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Volumn 31, Issue 6, 2010, Pages 546-557

Recommending flavanols and procyanidins for cardiovascular health: Current knowledge and future needs

Author keywords

Cardiovascular disease; Cocoa; Diet; Epicatechin; Nutrition; Phytonutrient; Proanthocyanidins; Tea

Indexed keywords

FLAVONOL DERIVATIVE; PROCYANIDIN DERIVATIVE;

EID: 78649631404     PISSN: 00982997     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mam.2010.09.008     Document Type: Review
Times cited : (108)

References (84)
  • 1
    • 12844272321 scopus 로고    scopus 로고
    • Polyphenols and disease risk in epidemiologic studies
    • Arts I.C., Hollman P.C. Polyphenols and disease risk in epidemiologic studies. Am J Clin Nutr 2005, 81(1 Suppl.):317S-325S.
    • (2005) Am J Clin Nutr , vol.81 , Issue.SUPPL. 1
    • Arts, I.C.1    Hollman, P.C.2
  • 2
    • 0035214759 scopus 로고    scopus 로고
    • Dietary catechins in relation to coronary heart disease death among postmenopausal women
    • Arts I.C., Jacobs D.R., Harnack L.J., Gross M., Folsom A.R. Dietary catechins in relation to coronary heart disease death among postmenopausal women. Epidemiology 2001, 12(6):668-675.
    • (2001) Epidemiology , vol.12 , Issue.6 , pp. 668-675
    • Arts, I.C.1    Jacobs, D.R.2    Harnack, L.J.3    Gross, M.4    Folsom, A.R.5
  • 3
    • 49449085678 scopus 로고    scopus 로고
    • Bioavailability of polyphenon E flavan-3-ols in humans with an ileostomy
    • Auger C., Mullen W., Hara Y., Crozier A. Bioavailability of polyphenon E flavan-3-ols in humans with an ileostomy. J Nutr 2008, 138(8):1535S-1542S.
    • (2008) J Nutr , vol.138 , Issue.8
    • Auger, C.1    Mullen, W.2    Hara, Y.3    Crozier, A.4
  • 4
    • 0035167804 scopus 로고    scopus 로고
    • In vivo comparison of the bioavailability of (+)-catechin, (-)-epicatechin and their mixture in orally administered rats
    • Baba S., Osakabe N., Natsume M., Muto Y., Takizawa T., Terao J. In vivo comparison of the bioavailability of (+)-catechin, (-)-epicatechin and their mixture in orally administered rats. J Nutr 2001, 131(11):2885-2891.
    • (2001) J Nutr , vol.131 , Issue.11 , pp. 2885-2891
    • Baba, S.1    Osakabe, N.2    Natsume, M.3    Muto, Y.4    Takizawa, T.5    Terao, J.6
  • 5
    • 0034493222 scopus 로고    scopus 로고
    • Bioavailability of (-)-epicatechin upon intake of chocolate and cocoa in human volunteers
    • Baba S., Osakabe N., Yasuda A., Natsume M., Takizawa T., Nakamura T., Terao J. Bioavailability of (-)-epicatechin upon intake of chocolate and cocoa in human volunteers. Free Radic Res 2000, 33(5):635-641.
    • (2000) Free Radic Res , vol.33 , Issue.5 , pp. 635-641
    • Baba, S.1    Osakabe, N.2    Yasuda, A.3    Natsume, M.4    Takizawa, T.5    Nakamura, T.6    Terao, J.7
  • 6
    • 44049096970 scopus 로고    scopus 로고
    • Sustained benefits in vascular function through flavanol-containing cocoa in medicated diabetic patients a double-masked, randomized, controlled trial
    • Balzer J., Rassaf T., Heiss C., Kleinbongard P., Lauer T., Merx M., Heussen N., Gross H.B., Keen C.L., Schroeter H., Kelm M. Sustained benefits in vascular function through flavanol-containing cocoa in medicated diabetic patients a double-masked, randomized, controlled trial. J Am Coll Cardiol 2008, 51(22):2141-2149.
