메뉴 건너뛰기




Volumn 102, Issue 6, 2015, Pages 1425-1435

Safety and efficacy of cocoa flavanol intake in healthy adults: A randomized, controlled, double-masked trial1,2

Author keywords

Cocoa; Epicatechin; Flavanol; Procyanidin; Safety

Indexed keywords

COCOA FLAVANOL; FLAVANOL DERIVATIVE; UNCLASSIFIED DRUG; ANTIOXIDANT; BIOLOGICAL MARKER; FLAVONOL DERIVATIVE; XANTHINE DERIVATIVE;

EID: 84948807551     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.115.116178     Document Type: Article
Times cited : (42)

References (38)
  • 2
    • 78649631404 scopus 로고    scopus 로고
    • Recommending flavanols and procyanidins for cardiovascular health: Current knowledge and future needs
    • Schroeter H, Heiss C, Spencer JP, Keen CL, Lupton JR, Schmitz HH. Recommending flavanols and procyanidins for cardiovascular health: current knowledge and future needs. Mol Aspects Med 2010;31:546-57
    • (2010) Mol Aspects Med , vol.31 , pp. 546-557
    • Schroeter, H.1    Heiss, C.2    Spencer, J.P.3    Keen, C.L.4    Lupton, J.R.5    Schmitz, H.H.6
  • 3
    • 84857892715 scopus 로고    scopus 로고
    • Effects of chocolate, cocoa, and flavan-3-ols on cardiovascular health: A systematic review and meta-analysis of randomized trials
    • Hooper L, Kay C, Abdelhamid A, Kroon PA, Cohn JS, Rimm EB, Cassidy A. Effects of chocolate, cocoa, and flavan-3-ols on cardiovascular health: a systematic review and meta-analysis of randomized trials. Am J Clin Nutr 2012;95:740-51
    • (2012) Am J Clin Nutr , vol.95 , pp. 740-751
    • Hooper, L.1    Kay, C.2    Abdelhamid, A.3    Kroon, P.A.4    Cohn, J.S.5    Rimm, E.B.6    Cassidy, A.7
  • 10
    • 84867100985 scopus 로고    scopus 로고
    • Herbal hepatotoxicity: A tabular compilation of reported cases
    • Teschke R, Wolff A, Frenzel C, Schulze J, Eickhoff A. Herbal hepatotoxicity: a tabular compilation of reported cases. Liver Int 2012;32:1543-56
    • (2012) Liver Int , vol.32 , pp. 1543-1556
    • Teschke, R.1    Wolff, A.2    Frenzel, C.3    Schulze, J.4    Eickhoff, A.5
  • 12
    • 44049096970 scopus 로고    scopus 로고
    • Sustained benefits in vascular function through flavanol-containing cocoa in medicated diabetic patients a double-masked, randomized, controlled trial
    • Balzer J, Rassaf T, Heiss C, Kleinbongard P, Lauer T, Merx M, Heussen N, Gross HB, Keen CL, Schroeter H, et al. Sustained benefits in vascular function through flavanol-containing cocoa in medicated diabetic patients a double-masked, randomized, controlled trial. J Am Coll Cardiol 2008;51:2141-9
    • (2008) J Am Coll Cardiol , vol.51 , pp. 2141-2149
    • Balzer, J.1    Rassaf, T.2    Heiss, C.3    Kleinbongard, P.4    Lauer, T.5    Merx, M.6    Heussen, N.7    Gross, H.B.8    Keen, C.L.9    Schroeter, H.10
  • 14
    • 77955060311 scopus 로고    scopus 로고
    • Improvement of endothelial function with dietary flavanols is associated with mobilization of circulating angiogenic cells in patients with coronary artery disease
    • Heiss C, Jahn S, Taylor M, Real WM, Angeli FS, Wong ML, Amabile N, Prasad M, Rassaf T, Ottaviani JI, et al. Improvement of endothelial function with dietary flavanols is associated with mobilization of circulating angiogenic cells in patients with coronary artery disease. J Am Coll Cardiol 2010;56:218-24
    • (2010) J Am Coll Cardiol , vol.56 , pp. 218-224
