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Volumn 114, Issue 8, 2015, Pages 1246-1255

Cocoa flavanol intake improves endothelial function and Framingham Risk Score in healthy men and women: A randomised, controlled, double-masked trial: the Flaviola Health Study

Author keywords

Blood pressure; Cardiovascular health; Flavanols; Flow mediated dilation

Indexed keywords

BIOLOGICAL MARKER; CHOLESTEROL; FLAVANOL DERIVATIVE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID; FLAVONOL DERIVATIVE; LOW DENSITY LIPOPROTEIN CHOLESTEROL;

EID: 84944104588     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114515002822     Document Type: Article
Times cited : (135)

References (32)
  • 1
    • 0042922805 scopus 로고    scopus 로고
    • Vascular effects of cocoa rich in flavan-3-ols
    • Heiss C, Dejam A, Kleinbongard P, et al. (2003) Vascular effects of cocoa rich in flavan-3-ols. JAMA 290, 1030-1031.
    • (2003) JAMA , vol.290 , pp. 1030-1031
    • Heiss, C.1    Dejam, A.2    Kleinbongard, P.3
  • 2
    • 78149327504 scopus 로고    scopus 로고
    • Flavanols and cardiovascular disease prevention
    • Heiss C, Keen CL & Kelm M (2010) Flavanols and cardiovascular disease prevention. Eur Heart J 31, 2583-2592.
    • (2010) Eur Heart J , vol.31 , pp. 2583-2592
    • Heiss, C.1    Keen, C.L.2    Kelm, M.3
  • 3
    • 32244437985 scopus 로고    scopus 로고
    • Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans
    • Schroeter H, Heiss C, Balzer J, et al. (2006) (-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans. Proc Natl Acad Sci USA 103, 1024-1029.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 1024-1029
    • Schroeter, H.1    Heiss, C.2    Balzer, J.3
  • 4
    • 84857892715 scopus 로고    scopus 로고
    • Effects of chocolate, cocoa, and flavan-3-ols on cardiovascular health: A systematic review and meta-Analysis of randomized trials
    • Hooper L, Kay C, Abdelhamid A, et al. (2012) Effects of chocolate, cocoa, and flavan-3-ols on cardiovascular health: a systematic review and meta-Analysis of randomized trials. Am J Clin Nutr 95, 740-751.
    • (2012) Am J Clin Nutr , vol.95 , pp. 740-751
    • Hooper, L.1    Kay, C.2    Abdelhamid, A.3
  • 6
    • 84865458738 scopus 로고    scopus 로고
    • Benefits in cognitive function, blood pressure, and insulin resistance through cocoa flavanol consumption in elderly subjects with mild cognitive impairment: The Cocoa, Cognition, and Aging (CoCoA) study
    • Desideri G, Kwik-Uribe C, Grassi D, et al. (2012) Benefits in cognitive function, blood pressure, and insulin resistance through cocoa flavanol consumption in elderly subjects with mild cognitive impairment: the Cocoa, Cognition, and Aging (CoCoA) study. Hypertension 60, 794-801.
    • (2012) Hypertension , vol.60 , pp. 794-801
    • Desideri, G.1    Kwik-Uribe, C.2    Grassi, D.3
  • 7
    • 84928239194 scopus 로고    scopus 로고
    • Guidance on the scientific requirements for health claims related to antioxidants, oxidative damage and cardiovascular health
    • Efsa Panel on Dietetic Products N & Allergies.
    • Efsa Panel on Dietetic Products N & Allergies (2012) Guidance on the scientific requirements for health claims related to antioxidants, oxidative damage and cardiovascular health. EFSA J 9, 2474.
    • (2012) EFSA J , vol.9 , pp. 2474
  • 8
    • 39549093148 scopus 로고    scopus 로고
    • General cardiovascular risk profile for use in primary care: The Framingham Heart Study
    • D'Agostino RB Sr., Vasan RS, Pencina MJ, et al. (2008) General cardiovascular risk profile for use in primary care: the Framingham Heart Study. Circulation 117, 743-753.
    • (2008) Circulation , vol.117 , pp. 743-753
    • D'Agostino, R.B.1    Vasan, R.S.2    Pencina, M.J.3
  • 9
    • 0033213538 scopus 로고    scopus 로고
    • HPLC method for the quantification of procyanidins in cocoa and chocolate samples and correlation to total antioxidant capacity
