Bioinformatic analysis reveals a pattern of STAT3-associated gene expression specific to basal-like breast cancers in human tumors

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 35, 2014, Pages 12787-12792

  Tell, Robert W ^a   Horvath, Curt M ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

STAT3 PROTEIN; STRESS ACTIVATED PROTEIN KINASE;

ARTICLE; BASAL LIKE BREAST CANCER; BIOINFORMATICS; BREAST CANCER CELL LINE; GENE CONTROL; GENE EXPRESSION; HUMAN; MICROARRAY ANALYSIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

BREAST NEOPLASMS; COMPUTATIONAL BIOLOGY; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MAP KINASE SIGNALING SYSTEM; MICROARRAY ANALYSIS; MICRORNAS; NEOPLASMS, BASAL CELL; PHOSPHORYLATION; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; RNA, MESSENGER; STAT3 TRANSCRIPTION FACTOR;

EID: 84907228321     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1404881111     Document Type: Article

References (36)

1. Key TJ, Verkasalo PK, Banks E (2001) Epidemiology of breast cancer. Lancet Oncol 2(3): 133- 140.
2. Foulkes WD, Smith IE, Reis-Filho JS (2010) Triple-negative breast cancer. N Engl J Med 363(20):1938-1948.
3. Griffiths CL, Olin JL (2012) Triple negative breast cancer: A brief review of its characteristics and treatment options. J Pharm Pract 25(3):319-323.
4. Livasy CA, et al. (2006) Phenotypic evaluation of the basal-like subtype of invasive breast carcinoma. Mod Pathol 19(2):264-271. (Pubitemid 43117611)
5. Badve S, et al. (2011) Basal-like and triple-negative breast cancers: A critical review with an emphasis on the implications for pathologists and oncologists. Mod Pathol 24(2):157-167.
6. Prat A, Ellis MJ, Perou CM (2012) Practical implications of gene-expression-based assays for breast oncologists. Nat Rev Clin Oncol 9(1):48-57.
7. - stem cell-like breast cancer cells in human tumors. J Clin Invest 121(7): 2723-2735.
8. Yue P, Turkson J (2009) Targeting STAT3 in cancer: How successful are we? Expert Opin Investig Drugs 18(1):45-56.
9. Baba Y, Fujii M, Tokumaru Y, Kato Y (2012) Present and future of EGFR inhibitors for head and neck squamous cell cancer. J Oncol 2012:986725.
10. Hong DS, Angelo LS, Kurzrock R (2007) Interleukin-6 and its receptor in cancer: Implications for translational therapeutics. Cancer 110(9):1911-1928. (Pubitemid 350036849)
11. The Cancer Genome Atlas Network (2012) Comprehensive molecular portraits of human breast tumours. Nature 490(7418):61-70.
12. Reich M, et al. (2006) GenePattern 2.0. Nat Genet 38(5):500-501.
13. Benjamini Y, Hochberg Y (1995) Controlling the false discovery rate: A practical and powerful approach to multiple testing. J R Stat Soc Series B Stat Methodol 57(1): 289-300.
14. Reimand J, Kull M, Peterson H, Hansen J, Vilo J (2007) g:Profiler-A web-based toolset for functional profiling of gene lists from large-scale experiments. Nucleic Acids Res 35(Web Server issue):W193-W200.
15. Chatziioannou AA, Moulos P (2011) Exploiting statistical methodologies and controlled vocabularies for prioritized functional analysis of genomic experiments: The StRAnGER web application. Front Neurosci 5:8.
16. Supek F, Bošnjak M, Škunca N, Šmuc T (2011) REVIGO summarizes and visualizes long lists of Gene Ontology terms. PLoS ONE 6(7):e21800.
17. Slaney CY, Rautela J, Parker BS (2013) The emerging role of immunosurveillance in dictating metastatic spread in breast cancer. Cancer Res 73(19):5852-5857.
18. Bian CX, et al. (2010) P70S6K 1 regulation of angiogenesis through VEGF and HIF- 1alpha expression. Biochem Biophys Res Commun 398(3):395-399.
19. Kim JH, et al. (2010) Jnk signaling pathway-mediated regulation of Stat3 activation is linked to the development of doxorubicin resistance in cancer cell lines. Biochem Pharmacol 79(3):373-380.
20. Decker T, Kovarik P (2000) Serine phosphorylation of STATs. Oncogene 19(21): 2628-2637. (Pubitemid 30339219)
21. Garzon R, Calin GA, Croce CM (2009) MicroRNAs in cancer. Annu Rev Med 60:167-179.
22. Coussens LM, Werb Z (2002) Inflammation and cancer. Nature 420(6917):860-867. (Pubitemid 36019639)
23. Hedvat M, et al. (2009) The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors. Cancer Cell 16(6):487-497.
24. Looyenga BD, et al. (2012) STAT3 is activated by JAK2 independent of key oncogenic driver mutations in non-small cell lung carcinoma. PLoS ONE 7(2):e30820.
25. Mandal PK, et al. (2011) Potent and selective phosphopeptide mimetic prodrugs targeted to the Src homology 2 (SH2) domain of signal transducer and activator of transcription 3. J Med Chem 54(10):3549- 3563.
26. Kwon HK, et al. (2002) Constitutive activation of p70S6k in cancer cells. Arch Pharm Res 25(5):685-690.
27. Cho KH, et al. (2013) STAT3 mediates TGF-β1-induced TWIST1 expression and prostate cancer invasion. Cancer Lett 336(1):167-173.
28. Semenza GL (2003) Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3(10):721-732.
29. Pawlus MR, Wang L, Murakami A, Dai G, Hu CJ (2013) STAT3 or USF2 contributes to HIF target gene specificity. PLoS ONE 8(8):e72358.
30. Chen WX, et al. (2013) miR-221/222: Promising biomarkers for breast cancer. Tumour Biol 34(3):1361-1370.
31. Hwang MS, et al. (2013) miR-221/222 targets adiponectin receptor 1 to promote the epithelial-to-mesenchymal transition in breast cancer. PLoS ONE 8(6):e66502.
32. Shah MY, Calin GA (2011) MicroRNAs miR-221 and miR-222: A new level of regulation in aggressive breast cancer. Genome Med 3(8):56.
33. Cascio S, et al. (2010) miR-20b modulates VEGF expression by targeting HIF-1 alpha and STAT3 in MCF-7 breast cancer cells. J Cell Physiol 224(1):242-249.
34. Cerami E, et al. (2012) The cBio Cancer Genomics Portal: An open platform for exploring multidimensional cancer genomics data. Cancer Discov 2(5):401-404.
35. R Core Team (2013) R: A Language and Environment for Statistical Computing (R Found Stat Comput, Vienna). www.R-project.org.
36. Anders S, Huber W (2010) Differential expression analysis for sequence count data. Genome Biol 11(10):R106.