Tryptophan metabolism in animals: Important roles in nutrition and health

Frontiers in Bioscience - Scholar

Volumn 3 S, Issue 1, 2011, Pages 286-297

  Yao, Kang ^a,b,c   Fang, Jun ^b   Yin, Yu Long ^a   Feng, Ze Meng ^a,d   Tang, Zhi Ru ^a   Wu, Guoyao ^a,c,e  

^a INSTITUTE OF SUBTROPICAL AGRICULTURE   (China)

^b HUNAN AGRICULTURAL UNIVERSITY   (China)

^c TEXAS A AND M UNIVERSITY   (United States)

^d UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^e CHINA AGRICULTURAL UNIVERSITY   (China)

Author keywords

Feed Intake; Immunity; Metabolism; Review; Tryptophan

Indexed keywords

3 HYDROXYKYNURENINE; 5 HYDROXYTRYPTOPHAN; AMMONIA; ANTHRANILIC ACID; GHRELIN; INDOLEAMINE 2,3 DIOXYGENASE; KYNURENINE; MELATONIN; N ACETYLSEROTONIN; NICOTINIC ACID; PICOLINIC ACID; SEROTONIN; TRYPTOPHAN;

AMINO ACID DEFICIENCY; ARTICLE; CATABOLISM; CENTRAL NERVOUS SYSTEM FUNCTION; COLITIS; DIET SUPPLEMENTATION; DIETARY INTAKE; DRUG SAFETY; FOOD INTAKE; GENE EXPRESSION; IMMUNITY; MACROPHAGE; MULTIPLE TRAUMA; NERVOUS SYSTEM FUNCTION; NONHUMAN; NUTRITIONAL HEALTH; NUTRITIONAL REQUIREMENT; OXIDATIVE STRESS; PHAGOCYTOSIS; REPRODUCTION; SEROTONIN BRAIN LEVEL; TRYPTOPHAN DEFICIENCY; TRYPTOPHAN METABOLISM; ANIMAL; ANIMAL FOOD; GENE EXPRESSION REGULATION; HOMEOSTASIS; HUMAN; IMMUNOLOGY; METABOLISM; NERVOUS SYSTEM; PHYSIOLOGY; REVIEW;

ANIMALIA; AVES; MAMMALIA;

ANIMAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; ANIMALS; GENE EXPRESSION REGULATION; HOMEOSTASIS; HUMANS; MELATONIN; NERVOUS SYSTEM; NIACIN; NUTRITIONAL REQUIREMENTS; SEROTONIN; TRYPTOPHAN;

EID: 78751616103     PISSN: 19450516     EISSN: 19450524     Source Type: Journal    
DOI: None     Document Type: Article

References (130)

