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Volumn 9, Issue November, 2015, Pages

Effects of rapamycin treatment on neurogenesis and synaptic reorganization in the dentate gyrus after controlled cortical impact injury in mice

Author keywords

Adult neurogenesis; Dentate granule cell; Doublecortin; Epilepsy; Hippocampus; Mossy fiber sprouting; MTOR; Trauma

Indexed keywords

DOUBLECORTIN; MAMMALIAN TARGET OF RAPAMYCIN; RAPAMYCIN;

EID: 84948751694     PISSN: 16625137     EISSN: None     Source Type: Journal    
DOI: 10.3389/fnsys.2015.00163     Document Type: Article
Times cited : (63)

References (64)
  • 1
    • 0013855185 scopus 로고
    • Post-natal origin of microneurones in the rat brain
    • Altman, J., and Das, G. D. (1965). Post-natal origin of microneurones in the rat brain. Nature 207, 953-956. doi: 10.1038/207953a0
    • (1965) Nature , vol.207 , pp. 953-956
    • Altman, J.1    Das, G.D.2
  • 2
    • 84860162767 scopus 로고    scopus 로고
    • Pten deletion in adult hippocampal neural stem/progenitor cells causes cellular abnormalities and alters neurogenesis
    • Amiri, A., Cho, W., Zhou, J., Birnbaum, S. G., Sinton, C. M., McKay, R. M., et al. (2012). Pten deletion in adult hippocampal neural stem/progenitor cells causes cellular abnormalities and alters neurogenesis. J. Neurosci. 32, 5880-5890. doi: 10.1523/JNEUROSCI.5462-11.2012
    • (2012) J. Neurosci , vol.32 , pp. 5880-5890
    • Amiri, A.1    Cho, W.2    Zhou, J.3    Birnbaum, S.G.4    Sinton, C.M.5    McKay, R.M.6
  • 3
    • 16244417756 scopus 로고    scopus 로고
    • Regional distribution of fluoro-jade B staining in the hippocampus following traumatic brain injury
    • Anderson, K. J., Miller, K. M., Fugaccia, I., and Scheff, S. W. (2005). Regional distribution of fluoro-jade B staining in the hippocampus following traumatic brain injury. Exp. Neurol. 193, 125-130. doi: 10.1016/j.expneurol.2004.11.025
    • (2005) Exp. Neurol , vol.193 , pp. 125-130
    • Anderson, K.J.1    Miller, K.M.2    Fugaccia, I.3    Scheff, S.W.4
  • 4
    • 0031975401 scopus 로고    scopus 로고
    • A population-based study of seizures after traumatic brain injuries
    • Annegers, J. F., Hauser, W. A., Coan, S. P., and Rocca, W. A. (1998). A population-based study of seizures after traumatic brain injuries. N. Engl. J. Med. 338, 20-24. doi: 10.1056/nejm199801013380104
    • (1998) N. Engl. J. Med , vol.338 , pp. 20-24
    • Annegers, J.F.1    Hauser, W.A.2    Coan, S.P.3    Rocca, W.A.4
  • 5
    • 43649103735 scopus 로고    scopus 로고
    • A time course of contusion- induced oxidative stress and synaptic proteins in cortex in a rat model of TBI
    • Ansari, M. A., Roberts, K. N., and Scheff, S. W. (2008). A time course of contusion- induced oxidative stress and synaptic proteins in cortex in a rat model of TBI. J. Neurotrauma 25, 513-526. doi: 10.1089/neu.2007.0451
    • (2008) J. Neurotrauma , vol.25 , pp. 513-526
    • Ansari, M.A.1    Roberts, K.N.2    Scheff, S.W.3
  • 6
    • 0036735672 scopus 로고    scopus 로고
    • Neuronal replacement from endogenous precursors in the adult brain after stroke
    • Arvidsson, A., Collin, T., Kirik, D., Kokaia, Z., and Lindvall, O. (2002). Neuronal replacement from endogenous precursors in the adult brain after stroke. Nat. Med. 8, 963-970. doi: 10.1038/nm747
    • (2002) Nat. Med , vol.8 , pp. 963-970
    • Arvidsson, A.1    Collin, T.2    Kirik, D.3    Kokaia, Z.4    Lindvall, O.5
  • 7
    • 79961024077 scopus 로고    scopus 로고
    • Progesterone treatment normalizes the levels of cell proliferation and cell death in the dentate gyrus of the hippocampus after traumatic brain injury
    • Barha, C. K., Ishrat, T., Epp, J. R., Galea, L. A., and Stein, D. G. (2011). Progesterone treatment normalizes the levels of cell proliferation and cell death in the dentate gyrus of the hippocampus after traumatic brain injury. Exp. Neurol. 231, 72-81. doi: 10.1016/j.expneurol.2011.05.016
    • (2011) Exp. Neurol , vol.231 , pp. 72-81
    • Barha, C.K.1    Ishrat, T.2    Epp, J.R.3    Galea, L.A.4    Stein, D.G.5