    • Adamson GE, Lazarus SA, Mitchell AE, et al. (1999) HPLC method for the quantification of procyanidins in cocoa and chocolate samples and correlation to total antioxidant capacity. J Agric Food Chem 47, 4184-4188.
    • (1999) J Agric Food Chem , vol.47 , pp. 4184-4188
    • Adamson, G.E.1    Lazarus, S.A.2    Mitchell, A.E.3
  • 10
    • 77955060311 scopus 로고    scopus 로고
    • Improvement of endothelial function with dietary flavanols is associated with mobilization of circulating angiogenic cells in patients with coronary artery disease
    • Heiss C, Jahn S, Taylor M, et al. (2010) Improvement of endothelial function with dietary flavanols is associated with mobilization of circulating angiogenic cells in patients with coronary artery disease. J Am Coll Cardiol. 56, 218-224.
    • (2010) J Am Coll Cardiol. , vol.56 , pp. 218-224
    • Heiss, C.1    Jahn, S.2    Taylor, M.3
  • 11
    • 84900496760 scopus 로고    scopus 로고
    • Dietary flavanol intervention lowers the levels of endothelial microparticles in coronary artery disease patients
    • Horn P, Amabile N, Angeli FS, et al. (2014) Dietary flavanol intervention lowers the levels of endothelial microparticles in coronary artery disease patients. Br J Nutr, 1-8.
    • (2014) Br J Nutr , pp. 1-8
    • Horn, P.1    Amabile, N.2    Angeli, F.S.3
  • 12
    • 0000497985 scopus 로고    scopus 로고
    • PS power and sample size program available for free on the Internet
    • Dupont WD & Plummer WD (2007) PS power and sample size program available for free on the Internet. Controlled Clin Trials 18, 274.
    • (2007) Controlled Clin Trials , vol.18 , pp. 274
    • Dupont, W.D.1    Plummer, W.D.2
  • 13
    • 84857061063 scopus 로고    scopus 로고
    • Expert consensus document on the measurement of aortic stiffness in daily practice using carotid-femoral pulse wave velocity
    • Van Bortel LM, Laurent S, Boutouyrie P, et al. (2012) Expert consensus document on the measurement of aortic stiffness in daily practice using carotid-femoral pulse wave velocity. J Hypertens 30, 445-448.
    • (2012) J Hypertens , vol.30 , pp. 445-448
    • Van Bortel, L.M.1    Laurent, S.2    Boutouyrie, P.3
  • 14
    • 84897558515 scopus 로고    scopus 로고
    • A new tool for converting food frequency questionnaire data into nutrient and food group values: FETA research methods and availability
    • Mulligan AA, Luben RN, Bhaniani A, et al. (2014) A new tool for converting food frequency questionnaire data into nutrient and food group values: FETA research methods and availability. BMJ Open 4, e004503.
    • (2014) BMJ Open , vol.4 , pp. e004503
    • Mulligan, A.A.1    Luben, R.N.2    Bhaniani, A.3
  • 15
    • 84905405059 scopus 로고    scopus 로고
    • Assessment of the dietary intake of total flavan-3-ols, monomeric flavan-3-ols, proanthocyanidins and theaflavins in the European Union
    • Vogiatzoglou A, Mulligan AA, Luben RN, et al. (2013) Assessment of the dietary intake of total flavan-3-ols, monomeric flavan-3-ols, proanthocyanidins and theaflavins in the European Union. Br J Nutr, 1-11.
    • (2013) Br J Nutr , pp. 1-11
    • Vogiatzoglou, A.1    Mulligan, A.A.2    Luben, R.N.3
  • 16
    • 84859010162 scopus 로고    scopus 로고
    • Structurally related (-)-epicatechin metabolites in humans: Assessment using de novo chemically synthesized authentic standards
    • Ottaviani JI, Momma TY, Kuhnle GK, et al. (2012) Structurally related (-)-epicatechin metabolites in humans: Assessment using de novo chemically synthesized authentic standards. Free Radic Biol Med 52, 1403-1412.
    • (2012) Free Radic Biol Med , vol.52 , pp. 1403-1412
    • Ottaviani, J.I.1    Momma, T.Y.2    Kuhnle, G.K.3
  • 17
    • 84862119222 scopus 로고    scopus 로고
    • European guidelines on cardiovascular disease prevention in clinical practice (version 2012) developed with the special contribution of the european association for cardiovascular prevention & rehabilitation (eacpr)