1. Gerald Huether, Walter Kochen, Thomas J Simat and Steinhart Hans: Tryptophan, serotonin, and melatonin: Basic aspects and applications. Kluwer Academic/Plenum Publ, NY (1999)
2. Nathalie Le Floc'h and Bernard Seve: Biological roles of tryptophan and its metabolism: Potential implications for pig feeding. Livest Sci 112, 23-32 (2007)
3. Robert Schwarcz, Arash Rassoulpour, Hui-Qiu Wu, Deborah Medoff, Carol A. Tamminga and Rosalinda C. Roberts: Increased cortical kynurenate content in schizophrenia. Biol Psychiatry 50(7), 521-30 (2001) (Pubitemid 32971883)
4. Milton W. Taylor and Gensheng Feng: Relationship between interferon-gamma, indoleamine-2,3-dioxygenase, and tryptophan catabolism. FASEB 5(11), 2516-22 (1991) (Pubitemid 21905800)
5. R. R. Brown, Y. Ozaki, S. P. Datta, E. C. Borden, P. M. Sondel and D. G. Malone: Implications of interferon-induced tryptophan catabolism in cancer, auto-immune diseases and AIDS. Adv Exp Med Biol 294, 425-35 (1991)
6. Jon P. Ruddick, Andrew K. Evans, David J. Nutt, Stafford L. Lightman, Graham A.W. Rook and Christopher A. Lowry: Tryptophan metabolism in the central nervous system: medical implications. Expert Rev Mol Med 8(20), 1-27 (2006) (Pubitemid 44322753)
7. Trevor W. Stone and L. Gail Darlington: Endogenous kynurenines as targets for drug discovery and development. Nat Rev Drug Discov 1(8), 609-20 (2002) (Pubitemid 37361524)
8. Hideki Miura, Norio Ozaki, Makoto Sawada, Kenichi Isobe , Tatsuro Ohta and Toshiharu Nagatsu: A link between stress and depression: Shifts in the balance between the kynurenine and serotonin pathways of tryptopha n metabolism and the etiology and pathophysiology of depression. Stress 11(3), 198-209 (2008) (Pubitemid 351874183)
9. Peter G. McLeana, Richard A. Bormana and Kevin Lee: 5-HT in the enteric nervous system: gut function and neuropharmacology. Trends Neurosci 30(1), 9-13 (2007) (Pubitemid 46001679)
10. Dennis S. Charney: Monoamine dysfunction and the pathophysiology and treatment of depression. J Clin Psychiatry 59 Suppl 14, 11-4 (1998) (Pubitemid 28462383)
11. Irwin Lucki: The spectrum of behaviors influenced by serotonin. Biol Psychiatry 44(3), 151-62 (1998) (Pubitemid 28378297)
12. Luciane Rosa Feksa, Alexandra Latini, Virgínia Cielo Rech, Moacir Wajner, Carlos Severo Dutra-Filho, Angela Terezinha de Souza Wyse and Clovis Milton Duval Wannmacher: Promotion of oxidative stress by L-tryptophan in cerebral cortex of rats. Neurochem Int 49(1), 87-93 (2006)
13. Keiji Miyata, Takeshi Kamato, Akito Nishida, Hiroyukito, Hidenobu Yuki, Mayumi Yamano, Aie Tsutsumi, Yoshinori Katsuyama and Kazuo Honda: Role of the serotonin3 receptor in stress-induced defecation. J Pharmacol Exp Ther 261(1), 297-303 (1992)
14. Rüdiger Hardeland, S.R. Pandi-Perumal and Dan iel P. Cardinali: Melatonin. Int J Biochem Cell Biol 38(3), 313-316 (2006) (Pubitemid 41821880)
15. S. J. Konturek, P. C. Konturek, T. Brzozowski, G. A. Bubenik: Role of melatonin in upper gastrointestinal tract. J Physiol Pharmacol 58 Suppl 6, 23-52 (2007)
16. P. C. Konturek, G. Burnat, T. Brzozowski, Y. Zopf, S. J. Konturek: Tryptophan free diet delays healing of chronic gastric ulcers in rat. J Physiol Pharmacol 59 Suppl 2, 53-65 (2008)
17. Nawrot-Porabka K, Jaworek J, Leja-Szpak A, Szklarczyk J, Kot M, Mitis-Musioł M, Konturek SJ, Pawlik WW: Involvement of va gal nerves in the pancreatostimulatory effects of luminal melatonin, or its precursor L-tryptophan. Study in the rats. J Physiol Pharmacol 58 Suppl 6, 81-95 (2007)
18. Sergio D. Paredes, Ana M Marchena, Ignacio Bejarano, Javier Espino, Carmen Barriga, Ruben V. Rial, Russel J. Reiter and Ana B. Rodríguez: Melatonin and tryptophan affect the activity-rest rhythm, core and peripheral temperatures, and interleukin levels in the ring dove: changes with age. J Gerontol A Biol Sci Med Sci 64(3), 340-50 (2009)
19. Robert Schwarcz and Roberto Pellicciari: Manipulation of brain kynurenines: glial targets, neuronal effects, and clinic al opportunities. J Pharmacol Exp Ther 303(1), 1-10 (2002)
