-
1
-
-
84892795827
-
Breast cancer statistics, 2013
-
DeSantis, C., Ma, J., Bryan, L. & Jemal, A. Breast cancer statistics, 2013. CA Cancer J Clin 64, 52-62 (2014).
-
(2014)
CA Cancer J Clin
, vol.64
, pp. 52-62
-
-
DeSantis, C.1
Ma, J.2
Bryan, L.3
Jemal, A.4
-
2
-
-
79960015997
-
Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies
-
Lehmann, B. D. et al. Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. J Clin Invest 121, 2750-2767 (2011).
-
(2011)
J Clin Invest
, vol.121
, pp. 2750-2767
-
-
Lehmann, B.D.1
-
3
-
-
77952135293
-
Mechanisms of resistance to hormonal treatment in breast cancer
-
Eroles, P., Bosch, A., Bermejo, B. & Lluch, A. Mechanisms of resistance to hormonal treatment in breast cancer. Clin Transl Oncol 12, 246-252 (2010).
-
(2010)
Clin Transl Oncol
, vol.12
, pp. 246-252
-
-
Eroles, P.1
Bosch, A.2
Bermejo, B.3
Lluch, A.4
-
4
-
-
84907313480
-
Breast cancer cells condition lymphatic endothelial cells within pre-metastatic niches to promote metastasis
-
Lee, E. et al. Breast cancer cells condition lymphatic endothelial cells within pre-metastatic niches to promote metastasis. Nat Commun 5, 4715 (2014).
-
(2014)
Nat Commun
, vol.5
, pp. 4715
-
-
Lee, E.1
-
5
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
Hanahan, D. & Weinberg, R. A. Hallmarks of cancer: the next generation. Cell 144, 646-674 (2011).
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
6
-
-
84888633713
-
Inflammation-induced cancer: Crosstalk between tumours, immune cells and microorganisms
-
Elinav, E. et al. Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms. Nat Rev Cancer 13, 759-771 (2013).
-
(2013)
Nat Rev Cancer
, vol.13
, pp. 759-771
-
-
Elinav, E.1
-
7
-
-
2542428442
-
Chemokines in innate and adaptive host defense: Basic chemokinese grammar for immune cells
-
Rot, A. & von Andrian, U. H. Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells. Annu Rev Immunol 22, 891-928 (2004).
-
(2004)
Annu Rev Immunol
, vol.22
, pp. 891-928
-
-
Rot, A.1
Von Andrian, U.H.2
-
8
-
-
31744445943
-
The effects of EGF-receptor density on multiscale tumor growth patterns
-
Athale, C. A. & Deisboeck, T. S. The effects of EGF-receptor density on multiscale tumor growth patterns. J Theor Biol 238, 771-779 (2006).
-
(2006)
J Theor Biol
, vol.238
, pp. 771-779
-
-
Athale, C.A.1
Deisboeck, T.S.2
-
9
-
-
84864419163
-
Molecular regulation of lymphangiogenesis in development and tumor microenvironment
-
Li, T., Yang, J., Zhou, Q. & He, Y. Molecular regulation of lymphangiogenesis in development and tumor microenvironment. Cancer Microenviron 5, 249-260 (2012).
-
(2012)
Cancer Microenviron
, vol.5
, pp. 249-260
-
-
Li, T.1
Yang, J.2
Zhou, Q.3
He, Y.4
-
10
-
-
84255183765
-
Forty-year journey of angiogenesis translational research
-
Cao, Y. et al. Forty-year journey of angiogenesis translational research. Sci Transl Med 3, 114rv113 (2011).
-
(2011)
Sci Transl Med
, vol.3
, pp. 114rv113
-
-
Cao, Y.1
-
11
-
-
45549103524
-
Breast tumor microenvironment: Proteomics highlights the treatments targeting secretome
-
Chen, S. T. et al. Breast tumor microenvironment: proteomics highlights the treatments targeting secretome. J Proteome Res 7, 1379-1387 (2008).