    • The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts)
    • Perk J, De Backer G, Gohlke H, et al. (2012) European Guidelines on cardiovascular disease prevention in clinical practice (version 2012). The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts). Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR). Eur Heart J 33, 1635-1701.
    • (2012) Eur Heart J , vol.33 , pp. 1635-1701
    • Perk, J.1    De Backer, G.2    Gohlke, H.3
  • 18
    • 84859200618 scopus 로고    scopus 로고
    • Trends in cardiovascular health metrics and associations with all-cause and CVD mortality among US adults
    • Yang Q, Cogswell ME, Flanders WD, et al. (2012) Trends in cardiovascular health metrics and associations with all-cause and CVD mortality among US adults. JAMA 307, 1273-1283.
    • (2012) JAMA , vol.307 , pp. 1273-1283
    • Yang, Q.1    Cogswell, M.E.2    Flanders, W.D.3
  • 19
    • 84883790321 scopus 로고    scopus 로고
    • Flow-mediated dilation and cardiovascular risk prediction: A systematic review with meta-Analysis
    • Ras RT, Streppel MT, Draijer R, et al. (2013) Flow-mediated dilation and cardiovascular risk prediction: a systematic review with meta-Analysis. Int J Cardiol 168, 344-351.
    • (2013) Int J Cardiol , vol.168 , pp. 344-351
    • Ras, R.T.1    Streppel, M.T.2    Draijer, R.3
  • 20
    • 80054867174 scopus 로고    scopus 로고
    • Effects of statins on coronary and peripheral endothelial function in humans: A systematic review and meta-Analysis of randomized controlled trials
    • Reriani MK, Dunlay SM, Gupta B, et al. (2011) Effects of statins on coronary and peripheral endothelial function in humans: a systematic review and meta-Analysis of randomized controlled trials. Eur J Cardiovasc Prev Rehabil 18, 704-716.
    • (2011) Eur J Cardiovasc Prev Rehabil , vol.18 , pp. 704-716
    • Reriani, M.K.1    Dunlay, S.M.2    Gupta, B.3
  • 21
    • 0033966627 scopus 로고    scopus 로고
    • Comparative study of ACE-inhibition, angiotensin II antagonism, and calcium channel blockade on flow-mediated vasodilation in patients with coronary disease (BANFF study)
    • Anderson TJ, Elstein E, Haber H, et al. (2000) Comparative study of ACE-inhibition, angiotensin II antagonism, and calcium channel blockade on flow-mediated vasodilation in patients with coronary disease (BANFF study). J Am Coll Cardiol 35, 60-66.
    • (2000) J Am Coll Cardiol , vol.35 , pp. 60-66
    • Anderson, T.J.1    Elstein, E.2    Haber, H.3
  • 22
    • 84866260952 scopus 로고    scopus 로고
    • Effect of high-dose statin versus low-dose statin plus ezetimibe on endothelial function: A meta-Analysis of randomized trials
    • Ye Y, Zhao X, Zhai G, et al. (2012) Effect of high-dose statin versus low-dose statin plus ezetimibe on endothelial function: a meta-Analysis of randomized trials. J Cardiovasc Pharmacol Ther 17, 357-365.
    • (2012) J Cardiovasc Pharmacol Ther , vol.17 , pp. 357-365
    • Ye, Y.1    Zhao, X.2    Zhai, G.3
  • 23
    • 84879521118 scopus 로고    scopus 로고
    • Role of exercise in the prevention of cardiovascular disease: Results, mechanisms, and new perspectives
    • Schuler G, Adams V & Goto Y (2013) Role of exercise in the prevention of cardiovascular disease: results, mechanisms, and new perspectives. Eur Heart J 34, 1790-1799.
    • (2013) Eur Heart J , vol.34 , pp. 1790-1799
    • Schuler, G.1    Adams, V.2    Goto, Y.3
  • 24
    • 0037079309 scopus 로고    scopus 로고
    • Age-specific relevance of usual blood pressure to vascular mortality: A meta-Analysis of individual data for one million adults in 61 prospective studies
    • Lewington S, Clarke R, Qizilbash N, et al. (2002) Age-specific relevance of usual blood pressure to vascular mortality: a meta-Analysis of individual data for one million adults in 61 prospective studies. Lancet 360, 1903-1913.