    • (2008) J Am Coll Cardiol , vol.51 , Issue.22 , pp. 2141-2149
    • Balzer, J.1    Rassaf, T.2    Heiss, C.3    Kleinbongard, P.4    Lauer, T.5    Merx, M.6    Heussen, N.7    Gross, H.B.8    Keen, C.L.9    Schroeter, H.10    Kelm, M.11
  • 7
    • 33846661267 scopus 로고    scopus 로고
    • Does flavanol intake influence mortality from nitric oxide-dependent processes? Ischemic heart disease, stroke, diabetes mellitus, and cancer in Panama
    • Bayard V., Chamorro F., Motta J., Hollenberg N.K. Does flavanol intake influence mortality from nitric oxide-dependent processes? Ischemic heart disease, stroke, diabetes mellitus, and cancer in Panama. Int J Med Sci 2007, 4(1):53-58.
    • (2007) Int J Med Sci , vol.4 , Issue.1 , pp. 53-58
    • Bayard, V.1    Chamorro, F.2    Motta, J.3    Hollenberg, N.K.4
  • 9
    • 3042517763 scopus 로고    scopus 로고
    • Re-evaluation of the relative potency of synthetic and natural alpha-tocopherol: experimental and clinical observations
    • Blatt D.H., Pryor W.A., Mata J.E., Rodriguez-Proteau R. Re-evaluation of the relative potency of synthetic and natural alpha-tocopherol: experimental and clinical observations. J Nutr Biochem 2004, 15(7):380-395.
    • (2004) J Nutr Biochem , vol.15 , Issue.7 , pp. 380-395
    • Blatt, D.H.1    Pryor, W.A.2    Mata, J.E.3    Rodriguez-Proteau, R.4
  • 10
    • 33751574640 scopus 로고    scopus 로고
    • Drug disposition in three dimensions: an update on stereoselectivity in pharmacokinetics
    • Brocks D.R. Drug disposition in three dimensions: an update on stereoselectivity in pharmacokinetics. Biopharm Drug Dispos 2006, 27(8):387-406.
    • (2006) Biopharm Drug Dispos , vol.27 , Issue.8 , pp. 387-406
    • Brocks, D.R.1
  • 11
    • 78649631372 scopus 로고    scopus 로고
    • CFSAN, Guidance for industry: evidence-based review system for the scientific evaluation of health claims. Available from:
    • CFSAN, 2009. Guidance for industry: evidence-based review system for the scientific evaluation of health claims. Available from: http://www.fda.gov/Food/GuidanceComplianceRegulatoryInformation/GuidanceDocuments/FoodLabelingNutrition/ucm073332.htm.
    • (2009)
  • 13
    • 62249093192 scopus 로고    scopus 로고
    • Reassessing the validity of surrogate markers of drug efficacy in the treatment of coronary artery disease
    • Colatsky T.J. Reassessing the validity of surrogate markers of drug efficacy in the treatment of coronary artery disease. Curr Opin Investig Drugs 2009, 10(3):239-244.
    • (2009) Curr Opin Investig Drugs , vol.10 , Issue.3 , pp. 239-244
    • Colatsky, T.J.1
  • 15
    • 33645065564 scopus 로고    scopus 로고
    • Blood pressure as an example of a biomarker that functions as a surrogate
    • Desai M., Stockbridge N., Temple R. Blood pressure as an example of a biomarker that functions as a surrogate. AAPS J 2006, 8(1):E146-152.
    • (2006) AAPS J , vol.8 , Issue.1
    • Desai, M.1    Stockbridge, N.2    Temple, R.3
  • 17
    • 0033868799 scopus 로고    scopus 로고
    • Food of the gods: cure for humanity? A cultural history of the medicinal and ritual use of chocolate
    • Dillinger T.L., Barriga P., Escarcega S., Jimenez M., Salazar Lowe D., Grivetti L.E. Food of the gods: cure for humanity? A cultural history of the medicinal and ritual use of chocolate. J Nutr 2000, 130(8S Suppl.):2057S-2072S.