20. Kenton J. Swartz, Matthew J. During, Andrew Freese and M. Flint Beal: Cerebral synthesis and release of kynurenic acid: an endogenous antagonist of excitatory amino acid receptors. J Neurosci 10(9), 2965-73 (1990)
21. Trevor W Stone: Inhibitors of the kynurenine pathway. Eur J Med Chem 35(2), 179-86 (2000) (Pubitemid 30165682)
22. Erhardt S, Engberg G: Increased phasic activity of dopaminergic neurones in the rat ventral tegmental area following pharmacologically elevated levels of endogenous kynurenic acid. Acta Physiol Scand 175(1), 45-53 (2002) (Pubitemid 34534004)
23. Sophie Erhardt, Lilly Schwieler, Carolina Emanuelsson, Mark Geyer: Endogenous kynurenic acid disrupts prepulse inhibition. Biol Psychiatry 56(4), 255-60 (2004) (Pubitemid 39092940)
24. R. Car penedo, A. Pittaluga , A. Cozzi , S. Attucci, A Galli, M. Raiteri, F. Moroni: Presynaptic kynurenate-sensitive receptors inhibit glutamate release. Eur J Neurosci 13(11), 2141-7 (2001) (Pubitemid 32578800)
25. Hui-Qiu Wu, Kjell Fuxe and Robert Schwarcz: Neuronal A1 receptors mediate increase in extracellular kynurenic acid after local intrastriatal adenosine infusion. J Neurochem 90(3), 621-8 (2004) (Pubitemid 38989392)
26. Fabienne Peyrot and Claire Ducrocq: Potential role of tryptophan derivatives in stress responses characterized by the generation of reactive oxygen and nitrogen species. J Pineal Res 45(3), 235-46 (2008)
27. Naho Sasaki, Yukari Egashira and Hiroo Sanada: Production of L-tryptophan-derived catabolites in hepatocytes from streptozotocin-induced diabetic rats. Eur J Nutr 48(3), 145-53 (2009)
28. Gerard Clarke, Peter Fitzgerald, John J Cryan, Eugene M Cassidy, Eamonn Quigley and Timothy G Dinan: Tryptophan degradation in irritable bowel syndrome: evidence of indoleamine 2,3-dioxygenase activation in a male cohort. BMC Gastroenterol 9:6 (2009)
29. N. Müller and M.J. Schwarz: The immune-mediated alteration of serotonin and glutamate: towards an integrated view of depression. Mol Psychiatry 12(11), 988-1000 (2007) (Pubitemid 350006207)
30. Ursula Grohmann, Francesca Fallarino and Paolo Puccetti: Tolerance, DCs and tryptophan: much ado about IDO. Trends Immunol 24(5), 242-8 (2003) (Pubitemid 36555962)
31. Peng Li, Yu-Long Yin, Defa Li, Sung Woo Kim and Guoyao Wu: Amino Acids and Immune Function. Br J Nutr 98, 237-252 (2007) (Pubitemid 47091364)
32. Sung Woo Kim, Ronald D. Mateo, Yu-long Yin and Guoyao Wu: Functional amino acids and fatty acids for enhancing production performance of sows and piglets. Asian-Aust. J. Anim. Sci. 20: 295-306 (2007) (Pubitemid 46292894)
33. E. R. Pfefferkorn: Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptopha n. Proc Natl Acad Sci USA 81(3), 908-12 (1984) (Pubitemid 14197611)
34. J. M. Carlin, Y. Ozaki, G I. Byrne, R. R. Brown and E. C. Borden: Interferons and indoleamine-2,3-dioxygenase: role in antimicrobial and antitumor effects. Cellular and Molecular Life Sciences 45(6), 535-41 (1989) (Pubitemid 19151363)
35. Silvia Bozza, Francesca Fallarino, Lucia Pitzurra, Teresa Zelante, Claudia Montagnoli, Silvia Bellocchio, Paolo Mosci, Carmine Vacca, Paolo Puccetti and Luigina Romani: A crucial role for tryptophan catabolism at the host/Candida albicans interface. J Immunol 174(5), 2910-8 (2005) (Pubitemid 40279709)
36. Claudia Montagnoli, Francesca Fallarino, Roberta Gaziano, Bozza S, Silvia Bellocchio, Teresa Zelante, Wiswanath P. Kurup, Lucia Pitzurra, Paolo Puccetti and Luigina Romani: Immunity and tolerance to Aspergillus involve functionally distinct regulatory T cells and tryptophan catabolism. J Immunol 176(3), 1712-23 (2006) (Pubitemid 43134316)
37. Luigina Romani and Paolo Puccetti: Protective tolerance to fungi: the role of IL-10 and tryptophan catabolism. Trends Microbiol 14(4), 183-9 (2006)
38. Deborah Braun, Randy S. Longman and Matthew L. Albert: A two-step induction of indoleamine-2,3-dioxygenase (IDO) activity during dendritic-cell maturation. Blood 106(7), 2375-2381 (2005) (Pubitemid 41510810)
39. Francesca Fallarino, Ciriana Orabona, Carmine Vacca, Roberta Bianchi, Stefania Gizzi, Carine AsselinPaturel, Maria Cristina Fioretti, Giorgio Trinchieri, Ursula Grohmann and Paolo Puccetti: Ligand and cytokine dependence of the immunosuppressive pathway of tryptophan catabolism in plasmacytoid dendritic cells. Int Immunol 17(11), 1429-1438 (2005) (Pubitemid 41631319)