    • (2002) Lancet , vol.360 , pp. 1903-1913
    • Lewington, S.1    Clarke, R.2    Qizilbash, N.3
  • 25
    • 84862556950 scopus 로고    scopus 로고
    • A change in paradigm: Lowering blood pressure in everyone over a certain age
    • Law M (2012) A change in paradigm: lowering blood pressure in everyone over a certain age. Ann Med 44,, Suppl. 1, S30-S35.
    • (2012) Ann Med , vol.44 , pp. S30-S35
    • Law, M.1
  • 26
    • 84859327058 scopus 로고    scopus 로고
    • Comparative effectiveness of antihypertensive medication for primary prevention of cardiovascular disease: Systematic review and multiple treatments meta-Analysis
    • Fretheim A, Odgaard-Jensen J, Brors O, et al. (2012) Comparative effectiveness of antihypertensive medication for primary prevention of cardiovascular disease: systematic review and multiple treatments meta-Analysis. BMC Med 10, 33.
    • (2012) BMC Med , vol.10 , pp. 33
    • Fretheim, A.1    Odgaard-Jensen, J.2    Brors, O.3
  • 27
    • 77952953215 scopus 로고    scopus 로고
    • Does dark chocolate have a role in the prevention and management of hypertension?: Commentary on the evidence
    • Egan BM, Laken MA, Donovan JL, et al. (2010) Does dark chocolate have a role in the prevention and management of hypertension?: commentary on the evidence. Hypertension 55, 1289-1295.
    • (2010) Hypertension , vol.55 , pp. 1289-1295
    • Egan, B.M.1    Laken, M.A.2    Donovan, J.L.3
  • 28
    • 0242654867 scopus 로고    scopus 로고
    • Effects of different blood-pressurelowering regimens on major cardiovascular events: Results of prospectively-designed overviews of randomised trials
    • Blood Pressure Lowering Treatment Trialists Collaboration.
    • Turnbull F & Blood Pressure Lowering Treatment Trialists Collaboration (2003) Effects of different blood-pressurelowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials. Lancet 362, 1527-1535.
    • (2003) Lancet , vol.362 , pp. 1527-1535
    • Turnbull, F.1
  • 29
    • 84916884031 scopus 로고    scopus 로고
    • Hemodynamic aging as the consequence of structural changes associated with early vascular aging (eva)
    • Nilsson PM (2014) Hemodynamic Aging as the Consequence of Structural Changes Associated with Early Vascular Aging (EVA). Aging Dis 5, 109-113.
    • (2014) Aging Dis , vol.5 , pp. 109-113
    • Nilsson, P.M.1
  • 30
    • 84930226092 scopus 로고    scopus 로고
    • Impact of cocoa flavanol intake on age-dependent vascular stiffness in healthy men: A randomized, controlled, double-masked trial
    • Heiss C, Sansone R, Karimi H, et al. (2015) Impact of cocoa flavanol intake on age-dependent vascular stiffness in healthy men: a randomized, controlled, double-masked trial. Age (Dordr) 37, 9794.
    • (2015) Age (Dordr , vol.37 , pp. 9794
    • Heiss, C.1    Sansone, R.2    Karimi, H.3
  • 31
    • 36549034768 scopus 로고    scopus 로고
    • Blood cholesterol and vascular mortality by age, sex, and blood pressure: A meta-Analysis of individual data from 61 prospective studies with 55 000 vascular deaths
    • Prospective Studies Collaboration
    • Prospective Studies Collaboration, Lewington S, Whitlock G, et al. (2007) Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-Analysis of individual data from 61 prospective studies with 55 000 vascular deaths. Lancet 370, 1829-1839.
    • (2007) Lancet , vol.370 , pp. 1829-1839
    • Lewington, S.1    Whitlock, G.2
  • 32
    • 80051475339 scopus 로고    scopus 로고
    • Effects of cocoa products/dark chocolate on serum lipids: A meta-Analysis
    • Tokede OA, Gaziano JM & Djousse L (2011) Effects of cocoa products/dark chocolate on serum lipids: a meta-Analysis. Eur J Clin Nutr 65, 879-886.
    • (2011) Eur J Clin Nutr , vol.65 , pp. 879-886
    • Tokede, O.A.1    Gaziano, J.M.2    Djousse, L.3


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