    • (2000) J Nutr , vol.130 , Issue.SUPPL. 8
    • Dillinger, T.L.1    Barriga, P.2    Escarcega, S.3    Jimenez, M.4    Salazar Lowe, D.5    Grivetti, L.E.6
  • 19
    • 33749241530 scopus 로고    scopus 로고
    • (+)-Catechin is more bioavailable than (-)-catechin: relevance to the bioavailability of catechin from cocoa
    • Donovan J.L., Crespy V., Oliveira M., Cooper K.A., Gibson B.B., Williamson G. (+)-Catechin is more bioavailable than (-)-catechin: relevance to the bioavailability of catechin from cocoa. Free Radic Res 2006, 40(10):1029-1034.
    • (2006) Free Radic Res , vol.40 , Issue.10 , pp. 1029-1034
    • Donovan, J.L.1    Crespy, V.2    Oliveira, M.3    Cooper, K.A.4    Gibson, B.B.5    Williamson, G.6
  • 20
    • 0035838446 scopus 로고    scopus 로고
    • Short- and long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease
    • Duffy S.J., Keaney J.F., Holbrook M., Gokce N., Swerdloff P.L., Frei B., Vita J.A. Short- and long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease. Circulation 2001, 104(2):151-156.
    • (2001) Circulation , vol.104 , Issue.2 , pp. 151-156
    • Duffy, S.J.1    Keaney, J.F.2    Holbrook, M.3    Gokce, N.4    Swerdloff, P.L.5    Frei, B.6    Vita, J.A.7
  • 22
    • 78649629877 scopus 로고    scopus 로고
    • EFSA, Regulation on nutrition and health claims made on foods. Available from:
    • EFSA, 2006. Regulation on nutrition and health claims made on foods. Available from: http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=CONSLEG:2006R1924:200803.
    • (2006)
  • 24
    • 78649635623 scopus 로고
    • Ueber Catechin, Justus Liebig Annalen der Chemie.
    • Etti, K., 1877. Ueber Catechin, Justus Liebig Annalen der Chemie.
    • (1877)
    • Etti, K.1
  • 25
    • 78649634287 scopus 로고    scopus 로고
    • FDA, Significant scientific agreement in the review of health claims for conventional foods and dietary supplements. Available from:
    • FDA, 1999. Significant scientific agreement in the review of health claims for conventional foods and dietary supplements. Available from: http://www.fda.gov/Food/GuidanceComplianceRegulatoryInformation/GuidanceDocuments/FoodLabelingNutrition/ucm073332.htm.
    • (1999)
  • 26
    • 0020676313 scopus 로고
    • Coronary physiology
    • Feigl E.O. Coronary physiology. Physiol Rev 1983, 63(1):1-205.
    • (1983) Physiol Rev , vol.63 , Issue.1 , pp. 1-205
    • Feigl, E.O.1
  • 27
    • 78649630064 scopus 로고
    • King's American Dispensatory.
    • Felter, H.W., Lloyd, J.U., 1854. King's American Dispensatory.
    • (1854)
    • Felter, H.W.1    Lloyd, J.U.2
  • 28
    • 1442274617 scopus 로고    scopus 로고
    • Flavanol-rich cocoa induces nitric-oxide-dependent vasodilation in healthy humans
    • Fisher N.D., Hughes M., Gerhard-Herman M., Hollenberg N.K. Flavanol-rich cocoa induces nitric-oxide-dependent vasodilation in healthy humans. J Hypertens 2003, 21(12):2281-2286.