40. Patrick Hwu, Mark X. Du, Rejean Lapointe, My Do, Milton W. Taylor and Howard A. Young: Indoleamine-2,3-Dioxyge nase Production by Human Dendritic Cells Results in the Inhibition of T Cell Proliferation. J Immunol 164(7), 3596-3599 (2000) (Pubitemid 30169812)
41. Tomoko Hayashi, Lucinda Beck, Cyprian Rossetto, Xing Gong, Osamu Takikawa, Kenji Takabayashi, David H. Broide, Dennis A. Carson and Eyal Raz: Inhibition of experimental asthma by indoleamine 2,3-dioxygenase. J Clin Invest 114(2), 270-279 (2004) (Pubitemid 39071632)
42. Andrew L. Mellor and David H. Munn: Tryptophan catabolism and T-cell tolerance: immunosuppression by starvation? Immunol Today 20(10), 469-73 (1999) (Pubitemid 29476077)
43. Wei Dai, Huiqi Pan, Oliver Kwok, J.P. D ubey: Human indoleamine-2, 3-dioxygenase inhibits Toxoplasma gondii growth in fibroblast cells. J Interferon Res 14(6), 313-7 (1994)
44. Christian Hucke, Colin R. MacKenzie, Koku D. Z. Adjogble, Osamu Takikawa and Walter Däubener: Nitric oxide-mediated regulation of gamma interferon-induced bacteriostasis: inhibition and degradation of human indoleamine-2, 3-dioxygenase. Infect Immun 72(5), 2723-30 (2004) (Pubitemid 38542399)
45. U. von Rango, C.A. Krusche, H.M. Beier, I. Classen-Linke: Indoleamine-dioxygenase is expressed in human decidua at the time maternal tolerance is established. J Reprod Immunol 74(1 -2), 34-45 (2007) (Pubitemid 46679063)
46. P. Sedlmayr, A. Blaschitz, R. Wintersteiger, M. Semlitsch, A. Hammer, C.R. MacKenzie, W. Walcher, O. Reich, O. Takikawa and G. Dohr: Localization of indoleamine-2,3-dioxygenase in human female reproductive organs and the placenta. Mol Hum Reprod 8(4), 385-91 (2002) (Pubitemid 34303247)
47. Yoshiki Kudo, C.A.R. Boyd, Isabella Spyropoulou, C.W.G. Redman, Osamu Takikawa, Takafumi Katsuki, Tetsuaki Hara, Koso Ohama and I.L. Sargent: Indoleamine-2,3-dioxygenase: distribution and function in the developing human placenta. J Reprod Immunol 61(2), 87-98 (2004) (Pubitemid 38446982)
48. P. Ligam, U. Manuelpillai, E. M. Wallace and D. Walker: Localisation of indoleamine-2,3-dioxygenase and kynurenine hydroxylase in the human placenta and decidua: implications for role of the kynurenine pathway in pregnancy. Placenta 26(6), 498-504 (2005) (Pubitemid 40796578)
49. Koji Narui, Norihisa Noguchi, Aya Saito, Kazuhiro Kakimi, Noboru Motomura, Kinya Kubo, Shinichi Takamoto and Masanori Sasatsu: Anti-infectious activity of tryptophan metabolites in the L-tryptophan-L-kynurenine pathway. Biol Pharm Bull 32(1), 41-4 (2009)
50. Shanshan Cai, Katsumasa Sato, Toshiaki Shimizu, Seiko Yamabe, Miho Hiraki, Chiaki Sano and Haruaki Tomioka: Antimicrobial activity of picolinic acid against extracellular and intracellular Mycobacterium avium complex and its combined activity with clarithromycin, rifampicin and fluoroquinolones. J Antimicrob Chemother 5 7(1), 85-93 (2006) (Pubitemid 43057063)
51. Katharina Pellegrin, Gabriele Neurauter, Barbara Wirleitner, Arthur W Fleming, Verlyn M Peterson, Dietmar Fuchs: Enhanced enzymatic degradation of tryptophan by indoleamine-2, 3-dioxygenase contributes to the tryptophan-deficient state seen after major trauma. Shock 23(3), 209-15 (2005) (Pubitemid 40293819)
52. Martin Ploder, Andreas Spittler, Katharina Schroecksnadel, Gabriele Neurauter, Linda E. Pelinka, Erich Roth and Dietmar Fuchs: Tryptophan degradation in multiple trauma patients: survivors compared with non-survivors. Clin Sci (Lond) 116(7), 593-8 (2009)
53. N. Le Floc'h, D. Melchior, B. Sève: Dietary tryptophan helps to preserve tryptophan homeostasis in pigs suffering from lung inflammation. J Anim Sci 86(12), 3473-9 (2008)
54. D. Melchior, N. Le Floc'h, B. Sève: Effects of chronic lung inflammation on tryptophan metabolism in piglets. Adv Exp Med Biol 527, 359-62 (2003) (Pubitemid 38197661)
55. N. Le Floc'h, L. Lebellego, J.J. Matte, D. Melchior, B. Sève: The effect of sanitary status degradation and dietary tryptophan content on growth rate and tryptophan metabolism in weaning pigs. J Ani m Sci 87(5), 1686-94 (2009)