  • 8
    • 77952552716 scopus 로고    scopus 로고
    • Effects of TRPV1 activation on synaptic excitation in the dentate gyrus of a mouse model of temporal lobe epilepsy
    • Bhaskaran, M., and Smith, B. (2010). Effects of TRPV1 activation on synaptic excitation in the dentate gyrus of a mouse model of temporal lobe epilepsy. Exp. Neurol. 223, 529-536. doi: 10.1016/j.expneurol.2010.01.021
    • (2010) Exp. Neurol , vol.223 , pp. 529-536
    • Bhaskaran, M.1    Smith, B.2
  • 9
    • 0030773376 scopus 로고    scopus 로고
    • Neuron loss, granule cell axon reorganization and functional changes in the dentate gyrus of epileptic kainate-treated rats
    • Buckmaster, P. S., and Dudek, F. E. (1997). Neuron loss, granule cell axon reorganization and functional changes in the dentate gyrus of epileptic kainate-treated rats. J. Comp. Neurol. 385, 385-404. doi: 10.1002/(sici)1096-861(19970901)385:3<385::aid-cne4>3.3.co;2-y
    • (1997) J. Comp. Neurol , vol.385 , pp. 385-404
    • Buckmaster, P.S.1    Dudek, F.E.2
  • 10
    • 67649382228 scopus 로고    scopus 로고
    • Inhibition of the mammalian target of rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a rodent model of temporal lobe epilepsy
    • Buckmaster, P. S., Ingram, E. A., and Wen, X. (2009). Inhibition of the mammalian target of rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a rodent model of temporal lobe epilepsy. J. Neurosci. 29, 8259-8269. doi: 10.1523/JNEUROSCI.4179-08.2009
    • (2009) J. Neurosci , vol.29 , pp. 8259-8269
    • Buckmaster, P.S.1    Ingram, E.A.2    Wen, X.3
  • 11
    • 79951531485 scopus 로고    scopus 로고
    • Rapamycin suppresses mossy fiber sprouting but not seizure frequency in a mouse model of temporal lobe epilepsy
    • Buckmaster, P. S., and Lew, F. H. (2011). Rapamycin suppresses mossy fiber sprouting but not seizure frequency in a mouse model of temporal lobe epilepsy. J. Neurosci. 31, 2337-2347. doi: 10.1523/JNEUROSCI.4852-10.2011
    • (2011) J. Neurosci , vol.31 , pp. 2337-2347
    • Buckmaster, P.S.1    Lew, F.H.2
  • 12
    • 80255137186 scopus 로고    scopus 로고
    • Rapamycin suppresses axon sprouting by somatostatin interneurons in a mouse model of temporal lobe epilepsy
    • Buckmaster, P. S., and Wen, X. (2011). Rapamycin suppresses axon sprouting by somatostatin interneurons in a mouse model of temporal lobe epilepsy. Epilepsia 52, 2057-2064. doi: 10.1111/j.1528-1167.2011.03253.x
    • (2011) Epilepsia , vol.52 , pp. 2057-2064
    • Buckmaster, P.S.1    Wen, X.2
  • 13
    • 84904760808 scopus 로고    scopus 로고
    • Conditional overexpression of insulin-like growth factor-1 enhances hippocampal neurogenesis and restores immature neuron dendritic processes after traumatic brain injury
    • Carlson, S. W., Madathil, S. K., Sama, D. M., Gao, X., Chen, J., and Saatman, K. E. (2014). Conditional overexpression of insulin-like growth factor-1 enhances hippocampal neurogenesis and restores immature neuron dendritic processes after traumatic brain injury. J. Neuropathol. Exp. Neurol. 73, 734-746. doi: 10.1097/NEN.0000000000000092
    • (2014) J. Neuropathol. Exp. Neurol , vol.73 , pp. 734-746
    • Carlson, S.W.1    Madathil, S.K.2    Sama, D.M.3    Gao, X.4    Chen, J.5    Saatman, K.E.6
  • 15
    • 0036317901 scopus 로고    scopus 로고
    • Traumatic brain injury induced cell proliferation in the adult mammalian central nervous system
    • Chirumamilla, S., Sun, D., Bullock, M. R., and Colello, R. J. (2002). Traumatic brain injury induced cell proliferation in the adult mammalian central nervous system. J. Neurotrauma 19, 693-703. doi: 10.1089/08977150260139084
    • (2002) J. Neurotrauma , vol.19 , pp. 693-703
    • Chirumamilla, S.1    Sun, D.2    Bullock, M.R.3    Colello, R.J.4
  • 16
    • 0035866067 scopus 로고    scopus 로고
    • Enhanced neurogenesis in the rodent hippocampus following traumatic brain injury
    • Dash, P. K., Mach, S. A., and Moore, A. N. (2001). Enhanced neurogenesis in the rodent hippocampus following traumatic brain injury. J. Neurosci. Res. 63, 313-319. doi: 10.1002/1097-4547(20010215)63:4<313::aid-jnr1025>3.0.co;2-4