-
(2008)
J Proteome Res
, vol.7
, pp. 1379-1387
-
-
Chen, S.T.1
-
12
-
-
84905192728
-
Lymphatic endothelial cells support tumor growth in breast cancer
-
Lee, E., Pandey, N. B. & Popel, A. S. Lymphatic endothelial cells support tumor growth in breast cancer. Sci Rep 4, 5853 (2014).
-
(2014)
Sci Rep
, vol.4
, pp. 5853
-
-
Lee, E.1
Pandey, N.B.2
Popel, A.S.3
-
13
-
-
84894568529
-
Lymphangiogenesis and lymphatic vessel remodelling in cancer
-
Stacker, S. A. et al. Lymphangiogenesis and lymphatic vessel remodelling in cancer. Nat Rev Cancer 14, 159-172 (2014).
-
(2014)
Nat Rev Cancer
, vol.14
, pp. 159-172
-
-
Stacker, S.A.1
-
14
-
-
84877028141
-
Comprehensive molecular portraits of human breast tumours
-
Cancer Genome Atlas Network, Comprehensive molecular portraits of human breast tumours. Nature 490, 61-70 (2012).
-
(2012)
Nature
, vol.490
, pp. 61-70
-
-
Cancer Genome Atlas Network1
-
15
-
-
84861527388
-
The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups
-
Curtis, C. et al. The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups. Nature 486, 346-352 (2012).
-
(2012)
Nature
, vol.486
, pp. 346-352
-
-
Curtis, C.1
-
16
-
-
84877826703
-
The role of intratumoral and systemic IL-6 in breast cancer
-
Dethlefsen, C., Hojfeldt, G. & Hojman, P. The role of intratumoral and systemic IL-6 in breast cancer. Breast Cancer Res Treat 138, 657-664 (2013).
-
(2013)
Breast Cancer Res Treat
, vol.138
, pp. 657-664
-
-
Dethlefsen, C.1
Hojfeldt, G.2
Hojman, P.3
-
17
-
-
79952121979
-
Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion
-
Iliopoulos, D., Hirsch, H. A., Wang, G. & Struhl, K. Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion. Proc Natl Acad Sci U S A 108, 1397-1402 (2011).
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 1397-1402
-
-
Iliopoulos, D.1
Hirsch, H.A.2
Wang, G.3
Struhl, K.4
-
18
-
-
84866481797
-
Mesenchymal stem cell-derived interleukin-6 and vascular endothelial growth factor promote breast cancer cell migration
-
De Luca, A., Lamura, L., Gallo, M., Maffia, V. & Normanno, N. Mesenchymal stem cell-derived interleukin-6 and vascular endothelial growth factor promote breast cancer cell migration. J Cell Biochem 113, 3363-3370 (2012).
-
(2012)
J Cell Biochem
, vol.113
, pp. 3363-3370
-
-
De Luca, A.1
Lamura, L.2
Gallo, M.3
Maffia, V.4
Normanno, N.5
-
19
-
-
84873033728
-
STAT3-RANTES autocrine signaling is essential for tamoxifen resistance in human breast cancer cells
-
Yi, E. H. et al. STAT3-RANTES autocrine signaling is essential for tamoxifen resistance in human breast cancer cells. Mol Cancer Res 11, 31-42 (2013).
-
(2013)
Mol Cancer Res
, vol.11
, pp. 31-42
-
-
Yi, E.H.1
-
20
-
-
84865847694
-
Protein expression changes during human triple negative breast cancer cell line progression to lymph node metastasis in a xenografted model in nude mice
-
Roberti, M. P. et al. Protein expression changes during human triple negative breast cancer cell line progression to lymph node metastasis in a xenografted model in nude mice. Cancer Biol Ther 13, 1123-1140 (2012).