    • Heiss, C.1    Jahn, S.2    Taylor, M.3    Real, W.M.4    Angeli, F.S.5    Wong, M.L.6    Amabile, N.7    Prasad, M.8    Rassaf, T.9    Ottaviani, J.I.10
  • 16
    • 84865458738 scopus 로고    scopus 로고
    • Benefits in cognitive function, blood pressure, and insulin resistance through cocoa flavanol consumption in elderly subjects with mild cognitive impairment: The Cocoa, Cognition, and Aging (CoCoA) study
    • Desideri G, Kwik-Uribe C, Grassi D, Necozione S, Ghiadoni L, Mastroiacovo D, Raffaele A, Ferri L, Bocale R, Lechiara MC, et al. Benefits in cognitive function, blood pressure, and insulin resistance through cocoa flavanol consumption in elderly subjects with mild cognitive impairment: the Cocoa, Cognition, and Aging (CoCoA) study. Hypertension 2012;60:794-801
    • (2012) Hypertension , vol.60 , pp. 794-801
    • Desideri, G.1    Kwik-Uribe, C.2    Grassi, D.3    Necozione, S.4    Ghiadoni, L.5    Mastroiacovo, D.6    Raffaele, A.7    Ferri, L.8    Bocale, R.9    Lechiara, M.C.10
  • 18
    • 33645455557 scopus 로고    scopus 로고
    • High-performance liquid chromatography separation and purification of cacao (Theobroma cacao L) procyanidins according to degree of polymerization using a diol stationary phase
    • Kelm MA, Johnson JC, Robbins RJ, Hammerstone JF, Schmitz HH. High-performance liquid chromatography separation and purification of cacao (Theobroma cacao L.) procyanidins according to degree of polymerization using a diol stationary phase. J Agric Food Chem 2006; 54:1571-6
    • (2006) J Agric Food Chem , vol.54 , pp. 1571-1576
    • Kelm, M.A.1    Johnson, J.C.2    Robbins, R.J.3    Hammerstone, J.F.4    Schmitz, H.H.5
  • 19
    • 84883267783 scopus 로고    scopus 로고
    • Flavanol and procyanidin content (by degree of polymerization 1-10) of chocolate, cocoa liquors, cocoa powders, and cocoa extracts: First action 2012.24
    • Robbins RJ, Leonczak J, Li J, Johnson JC, Collins T, Kwik-Uribe C, Schmitz HH. Flavanol and procyanidin content (by degree of polymerization 1-10) of chocolate, cocoa liquors, cocoa powders, and cocoa extracts: first action 2012.24. J AOAC Int 2013;96:705-11
    • (2013) J AOAC Int , vol.96 , pp. 705-711
    • Robbins, R.J.1    Leonczak, J.2    Li, J.3    Johnson, J.C.4    Collins, T.5    Kwik-Uribe, C.6    Schmitz, H.H.7
  • 20
    • 82555204534 scopus 로고    scopus 로고
    • Health effects of green tea catechins in overweight and obese men: A randomised controlled cross-over trial
    • Brown AL, Lane J, Holyoak C, Nicol B, Mayes AE, Dadd T. Health effects of green tea catechins in overweight and obese men: a randomised controlled cross-over trial. Br J Nutr 2011;106:1880-9
    • (2011) Br J Nutr , vol.106 , pp. 1880-1889
    • Brown, A.L.1    Lane, J.2    Holyoak, C.3    Nicol, B.4    Mayes, A.E.5    Dadd, T.6
  • 21
    • 80052145967 scopus 로고    scopus 로고
    • Does supplementation with green tea extract improve insulin resistance in obese type 2 diabetics? A randomized, double-blind, and placebo-controlled clinical trial
    • Hsu CH, Liao YL, Lin SC, Tsai TH, Huang CJ, Chou P. Does supplementation with green tea extract improve insulin resistance in obese type 2 diabetics? A randomized, double-blind, and placebo-controlled clinical trial. Altern Med Rev 2011;16:157-63
    • (2011) Altern Med Rev , vol.16 , pp. 157-163
    • Hsu, C.H.1    Liao, Y.L.2    Lin, S.C.3    Tsai, T.H.4    Huang, C.J.5    Chou, P.6
  • 22