    • (2001) J. Neurosci. Res , vol.63 , pp. 313-319
    • Dash, P.K.1    Mach, S.A.2    Moore, A.N.3
  • 17
    • 0033734198 scopus 로고    scopus 로고
    • Neurophysiologic and neuroradiologic features of intractable epilepsy after traumatic brain injury in adults
    • Diaz-Arrastia, R., Agostini, M. A., Frol, A. B., Mickey, B., Fleckenstein, J., Bigio, E., et al. (2000). Neurophysiologic and neuroradiologic features of intractable epilepsy after traumatic brain injury in adults. Arch. Neurol. 57, 1611-1616. doi: 10.1001/archneur.57.11.1611
    • (2000) Arch. Neurol , vol.57 , pp. 1611-1616
    • Diaz-Arrastia, R.1    Agostini, M.A.2    Frol, A.B.3    Mickey, B.4    Fleckenstein, J.5    Bigio, E.6
  • 18
    • 84864630240 scopus 로고    scopus 로고
    • Targeting mTOR as a novel therapeutic strategy for traumatic CNS injuries
    • Don, A. S., Tsang, C. K., Kazdoba, T. M., D’Arcangelo, G., Young, W., and Zheng, X. F. (2012). Targeting mTOR as a novel therapeutic strategy for traumatic CNS injuries. Drug Discov. Today 17, 861-868. doi: 10.1016/j.drudis.2012.04.010
    • (2012) Drug Discov. Today , vol.17 , pp. 861-868
    • Don, A.S.1    Tsang, C.K.2    Kazdoba, T.M.3    D’Arcangelo, G.4    Young, W.5    Zheng, X.F.6
  • 19
    • 0031394539 scopus 로고    scopus 로고
    • Hypothetical mechanisms for the cellular and neurophysiologic basis of secondary epileptogenesis: Proposed role of synaptic reorganization
    • Dudek, F. E., and Spitz, M. (1997). Hypothetical mechanisms for the cellular and neurophysiologic basis of secondary epileptogenesis: proposed role of synaptic reorganization. J. Clin. Neurophysiol. 14, 90-101. doi: 10.1097/00004691-199703000-00002
    • (1997) J. Clin. Neurophysiol , vol.14 , pp. 90-101
    • Dudek, F.E.1    Spitz, M.2
  • 20
    • 0037336171 scopus 로고    scopus 로고
    • Analyzing risk factors for late posttraumatic seizures: A prospective, multicenter investigation
    • Englander, J., Bushnik, T., Duong, T. T., Cifu, D. X., Zafonte, R., Wright, J., et al. (2003). Analyzing risk factors for late posttraumatic seizures: a prospective, multicenter investigation. Arch. Phys. Med. Rehabil. 84, 365-373. doi: 10.1053/apmr.2003.50022
    • (2003) Arch. Phys. Med. Rehabil , vol.84 , pp. 365-373
    • Englander, J.1    Bushnik, T.2    Duong, T.T.3    Cifu, D.X.4    Zafonte, R.5    Wright, J.6
  • 22
    • 0030842997 scopus 로고    scopus 로고
    • Lesion-induced proliferation of neuronal progenitors in the dentate gyrus of the adult rat
    • Gould, E., and Tanapat, P. (1997). Lesion-induced proliferation of neuronal progenitors in the dentate gyrus of the adult rat. Neuroscience 80, 427-436. doi: 10.1016/s0306-4522(97)00127-9
    • (1997) Neuroscience , vol.80 , pp. 427-436
    • Gould, E.1    Tanapat, P.2
  • 23
    • 0142089193 scopus 로고    scopus 로고
    • Neuronal and glial cell number in the hippocampus after experimental traumatic brain injury: Analysis by stereological estimation
    • Grady, M. S., Charleston, J. S., Maris, D., Witgen, B. M., and Lifshitz, J. (2003). Neuronal and glial cell number in the hippocampus after experimental traumatic brain injury: analysis by stereological estimation. J. Neurotrauma 20, 929-941. doi: 10.1089/089771503770195786
    • (2003) J. Neurotrauma , vol.20 , pp. 929-941
    • Grady, M.S.1    Charleston, J.S.2    Maris, D.3    Witgen, B.M.4    Lifshitz, J.5
  • 24
    • 0033973418 scopus 로고    scopus 로고
    • Tissue tears in the white matter after lateral fluid percussion brain injury in the rat: Relevance to human brain injury
    • Graham, D. I., Raghupathi, R., Saatman, K. E., Meaney, D., and McIntosh, T. K. (2000). Tissue tears in the white matter after lateral fluid percussion brain injury in the rat: relevance to human brain injury. Acta Neuropathol. 99, 117-124. doi: 10.1007/pl00007414
    • (2000) Acta Neuropathol , vol.99 , pp. 117-124
    • Graham, D.I.1    Raghupathi, R.2    Saatman, K.E.3    Meaney, D.4    McIntosh, T.K.5
  • 25
    • 84877727515 scopus 로고    scopus 로고