-
(2012)
Cancer Biol Ther
, vol.13
, pp. 1123-1140
-
-
Roberti, M.P.1
-
21
-
-
84894455965
-
The IL-6/JAK/STAT3 pathway: Potential therapeutic strategies in treating colorectal cancer (Review)
-
Wang, S. W. & Sun, Y. M. The IL-6/JAK/STAT3 pathway: potential therapeutic strategies in treating colorectal cancer (Review). Int J Oncol 44, 1032-1040 (2014).
-
(2014)
Int J Oncol
, vol.44
, pp. 1032-1040
-
-
Wang, S.W.1
Sun, Y.M.2
-
22
-
-
84907228321
-
Bioinformatic analysis reveals a pattern of STAT3-associated gene expression specific to basal-like breast cancers in human tumors
-
Tell, R. W. & Horvath, C. M. Bioinformatic analysis reveals a pattern of STAT3-associated gene expression specific to basal-like breast cancers in human tumors. Proc Natl Acad Sci U S A 111, 12787-12792 (2014).
-
(2014)
Proc Natl Acad Sci U S A
, vol.111
, pp. 12787-12792
-
-
Tell, R.W.1
Horvath, C.M.2
-
23
-
-
84880062835
-
Critical role of STAT3 in IL-6-mediated drug resistance in human neuroblastoma
-
Ara, T. et al. Critical Role of STAT3 in IL-6-Mediated Drug Resistance in Human Neuroblastoma. Cancer Res 73, 3852-3864 (2013).
-
(2013)
Cancer Res
, vol.73
, pp. 3852-3864
-
-
Ara, T.1
-
24
-
-
18544364182
-
Clinical significance of interleukin-6 (IL-6) in the spread of gastric cancer: Role of IL-6 as a prognostic factor
-
Ashizawa, T. et al. Clinical significance of interleukin-6 (IL-6) in the spread of gastric cancer: role of IL-6 as a prognostic factor. Gastric Cancer 8, 124-131 (2005).
-
(2005)
Gastric Cancer
, vol.8
, pp. 124-131
-
-
Ashizawa, T.1
-
25
-
-
84863115473
-
Roles of STAT3 and ZEB1 proteins in E-cadherin down-regulation and human colorectal cancer epithelialmesenchymal transition
-
Xiong, H. et al. Roles of STAT3 and ZEB1 proteins in E-cadherin down-regulation and human colorectal cancer epithelialmesenchymal transition. J Biol Chem 287, 5819-5832 (2012).
-
(2012)
J Biol Chem
, vol.287
, pp. 5819-5832
-
-
Xiong, H.1
-
26
-
-
78649982367
-
STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors
-
Lee, H. et al. STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors. Nat Med 16, 1421-1428 (2010).
-
(2010)
Nat Med
, vol.16
, pp. 1421-1428
-
-
Lee, H.1
-
27
-
-
0026470972
-
IL6 signalling through IL6 receptor and receptor-associated signal transducer, gp130
-
Taga, T. IL6 signalling through IL6 receptor and receptor-associated signal transducer, gp130. Res Immunol 143, 737-739 (1992).
-
(1992)
Res Immunol
, vol.143
, pp. 737-739
-
-
Taga, T.1
-
28
-
-
84883474791
-
HOXB13 mediates tamoxifen resistance and invasiveness in human breast cancer by suppressing ERalpha and inducing IL-6 expression
-
Shah, N. et al. HOXB13 mediates tamoxifen resistance and invasiveness in human breast cancer by suppressing ERalpha and inducing IL-6 expression. Cancer Res 73, 5449-5458 (2013).
-
(2013)
Cancer Res
, vol.73
, pp. 5449-5458
-
-
Shah, N.1
-
29
-
-
33748040055
-
Breast cancers with brain metastases are more likely to be estrogen receptor negative, express the basal cytokeratin CK5/6, and overexpress HER2 or EGFR
-
Hicks, D. G. et al. Breast cancers with brain metastases are more likely to be estrogen receptor negative, express the basal cytokeratin CK5/6, and overexpress HER2 or EGFR. Am J Surg Pathol 30, 1097-1104 (2006).
