Preventing environmental enteric dysfunction through improved water, sanitation and hygiene: An opportunity for stunting reduction in developing countries

Maternal and Child Nutrition

Volumn 12, Issue , 2016, Pages 106-120

  Mbuya, Mduduzi N N ^a,b   Humphrey, Jean H ^a,b  

^a Zvitambo Institute for Maternal and Child Health Research   (Zimbabwe)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Disease; Early growth; Infant and child nutrition; Nutrition; Sanitation; Stunting

Indexed keywords

SOAP;

DEVELOPING COUNTRY; DISEASE ACTIVITY; DISEASE ASSOCIATION; ENTEROPATHY; ENVIRONMENTAL ENTERIC DYSFUNCTION; ENVIRONMENTAL FACTOR; ENVIRONMENTAL SANITATION; HAND WASHING; HUMAN; HYGIENE; INCIDENCE; MOLECULAR PATHOLOGY; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE; WATER ANALYSIS; COMPLICATION; DIARRHEA; DIET; ENVIRONMENT; FEEDING BEHAVIOR; GROWTH DISORDERS; HAND DISINFECTION; INFANT; INTESTINAL DISEASES; NEWBORN; PATHOPHYSIOLOGY; PRESCHOOL CHILD; SANITATION; STATISTICS AND NUMERICAL DATA; WATER SUPPLY;

CHILD, PRESCHOOL; DEVELOPING COUNTRIES; DIARRHEA; DIET; ENVIRONMENT; FEEDING BEHAVIOR; GROWTH DISORDERS; HAND DISINFECTION; HUMANS; HYGIENE; INFANT; INFANT, NEWBORN; INTESTINAL DISEASES; SANITATION; WATER SUPPLY;

EID: 84948845928     PISSN: 17408695     EISSN: 17408709     Source Type: Journal    
DOI: 10.1111/mcn.12220     Document Type: Review

References (108)