    • Rapamycin attenuates the development of posttraumatic epilepsy in a mouse model of traumatic brain injury
    • Guo, D., Zeng, L., Brody, D. L., and Wong, M. (2013). Rapamycin attenuates the development of posttraumatic epilepsy in a mouse model of traumatic brain injury. PLoS One 8:e64078. doi: 10.1371/journal.pone.0064078
    • (2013) Plos One , vol.8
    • Guo, D.1    Zeng, L.2    Brody, D.L.3    Wong, M.4
  • 26
    • 40949158910 scopus 로고    scopus 로고
    • Evolution of post-traumatic neurodegeneration after controlled cortical impact traumatic brain injury in mice and rats as assessed by the de Olmos silver and fluorojade staining methods
    • Hall, E. D., Bryant, Y. D., Cho, W., and Sullivan, P. G. (2008). Evolution of post-traumatic neurodegeneration after controlled cortical impact traumatic brain injury in mice and rats as assessed by the de Olmos silver and fluorojade staining methods. J. Neurotrauma 25, 235-247. doi: 10.1089/neu.2007.0383
    • (2008) J. Neurotrauma , vol.25 , pp. 235-247
    • Hall, E.D.1    Bryant, Y.D.2    Cho, W.3    Sullivan, P.G.4
  • 27
    • 84883744206 scopus 로고    scopus 로고
    • High-dose rapamycin blocks mossy fiber sprouting but not seizures in a mouse model of temporal lobe epilepsy
    • Heng, K., Haney, M. M., and Buckmaster, P. S. (2013). High-dose rapamycin blocks mossy fiber sprouting but not seizures in a mouse model of temporal lobe epilepsy. Epilepsia 54, 1535-1541. doi: 10.1111/epi.12246
    • (2013) Epilepsia , vol.54 , pp. 1535-1541
    • Heng, K.1    Haney, M.M.2    Buckmaster, P.S.3
  • 28
    • 84877994145 scopus 로고    scopus 로고
    • Accumulation of abnormal adult-generated hippocampal granule cells predicts seizure frequency and severity
    • Hester, M. S., and Danzer, S. C. (2013). Accumulation of abnormal adult-generated hippocampal granule cells predicts seizure frequency and severity. J. Neurosci. 33, 8926-8936. doi: 10.1523/JNEUROSCI.5161-12.2013
    • (2013) J. Neurosci , vol.33 , pp. 8926-8936
    • Hester, M.S.1    Danzer, S.C.2
  • 29
    • 0027764250 scopus 로고
    • Mild experimental brain injury in the rat induces cognitive deficits associated with regional neuronal loss in the hippocampus
    • Hicks, R. R., Smith, D. H., Lowenstein, D. H., Saint Marie, R., and McIntosh, T. K. (1993). Mild experimental brain injury in the rat induces cognitive deficits associated with regional neuronal loss in the hippocampus. J. Neurotrauma 10, 405-414. doi: 10.1089/neu.1993.10.405
    • (1993) J. Neurotrauma , vol.10 , pp. 405-414
    • Hicks, R.R.1    Smith, D.H.2    Lowenstein, D.H.3    Saint Marie, R.4    McIntosh, T.K.5
  • 30
    • 3142699846 scopus 로고    scopus 로고
    • Evaluation of seizure-like episodes in survivors of moderate and severe traumatic brain injury
    • Hudak, A. M., Trivedi, K., Harper, C. R., Booker, K., Caesar, R. R., Agostini, M., et al. (2004). Evaluation of seizure-like episodes in survivors of moderate and severe traumatic brain injury. J. Head Trauma Rehabil. 19, 290-295. doi: 10.1097/00001199-200407000-00003
    • (2004) J. Head Trauma Rehabil , vol.19 , pp. 290-295
    • Hudak, A.M.1    Trivedi, K.2    Harper, C.R.3    Booker, K.4    Caesar, R.R.5    Agostini, M.6
  • 31
    • 84857910163 scopus 로고    scopus 로고
    • Posttraumatic mossy fiber sprouting is related to the degree of cortical damage in three mouse strains
    • Hunt, R. F., Haselhorst, L. A., Schoch, K. M., Bach, E. C., Rios-Pilier, J., Scheff, S. W., et al. (2012). Posttraumatic mossy fiber sprouting is related to the degree of cortical damage in three mouse strains. Epilepsy Res. 99, 167-170. doi: 10.1016/j.eplepsyres.2011.10.011
    • (2012) Epilepsy Res , vol.99 , pp. 167-170
    • Hunt, R.F.1    Haselhorst, L.A.2    Schoch, K.M.3    Bach, E.C.4    Rios-Pilier, J.5    Scheff, S.W.6
  • 32
    • 58149500278 scopus 로고    scopus 로고
    • Posttraumatic epilepsy after controlled cortical impact injury in mice
    • Hunt, R. F., Scheff, S. W., and Smith, B. N. (2009). Posttraumatic epilepsy after controlled cortical impact injury in mice. Exp. Neurol. 215, 243-252. doi: 10.1016/j.expneurol.2008.10.005
