, Bhatnagar KP, Cardinali DP (2011) Melatonin, immune function and cancer. Recent Pat Endocr Metab Immune Drug Discov 5:109-123
62. Sugden D, Davidson K, Hough KA, Teh MT (2004) Melatonin, melatonin receptors and melano-phores: a moving story. Pigment Cell Res 17:454-460
63. Tajes M, Gutierrez-Cuesta J, Ortuno-Sahagun D, Camins A, Pallas M (2009) Anti-aging properties of melatonin in an in vitro murine senescence model: involvement of the sirtuin 1 pathway. J Pineal Res 47:228-237
64. Takahashi JS, Hong HK, Ko CH, Mcdearmon EL (2008) The genetics of mammalian circadian order and disorder: implications for physiology and disease. Nat Rev Genet 9:764-775
65. Touitou Y (2001) Human aging and melatonin. Clinical relevance. Exp Gerontol 36:1083-1100
66. Toussaint O, Dumont P, Dierick JF, Pascal T, Frippiat C, Chainiaux F, Sluse F, Eliaers F, Remacle J (2000) Stress-induced premature senescence. Essence of life, evolution, stress, and aging. Ann N Y Acad Sci 908:85-98
67. Tsutsui K, Inoue K, Miyabara H, Suzuki S, Ogura Y, Tobari Y, Haraguchi S (2009) Discovery of a novel avian neurosteroid, 7alpha-hydroxypregnenolone, and its role in the regulation of the diurnal rhythm of locomotor activity in Japanese quail. Gen Comp Endocrinol 163:117-122
68. Turek FW, Gillette MU (2004) Melatonin, sleep, and circadian rhythms: rationale for development of specific melatonin agonists. Sleep Med 5:523-532
69. Van Dyck CH, Malison RT, Seibyl JP, Laruelle M, Klumpp H, Zoghbi SS, Baldwin RM, Innis RB (2000) Age-related decline in central serotonin transporter availability with [(123)I]beta-CIT SPECT. Neurobiol Aging 21:497-501
70. van Geijlswijk IM, Korzilius HP, Smits MG (2010) The use of exogenous melatonin in delayed sleep phase disorder: a meta-analysis. Sleep 33:1605-1671
71. Wade AG, Ford I, Crawford G, Mcmahon AD, Nir T, Laudon M, Zisapel N (2007) Efficacy of prolonged release melatonin in insomnia patients aged 55-80 years: quality of sleep and next-day alertness outcomes. Curr Med Res Opin 23:2597-2605
72. Welsh DK, Takahashi JS, Kay SA (2010) Suprachiasmatic nucleus: cell autonomy and network properties. Annu Rev Physiol 72:551-577
73. Whitehead DL, Davies AD, Playfer JR, Turnbull CJ (2008) Circadian rest-activity rhythm is altered in Parkinson’s disease patients with hallucinations. Mov Disord 23:1137-1145
74. Whittom S, Dumont M, Petit D, Desautels A, Adam B, Lavigne G, Montplaisir J (2010) Effects of melatonin and bright light administration on motor and sensory symptoms of RLS. Sleep Med 11:351-355
75. Wu YH, Zhou JN, Van Heerikhuize J, Jockers R, Swaab DF (2007) Decreased MT1 melatonin receptor expression in the suprachiasmatic nucleus in aging and Alzheimer’s disease. Neurobiol Aging 28:1239-1347
76. Yagita K, Tamanini F, Yasuda M, Hoeijmakers JH, Van Der Horst GT, Okamura H (2002) Nucleo-cytoplasmic shuttling and mCRY-dependent inhibition of ubiquitylation of the mPER2 clock protein. EMBO J 21:1301-1314
77. Yao K, Fang J, Yin YL, Feng ZM, Tang ZR, Wu G (2011) Tryptophan metabolism in animals: important roles in nutrition and health. Front Biosci 3:286-297
78. Yonei Y, Hatton A, Tsutsui K, Okawa M, Ishizuka B (2010) Effects of melatonin: basic studies and clinical applications. Anti Aging Med 7:85-91
79. Yoon SO, Yun CH, Chung AS (2002) Dose effect of oxidative stress on signal transduction in aging. Mech Aging 123:1597-1604
80. Yu EA, Weaver DR (2011) Disrupting the circadian clock: gene-specific effects on aging, cancer, and other phenotypes. Aging 3:479-493
81. Zisapel N (2001) Circadian rhythm sleep disorders: pathophysiology and potential approaches to management. CNS Drugs 15:311-328