1. Alderman H., Hoddinott J. & Kinsey B. (2006) Long term consequences of early childhood malnutrition. Oxford Economic Papers 58, 450-474.
2. Arrieta M.C., Bistritz L. & Meddings J.B. (2006) Alterations in intestinal permeability. Gut 55, 1512-1520.
3. Baker S.J. (1976) Subclinical intestinal malabsorption in developing countries. Bulletin of the World Health Organization 54, 485-494.
4. Behrens R.H., Lunn P.G., Northrop C.A., Hanlon P.W. & Neale G. (1987) Factors affecting the integrity of the intestinal mucosa of Gambian children. American Journal of Clinical Nutrition 45, 1433-1441.
5. Bertolini D.R., Nedwin G.E., Bringman T.S., Smith D.D. & Mundy G.R. (1986) Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factors. Nature 319, 516-518.
6. Bhutta Z.A., Das J.K., Rizvi A., Gaffey M.F., Walker N., Horton S., et al. (2013) Evidence-based interventions for improvement of maternal and child nutrition: what can be done and at what cost? Lancet 382, 452-477.
7. Black R.E., Victora C.G., Walker S.P., Bhutta Z.A., Christian P., de Onis M., et al. (2013) Maternal and child undernutrition and overweight in low-income and middle-income countries. Lancet 382, 427-451.
8. Brenchley J.M. & Douek D.C. (2012) Microbial translocation across the GI tract. Annual Review of Immunology 30, 149-173.
9. Briend A. (1990) Is diarrhoea a major cause of malnutrition among the under-fives in developing countries? A review of available evidence. European Journal of Clinical Nutrition 44, 611-628.
10. Briend A., Hasan K.Z., Aziz K.M. & Hoque B.A. (1990) Diarrhoea and catch-up growth. Lancet 335, 1157-1158.
11. Brown J., Cairncross S. & Ensink J.H. (2013) Water, sanitation, hygiene and enteric infections in children. Archives of Disease in Childhood 98, 629-634.
12. Butte N.F., Wong W.W., Hopkinson J.M., Heinz C.J., Mehta N.R. & Smith E.O. (2000) Energy requirements derived from total energy expenditure and energy deposition during the first 2 y of life. American Journal of Clinical Nutrition 72, 1558-1569.
13. Campbell D.I., Lunn P.G. & Elia M. (2002) Age-related association of small intestinal mucosal enteropathy with nutritional status in rural Gambian children. British Journal of Nutrition 88, 499-505.
14. Campbell D.I., Elia M. & Lunn P.G. (2003) Growth faltering in rural Gambian infants is associated with impaired small intestinal barrier function, leading to endotoxemia and systemic inflammation. Journal of Nutrition 133, 1332-1338.
15. Caulfield L.E., De Onis M., Blossner M. & Black R.E. (2004) Undernutrition as an underlying cause of child associated with diarrhea, pneumonia, malaria, and measles. American Journal of Clinical Nutrition 80, 193-198.
16. Checkley W., Buckley G., Gilman R.H., Assis A.M., Guerrant R.L., Morris S.S., et al. (2008) Multi-country analysis of the effects of diarrhoea on childhood stunting. International Journal of Epidemiology 37, 816-830.
17. Cook G.C., Kajubi S.K. & Lee F.D. (1969) Jejunal morphology of the African in Uganda. Journal of Pathology 98, 157-169.
18. Curtis V., Cairncross S. & Yonli R. (2000) Domestic hygiene and diarrhoea - pinpointing the problem. Tropical Medicine and International Health 5, 22-32.
19. De Benedetti F., Alonzi T., Moretta A., Lazzaro D., Costa P., Poli V., et al. (1997) Interleukin 6 causes growth impairment in transgenic mice through a decrease in insulin-like growth factor-I. A model for stunted growth in children with chronic inflammation. Journal of Clinical Investigation 99, 643-650.
20. Desai H.G., Borkar A.V., Pathare S.M., Dighe P.K. & Jeejeebhoy K.N. (1969) 'Flat' jejunal mucosa in the tropics. Indian Journal of Medical Sciences 23, 1-5.
21. Dewey K.G. (2013) The challenge of meeting nutrient needs of infants and young children during the period of complementary feeding: an evolutionary perspective. Journal of Nutrition. 143, 2050-205.
22. Dewey K.G. & Adu-Afarwuah S. (2008) Systematic review of the efficacy and effectiveness of complementary feeding interventions in developing countries. Maternal & Child Nutrition 4 Suppl 1, 24-85.
23. Dewey K.G., Heinig M.J., Nommsen L.A., Peerson J.M. & Lonnerdal B. (1992) Growth of breast-fed and formula-fed infants from 0 to 18months: the DARLING Study. Pediatrics 89, 1035-1041.