    • (2003) J Hypertens , vol.21 , Issue.12 , pp. 2281-2286
    • Fisher, N.D.1    Hughes, M.2    Gerhard-Herman, M.3    Hollenberg, N.K.4
  • 30
    • 33750305274 scopus 로고    scopus 로고
    • The effect of flavanol-rich cocoa on the fMRI response to a cognitive task in healthy young people
    • Francis S.T., Head K., Morris P.G., Macdonald I.A. The effect of flavanol-rich cocoa on the fMRI response to a cognitive task in healthy young people. J Cardiovasc Pharmacol 2006, 47(Suppl. 2):S215-S220.
    • (2006) J Cardiovasc Pharmacol , vol.47 , Issue.SUPPL. 2
    • Francis, S.T.1    Head, K.2    Morris, P.G.3    Macdonald, I.A.4
  • 32
    • 67650624058 scopus 로고    scopus 로고
    • Biomarkers in clinical drug development
    • Gobburu J.V. Biomarkers in clinical drug development. Clin Pharmacol Ther 2009, 86(1):26-27.
    • (2009) Clin Pharmacol Ther , vol.86 , Issue.1 , pp. 26-27
    • Gobburu, J.V.1
  • 33
    • 33645834300 scopus 로고    scopus 로고
    • Analysis of catechins in Theobroma cacao beans by cyclodextrin-modified micellar electrokinetic chromatography
    • Gotti R., Furlanetto S., Pinzauti S., Cavrini V. Analysis of catechins in Theobroma cacao beans by cyclodextrin-modified micellar electrokinetic chromatography. J Chromatogr A 2006, 1112(1-2):345-352.
    • (2006) J Chromatogr A , vol.1112 , Issue.1-2 , pp. 345-352
    • Gotti, R.1    Furlanetto, S.2    Pinzauti, S.3    Cavrini, V.4
  • 35
    • 0035100888 scopus 로고    scopus 로고
    • Biomarker Definitions Working Group, Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther
    • Biomarker Definitions Working Group, 2001. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther 69(3), 89-95.
    • (2001) , vol.69 , Issue.3 , pp. 89-95
  • 38
    • 54749098847 scopus 로고    scopus 로고
    • Expanded approach to tolerable upper intake guidelines for nutrients and bioactive substances
    • Hathcock J.N., Shao A. Expanded approach to tolerable upper intake guidelines for nutrients and bioactive substances. J Nutr 2008, 138(10):1992S-1995S.
    • (2008) J Nutr , vol.138 , Issue.10
    • Hathcock, J.N.1    Shao, A.2
  • 40
    • 33847216227 scopus 로고    scopus 로고
    • Sustained increase in flow-mediated dilation after daily intake of high-flavanol cocoa drink over 1 week
    • Heiss C., Finis D., Kleinbongard P., Hoffmann A., Rassaf T., Kelm M., Sies H. Sustained increase in flow-mediated dilation after daily intake of high-flavanol cocoa drink over 1 week. J Cardiovasc Pharmacol 2007, 49(2):74-80.
    • (2007) J Cardiovasc Pharmacol , vol.49 , Issue.2 , pp. 74-80
    • Heiss, C.1    Finis, D.2    Kleinbongard, P.3    Hoffmann, A.4    Rassaf, T.5    Kelm, M.6    Sies, H.7
  • 42
    • 78149327504 scopus 로고    scopus 로고
    • Flavanols and cardiovascular disease prevention. Eur Heart J, [Epub ahead of print].
    • Heiss, C., Keen, C.L., Kelm, M., 2010b. Flavanols and cardiovascular disease prevention. Eur Heart J, [Epub ahead of print].
    • (2010)
    • Heiss, C.1    Keen, C.L.2    Kelm, M.3
  • 43
    • 27744449813 scopus 로고    scopus 로고
    • Acute consumption of flavanol-rich cocoa and the reversal of endothelial dysfunction in smokers
    • Heiss C., Kleinbongard P., Dejam A., Perre S., Schroeter H., Sies H., Kelm M. Acute consumption of flavanol-rich cocoa and the reversal of endothelial dysfunction in smokers. J Am Coll Cardiol 2005, 46(7):1276-1283.