56. Beryl APD Dawson and Emmanuel J. Favaloro: High rate of deficiency in the amino acids tryptophan and histidine in people with wounds: implication for nutrient targeting in woun d management - a pilot study. Adv Skin Wound Care 22(2), 79-82 (2009)
57. Maria L. Belladonna, Ciriana Orabona, Ursula Grohmann and Paolo Puccetti: TGF-beta and kynurenines as the key to infe ctious tolerance. Trends Mol Med 15(2), 41-9 (2009)
58. S. Sanchez, S.D. Paredes, C.L. Sanchez, C. Barriga, R.J. Reiter, A.B. Rodriguez: Tryptophan administration in rats enhances ph agocytic function and reduces oxidative metabolism. Neuro Endocrinol Lett 29(6), 1026-32 (2008)
59. ConnieJ. Kim, Jennifer A. Kovacs-Nolan, Chengbo Yang, Tania Archbold, Ming Z. Fan, Yosh inori Mine: L-Tryptophan exhibits therapeutic function in a porcine model of dextran sodium sulfate (DSS)-induced colitis. J Nutr Biochem 21, 468- 475 (2010)
60. C Rob Markus, Berend Olivier, Geert EM Panhuysen, Jan Van Der Gugten, Martine S Alles, Adriaan Tuiten, Herman GM Westenberg, Durk Fekkes, Hans F Koppeschaar and Edward EHF de Haan: The bovine protein alpha-lactalbumin increases the plasma ratio of trypto phan to the other large neutral amino acids, and in vulnerable subjects raises brain serotonin activity, reduces cortisol concentration, and improves mood under stress. Am J Clin Nutr 71(6), 1536-44 (2000) (Pubitemid 30395902)
61. Susana Esteban, Cristina Nicolaus, Antonio Garmundi, Ruben Victor Rial, Ana Beatriz Rodríguez, Eduardo Ortega and Carmen Barriga Ibars: Effect of orally administered L-tryptophan on serotonin, melatonin, and the innate immune response in the rat. Mol Cell Biochem 267(1- 2), 39-46 (2004) (Pubitemid 39562383)
62. Patricia Gaspar, Olivier Cases and Luc Maroteaux: The developmental role of serotonin: news from mouse molecular g enetics. Nat Rev Neurosci 4(12), 1002-12 (2003) (Pubitemid 37486676)
63. Soledad Sánchez Mateos, Cristina L. Sánchez, Sergio D. Paredes, Carmen Barriga and Ana B. Rodríguez: Circadian levels of serotonin in plasma and brain after oral administration of tryptophan in rats. Basic Clin Pharmacol Toxicol 104(1), 52-9 (2009)
64. A. Neumeister: Tryptophan depletion, serotonin, and depression: where do we stand? Psychopharmacol Bull 37(4), 99-115 (2003)
65. Michael S. McCloskey, Dror Ben-Zeev, Royce Lee, Mitchell E. Berman and Emil F. Coccaro: Acute tryptophan depletion and self-injurious behavior in aggressive patients and healthy volunteers. Psychopharmacology (Berl) 203(1), 53-61 (2009)
66. Sherry L. Pagoto, Bonnie Spring, Dennis McChargue, Brian Hitsman, Malaina Smith, Bradley Appelhans and Donald Hedeker: Acute tryptophan depletion and sweet food consumption by overweight adults. Eat Behav 10(1), 36-41 (2009)
67. Christine Firk and C. Rob Markus: Mood and cortisol responses following tryptophan-rich hydrolyzed protein and acute stress in healthy subjects with high and low cognitive reactivity to depression. Clin Nutr 28(3), 266-271 (2009)
68. Gerald Huether, Burkhard Poeggeler, Andreas Reimer and Annette George: Effect of tryptophan administration on circulating melatonin levels in chicks and rats: evidence for stimula tion of melatonin synthesis and release in the gastrointestinal tract. Life Sci 51(12), 945-53 (1992)
69. Ken Yaga, Russel J. Reiter and Bruce A. Richardson: Tryptophan loading increases daytime serum melatonin levels in intact and pinealectomized rats. Life Sci 52(14), 1231-8 (1993)
70. Maurizio Bossola, Donata Scribano, Luigi Colacicco, Barbara Tavazzi, Stefania Giungi, Cecili a Zuppi, Giovanna Luciani, Luigi Tazza: Anorexia and plasma levels of free tryptophan, branched chain amino acids, and ghrelin in hemodialysis patients. J Ren Nutr 19(3), 248-55 (2009)
71. Huawei Zhang, Jingdong Yin, Defa Li, Xuan Zhou and Xilong Li: Tryptophan enhances ghrelin expression and secretion associated with increased food intake and weight gain in weanling pigs. Domest Anim Endocrinol 33(1), 47-61 (2007) (Pubitemid 46843480)