24. Edwards H.M., Fuller H.L. & Hess C.W. (1960) The effect of environment on chick growth. Journal of Nutrition 70, 302-306.
25. Esrey S.A. (1996) Water, waste, and well-being: a multicountry study. American Journal of Epidemiology 143, 608-623.
26. Fagundes Neto U., Martins M.C., Lima F.L., Patricio F.R. & Toledo M.R. (1994) Asymptomatic environmental enteropathy among slum-dwelling infants. Journal of the American College of Nutrition 13, 51-56.
27. Fagundes-Neto U., Viaro T., Wehba J., Patricio F.R.d.S. & Machado N.L. (1984) Tropical Enteropathy (environmental enteropathy) in early childhood: a syndrome caused by contaminated environment. Journal of Tropical Pediatrics 30, 204-209.
28. Ferreira R.C., Forsyth L.E., Richman P.I., Wells C., Spencer J. & MacDonald T.T. (1990) Changes in the rate of crypt epithelial cell proliferation and mucosal morphology induced by a T-cell-mediated response in human small intestine. Gastroenterology 98, 1255-1263.
29. Galpin L., Manary M.J., Fleming K., Ou C.N., Ashorn P. & Shulman R.J. (2005) Effect of lactobacillus GG on intestinal integrity in Malawian children at risk of tropical enteropathy. American Journal of Clinical Nutrition 82, 1040-1045.
30. Ganeshan K. & Chawla A. (2014) Metabolic regulation of immune responses. Annual Review of Immunology 32, 609-634.
31. George C.M., Oldja L., Biswas S., Perin J., Lee G.O., Kosek M., et al. (2015) Geophagy is associated with environmental enteropathy and stunting in children in Rural Bangladesh. American Journal of Tropical Medicine and Hygiene 92, 1117-1124.
32. Gerson C.D., Kent T.H., Saha J.R., Siddiqi N. & Lindernbaum J. (1971) Recovery of small-intestinal structure and function after residence in the tropics: II. Studies in Indians and Pakistanis living in New York City. Annals of Internal Medicine 75, 41-48.
33. Grantham-McGregor S., Cheung Y.B., Cueto S., Glewwe P., Richter L., Strupp B., et al. (2007) Developmental potential in the first 5years for children in developing countries. Lancet 369, 60-70.
34. Guerrant R.L., Oria R.B., Moore S.R., Oria M.O. & Lima A.A. (2008) Malnutrition as an enteric infectious disease with long-term effects on child development. Nutrition Reviews 66, 487-505.
35. Guerrant R.L., DeBoer M.D., Moore S.R., Scharf R.J. & Lima A.A. (2013) The impoverished gut - a triple burden of diarrhoea, stunting and chronic disease. Nature Reviews Gastroenterology & Hepatology 10, 220-229.
36. Habicht J.P. & Pelletier D.L. (1990) The importance of context in choosing nutritional indicators. Journal of Nutrition 120 (Suppl 11), 1519-1524.
37. Habicht J.P. & Stoltzfus R.J. (1997) What do indicators indicate? American Journal of Clinical Nutrition 60, 190-191.
38. Habicht J.P., Meyers L.D. & Brownie C. (1982) Indicators for identifying and counting the improperly nourished. American Journal of Clinical Nutrition 35, 1241-1254.
39. Haghighi P. & Wolf P.L. (1997) Tropical sprue and subclinical enteropathy: a vision for the nineties. Critical Reviews in Clinical Laboratory Sciences 34, 313-341.
40. Hoddinott J., Behrman J.R., Maluccio J.A., Melgar P., Quisumbing A.R., Ramirez-Zea M., et al. (2013) Adult consequences of growth failure in early childhood. American Journal of Clinical Nutrition 98, 1170-1178.
41. Hodin R. & Matthews J. (2008) Small Intestine. In: Surgery. (eds J. Norton, P. Barie, R.R. Bollinger, A. Chang, S. Lowry, S. Mulvihill, et al.). Springer: New York.
42. van der Hulst R.R., von Meyenfeldt M.F., van Kreel B.K., Thunnissen F.B., Brummer R.J., Arends J.W., et al. (1998) Gut permeability, intestinal morphology, and nutritional depletion. Nutrition 14, 1-6.
43. Humphrey J.H. (2009) Child undernutrition, tropical enteropathy, toilets, and handwashing. Lancet 374, 1032-1035.
44. Imdad A., Yakoob M.Y. & Bhutta Z.A. (2011) Impact of maternal education about complementary feeding and provision of complementary foods on child growth in developing countries. BMC Public Health 11 (Suppl 3), S25.
45. Jaladanki R.N. & Wang J.-Y. (2011) Regulation of gastrointestinal mucosal growth. Colloquium Series on Integrated Systems Physiology: From Molecule to Function 3, 1-114.
46. Jinadu M.K. (2004) Disposal of children's faeces and implications for the control of childhood diarrhoea. The Journal of the Royal Society for the Promotion of Health 124, 276-279.