    • (2005) J Am Coll Cardiol , vol.46 , Issue.7 , pp. 1276-1283
    • Heiss, C.1    Kleinbongard, P.2    Dejam, A.3    Perre, S.4    Schroeter, H.5    Sies, H.6    Kelm, M.7
  • 44
    • 31844443695 scopus 로고
    • The environment and disease: association or causation?
    • Hill A.B. The environment and disease: association or causation?. Proc R Soc Med 1965, 58:295-300.
    • (1965) Proc R Soc Med , vol.58 , pp. 295-300
    • Hill, A.B.1
  • 47
    • 78649630514 scopus 로고    scopus 로고
    • IOM, Consensus Report: Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc, 246-9. Available from:
    • IOM, 2001. Consensus Report: Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc, 246-9. Available from: http://www.iom.edu/Reports/2001/Dietary-Reference-Intakes-for-Vitamin-A-Vitamin-K-Arsenic-Boron-Chromium-Copper-Iodine-Iron-Manganese-Molybdenum-Nickel-Silicon-Vanadium-and-Zinc.aspx.
    • (2001)
  • 48
    • 78649636316 scopus 로고    scopus 로고
    • IOM, Consensus report: evaluation of biomarkers and surrogate endpoints in chronic disease. Available from:
    • IOM, 2010. Consensus report: evaluation of biomarkers and surrogate endpoints in chronic disease. Available from: http://www.iom.edu/Reports/2010/Evaluation-of-Biomarkers-and-Surrogate-Endpoints-in-Chronic-Disease.aspx.
    • (2010)
  • 49
    • 0025277646 scopus 로고
    • Control of coronary vascular tone by nitric oxide
    • Kelm M., Schrader J. Control of coronary vascular tone by nitric oxide. Circ Res 1990, 66(6):1561-1575.
    • (1990) Circ Res , vol.66 , Issue.6 , pp. 1561-1575
    • Kelm, M.1    Schrader, J.2
  • 50
    • 4544291039 scopus 로고    scopus 로고
    • Direct enantioseparation of catechin and epicatechin in tea drinks by 6-O-alpha-D-glucosyl-beta-cyclodextrin-modified micellar electrokinetic chromatography
    • Kodama S., Yamamoto A., Matsunaga A., Yanai H. Direct enantioseparation of catechin and epicatechin in tea drinks by 6-O-alpha-D-glucosyl-beta-cyclodextrin-modified micellar electrokinetic chromatography. Electrophoresis 2004, 25(16):2892-2898.
    • (2004) Electrophoresis , vol.25 , Issue.16 , pp. 2892-2898
    • Kodama, S.1    Yamamoto, A.2    Matsunaga, A.3    Yanai, H.4
  • 52
    • 76749106057 scopus 로고    scopus 로고
    • Dietary factors and the risk for acute infant leukemia: evaluating the effects of cocoa-derived flavanols on DNA topoisomerase activity
    • Lanoue L., Green K.K., Kwik-Uribe C., Keen C.L. Dietary factors and the risk for acute infant leukemia: evaluating the effects of cocoa-derived flavanols on DNA topoisomerase activity. Exp Biol Med (Maywood) 2010, 235(1):77-89.
    • (2010) Exp Biol Med (Maywood) , vol.235 , Issue.1 , pp. 77-89
    • Lanoue, L.1    Green, K.K.2    Kwik-Uribe, C.3    Keen, C.L.4
  • 55
    • 53849146739 scopus 로고    scopus 로고
    • Pure dietary flavonoids quercetin and (-)-epicatechin augment nitric oxide products and reduce endothelin-1 acutely in healthy men
    • Loke W.M., Hodgson J.M., Proudfoot J.M., McKinley A.J., Puddey I.B., Croft K.D. Pure dietary flavonoids quercetin and (-)-epicatechin augment nitric oxide products and reduce endothelin-1 acutely in healthy men. Am J Clin Nutr 2008, 88(4):1018-1025.