    • (2009) Exp. Neurol , vol.215 , pp. 243-252
    • Hunt, R.F.1    Scheff, S.W.2    Smith, B.N.3
  • 33
    • 77949697191 scopus 로고    scopus 로고
    • Regionally localized recurrent excitation in the dentate gyrus of a cortical contusion model of posttraumatic epilepsy
    • Hunt, R. F., Scheff, S. W., and Smith, B. N. (2010). Regionally localized recurrent excitation in the dentate gyrus of a cortical contusion model of posttraumatic epilepsy. J. Neurophysiol. 103, 1490-1500. doi: 10.1152/jn.00957.2009
    • (2010) J. Neurophysiol , vol.103 , pp. 1490-1500
    • Hunt, R.F.1    Scheff, S.W.2    Smith, B.N.3
  • 34
    • 79955783315 scopus 로고    scopus 로고
    • Synaptic reorganization of inhibitory hilar interneuron circuitry after traumatic brain injury in mice
    • Hunt, R. F., Scheff, S. W., and Smith, B. N. (2011). Synaptic reorganization of inhibitory hilar interneuron circuitry after traumatic brain injury in mice. J. Neurosci. 31, 6880-6890. doi: 10.1523/JNEUROSCI.0032-11.2011
    • (2011) J. Neurosci , vol.31 , pp. 6880-6890
    • Hunt, R.F.1    Scheff, S.W.2    Smith, B.N.3
  • 35
    • 76649118410 scopus 로고    scopus 로고
    • The developmental stage of dentate granule cells dictates their contribution to seizure-induced plasticity
    • Kron, M. M., Zhang, H., and Parent, J. M. (2010). The developmental stage of dentate granule cells dictates their contribution to seizure-induced plasticity. J. Neurosci. 30, 2051-2059. doi: 10.1523/JNEUROSCI.5655-09.2010
    • (2010) J. Neurosci , vol.30 , pp. 2051-2059
    • Kron, M.M.1    Zhang, H.2    Parent, J.M.3
  • 36
    • 84921829979 scopus 로고    scopus 로고
    • PTEN deletion from adult-generated dentate granule cells disrupts granule cell mossy fiber axon structure
    • Lasarge, C. L., Santos, V. R., and Danzer, S. C. (2015). PTEN deletion from adult-generated dentate granule cells disrupts granule cell mossy fiber axon structure. Neurobiol. Dis. 75, 142-150. doi: 10.1016/j.nbd.2014.12.029
    • (2015) Neurobiol. Dis , vol.75 , pp. 142-150
    • Lasarge, C.L.1    Santos, V.R.2    Danzer, S.C.3
  • 37
    • 0032189609 scopus 로고    scopus 로고
    • Increased neurogenesis in the dentate gyrus after transient global ischemia in gerbils
    • Liu, J., Solway, K., Messing, R. O., and Sharp, F. R. (1998). Increased neurogenesis in the dentate gyrus after transient global ischemia in gerbils. J. Neurosci. 18, 7768-7778.
    • (1998) J. Neurosci , vol.18 , pp. 7768-7778
    • Liu, J.1    Solway, K.2    Messing, R.O.3    Sharp, F.R.4
  • 38
    • 0026488694 scopus 로고
    • Selective vulnerability of dentate hilar neurons following traumatic brain injury: A potential mechanistic link between head trauma and disorders of the hippocampus
    • Lowenstein, D. H., Thomas, M. J., Smith, D. H., and McIntosh, T. K. (1992). Selective vulnerability of dentate hilar neurons following traumatic brain injury: a potential mechanistic link between head trauma and disorders of the hippocampus. J. Neurosci. 12, 4846-4853.
    • (1992) J. Neurosci , vol.12 , pp. 4846-4853
    • Lowenstein, D.H.1    Thomas, M.J.2    Smith, D.H.3    McIntosh, T.K.4
  • 39
    • 25444461637 scopus 로고    scopus 로고
    • Erythropoietin enhances neurogenesis and restores spatial memory in rats after traumatic brain injury
    • Lu, D., Mahmood, A., Qu, C., Goussev, A., Schallert, T., and Chopp, M. (2005). Erythropoietin enhances neurogenesis and restores spatial memory in rats after traumatic brain injury. J. Neurotrauma 22, 1011-1017. doi: 10.1089/neu.2005.22.1011
    • (2005) J. Neurotrauma , vol.22 , pp. 1011-1017
    • Lu, D.1    Mahmood, A.2    Qu, C.3    Goussev, A.4    Schallert, T.5    Chopp, M.6
  • 40
    • 0033975195 scopus 로고    scopus 로고
    • Recurrent excitatory connectivity in the dentate gyrus of kindled and kainic acid-treated rats
    • Lynch, M., and Sutula, T. (2000). Recurrent excitatory connectivity in the dentate gyrus of kindled and kainic acid-treated rats. J. Neurophysiol. 83, 693-704.