47. Jones K.D., Hunten-Kirsch B., Laving A.M., Munyi C.W., Ngari M., Mikusa J., et al. (2014) Mesalazine in the initial management of severely acutely malnourished children with environmental enteric dysfunction: a pilot randomized controlled trial. BMC Medicine 12, 133.
48. Kayentao K., Garner P., van Eijk A.M., Naidoo I., Roper C., Mulokozi A., et al. (2013) Intermittent preventive therapy for malaria during pregnancy using 2 vs 3 or more doses of sulfadoxine-pyrimethamine and risk of low birth weight in Africa: systematic review and meta-analysis. JAMA 309, 594-604.
49. Kelly P., Davies S.E., Mandanda B., Veitch A., McPhail G., Zulu I., et al. (1997) Enteropathy in Zambians with HIV related diarrhoea: regression modelling of potential determinants of mucosal damage. Gut 41, 811-816.
50. Kelly P., Menzies I., Crane R., Zulu I., Nickols C., Feakins R., et al. (2004) Responses of small intestinal architecture and function over time to environmental factors in a tropical population. American Journal of Tropical Medicine and Hygiene 70, 412-419.
51. Keusch G.T. (1972) Subclinical malabsorption in Thailand. I. Intestinal absorption in Thai children. American Journal of Clinical Nutrition 25, 1062-1066.
52. Keusch G.T., Rosenberg I.H., Denno D.M., Duggan C., Guerrant R.L., Lavery J.V., et al. (2013) Implications of acquired environmental enteric dysfunction for growth and stunting in infants and children living in low- and middle-income countries. Food and Nutrition Bulletin 34, 357-364.
53. Keusch G.T., Denno D.M., Black R.E., Duggan C., Guerrant R.L., Lavery J.V., et al. (2014) Environmental enteric dysfunction: pathogenesis, diagnosis, and clinical consequences. Clinical Infectious Diseases 59 Suppl 4, S207-S212.
54. Korpe P.S. & Petri W.A., Jr. (2012) Environmental enteropathy: critical implications of a poorly understood condition. Trends in Molecular Medicine 18, 328-336.
55. Kosek M., Haque R., Lima A., Babji S., Shrestha S., Qureshi S., et al. (2013) Fecal markers of intestinal inflammation and permeability associated with the subsequent acquisition of linear growth deficits in infants. American Journal of Tropical Medicine and Hygiene 88, 390-396.
56. Kosek M., Guerrant R.L., Kang G., Bhutta Z., Yori P.P., Gratz J., et al. (2014) Assessment of environmental enteropathy in the MAL-ED cohort study: theoretical and analytic framework. Clinical Infectious Diseases 59 Suppl 4, S239-S247.
57. Kotloff K.L., Nataro J.P., Blackwelder W.C., Nasrin D., Farag T.H., Panchalingam S., et al. (2013) Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study. Lancet 382, 209-222.
58. Lanata C.F., Huttly S.R. & Yeager B.A. (1998) Diarrhea: whose feces matter? Reflections from studies in a Peruvian shanty town. Pediatric Infectious Disease Journal 17, 7-9.
59. Langford R., Lunn P. & Panter-Brick C. (2011) Hand-washing, subclinical infections, and growth: a longitudinal evaluation of an intervention in Nepali slums. American Journal of Human Biology 23, 621-629.
60. Lassi Z.S., Das J.K., Zahid G., Imdad A. & Bhutta Z.A. (2013) Impact of education and provision of complementary feeding on growth and morbidity in children less than 2years of age in developing countries: a systematic review. BMC Public Health 13 (Suppl 3), S13.
61. Lin A., Arnold B.F., Afreen S., Goto R., Huda T.M., Haque R., et al. (2013) Household environmental conditions are associated with enteropathy and impaired growth in rural Bangladesh. American Journal of Tropical Medicine and Hygiene 89, 130-137.
62. Lindenbaum J., Greson C.D. & Kent T.H. (1971) Recovery of small-intestinal structure and function after residence in the tropics: I. Studies in Peace Corps volunteers. Annals of Internal Medicine 74, 218-222.
63. Lindenbaum J., Harmon J.W. & Gerson C.D. (1972) Subclinical malabsorption in developing countries. American Journal of Clinical Nutrition 25, 1056-1061.
64. Lionetti P., Breese E., Braegger C.P., Murch S.H., Taylor J. & MacDonald T.T. (1993) T-cell activation can induce either mucosal destruction or adaptation in cultured human fetal small intestine. Gastroenterology 105, 373-381.
65. Lunn P.G. (2000) The impact of infection and nutrition on gut function and growth in childhood. Proceedings of the Nutrition Society 59, 147-154.