    • (2008) Am J Clin Nutr , vol.88 , Issue.4 , pp. 1018-1025
    • Loke, W.M.1    Hodgson, J.M.2    Proudfoot, J.M.3    McKinley, A.J.4    Puddey, I.B.5    Croft, K.D.6
  • 56
    • 13844281685 scopus 로고    scopus 로고
    • Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
    • Manach C., Williamson G., Morand C., Scalbert A., Remesy C. Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr 2005, 81(1 Suppl.):230S-242S.
    • (2005) Am J Clin Nutr , vol.81 , Issue.SUPPL. 1
    • Manach, C.1    Williamson, G.2    Morand, C.3    Scalbert, A.4    Remesy, C.5
  • 59
    • 66849115650 scopus 로고    scopus 로고
    • Milk decreases urinary excretion but not plasma pharmacokinetics of cocoa flavan-3-ol metabolites in humans
    • Mullen W., Borges G., Donovan J.L., Edwards C.A., Serafini M., Lean M.E., Crozier A. Milk decreases urinary excretion but not plasma pharmacokinetics of cocoa flavan-3-ol metabolites in humans. Am J Clin Nutr 2009, 89(6):1784-1791.
    • (2009) Am J Clin Nutr , vol.89 , Issue.6 , pp. 1784-1791
    • Mullen, W.1    Borges, G.2    Donovan, J.L.3    Edwards, C.A.4    Serafini, M.5    Lean, M.E.6    Crozier, A.7
  • 60
    • 0037376885 scopus 로고    scopus 로고
    • Structures of (-)-epicatechin glucuronide identified from plasma and urine after oral ingestion of (-)-epicatechin: differences between human and rat
    • Natsume M., Osakabe N., Oyama M., Sasaki M., Baba S., Nakamura Y., Osawa T., Terao J. Structures of (-)-epicatechin glucuronide identified from plasma and urine after oral ingestion of (-)-epicatechin: differences between human and rat. Free Radic Biol Med 2003, 34(7):840-849.
    • (2003) Free Radic Biol Med , vol.34 , Issue.7 , pp. 840-849
    • Natsume, M.1    Osakabe, N.2    Oyama, M.3    Sasaki, M.4    Baba, S.5    Nakamura, Y.6    Osawa, T.7    Terao, J.8
  • 61
    • 84855427195 scopus 로고    scopus 로고
    • Phenol-explorer: an online comprehensive database on polyphenol contents in foods. Database, doi: 10.1093/database/bap024 (version 1.5.2). Available at:).
    • Neveu, V., Perez-Jiménez, J., Vos, F., Crespy, V., du Chaffaut, L., Mennen, L., Knox, C., Eisner, R., Cruz, J., Wishart, D., Scalbert, A., 2010. Phenol-explorer: an online comprehensive database on polyphenol contents in foods. Database, doi: 10.1093/database/bap024 (version 1.5.2). Available at:). http://www.phenol-explorer.eu.
    • (2010)
    • Neveu, V.1    Perez-Jiménez, J.2    Vos, F.3    Crespy, V.4    du Chaffaut, L.5    Mennen, L.6    Knox, C.7    Eisner, R.8    Cruz, J.9    Wishart, D.10    Scalbert, A.11
  • 63
    • 0031820964 scopus 로고    scopus 로고
    • Accumulation of (-)-epicatechin metabolites in rat plasma after oral administration and distribution of conjugation enzymes in rat tissues
    • Piskula M.K., Terao J. Accumulation of (-)-epicatechin metabolites in rat plasma after oral administration and distribution of conjugation enzymes in rat tissues. J Nutr 1998, 128(7):1172-1178.
