The effect of antenatal monthly sulphadoxine-pyrimethamine, alone or with azithromycin, on foetal and neonatal growth faltering in Malawi: A randomised controlled trial

Tropical Medicine and International Health

Volumn 18, Issue 4, 2013, Pages 386-397

  Luntamo, Mari ^a   Kulmala, Teija ^a   Cheung, Yin Bun ^a,b,c   Maleta, Kenneth ^d   Ashorn, Per ^a,e  

^a TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^b SINGAPORE CLINICAL RESEARCH INSTITUTE   (Singapore)

^c DUKE NUS MEDICAL SCHOOL   (Singapore)

^d UNIVERSITY OF MALAWI   (Malawi)

^e TAMPERE UNIVERSITY HOSPITAL   (Finland)

Author keywords

Azithromycin; Birthweight; Growth faltering; Intermittent preventive treatment in pregnancy; Low birthweight; Malaria; Randomised controlled trial; Reproductive tract infection; Stunting; Sub Saharan Africa; Sulphadoxine pyrimethamine; Underweight

Indexed keywords

AZITHROMYCIN; PLACEBO; PYRIMETHAMINE PLUS SULFADOXINE;

AGE CLASS; ANTIBIOTICS; BODY SIZE; DISEASE TREATMENT; EPIDEMIOLOGY; GROWTH RATE; HEALTH RISK; MALARIA; PREGNANCY; REPRODUCTIVE HEALTH; WEIGHT; WOMENS HEALTH;

ADULT; ANTHROPOMETRY; ARTICLE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; FEMALE; FETUS; FETUS GROWTH; HUMAN; LOW BIRTH WEIGHT; MAJOR CLINICAL STUDY; MALARIA; MALAWI; NEWBORN; PERINATAL DEVELOPMENT; PRENATAL CARE; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; STUNTING; UNDERWEIGHT;

ADOLESCENT; ADULT; ANTI-BACTERIAL AGENTS; ANTIMALARIALS; AZITHROMYCIN; BIRTH WEIGHT; DRUG ADMINISTRATION SCHEDULE; DRUG COMBINATIONS; DRUG THERAPY, COMBINATION; FEMALE; FETAL DEVELOPMENT; HUMANS; INFANT, NEWBORN; MALARIA, FALCIPARUM; MALAWI; PREGNANCY; PREGNANCY COMPLICATIONS, PARASITIC; PYRIMETHAMINE; REPRODUCTIVE TRACT INFECTIONS; SULFADOXINE; YOUNG ADULT;

MALAWI; SUB-SAHARAN AFRICA;

EID: 84875272261     PISSN: 13602276     EISSN: 13653156     Source Type: Journal    
DOI: 10.1111/tmi.12074     Document Type: Article

References (47)