66. Lunn P.G., Northrop-Clewes C.A. & Downes R.M. (1991) Intestinal permeability, mucosal injury, and growth faltering in Gambian infants. Lancet 338, 907-910.
67. Luntamo M., Kulmala T., Cheung Y.B., Maleta K. & Ashorn P. (2013) The effect of antenatal monthly sulphadoxine-pyrimethamine, alone or with azithromycin, on foetal and neonatal growth faltering in Malawi: a randomised controlled trial. Tropical Medicine and International Health 18, 386-397.
68. MacDonald T.T. & Spencer J. (1988) Evidence that activated mucosal T cells play a role in the pathogenesis of enteropathy in human small intestine. Journal of Experimental Medicine 167, 1341-1349.
69. Maluccio J.A., Hoddinott J., Behrman J.R., Martorell R., Quisumbing A.R. & Stein A.D. (2009) The impact of improving nutrition during early childhood on education among Guatemalan adults. The Economic Journal 119, 734-763.
70. Marquis G.S., Ventura G., Gilman R.H., Porras E., Miranda E., Carbajal L., et al. (1990) Fecal contamination of shanty town toddlers in households with non-corralled poultry, Lima, Peru. American Journal of Public Health 80, 146-149.
71. McKay S., Gaudier E., Campbell D.I., Prentice A.M. & Albers R. (2010) Environmental enteropathy: new targets for nutritional interventions. International Health 2, 172-180.
72. Meddings J.B. (2010) Review article: intestinal permeability in Crohn's disease. Alimentary Pharmacology & Therapeutics 11, 47-56.
73. Menzies I.S., Zuckerman M.J., Nukajam W.S., Somasundaram S.G., Murphy B., Jenkins A.P., et al. (1999) Geography of intestinal permeability and absorption. Gut 44, 483-489.
74. Miller B.G., James P.S., Smith M.W. & Bourne F.J. (1986) Effect of weaning on the capacity of pig intestinal villi to digest and absorb nutrients. The Journal of Agricultural Science 107, 579-590.
75. Mondal D., Minak J., Alam M., Liu Y., Dai J., Korpe P., et al. (2012) Contribution of enteric infection, altered intestinal barrier function, and maternal malnutrition to infant malnutrition in Bangladesh. Clinical Infectious Diseases 54, 185-192.
76. Murray J.A. (1999) The widening spectrum of celiac disease. The American Journal of Clinical Nutrition 69(3), 354-365.
77. Nabuurs M.J.A., Hoogendoorn A., Van Der Molen E.J. & Van Osta A.L.M. (1993) Villus height and crypt depth in weaned and unweaned pigs, reared under various circumstances in the Netherlands. Research in Veterinary Science 55, 78-84.
78. Ngure F.M., Humphrey J.H., Mbuya M.N., Majo F., Mutasa K., Govha M., et al. (2013) Formative research on hygiene behaviors and geophagy among infants and young children and implications of exposure to fecal bacteria. American Journal of Tropical Medicine and Hygiene 89, 709-716.
79. Ngure F.M., Reid B.M., Humphrey J.H., Mbuya M.N., Pelto G. & Stoltzfus R.J. (2014) Water, sanitation, and hygiene (WASH), environmental enteropathy, nutrition, and early child development: making the links. Annals of the New York Academy of Sciences 1308, 118-128.
80. O'Dwyer S.T., Michie H.R., Ziegler T.R., Revhaug A., Smith R.J. & Wilmore D.W. (1988) A single dose of endotoxin increases intestinal permeability in healthy humans. Archives of Surgery 123, 1459-1464.
81. Pelletier D.L., Frongillo E.A., Jr., Schroeder D.G. & Habicht J.P. (1995) The effects of malnutrition on child mortality in developing countries. Bulletin of the World Health Organization 73, 443-448.
82. Peterson L.W. & Artis D. (2014) Intestinal epithelial cells: regulators of barrier function and immune homeostasis. Nature Reviews Immunology 14, 141-153.
83. Petri W.A., Naylor C. & Haque R. (2014) Environmental enteropathy and malnutrition: do we know enough to intervene? BMC Medicine 12, 187.
84. Poskitt E.M., Cole T.J. & Whitehead R.G. (1999) Less diarrhoea but no change in growth: 15years' data from three Gambian villages. Archives of Disease in Childhood 80, 115-119; discussion 119-120.
85. Prendergast A.J. & Humphrey J.H. (2014) The stunting syndrome in developing countries. Paediatrics and International Child Health 34, 250-265.
86. Prendergast A. & Kelly P. (2012) Enteropathies in the developing world: neglected effects on global health. American Journal of Tropical Medicine and Hygiene 86, 756-763.