    • 84859048094 scopus 로고    scopus 로고
    • Intake of dietary procyanidins does not contribute to the pool of circulating flavanols in humans
    • Ottaviani JI, Kwik-Uribe C, Keen CL, Schroeter H. Intake of dietary procyanidins does not contribute to the pool of circulating flavanols in humans. Am J Clin Nutr 2012;95:851-8
    • (2012) Am J Clin Nutr , vol.95 , pp. 851-858
    • Ottaviani, J.I.1    Kwik-Uribe, C.2    Keen, C.L.3    Schroeter, H.4
  • 24
    • 15744388677 scopus 로고    scopus 로고
    • Short-term administration of dark chocolate is followed by a significant increase in insulin sensitivity and a decrease in blood pressure in healthy persons
    • Grassi D, Lippi C, Necozione S, Desideri G, Ferri C. Short-term administration of dark chocolate is followed by a significant increase in insulin sensitivity and a decrease in blood pressure in healthy persons. Am J Clin Nutr 2005;81:611-4
    • (2005) Am J Clin Nutr , vol.81 , pp. 611-614
    • Grassi, D.1    Lippi, C.2    Necozione, S.3    Desideri, G.4    Ferri, C.5
  • 25
    • 84859010162 scopus 로고    scopus 로고
    • Structurally related (-)-epicatechin metabolites in humans: Assessment using de novo chemically synthesized authentic standards
    • Ottaviani JI, Momma TY, Kuhnle GK, Keen CL, Schroeter H. Structurally related (-)-epicatechin metabolites in humans: assessment using de novo chemically synthesized authentic standards. Free Radic Biol Med 2012;52:1403-12
    • (2012) Free Radic Biol Med , vol.52 , pp. 1403-1412
    • Ottaviani, J.I.1    Momma, T.Y.2    Kuhnle, G.K.3    Keen, C.L.4    Schroeter, H.5
  • 26
    • 0032502965 scopus 로고    scopus 로고
    • Simple high-performance liquid chromatography method for the simultaneous determination of serum caffeine and paraxanthine following rapid sample preparation
    • Holland DT, Godfredsen KA, Page T, Connor JD. Simple high-performance liquid chromatography method for the simultaneous determination of serum caffeine and paraxanthine following rapid sample preparation. J Chromatogr B Biomed Sci Appl 1998;707:105-10
    • (1998) J Chromatogr B Biomed Sci Appl , vol.707 , pp. 105-110
    • Holland, D.T.1    Godfredsen, K.A.2    Page, T.3    Connor, J.D.4
  • 29
    • 70449593430 scopus 로고    scopus 로고
    • Release 3.1 [cited 2014 Jun 1]
    • USDA. USDA database for the flavonoid content of selected foods. 2013. Release 3.1 [cited 2014 Jun 1]. Available from: http://www.nal. usda.gov/fnic/foodcomp/Data/Flav/Flav02-1.pdf
    • (2013) USDA Database for the Flavonoid Content of Selected Foods
  • 30
    • 84876710990 scopus 로고    scopus 로고
    • Chemical synthesis and characterization of epicatechin glucuronides and sulfates: Bioanalytical standards for epicatechin metabolite identification
    • Zhang M, Jagdmann GE Jr., Van Zandt M, Sheeler R, Beckett P, Schroeter H. Chemical synthesis and characterization of epicatechin glucuronides and sulfates: bioanalytical standards for epicatechin metabolite identification. J Nat Prod 2013;76:157-69
    • (2013) J Nat Prod , vol.76 , pp. 157-169
    • Zhang, M.1    Jagdmann, G.E.2    Van Zandt, M.3    Sheeler, R.4    Beckett, P.5    Schroeter, H.6
  • 31
    • 77955402178 scopus 로고    scopus 로고
    • Synthesis of optically pure lactone metabolites of tea catechins
    • Hamada M, Furuno A, Nakano S, Kishimoto T, Nakajima N. Synthesis of optically pure lactone metabolites of tea catechins. Synthesis 2010; 9:1512-20