72. A. A. Pontera1, N. O. Cortamira, B. Sevea, D. N. Saltera and L. M. Morgana: The effects of energy source and tryptophan on the rate of protein synthesis and on hormones of the entero-insular axis in the piglet. Br J Nutr 71(5), 661-74 (1994) (Pubitemid 24155484)
73. A. J. M. Jansman, J. Th. M. van Diepen and D. Melchior: The effect of diet composition on tryptophan requirement of young piglets. J Anim Sci 88, 1017-27 (2010)
74. T. Ettle and F. X. Roth: Specific dietary selection for tryptophan by the piglet. J Anim Sci 82(4), 1115-21 (2004) (Pubitemid 38572311)
75. A. C. Guzik, J. O. Matthews, B. J. Kerr, T. D. Bidner and L. L. Souther: Dietary tryptophan effects on plasma and salivary cortisol and meat quality in pigs. J Anim Sci 84(8):2251-9 (2006) (Pubitemid 44342997)
76. T. K. Chung, H. B. Geiberg, J. L. Domer and D. H. Bake: Safety of L-tryptophan for pigs. J Anim Sci 69(7), 2955-60 (1991)
77. K. Edera, Svetlana Peganovab, H. Kluge: Studies on the tryptophan requirement of piglets. Arch Tierernah 55(4), 281-97 (2001) (Pubitemid 33633437)
78. P. Trevisi, D. Melchior, M. Mazzoni, L. Casini, S. De Filippi, L. Minieri, G. Lalatta-Costerbosa and P. Bosi: A tryptophan-enriched diet improves feed intake and growth performance of susceptible weanling pigs orally challenged with Escherichia coli K88. J Anim Sci 87(1), 148-56 (2009)
79. Yvonne M. van Hierden, Jaap M. Koolhaas, S. Mechiel Korte: Chronic increase of dietary L-tryptophan decreases gentle feather pecking behaviour. Appl Anim Behav Sci 89, 71-84 (2004) (Pubitemid 39301102)
80. Nathalie L. Trottier and Robert A. Eastel: Dietary and plasma branched-chain amino acids in relation to tryptophan: effect on voluntary feed intake and lactation metabolism in the primiparous sow. J Anim Sci 73(4), 1086-92 (1995)
81. D. W. Pethick, R. D. Warner, D. N. D' Souza, F. D. Dunshea. Nutritional manipulation of meat quality. Pages 100-115 in Manipulating Pig Production VI. P. D. Cranwell, ed. Australasian Pig Sci. Assoc, Roseworthy, SA, Australia (1997)
82. NRC. Nutrient Requirements of Swine. 10th ed. National Academy Press, Washington, DC. 1998.
83. J. Heger, T. Van Phung, L. Krizová: Ef ficiency of amino acid utilization in the growing pig at suboptimal levels of intake: lysine, threonine, sulphur amino acids and tryptophan. J Anim Physiol Anim Nutr (Berl) 86(5- 6), 153-65 (2002) (Pubitemid 34731281)
84. A. Susenbeth, U. Lucanus: The effect of tryptophan supplementation of diets of restricted- and unrestricted-fed young pigs. J Anim Physiol Anim Nutr (Berl) 89(9 -10), 331-6 (2005) (Pubitemid 41335791)
85. A. C. Guzik, M. J. Pettitt, E. Beltranena, L. L. Southern, B. J. Kerr. Threonine and tryptophan ratios fed to nursery pigs. J Anim Physiol Anim Nutr (Berl) 89(7 -8):297-302 (2005) (Pubitemid 40991953)
86. S. J. K oopmans, A. C. Guzik, J. van der Meulen, R. Dekker, J. Kogut, B. J. Kerr, L. L. Southern: Effects of supplemental L-tryptophan on serotonin, cortisol, intestinal integrity and behavior in weanling piglets. J Anim Sci 84(4), 963-71 (2006) (Pubitemid 44405656)
87. A. C. Guzik, L. L. Southern, T. D. Bidner, B. J. Kerr: The tryptophan requirement of nursery pigs. J Anim Sci 80(10), 2646-55 (2002) (Pubitemid 41138384)
88. Yanming Han, Thau Kiong Chung and David H. Baker: Tryptophan requirement of pigs in the weight category 10 to 20 kilograms. J Anim Sci 71(1), 139-43 (1993)
89. M. L. Sawadogo, A. Piva, A. Panciroli, E. Meola, A. Mordenti , B. Sève: Marginal efficiency of free or protected crystalline L-tryptophan for tryptophan and protein accretion in early-weaned pigs. J Anim Sci 75(6), 1561 -8 (1997) (Pubitemid 127443304)
90. K. Shibata, M. Swabe, T. Fukuwatari, E. Sugimoto: Efficiency of D-tryptophan as niacin in rats. Biosci Biotechnol Biochem 64(1), 206-9 (2000)
91. L. R. Feksa, A. Latini, V. C. Rech, P. B. Feksa, G. D. Koch, M. F. Amaral, G. Leipnitz, C. S. Dutra-Filho, M. Wajner, C. M. Wannmacher: Tryptophan administration induces oxidative stress in brain cortex of rats. Metab Brain Dis 23(2, 221- 33 (2008)
92. P. A. Hertzman, W. L. Blevins, J. Mayer, B. Greenfield, M. Ting, G. J. Gleich: Association of the eosinophilia-myalgia syndrome with the ingestion of tryptophan. N Engl J Med 322(13), 869-73 (1990) (Pubitemid 20108375)