    • (1998) J Nutr , vol.128 , Issue.7 , pp. 1172-1178
    • Piskula, M.K.1    Terao, J.2
  • 64
    • 40949089337 scopus 로고    scopus 로고
    • Information-theory based surrogate marker evaluation from several randomized clinical trials with continuous true and binary surrogate endpoints
    • Pryseley A., Tilahun A., Alonso A., Molenberghs G. Information-theory based surrogate marker evaluation from several randomized clinical trials with continuous true and binary surrogate endpoints. Clin Trials 2007, 4(6):587-597.
    • (2007) Clin Trials , vol.4 , Issue.6 , pp. 587-597
    • Pryseley, A.1    Tilahun, A.2    Alonso, A.3    Molenberghs, G.4
  • 65
    • 26844440855 scopus 로고    scopus 로고
    • Chiral cardiovascular drugs: an overview
    • Ranade V.V., Somberg J.C. Chiral cardiovascular drugs: an overview. Am J Ther 2005, 12(5):439-459.
    • (2005) Am J Ther , vol.12 , Issue.5 , pp. 439-459
    • Ranade, V.V.1    Somberg, J.C.2
  • 66
    • 77951258383 scopus 로고    scopus 로고
    • Chiral separation of (+)/(-)-catechin from sulfated and glucuronidated metabolites in human plasma after cocoa consumption
    • Ritter C., Zimmermann B.F., Galensa R. Chiral separation of (+)/(-)-catechin from sulfated and glucuronidated metabolites in human plasma after cocoa consumption. Anal Bioanal Chem 2010, 397(2):723-730.
    • (2010) Anal Bioanal Chem , vol.397 , Issue.2 , pp. 723-730
    • Ritter, C.1    Zimmermann, B.F.2    Galensa, R.3
  • 67
    • 0344613481 scopus 로고    scopus 로고
    • Procyanidin B1 is detected in human serum after intake of proanthocyanidin-rich grape seed extract
    • Sano A., Yamakoshi J., Tokutake S., Tobe K., Kubota Y., Kikuchi M. Procyanidin B1 is detected in human serum after intake of proanthocyanidin-rich grape seed extract. Biosci Biotechnol Biochem 2003, 67(5):1140-1143.
    • (2003) Biosci Biotechnol Biochem , vol.67 , Issue.5 , pp. 1140-1143
    • Sano, A.1    Yamakoshi, J.2    Tokutake, S.3    Tobe, K.4    Kubota, Y.5    Kikuchi, M.6
  • 69
    • 44049086528 scopus 로고    scopus 로고
    • Cerebral blood flow response to flavanol-rich cocoa in healthy elderly humans
    • Sorond F.A., Lipsitz L.A., Hollenberg N.K., Fisher N.D. Cerebral blood flow response to flavanol-rich cocoa in healthy elderly humans. Neuropsychiatr Dis Treat 2008, 4(2):433-440.
    • (2008) Neuropsychiatr Dis Treat , vol.4 , Issue.2 , pp. 433-440
    • Sorond, F.A.1    Lipsitz, L.A.2    Hollenberg, N.K.3    Fisher, N.D.4
  • 72
    • 77649307443 scopus 로고    scopus 로고
    • Absorption, metabolism, and excretion of green tea flavan-3-ols in humans with an ileostomy
    • Stalmach A., Mullen W., Steiling H., Williamson G., Lean M.E., Crozier A. Absorption, metabolism, and excretion of green tea flavan-3-ols in humans with an ileostomy. Mol Nutr Food Res 2010, 54(3):323-334.
    • (2010) Mol Nutr Food Res , vol.54 , Issue.3 , pp. 323-334
    • Stalmach, A.1    Mullen, W.2    Steiling, H.3    Williamson, G.4    Lean, M.E.5    Crozier, A.6
  • 73
    • 0034712748 scopus 로고    scopus 로고
    • Dietary bioflavonoids induce cleavage in the MLL gene and may contribute to infant leukemia
    • Strick R., Strissel P.L., Borgers S., Smith S.L., Rowley J.D. Dietary bioflavonoids induce cleavage in the MLL gene and may contribute to infant leukemia. Proc Natl Acad Sci USA 2000, 97(9):4790-4795.