-
(2006)
Am J Surg Pathol
, vol.30
, pp. 1097-1104
-
-
Hicks, D.G.1
-
30
-
-
84857291505
-
Systemic treatment of brain metastases in HER2-positive breast cancer: Current status and future directions
-
Azim, H. A. & Azim, H. A., Jr. Systemic treatment of brain metastases in HER2-positive breast cancer: current status and future directions. Future Oncol 8, 135-144 (2012).
-
(2012)
Future Oncol
, vol.8
, pp. 135-144
-
-
Azim, H.A.1
Azim, H.A.2
-
31
-
-
84862902435
-
Tumor resistance to HER2 inhibitors: The drug sedimentation concept
-
Campone, M., Frenel, J. S., Andre, F., Bachelot, T. & Juin, P. [Tumor resistance to HER2 inhibitors: the drug sedimentation concept]. Bull Cancer 99, 665-672 (2012).
-
(2012)
Bull Cancer
, vol.99
, pp. 665-672
-
-
Campone, M.1
Frenel, J.S.2
Andre, F.3
Bachelot, T.4
Juin, P.5
-
32
-
-
84876286931
-
Crosstalk between HER2 signaling and angiogenesis in breast cancer: Molecular basis, clinical applications and challenges
-
Alameddine, R. S., Otrock, Z. K., Awada, A. & Shamseddine, A. Crosstalk between HER2 signaling and angiogenesis in breast cancer: molecular basis, clinical applications and challenges. Curr Opin Oncol 25, 313-324 (2013).
-
(2013)
Curr Opin Oncol
, vol.25
, pp. 313-324
-
-
Alameddine, R.S.1
Otrock, Z.K.2
Awada, A.3
Shamseddine, A.4
-
33
-
-
70450105849
-
Angiogenesis and co-expressed of ER and c-ERBB-2 (HER2/neu) protein in primary breast cancer patients: An analysis of 158 needle core biopsies
-
Vamesu, S. Angiogenesis and co-expressed of ER and c-erbB-2 (HER2/neu) protein in primary breast cancer patients: an analysis of 158 needle core biopsies. Rom J Morphol Embryol 49, 469-478 (2008).
-
(2008)
Rom J Morphol Embryol
, vol.49
, pp. 469-478
-
-
Vamesu, S.1
-
34
-
-
0142027766
-
Angiogenesis impairment in Id-deficient mice cooperates with an Hsp90 inhibitor to completely suppress HER2/neu-dependent breast tumors
-
de Candia, P. et al. Angiogenesis impairment in Id-deficient mice cooperates with an Hsp90 inhibitor to completely suppress HER2/neu-dependent breast tumors. Proc Natl Acad Sci U S A 100, 12337-12342 (2003).
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 12337-12342
-
-
De Candia, P.1
-
35
-
-
84877300380
-
Expression of VEGF and semaphorin genes define subgroups of triple negative breast cancer
-
Bender, R. J. & Mac Gabhann, F. Expression of VEGF and semaphorin genes define subgroups of triple negative breast cancer. PLoS One 8, e61788 (2013).
-
(2013)
PLoS One
, vol.8
-
-
Bender, R.J.1
Mac Gabhann, F.2
-
36
-
-
84855486320
-
Semaphorin signaling in angiogenesis, lymphangiogenesis and cancer
-
Sakurai, A., Doci, C. L. & Gutkind, J. S. Semaphorin signaling in angiogenesis, lymphangiogenesis and cancer. Cell Res 22, 23-32 (2012).
-
(2012)
Cell Res
, vol.22
, pp. 23-32
-
-
Sakurai, A.1
Doci, C.L.2
Gutkind, J.S.3
-
37
-
-
77953342817
-
HER2/neu expression correlates with vascular endothelial growth factor-C and lymphangiogenesis in lymph node-positive breast cancer
-
Schoppmann, S. F. et al. HER2/neu expression correlates with vascular endothelial growth factor-C and lymphangiogenesis in lymph node-positive breast cancer. Ann Oncol 21, 955-960 (2010).