1. ACC/SCN (2000) Low Birthweight: Report of a Meeting in Dhaka, Bangladesh on 14-17 June 1999. Eds. J Pojda & L Kelley. Nutrition Policy Paper #18. ACC/SCN in collaboration with ICDDR, B, Geneva.
2. Beck S, Wojdyla D, Say L et al. (2010) The worldwide incidence of preterm birth: a WHO systematic review of maternal mortality and morbidity. Bulletin of the World Health Organization 88, 31-38.
3. Black RE, Allen LH, Bhutta ZA et al. (2008) Maternal and child undernutrition: global and regional exposures and health consequences. Maternal and Child Undernutrition Study Group. Lancet 371, 243-260.
4. van den Broek N, Ntonya C, Kayira E, White S & Neilson JP (2005) Preterm birth in rural Malawi: high incidence in ultrasound-dated population. Human Reproduction 20, 3235-3237.
5. van den Broek NR, White SA, Goodall M et al. (2009) The APPLe study: A randomized, community-based, placebo-controlled trial of azithromycin for the prevention of preterm birth, with meta-analysis. PLoS Medicine 6, e1000191.
6. van Buuren S, Boshuizen HC & Knook DL (1999) Multiple imputation of missing blood pressure covariates in survival analysis. Statistics in Medicine 18, 681-694.
7. Chico RM & Chandramohan D (2011a) Intermittent preventive treatment of malaria in pregnancy: at the crossroads of public health policy. Tropical Medicine and International Health 16, 774-785.
8. Chico RM & Chandramohan D (2011b) Azithromycin plus chloroquine: combination therapy for protection against malaria and sexually transmitted infections in pregnancy. Expert Opinion on Drug Metabolism & Toxicology 7, 1153-67.
9. Chico RM, Mayaud P, Ariti C, Mabey D, Ronsmans C & Chandramohan D (2012) Prevalence of malaria and sexually transmitted and reproductive tract infections in pregnancy in sub-Saharan Africa: a systematic review. JAMA 307, 2079-2086.
10. Desai M, ter Kuile FO, Nosten F et al. (2007) Epidemiology and burden of malaria in pregnancy. The Lancet Infectious Diseases 7, 93-104.
11. van Eijk AM, Hill J, Alegana VA et al. (2011) Coverage of malaria protection in pregnant women in sub-Saharan Africa: a synthesis and analysis of national survey data. The Lancet Infectious Diseases 11, 190-207.
12. Espo M, Kulmala T, Maleta K, Cullinan T, Salin ML & Ashorn P (2002) Determinants of linear growth and predictors of severe stunting during infancy in rural Malawi. Acta Paediatrica 91, 1364-1370.
13. Filler SJ, Kazembe P, Thigpen M et al. (2006) Randomized trial of 2-dose versus monthly sulfadoxine-pyrimethamine intermittent preventive treatment for malaria in HIV-positive and HIV-negative pregnant women in Malawi. Journal of Infectious Diseases 194, 286-293.
14. Gill CJ, Macleod WB, Mwanakasale V et al. (2007) Inferiority of single-dose sulfadoxine-pyrimethamine intermittent preventive therapy for malaria during pregnancy among HIV-positive Zambian women. Journal of Infectious Diseases 196, 1577-1584.
15. Gray RH, Wabwire-Mangen F, Kigozi G et al. (2001) Randomized trial of presumptive sexually transmitted disease therapy during pregnancy in Rakai, Uganda. American Journal of Obstetrics and Gynecology 185, 1209-1217.
16. Guyatt HL & Snow RW (2004) Impact of malaria during pregnancy on low birth weight in sub-Saharan Africa. Clinical Microbiology Reviews 17, 760-769.
17. Hamer DH, Mwanakasale V, Macleod WB et al. (2007) Two-dose versus monthly intermittent preventive treatment of malaria with sulfadoxine-pyrimethamine in HIV-seropositive pregnant Zambian women. Journal of Infectious Diseases 196, 1585-1594.
18. ter Kuile FO & Steketee RW (2007) Intermittent preventive therapy with sulfadoxine-pyrimethamine during pregnancy: seeking information on optimal dosing frequency. Journal of Infectious Diseases 196, 1574-1576.
19. ter Kuile FO, van Eijk AM & Filler SJ (2007) Effect of sulfadoxine-pyrimethamine resistance on the efficacy of intermittent preventive therapy for malaria control during pregnancy: a systematic review. Journal of the American Medical Association 297, 2603-2616.
20. Kayentao K, Garner P, van Eijk AM et al. (2013) Intermittent preventive therapy for malaria during pregnancy using 2 vs 3 or more doses of sulfadoxine-pyrimethamine and risk of low birth weight in Africa. Systematic review and meta-analysis. Journal of the American Medical Association 309, 594-604.
21. Kulmala T, Vaahtera M, Ndekha M et al. (2000) The importance of preterm births for peri- and neonatal mortality in rural Malawi. Paediatric and Perinatal Epidemiology 14, 219-226.
22. Kulmala T, Vaahtera M, Ndekha M et al. (2001) Gestational health and predictors of newborn weight amongst pregnant women in rural Malawi. African Journal of Reproductive Health 5, 99-108.