93. E. M. Kilbourne: Eosinophilia-myalgia syndrome: coming to grips with a new illness. Epidemiol Rev 14, 16-36 (1992) (Pubitemid 23024552)
94. A. Okuno, T. Fukuwatari, K. Shibata: Urinary excretory ratio of anthranilic acid/kynurenic acid as an index of the tolerable amount of tryptophan. Biosci Biotechnol Biochem 72(7), 1667-72 (2008)
95. R. I. Horwitz, S. R. Daniels: Bias or biology: Evaluating the epidemiologic studies of L-tryptophan and the eosinophilia-myalgia syndrome. J Rheum 23(Suppl 46), 60-72 (1996) (Pubitemid 26342616)
96. S. R. Daniels, K. I. Hudson, R. I. Horwitz: Epidemiology of potential association between L-tryptophan ingestion and eosinophilia-myalgia syndrome. J Clin Epidemiol 48, 1413-1427 (1995) (Pubitemid 26035523)
97. J. B. Houpt, M. A. Ogryzlo, M. Hunt: Tryptophan metabolism in man (with special reference to rheumatoid arthritis and scleroderma). Semin Arthritis Rheumatism 2(4), 333-353 (1973)
98. M. Aviram, U. Cogan, S. Mokady: Excessive dietary tryptophan enhances plasma lipid peroxidation in rats. Atherosclerosis 88(1), 29-34 (1991)
99. I. Magnussen, F. Nielsen-Kudsk: Bioavailability and related phar macokinetics in man of orally administered L-5-hydroxytryptophan in steady state. Acta Pharmacol Toxicol (Copenh) 46(4), 257-62 (1980) (Pubitemid 10129193)
100. Y. T. Das, M. Bagchi, D. Bagchi, H. G. Preuss: Safety of 5-hydroxy-L-tryptophan. Toxicol Lett 150(1), 111-22 (2004) (Pubitemid 38447240)
101. Peng Li, Yu-Long Yin, Defa Li, Sung Woo Kim and Guoyao Wu: Amino acids and immune function. Br J Nutr 98, 237-252 (2007) (Pubitemid 47091364)
102. Guoyao Wu: Amino acids: metabolism, functions, and nutrition. Amino Acids 37, 1-17 (2009)
103. Rajavel Elango, Ronald O. Ball, Paul B. Pencharz : Amino acid requirements in humans: with a special emphasis on the metabolic availability of amino acids. Amino Acids 37, 19-27 (2009)
104. David H. Baker: Advances in protein-amino acid nutrition of poultry. Amino Acids 37, 29-41 (2009)
105. Peng Li, Kangsen Mai, Jesse Trushenski and Guoyao Wu: New developments in fish amino acid nutrition: towards functional and environmentally oriented aquafeeds. Amino Acids 37, 43-53 (2009)
106. Lixiang Chen, Peng Li, Junjun Wang, Xilong Li, Haijun Gao, Yulong Yin, Yongqing Hou, Guoyao Wu: Catabolism of nutritionally essential amin o acids in developing porcine enterocytes. Amino Acids 37, 143-152 (2009)
107. W. W. Wang, S. Y. Qiao and D. F. Li: Amino acids and gut function. Amino Acids 37, 105-110 (2009)
108. Sung W. Kim and Guoyao Wu: Regulatory role for amino acids in mammary gland growth and milk synthesis. Amino Aci ds 37, 89-95 (2009)
109. Xiangfang Zeng, Fenglai, Xia Fan, Wenjun Yang, Bo Zhou, Pengfei Li, Yulong Yin*, Guoyao Wu and Junjun Wang. Dietary arginine supplementation during early pregnancy enhances emb ryonic survival in rates.J Nutr138:1421-1425 (2008)
110. G. Wu, F. W. Bazer, J. M. Wallace and T. E. Spencer: Intrauterine growth retardation: Implications for the animal sciences. J Anim Sci 84, 2316-2337 (2006) (Pubitemid 44367856)
111. G. Wu, F. W. Bazer, R. C. Burghardt, G. A. Johnson, S. W. Kim , X. L. Li, M. C. Satterfield and T. E. Spencer: Impacts of amino acid nutrition on pregnancy outcome in pigs: mechanisms and implications for swine production. J Anim Sci 88, E195-E204 (2010)
112. Xilong Li, Fuller W. Bazer, Haijun Gao, Wenjuan Jobgen, Gregory A. Johnson, Peng Li, Jason R. McKnight, M. Carey Satterfield, Thomas E. Spencer and Guoyao Wu: Amino acids and gaseous signaling. Amino Acids 37, 65-78 (2009)
113. Bie Tan, Yulong Yin, Zhiqiang Liu, Xinguo Li, Haijun Xu, Xiangfeng Kong, Ruilin Huang, Wenjie Tang, Izuru Shinzato, Stephen B. Smith and Guoyao Wu: Dietary L-Arginine supplementation increases muscle gain and reduces body fat mass in growing-finishing pigs. Amino Acids 37, 169-175 (2009)
114. Bie Tan, Yulong Yin, Xiangfeng Kong, Peng Li, Xilong Li, Haijun Gao, Xinguo Li, Ruilin Huang and Guoyao Wu. L-Arginine stimulates proliferation and prevents endotoxin-induced death of intestinal cells. Amino Acids 38:1227-1235 (2010)