    • (2000) J. Neurophysiol , vol.83 , pp. 693-704
    • Lynch, M.1    Sutula, T.2
  • 41
    • 0037339576 scopus 로고    scopus 로고
    • There is differential loss of pyramidal cells from the human hippocampus with survival after blunt head injury
    • Maxwell, W. L., Dhillon, K., Harper, L., Espin, J., MacIntosh, T. K., Smith, D. H., et al. (2003). There is differential loss of pyramidal cells from the human hippocampus with survival after blunt head injury. J. Neuropathol. Exp. Neurol. 62, 272-279.
    • (2003) J. Neuropathol. Exp. Neurol , vol.62 , pp. 272-279
    • Maxwell, W.L.1    Dhillon, K.2    Harper, L.3    Espin, J.4    Macintosh, T.K.5    Smith, D.H.6
  • 42
    • 29944442275 scopus 로고    scopus 로고
    • Aberrant seizure-induced neurogenesis in experimental temporal lobe epilepsy
    • Parent, J. M., Elliott, R. C., Pleasure, S. J., Barbaro, N. M., and Lowenstein, D. H. (2006). Aberrant seizure-induced neurogenesis in experimental temporal lobe epilepsy. Ann. Neurol. 59, 81-91. doi: 10.1002/ana.20699
    • (2006) Ann. Neurol , vol.59 , pp. 81-91
    • Parent, J.M.1    Elliott, R.C.2    Pleasure, S.J.3    Barbaro, N.M.4    Lowenstein, D.H.5
  • 43
    • 0032496069 scopus 로고    scopus 로고
    • Increased dentate granule cell neurogenesis following amygdala kindling in the adult rat
    • Parent, J. M., Janumpalli, S., McNamara, J. O., and Lowenstein, D. H. (1998). Increased dentate granule cell neurogenesis following amygdala kindling in the adult rat. Neurosci. Lett. 247, 9-12. doi: 10.1016/s0304-3940(98)00269-9
    • (1998) Neurosci. Lett , vol.247 , pp. 9-12
    • Parent, J.M.1    Janumpalli, S.2    McNamara, J.O.3    Lowenstein, D.H.4
  • 44
    • 0030609963 scopus 로고    scopus 로고
    • Mossy fiber reorganization in the epileptic hippocampus
    • Parent, J. M., and Lowenstein, D. H. (1997). Mossy fiber reorganization in the epileptic hippocampus. Curr. Opin. Neurol. 10, 103-109. doi: 10.1097/00019052-199704000-00006
    • (1997) Curr. Opin. Neurol , vol.10 , pp. 103-109
    • Parent, J.M.1    Lowenstein, D.H.2
  • 45
    • 0030907041 scopus 로고    scopus 로고
    • Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus
    • Parent, J. M., Yu, T. W., Leibowitz, R. T., Geschwind, D. H., Sloviter, R. S., and Lowenstein, D. H. (1997). Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus. J. Neurosci. 17, 3727-3738.
    • (1997) J. Neurosci , vol.17 , pp. 3727-3738
    • Parent, J.M.1    Yu, T.W.2    Leibowitz, R.T.3    Geschwind, D.H.4    Sloviter, R.S.5    Lowenstein, D.H.6
  • 46
    • 0031952614 scopus 로고    scopus 로고
    • Physiological unmasking of new glutamatergic pathways in the dentate gyrus of hippocampal slices from kainate-induced epileptic rats
    • Patrylo, P. R., and Dudek, F. E. (1998). Physiological unmasking of new glutamatergic pathways in the dentate gyrus of hippocampal slices from kainate-induced epileptic rats. J. Neurophysiol. 79, 418-429.
