Excessive Activation of mTOR in Postnatally Generated Granule Cells Is Sufficient to Cause Epilepsy

Neuron

Volumn 75, Issue 6, 2012, Pages 1022-1034

  Pun, Raymund Y K ^a   Rolle, Isaiah J ^b   LaSarge, Candi L ^a   Hosford, Bethany E ^b   Rosen, Jules M ^a   Uhl, Juli D ^a   Schmeltzer, Sarah N ^b   Faulkner, Christian ^a   Bronson, Stefanie L ^b   Murphy, Brian L ^b   Richards, David A ^a,b   Holland, Katherine D ^a   Danzer, Steve C ^a,b  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF CINCINNATI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ISOLATION; CELL POPULATION; CEREBELLAR MOSSY FIBER; CONTROLLED STUDY; DENTATE GYRUS; DISEASE COURSE; ENZYME ACTIVATION; ENZYME MECHANISM; EPILEPSY; EPILEPTOGENESIS; GENE; GENE DELETION; GENE EXPRESSION REGULATION; GLIOSIS; GRANULE CELL; MOUSE; NERVE ENDING; NERVE SPROUTING; NONHUMAN; OLFACTORY BULB; OLFACTORY NERVE; PERINATAL PERIOD; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE GENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TEMPORAL LOBE EPILEPSY; TRANSGENIC MOUSE;

ANIMALS; ANIMALS, NEWBORN; CARRIER PROTEINS; DENTATE GYRUS; DISEASE MODELS, ANIMAL; ELECTROENCEPHALOGRAPHY; EPILEPSY; GENE EXPRESSION REGULATION; GLIOSIS; GREEN FLUORESCENT PROTEINS; GUANYLATE KINASE; IMMUNOSUPPRESSIVE AGENTS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOSSY FIBERS, HIPPOCAMPAL; NEURONS; OLFACTORY PATHWAYS; PHOSPHOPYRUVATE HYDRATASE; PTEN PHOSPHOHYDROLASE; SIROLIMUS; TIME FACTORS; TOR SERINE-THREONINE KINASES;

EID: 84866498805     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2012.08.002     Document Type: Article

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