Age-related changes in muscarinic cholinergic receptors in the living brain: A PET study using N-[11C]methyl-4-piperidyl benzilate combined with cerebral blood flow measurement in conscious monkeys

Brain Research

Volumn 916, Issue 1-2, 2001, Pages 22-31

  Kakiuchi, Takeharu ^a   Ohba, Hiroyuki ^a   Nishiyama, Shingo ^a   Sato, Kengo ^a   Harada, Norihiro ^a   Nakanishi, Satoshi ^b   Tsukada, Hideo ^a  

^a CENTRAL RESEARCH LABORATORY   (Japan)

^b SUZUKA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

Author keywords

Aging; Cerebral blood flow; Monkey brain; Muscarinic receptor; N 11C Methyl 4 piperidyl benzilate; Positron emission tomography

Indexed keywords

1 METHYL 4 PIPERIDYL BENZILATE; CARBON 11; MUSCARINIC RECEPTOR; OXYGEN 15; WATER;

AGE; AGED; AGING; ANALYTIC METHOD; ANIMAL EXPERIMENT; ARTICLE; BRAIN BLOOD FLOW; BRAIN REGION; COMPARATIVE STUDY; COMPARTMENT MODEL; CONSCIOUSNESS; CONTROLLED STUDY; CORRELATION FUNCTION; DISTRIBUTION VOLUME; KINETICS; MALE; MONKEY; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; QUANTITATIVE ASSAY; RADIOACTIVITY; RECEPTOR BINDING;

ACETYLCHOLINE; AGING; ANIMALS; BENZILATES; BINDING, COMPETITIVE; BRAIN; BRAIN MAPPING; CEREBROVASCULAR CIRCULATION; CONSCIOUSNESS; MACACA MULATTA; MAGNETIC RESONANCE IMAGING; MALE; OXYGEN RADIOISOTOPES; PARASYMPATHOLYTICS; PHARMACOKINETICS; PIPERIDINES; RADIOLIGAND ASSAY; RECEPTORS, MUSCARINIC; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0035914159     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(01)02859-1     Document Type: Article

References (51)

1. Kinetic evaluation of positron-emitting muscarinic receptor ligands employing direct intracarotid injection
2. Cholinergic function and intellectual decline in Alzheimer's disease
3. Nicotinic and muscarinic cholinergic receptor binding in the human hippocampal formation during development and aging
4. 11C]levetimide
5. 11C-methyl]benztropine
6. Age-related decrease in muscarinic cholinergic receptor binding in the human brain measured with positron emission tomography (PET)
7. Differential regulation of molecular subtypes of muscarinic receptors in Alzheimer's disease
8. 11C]scopolamine and positron emission tomography
9. 15O. I. Theory and error analysis
10. Basal forebrain cholinergic neurons and Alzheimer's disease
11. Cortical effects of scopolamine compared to Alzheimer's disease
12. 2A receptors: PET study in the conscious monkey brain
13. 11C](-)McN5652 in conscious monkeys
14. 11C]Tropanyl benzilate binding to muscarinic cholinergic receptors: Methodology and kinetic modeling alterations
15. 11C]tropanyl benzilate
16. Studies on muscarinic binding sites in human brain identified with pirenzepine
17. Cholinergic neurotransmission studies in vivo using positron emission tomography or single photon emission computerized tomography
18. 18F]altanserin to serotonin type 2A receptors in aging: Persistence of effect after partial volume correction
19. Synthesis and regional brain distribution of [C-11]N-methyl-4-piperidyl benzilate ([C-11]NMPB) in the rat
20. 11C]formaldehyde
21. Synthesis, rodent biodistribution, dosimetry, metabolism and monkey images of carbon-11-labeled (+)-2α-tropanyl benzilate: A central muscarinic receptor imaging agent
22. 11C]methy-4-piperidyl benzilate in the conscious monkey brains
23. 11C]methy-3-piperidyl benzilate in the conscious monkey brain
24. 11C-methylspiperone binding in vivo: Positron emission tomography study using conscious rhesus monkey
25. Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data
26. The cholinergic hypothesis - Ten years on
27. 11C]QNB
28. 15O. II. Implementation and validation
29. Muscarinic and dopaminergic receptors in the aging human brain
30. Human serial learning: Enhancement with arecoline and choline and impairment with scopolamine
31. Biochemical identification of the mammalian muscarinic cholinergic receptor
32. Age-related changes inhuman muscarinic acetylcholine receptors measured by positron emission tomography
33. 11C]3NMPB enantiomers in rats for studying muscarinic cholinergic receptors using PET
34. 11C]methyl-3-piperidyl benzilate as a potent radioligand for positron emission tomography
35. 11C]raclopride binding with no alterations in static dopamine concentrations in the striatal extracellular fluid in the monkey brain: Multi-parametric PET studies combined with microdialysis analysis
36. 2 receptor availability in vivo by regulating receptor affinity induced by facilitated synaptic dopamine turnover: PET studies with microdialysis in the conscious monkey brain
37. Functional activation of cerebral blood flow abolished by scopolamine is reversed by cognitive enhancers associated with cholinesterase inhibition: A PET study in unanesthetized monkeys
38. Regulation of cerebral blood flow response to somatosensory stimulation through the cholinergic system: A PET study in unanesthetized monkey brain
39. Docosahexaenoic acid (DHA) improves the age-related impairment of the coupling mechanism between neuronal activation and functional cerebral blood flow response: A PET study in conscious monkey brain
40. 11C]methyl-3-piperidyl benzilate in the brains of conscious monkeys
41. 11C]raclopride?: PET studies combined with microdialysis in conscious monkeys
42. Isoflurane anesthesia enhances the inhibitory effects of cocaine and GBR12909 on dopamine transporter: PET studies in combination with microdialysis in the monkey brain
43. Age-related impairment of coupling mechanism between neuronal activation and functional cerebral blood flow response was restored by cholinesterase inhibition: PET study with microdialysis in the awake monkey brain
44. 11C]4-MPB
45. FK960 [N-(4-acetyl-1-piperazinyl)-P-fluorobenzamide monohydrate], a novel potential antidementia drug, restores the regional cerebral blood flow response abolished by scopolamine but not by HA-966: A PET study with unanesthetized rhesus monkeys
46. 11C]scopolamine: Synthesis and distribution in rat brain
47. Laminar organization and age-related loss of cholinergic receptors in temporal neocortex of rhesus monkey
48. A high resolution animal PET scanner using compact PS-PMT detectors
49. Age-related changes in multiple neurotransmitter systems in the monkey brain
50. Inhibition action of E2020, a novel acetylcholinesterase inhibitor, on cholinesterase: Comparison with other inhibitors
51. 11C]NMPB and positron emission tomography: Method development and differentiation of tracer delivery from receptor binding