115. A. Suryawan, P. M. J. O'Connor, J. A. Bush, H. V. Nguyen, T. A. Davis. Differential regulation of prot ein synthesis by amino acids and insulin in peripheral and visceral tissues of neonatal pigs. Amino Acids 37, 97-104 (2009)
116. J. Marc Rhoads and Guoyao Wu: Glutamine, arginine, and leucine signaling in the intestine. Amino Acids 37, 111-122 (2009)
117. Kang Yao, Yu-Long Yin, Wuyin Chu, Zhiqiang Liu,Dun Deng, Tiejun Li, Ruilin Huang, Jianshe Zhang, Bie Tan,Wence Wang, and Guoyao Wu. Dietary Arginine Supplementation Increases mTOR Signaling Activity in Skeletal Muscle of Neonatal Pigs. J Nutr 138, 867-872 (2008) (Pubitemid 351571584)
118. Xin Wu, Zheng Ruan,Yunling Gao, Yulong Yin, Xihong Zhou, Lei Wan g, Meimei Geng, Yongqing Hou Guoyao Wu. Dietary supplementation with L-arginine or N-carbamylglutamate enhances intestinal growth and heat shock protein-70 expression in weanling pigs fed a cornand soybean meal-based diet. Amino Acids 39, 831-839
119. Dun Deng, Kang Yao, Wuying Chu, Tiejun Li, Ruiling Huang, Yulong Yin, Zhiqiang Liu, Janshe Zhang and Guoyao Wu. Impaired translation initation activation and reduced protein synthesis in weaned piglets fed a low-protein diet. J Nutr Biochem 20, 544-552 (2009)
120. C. Brasse-Lagnel, A. Lavoinne, A. Husson: Control of mammalian gene expression by amino acids, especially glutamine. FEBS J 276, 1826-1844 (2009)
121. S. S. Palii, C. E. Kays, C. Deval, A. Bruhat, P. Fafournoux, M. S. Kilberg. Specificity of amino acid regulated gene expression: analysis of gene subjected to either complete or single amino acid deprivation. Amino Acids 37, 79-88 (2009)
122. Junjun Wang, Guoyao Wu, Huaijun Zhou and Fenglai Wang: Emerging technologies for amino acid nutrition research in the post-genome era. Amino Acids 37, 177-186 (2009)
123. Wenjuan Jobgen, Wenjiang J. Fu, Haijun Gao, Peng Li, Cynthia J. Meininger, Stephen B. Smith, Thomas E. Spencer and Guoyao Wu: High fat feeding and dietary L-arginine supplementation differentially regulate gene expression in rat white adipose tissue. Amino Acids 37, 187-198 (2009)
124. Q. H. He, X. F. Kong, G. Wu, P. P. Ren, H. R. Tang, F. H. Hao, R. L. Hu ang, T. J. Li, B. E. Tan, P. Li, Z. R. Tang, Y. L. Yin, Y. N. Wu: Metabolomic analysis of the response of growing pigs to dietary L-arginine supplementation. Amino Acids 37, 199-208 (2009)
125. Xiaogiu Wang, Deyuan Ou, Jingdong Yin, Guoyao Wu, Junjun Wang: Proteomic analysis reveals altered expression of proteins related to glutathione metabolism and apoptosis in the small intestine of zinc oxide-supplemented piglets. Amino Acids 37, 209-218 (2009)
126. Yulan Liu, Jingjing Huang, Yongqing Hou, Huiling Zhu, Shengjun Zhao, Binying Ding, Yulong Yin, Ganfeng Yi, Junxia Shi and Wei Fan. Dietary arginine supplementation alleviates intestinal mucosal disruption induced by Escherichia coli lipopolysaccharide in weaned pigs Dietary arginine supplementation alleviates intestinal mucosal disruption induced by Escherichia coli lipopolysaccharid e in weaned pigs.British Journal of Nutrition, 100:552-5608 (2008)
127. Christopher M Dekaney, Guoyao Wu, Yu Long Yin and Laurie A Jaeger. Regulation of ornithine aminotransferase gene expression and activity by all-transretinoic acid in Caco-2 intestinal epithelial cells.The Journal of Nutritional Biochemistry,19 : 674-681(2008)
128. Ping Kang, Yu Long Yin, Zhen Ruan,Jie Pan, Qing Hu, Ze Yuan Deng,Hua Xiong and Ming Yong Xie. Effect of replacement of lactose with partially hydrolysed rice syrup on small intestine development in weaned pigs from 7 to 21days. Journal of the Science of Food and Agriculture, 88:1932 -1938(2008)
129. Yulong Yin, Kang Yao, Zhaojin Liu, Min Gong, Zheng Ruan, Dun Deng, Bie Tan, Zhiqiang Liu, Guoyao Wu. Supplementing L-leucine to a low-prote -protein diet increases tissue protein synthesis in weanling pigs. Amino Acids.DOI 10.1007/s00726-010-06 12-5
130. Wenjiang J. Fu, Arnold J. Stromberg, Kert Viele, Raymond J. Carroll, Guoyao Wu: Statistics and bioinformatics in nutritional sciences: analysis of complex data in the era of systems biology. J Nutr Biochem 21, 561-572 (2010)