-
(2010)
Ann Oncol
, vol.21
, pp. 955-960
-
-
Schoppmann, S.F.1
-
38
-
-
71249095200
-
GM-CSF-secreting vaccines for solid tumors
-
Emens, L. A. GM-CSF-secreting vaccines for solid tumors. Curr Opin Investig Drugs 10, 1315-1324 (2009).
-
(2009)
Curr Opin Investig Drugs
, vol.10
, pp. 1315-1324
-
-
Emens, L.A.1
-
39
-
-
12144287913
-
A phase i vaccine safety and chemotherapy dose-finding trial of an allogeneic GM-CSF-secreting breast cancer vaccine given in a specifically timed sequence with immunomodulatory doses of cyclophosphamide and doxorubicin
-
Emens, L. A. et al. A phase I vaccine safety and chemotherapy dose-finding trial of an allogeneic GM-CSF-secreting breast cancer vaccine given in a specifically timed sequence with immunomodulatory doses of cyclophosphamide and doxorubicin. Hum Gene Ther 15, 313-337 (2004).
-
(2004)
Hum Gene Ther
, vol.15
, pp. 313-337
-
-
Emens, L.A.1
-
40
-
-
62449179631
-
Granulocyte macrophage colony-stimulating factor inhibits breast cancer growth and metastasis by invoking an anti-angiogenic program in tumor-educated macrophages
-
Eubank, T. D. et al. Granulocyte macrophage colony-stimulating factor inhibits breast cancer growth and metastasis by invoking an anti-angiogenic program in tumor-educated macrophages. Cancer Res 69, 2133-2140 (2009).
-
(2009)
Cancer Res
, vol.69
, pp. 2133-2140
-
-
Eubank, T.D.1
-
41
-
-
33846049299
-
NF-kappaB in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GMCSF
-
Park, B. K. et al. NF-kappaB in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GMCSF. Nat Med 13, 62-69 (2007).
-
(2007)
Nat Med
, vol.13
, pp. 62-69
-
-
Park, B.K.1
-
42
-
-
84913580379
-
Tumor-associated macrophages produce interleukin 6 and signal via STAT3 to promote expansion of human hepatocellular carcinoma stem cells
-
Wan, S. et al. Tumor-associated macrophages produce interleukin 6 and signal via STAT3 to promote expansion of human hepatocellular carcinoma stem cells. Gastroenterology 147, 1393-1404 (2014).
-
(2014)
Gastroenterology
, vol.147
, pp. 1393-1404
-
-
Wan, S.1
-
43
-
-
84900841536
-
Tumor-associated macrophage-derived IL-6 and IL-8 enhance invasive activity of LoVo cells induced by PRL-3 in a KCNN4 channel-dependent manner
-
Xu, H. et al. Tumor-associated macrophage-derived IL-6 and IL-8 enhance invasive activity of LoVo cells induced by PRL-3 in a KCNN4 channel-dependent manner. BMC Cancer 14, 330 (2014).
-
(2014)
BMC Cancer
, vol.14
, pp. 330
-
-
Xu, H.1
-
44
-
-
84891885126
-
Loss of let-7 microRNA upregulates IL-6 in bone marrow-derived mesenchymal stem cells triggering a reactive stromal response to prostate cancer
-
Sung, S. Y. et al. Loss of let-7 microRNA upregulates IL-6 in bone marrow-derived mesenchymal stem cells triggering a reactive stromal response to prostate cancer. PLoS One 8, e71637 (2013).
-
(2013)
PLoS One
, vol.8
-
-
Sung, S.Y.1
-
45
-
-
84875740314
-
Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal
-
Gao, J. et al. Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal 6, pl1 (2013).
-
(2013)
Sci Signal
, vol.6
, pp. pl1
-
-
Gao, J.1
|