    • (1998) J. Neurophysiol , vol.79 , pp. 418-429
    • Patrylo, P.R.1    Dudek, F.E.2
  • 48
    • 84866498805 scopus 로고    scopus 로고
    • Excessive activation of mTOR in postnatally generated granule cells is sufficient to cause epilepsy
    • Pun, R. Y., Rolle, I. J., Lasarge, C. L., Hosford, B. E., Rosen, J. M., Uhl, J. D., et al. (2012). Excessive activation of mTOR in postnatally generated granule cells is sufficient to cause epilepsy. Neuron 75, 1022-1034. doi: 10.1016/j.neuron.2012.08.002
    • (2012) Neuron , vol.75 , pp. 1022-1034
    • Pun, R.Y.1    Rolle, I.J.2    Lasarge, C.L.3    Hosford, B.E.4    Rosen, J.M.5    Uhl, J.D.6
  • 49
    • 0015309163 scopus 로고
    • Modification of seizure activity by electrical stimulation. II. Motor seizure
    • Racine, R. J. (1972). Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr. Clin. Neurophysiol. 32, 281-294. doi: 10.1016/0013-4694(72)90177-0
    • (1972) Electroencephalogr. Clin. Neurophysiol , vol.32 , pp. 281-294
    • Racine, R.J.1
  • 50
    • 33748418286 scopus 로고    scopus 로고
    • Alterations in hippocampal neurogenesis following traumatic brain injury in mice
    • Rola, R., Mizumatsu, S., Otsuka, S., Morhardt, D. R., Noble-Haeusslein, L. J., Fishman, K., et al. (2006). Alterations in hippocampal neurogenesis following traumatic brain injury in mice. Exp. Neurol. 202, 189-199. doi: 10.1016/j.expneurol.2006.05.034
    • (2006) Exp. Neurol , vol.202 , pp. 189-199
    • Rola, R.1    Mizumatsu, S.2    Otsuka, S.3    Morhardt, D.R.4    Noble-Haeusslein, L.J.5    Fishman, K.6
  • 51
    • 0036278510 scopus 로고    scopus 로고
    • Pilocarpine-induced status epilepticus results in mossy fiber sprouting and spontaneous seizures in C57BL/6 and CD-1 mice
    • Shibley, H., and Smith, B. N. (2002). Pilocarpine-induced status epilepticus results in mossy fiber sprouting and spontaneous seizures in C57BL/6 and CD-1 mice. Epilepsy Res. 49, 109-120. doi: 10.1016/s0920-1211(02)00012-8
    • (2002) Epilepsy Res , vol.49 , pp. 109-120
    • Shibley, H.1    Smith, B.N.2
  • 52
    • 0029054671 scopus 로고
    • A model of parasagittal controlled cortical impact in the mouse: Cognitive and histopathologic effects
    • Smith, D. H., Soares, H. D., Pierce, J. S., Perlman, K. G., Saatman, K. E., Meaney, D. F., et al. (1995). A model of parasagittal controlled cortical impact in the mouse: cognitive and histopathologic effects. J. Neurotrauma 12, 169-178. doi: 10.1089/neu.1995.12.169
    • (1995) J. Neurotrauma , vol.12 , pp. 169-178
    • Smith, D.H.1    Soares, H.D.2    Pierce, J.S.3    Perlman, K.G.4    Saatman, K.E.5    Meaney, D.F.6
  • 53
    • 59749104294 scopus 로고    scopus 로고
    • Basic fibroblast growth factor-enhanced neurogenesis contributes to cognitive recovery in rats following traumatic brain injury
    • Sun, D., Bullock, M. R., McGinn, M. J., Zhou, Z., Altememi, N., Hagood, S., et al. (2009). Basic fibroblast growth factor-enhanced neurogenesis contributes to cognitive recovery in rats following traumatic brain injury. Exp. Neurol. 216, 56-65. doi: 10.1016/j.expneurol.2008.11.011
    • (2009) Exp. Neurol , vol.216 , pp. 56-65
    • Sun, D.1    Bullock, M.R.2    McGinn, M.J.3    Zhou, Z.4    Altememi, N.5    Hagood, S.6
  • 54
    • 80155189536 scopus 로고    scopus 로고
    • Inhibition of the mammalian target of rapamycin blocks epilepsy progression in NS-Pten conditional knockout mice
    • Sunnen, C. N., Brewster, A. L., Lugo, J. N., Vanegas, F., Turcios, E., Mukhi, S., et al. (2011). Inhibition of the mammalian target of rapamycin blocks epilepsy progression in NS-Pten conditional knockout mice. Epilepsia 52, 2065-2075. doi: 10.1111/j.1528-1167.2011.03280.x
    • (2011) Epilepsia , vol.52 , pp. 2065-2075
    • Sunnen, C.N.1    Brewster, A.L.2    Lugo, J.N.3    Vanegas, F.4    Turcios, E.5    Mukhi, S.6
  • 55
    • 84881220459 scopus 로고    scopus 로고
    • Increased lysosomal biogenesis in activated microglia and exacerbated neuronal damage after traumatic brain injury in progranulin-deficient mice
    • Tanaka, Y., Matsuwaki, T., Yamanouchi, K., and Nishihara, M. (2013). Increased lysosomal biogenesis in activated microglia and exacerbated neuronal damage after traumatic brain injury in progranulin-deficient mice. Neuroscience 250, 8-19. doi: 10.1016/j.neuroscience.2013.06.049
    • (2013) Neuroscience , vol.250 , pp. 8-19
    • Tanaka, Y.1    Matsuwaki, T.2    Yamanouchi, K.3    Nishihara, M.4
  • 56
    • 0021917797 scopus 로고
    • Evidence of functional mossy fiber sprouting in hippocampal formation of kainic acid-treated rats
    • Tauck, D., and Nadler, J. (1985). Evidence of functional mossy fiber sprouting in hippocampal formation of kainic acid-treated rats. J. Neurosci. 5, 1016-1022.
