Enteropathy in Zambians with HIV related diarrhoea: Regression modelling of potential determinants of mucosal damage

Gut

Volumn 41, Issue 6, 1997, Pages 811-816

  Kelly, P ^a   Davies, S E ^a   Mandanda, B ^b   Veitch, A ^a   McPhail, G ^a   Zulu, I ^b   Drobniewski, F ^a   Fuchs, D ^c   Summerbell, C ^a   Luo, N P ^b   Pobee, J O M ^b   Farthing, M J G ^a  

^a ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

^b UNIVERSITY OF ZAMBIA   (Zambia)

^c UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Africa; AIDS; Enteropathy; Malnutrition; Protozoa; Small intestine; Tumour necrosis factor receptors

Indexed keywords

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; ENTEROPATHY; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; INTESTINE MUCOSA; MALE; PATHOGENESIS; PRIORITY JOURNAL; ZAMBIA;

EID: 6844241975     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.41.6.811     Document Type: Article

References (38)

1. Serwadda D, Mugerwa RD, Sewankambo NK, Lwegaba A, Carswell J, Kirya GB. Slim disease: a new disease in Uganda and its association with HTLV III infection. Lancet 1985;ii:849-52.
2. Colebunders R, Lusakumuni K, Nelson AM, Gigase P, Lebughe I, Van Marck E. Persistent diarrhoea in Zairian AIDS patients: an endoscopic and histological study, Gut 1988;29:1687-91.
3. Conlon C, Pinching AP, Perera CU, Moody A, Luo NP, Lucas SB. HIV related enteropathy in Zambia: a clinical, microbiological and histological study. Am J Trop Med Hyg 1990;42:83-8.
4. Batman PA, Miller ARO, Forster SM, Harris JRW, Pinching AJ, Griffin GE. Jejunal enteropathy associated with HIV infection: quantitative histology. J Clin Pathol 1989;42:275-81.
5. Cook GC. Tropical gastroenterology. Oxford: Oxford University Press, 1980.
6. Rene E, Marche C, Regnier B, Saimot AG, Vilde JL, Perrone C, et al. Intestinal infection in patients with AIDS. A prospective study in 132 patients. Dig Dis Sci 1989;34:773-80.
7. Smith PD, Lane HC, Gill VJ, Manishewitz JF, Quinnan GA, Fauci AS, Masur H. Intestinal infections in patients with AIDS. Ann Intern Med 1988;108:328-33.
8. Lucas SB. Missing infections in AIDS. Trans R Soc Trop Med Hyg 1990;84(suppl 1):S34-8.
9. Colebunders RL, Latif AS. Natural history and clinical presentation of HIV-I infection in adults. AIDS 1991; 5(suppl 1):S103-12.
10. Pankhurst CL, Luo N, Kelly P, Drobniewski F, Ngwenya B, Farthing MJG. Intestinal mycobacteria in African AIDS patients. Lancet 1995;345:585.
11. Trejdosiewicz LK, Howdle PD. T cell responses and cellular immunity, Baillieres Clin Gastroenterol 1995;9:251-72.
12. Lee RG, Nakamura K, Tsamandas A, Abu-Elmagd K, Furukawa H, Hutson WR, et al. Pathology of human intestinal transplantation. Gastroenterology 1996;110:1820-34.
13. Mowat AMcI, Felstein MV. Experimental studies of immunologically mediated enteropathy V. Destructive enteropathy during and acute graft-versus-host reaction in adult BDF1 mice. Clin Exp Immunol 1990;79:270-84.
14. Lionetti P, Breese E, Braegger CP, Murch SH, Taylor J, MacDonald TT. T cell activation can induce either mucosal destruction or adaptation in cultured human fetal small intestine. Gastroenterology 1993;105:373-81.
15. Batman PA, Fleming SC, Sedwick PM, MacDonald TT, Griffin GE. HIV infection of human fetal intestinal explant cultures induces epithelial cell proliferation. AIDS 1994;8: 161-7.
16. Fox CH, Kotler D, Tierney A, Wilson C, Fauci AS. Detection of HIV-1 RNA in the lamina propria of patients with AIDS and gastrointestinal disease. J Infect Dis 1989;159: 467-71.
17. Heise C, Dandekar S, Kumar P, DuPlantier R, Donovan RM, Halsted CH. HIV infection of enterocytes and mononuclear cells in human jejunal mucosa. Gastroenterology 1991;100:1521-7.