    • (2010) Synthesis , vol.9 , pp. 1512-1520
    • Hamada, M.1    Furuno, A.2    Nakano, S.3    Kishimoto, T.4    Nakajima, N.5
  • 33
    • 0031956125 scopus 로고    scopus 로고
    • Supplementation with quercetin markedly increases plasma quercetin concentration without effect on selected risk factors for heart disease in healthy subjects
    • Conquer JA, Maiani G, Azzini E, Raguzzini A, Holub BJ. Supplementation with quercetin markedly increases plasma quercetin concentration without effect on selected risk factors for heart disease in healthy subjects. J Nutr 1998;128:593-7
    • (1998) J Nutr , vol.128 , pp. 593-597
    • Conquer, J.A.1    Maiani, G.2    Azzini, E.3    Raguzzini, A.4    Holub, B.J.5
  • 35
    • 84865567726 scopus 로고    scopus 로고
    • Acute, quercetin-induced reductions in blood pressure in hypertensive individuals are not secondary to lower plasma angiotensin-converting enzyme activity or endothelin-1: Nitric oxide
    • Larson A,Witman MA, Guo Y, Ives S, Richardson RS, Bruno RS, Jalili T, Symons JD. Acute, quercetin-induced reductions in blood pressure in hypertensive individuals are not secondary to lower plasma angiotensin-converting enzyme activity or endothelin-1: nitric oxide. Nutr Res 2012;32:557-64
    • (2012) Nutr Res , vol.32 , pp. 557-564
    • Larson, A.1    Witman, M.A.2    Guo, Y.3    Ives, S.4    Richardson, R.S.5    Bruno, R.S.6    Jalili, T.7    Symons, J.D.8
  • 36
    • 84929657335 scopus 로고    scopus 로고
    • Effects of the pure flavonoids epicatechin and quercetin on vascular function and cardiometabolic health: A randomized, doubleblind, placebo-controlled, crossover trial
    • Dower JI, Geleijnse JM, Gijsbers L, Zock PL, Kromhout D, Hollman P. Effects of the pure flavonoids epicatechin and quercetin on vascular function and cardiometabolic health: a randomized, doubleblind, placebo-controlled, crossover trial. Am J Clin Nutr 2015;101: 914-21
    • (2015) Am J Clin Nutr , vol.101 , pp. 914-921
    • Dower, J.I.1    Geleijnse, J.M.2    Gijsbers, L.3    Zock, P.L.4    Kromhout, D.5    Hollman, P.6
  • 37
    • 84944104588 scopus 로고    scopus 로고
    • Cocoa flavanol intake improves endothelial function and Framingham Risk Score in healthy men and women: A randomised, controlled, double-masked trial: The Flaviola Health Study
    • Sansone R, Rodriguez-Mateos A, Heuel J, Falk D, Schuler D, Wagstaff R, Kuhnle GG, Spencer JP, Schroeter H, Merx MW, et al. Cocoa flavanol intake improves endothelial function and Framingham Risk Score in healthy men and women: a randomised, controlled, double-masked trial: the Flaviola Health Study. Br J Nutr 2015;114: 1246-55
    • (2015) Br J Nutr , vol.114 , pp. 1246-1255
    • Sansone, R.1    Rodriguez-Mateos, A.2    Heuel, J.3    Falk, D.4    Schuler, D.5    Wagstaff, R.6    Kuhnle, G.G.7    Spencer, J.P.8    Schroeter, H.9    Merx, M.W.10
  • 38
    • 84888224134 scopus 로고    scopus 로고
    • Human studies on the absorption, distribution, metabolism, and excretion of tea polyphenols
    • Clifford MN, van der Hooft JJ, Crozier A. Human studies on the absorption, distribution, metabolism, and excretion of tea polyphenols. Am J Clin Nutr 2013;98(6 Suppl):1619S-30S
    • (2013) Am J Clin Nutr , vol.98 , Issue.6 , pp. 1619S-1630S
    • Clifford, M.N.1    Vander Hooft, J.J.2    Crozier, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.