    • (1985) J. Neurosci , vol.5 , pp. 1016-1022
    • Tauck, D.1    Nadler, J.2
  • 57
    • 58849130137 scopus 로고    scopus 로고
    • Preventing and treating posttraumatic seizures: The human experience
    • Temkin, N. R. (2009). Preventing and treating posttraumatic seizures: the human experience. Epilepsia 50, 10-13. doi: 10.1111/j.1528-1167.2008.02005.x
    • (2009) Epilepsia , vol.50 , pp. 10-13
    • Temkin, N.R.1
  • 58
    • 0031602512 scopus 로고    scopus 로고
    • Clinical trials for seizure prevention. Adv
    • Temkin, N. R., Dikmen, S. S., and Winn, H. R. (1998). Clinical trials for seizure prevention. Adv. Neurol. 76, 179-188.
    • (1998) Neurol , vol.76 , pp. 179-188
    • Temkin, N.R.1    Dikmen, S.S.2    Winn, H.R.3
  • 59
    • 0034945680 scopus 로고    scopus 로고
    • Antiepileptogenic agents: How close are we?
    • Temkin, N. R., Jarell, A. D., and Anderson, G. D. (2001). Antiepileptogenic agents: how close are we? Drugs 61, 1045-1055. doi: 10.2165/00003495-200161080-00002
    • (2001) Drugs , vol.61 , pp. 1045-1055
    • Temkin, N.R.1    Jarell, A.D.2    Anderson, G.D.3
  • 60
    • 84861967895 scopus 로고    scopus 로고
    • The alpha1 subunit of the GABA(A) receptor modulates fear learning and plasticity in the lateral amygdala
    • Wiltgen, B. J., Godsil, B. P., Peng, Z., Saab, F., June, H. L., Linn, M. L., et al. (2009). The alpha1 subunit of the GABA(A) receptor modulates fear learning and plasticity in the lateral amygdala. Front. Behav. Neurosci. 3:37. doi: 10.3389/neuro.08.037.2009
    • (2009) Front. Behav. Neurosci , vol.3 , pp. 37
    • Wiltgen, B.J.1    Godsil, B.P.2    Peng, Z.3    Saab, F.4    June, H.L.5    Linn, M.L.6
  • 61
    • 2142824184 scopus 로고    scopus 로고
    • Recurrent excitation in the dentate gyrus of a murine model of temporal lobe epilepsy
    • Winokur, R. S., Kubal, T., Liu, D., Davis, S. F., and Smith, B. N. (2004). Recurrent excitation in the dentate gyrus of a murine model of temporal lobe epilepsy. Epilepsy Res. 58, 93-105. doi: 10.1016/j.eplepsyres.2004.01.002
    • (2004) Epilepsy Res , vol.58 , pp. 93-105
    • Winokur, R.S.1    Kubal, T.2    Liu, D.3    Davis, S.F.4    Smith, B.N.5
  • 62
    • 84860737622 scopus 로고    scopus 로고
    • Neuroprotective and neurorestorative effects of thymosin beta4 treatment initiated 6 hours after traumatic brain injury in rats
    • Xiong, Y., Zhang, Y., Mahmood, A., Meng, Y., Zhang, Z. G., Morris, D. C., et al. (2012). Neuroprotective and neurorestorative effects of thymosin beta4 treatment initiated 6 hours after traumatic brain injury in rats. J. Neurosurg. 116, 1081-1092. doi: 10.3171/2012.1.JNS111729
    • (2012) J. Neurosurg , vol.116 , pp. 1081-1092
    • Xiong, Y.1    Zhang, Y.2    Mahmood, A.3    Meng, Y.4    Zhang, Z.G.5    Morris, D.C.6
  • 63
    • 66149169973 scopus 로고    scopus 로고
    • The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy
    • Zeng, L. H., Rensing, N. R., and Wong, M. (2009). The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy. J. Neurosci. 29, 6964-6972. doi: 10.1523/JNEUROSCI.0066-09.2009
    • (2009) J. Neurosci , vol.29 , pp. 6964-6972
    • Zeng, L.H.1    Rensing, N.R.2    Wong, M.3
  • 64
    • 42949140259 scopus 로고    scopus 로고
    • Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex
    • Zeng, L. H., Xu, L., Gutmann, D. H., and Wong, M. (2008). Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex. Ann. Neurol. 63, 444-453. doi: 10.1002/ana.21331
    • (2008) Ann. Neurol , vol.63 , pp. 444-453
    • Zeng, L.H.1    Xu, L.2    Gutmann, D.H.3    Wong, M.4


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