18. Lim SG, MacDonald TT, Francis N, Gazzard BG. Alterations in mucosal immune cells in HIV positive patients with duodenal cryptosporidiosis [abstract]. Gastroenterology 1994;106:A721.
19. Ullrich R, Zeitz M, Heise W, L'Age M, Ziegler K, Bergs C., Riecken EO. Mucosal atrophy is associated with loss of activated T cells in the duodenal mucosa of HIV-infected patients. Digestion 1990;46:S302-7.
20. Veitch AM, Kelly MP, Luo N, Pohee JOM, Penney LS, Farthing MJG. T cell activation in small intestinal mucosa of African AIDS patients with chronic diarrhoea [abstract]. Gut 1995;36:A54.
21. Snijders E, van Deventer SJH, Bartelsman JFW, den Otter P, Jansen J, Mevissen MLCM, et al. Diarrhoea in HIV-infected patients: no evidence of cytokine-mediated inflammation in jejunal mucosa. AIDS 1995;9:367-73.
22. Mathan MM, Griffin GE, Miller A, Batman P, Forster S, Pinching A, Harris W. Ultrastructure of the jejunal mucosa in HIV infection. J Pathol 1990;161:119-27.
23. Ullrich R, Zeitz M, Heise W, L'age M, Hoffken G, Riecken EO. Small intestinal structure and function in patients infected with HIV: evidence for HIV induced enteropathy. Ann Intern Med 1989;111:15-21.
24. Kotler DP, Francisco A, Clayton F, Scholes JV, Orenstein JM. Small intestinal injury and parasitic diseases in AIDS. Ann Intern Med 1990;113:444-9.
25. Phillips AD, Thomas AG, Walker Smith JA. Cryptosporidium, chronic diarrhoea, and the proximal small intestinal mucosa. Gut 1992;33:1057-61.
26. Genta RM, Chappell CL, White AC, Kimball KT, Goodgame RW. Duodenal morphology and intensity of infection in AIDS-related intestinal cryptosporidiosis. Gastroenterology 1993;105:1769-75.
27. Kelly P, Summerbell C, Ngwenya B, Mandanda B, Hosp M, Luo N, et al. Systemic immune activation as a determinant of wasting in patients with AIDS and diarrhoea in Zambia. Q J Med 1996;89:831-7.
28. Slavin G, Sowter C, Robertson K, McDermott S, Paton K. Measurement in jejunal biopsies by computer-aided microscopy. J Clin Pathol 1980;33:254-61.
29. Drobniewski F, Kelly P, Karew A, Ngwenya B, Luo N, Pankhurst C, Farthing M. Human microsporidiosis in African AIDS patients with chronic diarrhoea. J Infect Dis 1995;171:515-6.
30. Zangerle R, Gallati H, Sarcletti M, Weiss G, Denz H, Wachter H, Fuchs D. Increased serum concentrations of soluble tumour necrosis factor receptors in HIV-1 infected individuals are associated with immune activation. J Acquir Immune Defic Syndr 1994;7:79-85.
31. Wood GM, Gearty JC, Cooper BT. Small bowel morphology in British and Afro-Caribbean subjects: evidence of tropical enteropathy. Gut 1991;32:256-9.
32. Greenson JK, Belitsos PC, Yardley JH, Bartlett JG. AIDS enteropathy: occult enteric infections and duodenal mucosal alterations in chronic diarrhea. Ann Intern Med 1991; 114:366-72.
33. Thea DM, Glass R, Grohmann GS, Perriens J, Ngoy B, Kapita B, et al. Prevalence of enteric viruses among hospitalised AIDS patients in Kinshasa, Zaire. Trans R Soc Trop Med Hyg 1993;87:263-6.
34. Zambonino-Infante JL, Rouanet JM, Besancon P. Mathematical correlation between villus height and the nutritional state in Sprague-Dawley rats, Gut 1993;34:1066-8.
35. Young A, Levin RJ. Diarrhoea of famine and malnutrition: investigations using a rat model. Gut 1990;31:43-53,162 9.
36. Grimble RE. Interaction between nutrients, pro-inflammatory cytokines and inflammation. Clin Sci 1996;91:121-30.
37. Marsh MN, Crowe PT. Morphology of the mucosal lesion in gluten sensitivity, Baillieres Clin Gastroenterol 1995;9: 273-93.
38. Macallan DC, Noble C, Baldwin C, Jebb SA, Prentice AM, Coward A, et al. Energy expenditure and wasting in HIV infection. N Engl J Med 1995;333:83-8.