    • (2000) Proc Natl Acad Sci USA , vol.97 , Issue.9 , pp. 4790-4795
    • Strick, R.1    Strissel, P.L.2    Borgers, S.3    Smith, S.L.4    Rowley, J.D.5
  • 74
    • 0041920912 scopus 로고    scopus 로고
    • Chocolate and blood pressure in elderly individuals with isolated systolic hypertension
    • Taubert D., Berkels R., Roesen R., Klaus W. Chocolate and blood pressure in elderly individuals with isolated systolic hypertension. JAMA 2003, 290(8):1029-1030.
    • (2003) JAMA , vol.290 , Issue.8 , pp. 1029-1030
    • Taubert, D.1    Berkels, R.2    Roesen, R.3    Klaus, W.4
  • 75
    • 34347404130 scopus 로고    scopus 로고
    • Effects of low habitual cocoa intake on blood pressure and bioactive nitric oxide: a randomized controlled trial
    • Taubert D., Roesen R., Lehmann C., Jung N., Schomig E. Effects of low habitual cocoa intake on blood pressure and bioactive nitric oxide: a randomized controlled trial. JAMA 2007, 298(1):49-60.
    • (2007) JAMA , vol.298 , Issue.1 , pp. 49-60
    • Taubert, D.1    Roesen, R.2    Lehmann, C.3    Jung, N.4    Schomig, E.5
  • 77
    • 78649630595 scopus 로고    scopus 로고
    • USDA, USDA database for the flavonoid content of selected foods. Available from:
    • USDA, 2003. USDA database for the flavonoid content of selected foods. Available from: http://www.nal.usda.gov/fnic/foodcomp/Data/Flav/flav.html.
    • (2003)
  • 78
    • 78649634644 scopus 로고    scopus 로고
    • USDA, USDA database for the proanthocyanidin content of selected foods. Available from:
    • USDA, 2004. USDA database for the proanthocyanidin content of selected foods. Available from: http://www.nal.usda.gov/fnic/foodcomp/Data/PA/PA.html.
    • (2004)
  • 79
    • 78649630762 scopus 로고    scopus 로고
    • USDA, USDHHS, Dietary Guidelines for Americans. Available from:
    • USDA, USDHHS, 2005. Dietary Guidelines for Americans. Available from: http://www.health.gov/dietaryguidelines.
    • (2005)
  • 80
    • 41149108215 scopus 로고    scopus 로고
    • Strategic approach to fit-for-purpose biomarkers in drug development
    • Wagner J.A. Strategic approach to fit-for-purpose biomarkers in drug development. Annu Rev Pharmacol Toxicol 2008, 48:631-651.
    • (2008) Annu Rev Pharmacol Toxicol , vol.48 , pp. 631-651
    • Wagner, J.A.1
  • 82
    • 78649629643 scopus 로고    scopus 로고
    • WHO, Biomarkers in risk assessment: Validity and Validation. Available from:
    • WHO, 2001. Biomarkers in risk assessment: Validity and Validation. Available from: http://www.inchem.org/documents/ehc/ehc/ehc222.htm.
    • (2001)
  • 83
    • 46649096835 scopus 로고    scopus 로고
    • Dietary reference intake (DRI) value for dietary polyphenols: are we heading in the right direction?
    • Williamson G., Holst B. Dietary reference intake (DRI) value for dietary polyphenols: are we heading in the right direction?. Br J Nutr 2008, 99(Suppl. 3):S55-S58.
    • (2008) Br J Nutr , vol.99 , Issue.SUPPL. 3
    • Williamson, G.1    Holst, B.2
  • 84
    • 13844271387 scopus 로고    scopus 로고
    • Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies
    • Williamson G., Manach C. Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies. Am J Clin Nutr 2005, 81(1 Suppl.):243S-255S.
    • (2005) Am J Clin Nutr , vol.81 , Issue.SUPPL. 1
    • Williamson, G.1    Manach, C.2


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