87. Prendergast A.J., Rukobo S., Chasekwa B., Mutasa K., Ntozini R., Mbuya M.N., et al. (2014) Stunting is characterized by chronic inflammation in Zimbabwean infants. PLoS One 9, e86928.
88. Richard S.A., Black R.E., Gilman R.H., Guerrant R.L., Kang G., Lanata C.F., et al. (2013) Diarrhea in early childhood: short-term association with weight and long-term association with length. American Journal of Epidemiology 178, 1129-1138.
89. Richard S.A., Black R.E., Gilman R.H., Guerrant R.L., Kang G., Lanata C.F., et al. (2014) Catch-up growth occurs after diarrhea in early childhood. Journal of Nutrition 144, 965-971.
90. Rosenberg I.H. & Solomons N.W. (1978) The potential for antidiarrheal and nutrient-sparing effects of oral antibiotic use in children: a position paper. American Journal of Clinical Nutrition 31, 2202-2207.
91. Rosenberg I.H., Beisel W.R. & Gordon J.E. (1974) Infant and child enteritis-malabsorption-malnutrition: the potential of limited studies with low-dose antibiotic feeding. American Journal of Clinical Nutrition 27, 304-309.
92. Roura E., Homedes J. & Klasing K.C. (1992) Prevention of immunologic stress contributes to the growth-permitting ability of dietary antibiotics in chicks. Journal of Nutrition 122, 2383-2390.
93. Rousham E.K. & Gracey M. (1997) Persistent growth faltering among aboriginal infants and young children in north-west Australia: a retrospective study from 1969 to 1993. Acta Paediatrica 86, 46-50.
94. Ryan K.N., Stephenson K.B., Trehan I., Shulman R.J., Thakwalakwa C., Murray E., et al. (2014) Zinc or albendazole attenuates the progression of environmental enteropathy: a randomized controlled trial. Clinical Gastroenterology and Hepatology 12, 1507-1513 e1501.
95. Sandler N.G. & Douek D.C. (2012) Microbial translocation in HIV infection: causes, consequences and treatment opportunities. Nature Reviews Microbiology 10, 655-666.
96. Scrimshaw N.S., Taylor C.E. & Gordon J.E. (1968) Interactions of nutrition and infection. Monograph Series. World Health Organization 57, 3-329.
97. Sheehy T.W., Legters L.J. & Wallace D.K. (1968) Tropical jejunitis in Americans serving in Vietnam. American Journal of Clinical Nutrition 21, 1013-1022.
98. Skerry T.M. (1994) The effects of the inflammatory response on bone growth. European Journal of Clinical Nutrition 48 (Suppl 1), S190-S197; discussion S198.
99. Prendergast L.E., Stoltzfus R.J. & Prendergast A. (2012) Food chain mycotoxin exposure, gut health, and impaired growth: a conceptual framework. Advances in Nutrition 3, 526-531.
100. Solomons N.W. (2003) Environmental contamination and chronic inflammation influence human growth potential. Journal of Nutrition 133, 1237.
101. Solomons N.W., Mazariegos M., Brown K.H. & Klasing K. (1993) The underprivileged, developing country child: environmental contamination and growth failure revisited. Nutrition Reviews 51, 327-332.
102. Sprinz H., Kundel D.W., Dammin G.J., Horowitz R.E., Schneider H. & Formal S.B. (1961) The response of the germ-free guinea pig to oral bacterial challenge with Escherichia coli and Shigella flexneri: with special reference to lymphatic tissue and the intestinal tract. The American Journal of Pathology 39, 681-695.
103. Stanfield J.P., Hutt M.S.R. & Tunnicliffe R. (1965) Intestinal biopsy in kwashiorkor. Lancet 2, 519-523.
104. Stephensen C.B. (1999) Burden of infection on growth failure. Journal of Nutrition 129, 534S-538S.
105. Trehan I., Shulman R.J., Ou C.N., Maleta K. & Manary M.J. (2009) A randomized, double-blind, placebo-controlled trial of rifaximin, a nonabsorbable antibiotic, in the treatment of tropical enteropathy. The American Journal of Gastroenterology 104, 2326-2333.
106. Veitch A.M., Kelly P., Zulu I.S., Segal I. & Farthing M.J. (2001) Tropical enteropathy: a T-cell-mediated crypt hyperplastic enteropathy. European Journal of Gastroenterology and Hepatology 13, 1175-1181.
107. Victora C.G., de Onis M., Hallal P.C., Blossner M. & Shrimpton R. (2010) Worldwide timing of growth faltering: revisiting implications for interventions. Pediatrics 125, e473-e480.
108. Walker S.P., Wachs T.D., Grantham-McGregor S., Black M.M., Nelson C.A., Huffman S.L., et al. (2011) Inequality in early childhood: risk and protective factors for early child development. Lancet 378, 1325-1338.