23. Lawn JE, Kerber K, Enweronu-Laryea C & Cousens S (2010) 3.6 million neonatal deaths-what is progressing and what is not? Seminars in Perinatology 34, 371-386.
24. Luntamo M, Kulmala T, Mbewe B, Cheung YB, Maleta K & Ashorn P (2010) Effect of repeated treatment of pregnant women with sulfadoxine-pyrimethamine and azithromycin on preterm delivery in Malawi: a randomized controlled trial. American Journal of Tropical Medicine and Hygiene 83, 1212-1220.
25. Luntamo M, Rantala AM, Meshnick SR et al. (2012) The Effect of monthly Sulfadoxine-Pyrimethamine, alone or with Azithromycin, on PCR-diagnosed malaria at delivery: a randomized controlled trial. PLoS ONE 7, e41123.
26. Menéndez C, D'Alessandro U & ter Kuile FO (2007) Reducing the burden of malaria in pregnancy by preventive strategies. The Lancet Infectious Diseases 7, 126-135.
27. Moster D, Lie RT & Markestad T (2008) Long-term medical and social consequences of preterm birth. New England Journal of Medicine 359, 262-273.
28. Mullick S, Watson-Jones D, Beksinska M & Mabey D (2005) Sexually transmitted infections in pregnancy: prevalence, impact on pregnancy outcomes, and approach to treatment in developing countries. Sexually Transmitted Infections 8, 294-302.
29. Osman NB, Challis K, Cotiro M, Nordahl G & Bergström S (2001) Perinatal outcome in an obstetric cohort of Mozambican women. Journal of Tropical Pediatrics 47, 30-38.
30. Parise ME, Ayisi JG, Nahlen BL et al. (1998) Efficacy of sulfadoxine-pyrimethamine for prevention of placental malaria in an area of Kenya with a high prevalence of malaria and human immunodeficiency virus infection. American Journal of Tropical Medicine and Hygiene 59, 813-822.
31. ® product information. http://labeling.pfizer.com/ShowLabeling.aspx?id=511 (accessed on 18 August 2012).
32. Royston P (2004) Multiple imputation of missing values. The Stata Journal 4, 227-241.
33. Saigal S & Doyle LW (2008) An overview of mortality and sequelae of preterm birth from infancy to adulthood. Lancet 371, 261-269.
34. Schultz LJ, Steketee RW, Macheso A, Kazembe P, Chitsulo L & Wirima JJ (1994) The efficacy of antimalarial regimens containing sulfadoxine-pyrimethamine and/or chloroquine in preventing peripheral and placental Plasmodium falciparum infection among pregnant women in Malawi. American Journal of Tropical Medicine and Hygiene 51, 515-522.
35. Sridaran S, McClintock SK, Syphard LM, Herman KM, Barnwell JW & Udhayakumar V (2010) Anti-folate drug resistance in Africa: meta-analysis of reported dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutant genotype frequencies in African Plasmodium falciparum parasite populations. Malaria Journal 9, 247.
36. Swadpanich U, Lumbiganon P, Prasertcharoensook W & Laopaiboon M (2008) Antenatal lower genital tract infection screening and treatment programs for preventing preterm delivery. The Cochrane Database of Systematic Reviews 2, CD006178.
37. Taylor SM, Antonia A, Feng G et al. (2012) Adaptive evolution and fixation of drug-resistant Plasmodium falciparum genotypes in pregnancy-associated malaria: 9-year results from the QuEERPAM study. Infection, Genetics and Evolution 12, 282-290.
38. UNICEF (2011). The State of the World's Children 2011. UNICEF, New York, NY.
39. University of Malawi, Save the Children Federation USA, Malawi Ministry of Health and Population & MEASURE Evaluation (2004). Avoiding Unwanted Pregnancy and Sexually Transmitted Infections: A Rural Malawi District Study. MEASURE Evaluation, Chapel Hill, NC.
40. th Report on the World Nutrition Situation. UNSCN, Geneva.
41. Victora CG, Adair L, Fall C et al. (2008) Maternal and child undernutrition: consequences for adult health and human capital. Maternal and Child Undernutrition Study Group. Lancet 371, 340-357.
42. Walraven GE, Mkanje RJ, van Roosmalen J, van Dongen PW & Dolmans WM (1994) Chest circumference as a screening method for low birth weight in newborns in rural Tanzania. Tropical and Geographical Medicine 46, 14-16.
43. White NJ (2005) Intermittent presumptive treatment for malaria. PLoS Medicine 2, e3.
44. WHO (1993) Use of a simple anthropometric measurement to predict birth weight. WHO Collaborative Study of Birth Weight Surrogates. Bulletin of the World Health Organization 71, 157-163.
45. WHO (2006). Child Growth Standards STATA Igrowup Package. WHO, Geneva.
46. WHO (2010). World Malaria Report 2010. WHO, Geneva.
47. WHO (2012) Global Malaria Program. Updated WHO Policy Recommendation (October 2012): Intermittent Preventive Treatment of malaria in pregnancy using Sulfadoxine-Pyrimethamine (IPTp-SP). WHO, Geneva.