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Volumn 112, Issue 48, 2015, Pages 14942-14947

Imbalanced signal transduction in regulatory T cells expressing the transcription factor FoxP3

Author keywords

Immunoregulation; Signal transduction

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; HERMES ANTIGEN; INTERLEUKIN 2; INTERLEUKIN 6; L SELECTIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; S6 KINASE; STAT PROTEIN; TRANSCRIPTION FACTOR FOXP3; CTLA4 PROTEIN, MOUSE; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; LEUKOCYTE ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; MKP2 PROTEIN, MOUSE; PDCD1 PROTEIN, MOUSE; PROGRAMMED DEATH 1 RECEPTOR; PROTEIN TYROSINE PHOSPHATASE;

EID: 84948699801     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1520393112     Document Type: Article
Times cited : (49)

References (47)
  • 1
    • 84859416933 scopus 로고    scopus 로고
    • Regulatory T cells: Mechanisms of differentiation and function
    • Josefowicz SZ, Lu LF, Rudensky AY (2012) Regulatory T cells: Mechanisms of differentiation and function. Annu Rev Immunol 30:531-564.
    • (2012) Annu Rev Immunol , vol.30 , pp. 531-564
    • Josefowicz, S.Z.1    Lu, L.F.2    Rudensky, A.Y.3
  • 2
    • 67649170980 scopus 로고    scopus 로고
    • Foxp3+ regulatory T cells: Differentiation, specification, subphenotypes
    • Feuerer M, Hill JA, Mathis D, Benoist C (2009) Foxp3+ regulatory T cells: Differentiation, specification, subphenotypes. Nat Immunol 10(7):689-695.
    • (2009) Nat Immunol , vol.10 , Issue.7 , pp. 689-695
    • Feuerer, M.1    Hill, J.A.2    Mathis, D.3    Benoist, C.4
  • 3
    • 84948652334 scopus 로고    scopus 로고
    • eds Mathis D, Rudensky A (Cold Spring Harbor Press, Cold Spring Harbor, NY)
    • Benoist C, Mathis D (2013) Immune Tolerance, eds Mathis D, Rudensky A (Cold Spring Harbor Press, Cold Spring Harbor, NY), pp 31-44.
    • (2013) Immune Tolerance , pp. 31-44
    • Benoist, C.1    Mathis, D.2
  • 4
    • 84930821357 scopus 로고    scopus 로고
    • Regulatory T cell identity: Formation and maintenance
    • Li X, Zheng Y (2015) Regulatory T cell identity: Formation and maintenance. Trends Immunol 36(6):344-353.
    • (2015) Trends Immunol , vol.36 , Issue.6 , pp. 344-353
    • Li, X.1    Zheng, Y.2
  • 5
    • 84899659467 scopus 로고    scopus 로고
    • FOXP3 and scurfy: How it all began
    • Ramsdell F, Ziegler SF (2014) FOXP3 and scurfy: How it all began. Nat Rev Immunol 14(5):343-349.
    • (2014) Nat Rev Immunol , vol.14 , Issue.5 , pp. 343-349
    • Ramsdell, F.1    Ziegler, S.F.2
  • 6
    • 84886694563 scopus 로고    scopus 로고
    • Regulatory T cells in nonlymphoid tissues
    • Burzyn D, Benoist C, Mathis D (2013) Regulatory T cells in nonlymphoid tissues. Nat Immunol 14(10):1007-1013.
    • (2013) Nat Immunol , vol.14 , Issue.10 , pp. 1007-1013
    • Burzyn, D.1    Benoist, C.2    Mathis, D.3
  • 7
    • 33645102841 scopus 로고    scopus 로고
    • An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires
    • Hsieh CS, Zheng Y, Liang Y, Fontenot JD, Rudensky AY (2006) An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires. Nat Immunol 7(4):401-410.
    • (2006) Nat Immunol , vol.7 , Issue.4 , pp. 401-410
    • Hsieh, C.S.1    Zheng, Y.2    Liang, Y.3    Fontenot, J.D.4    Rudensky, A.Y.5
  • 8
    • 33747099523 scopus 로고    scopus 로고
    • Origin and T cell receptor diversity of Foxp3+CD4+CD25+ T cells
    • Pacholczyk R, Ignatowicz H, Kraj P, Ignatowicz L (2006) Origin and T cell receptor diversity of Foxp3+CD4+CD25+ T cells. Immunity 25(2):249-259.
    • (2006) Immunity , vol.25 , Issue.2 , pp. 249-259
    • Pacholczyk, R.1    Ignatowicz, H.2    Kraj, P.3    Ignatowicz, L.4
  • 9
    • 34249814016 scopus 로고    scopus 로고
    • Adaptation of TCR repertoires to self-peptides in regulatory and nonregulatory CD4+ T cells
    • Wong J, et al. (2007) Adaptation of TCR repertoires to self-peptides in regulatory and nonregulatory CD4+ T cells. J Immunol 178(11):7032-7041.
    • (2007) J Immunol , vol.178 , Issue.11 , pp. 7032-7041
    • Wong, J.1
  • 10
    • 1642326161 scopus 로고    scopus 로고
    • MHC class II-independent CD25+ CD4+ CD8alpha beta+ alpha beta T cells attenuate CD4+ T cell-induced transfer colitis
    • Krajina T, Leithäuser F, Reimann J (2004) MHC class II-independent CD25+ CD4+ CD8alpha beta+ alpha beta T cells attenuate CD4+ T cell-induced transfer colitis. Eur J Immunol 34(3):705-714.
    • (2004) Eur J Immunol , vol.34 , Issue.3 , pp. 705-714
    • Krajina, T.1    Leithäuser, F.2    Reimann, J.3
  • 11
    • 0035320679 scopus 로고    scopus 로고
    • Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide
    • Jordan MS, et al. (2001) Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide. Nat Immunol 2(4):301-306.
    • (2001) Nat Immunol , vol.2 , Issue.4 , pp. 301-306
    • Jordan, M.S.1
  • 12
    • 9244244736 scopus 로고    scopus 로고
    • Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells
    • van Santen HM, Benoist C, Mathis D (2004) Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells. J Exp Med 200(10):1221-1230.
    • (2004) J Exp Med , vol.200 , Issue.10 , pp. 1221-1230
    • Van Santen, H.M.1    Benoist, C.2    Mathis, D.3
  • 13
    • 79958251745 scopus 로고    scopus 로고
    • T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse
    • Moran AE, et al. (2011) T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse. J Exp Med 208(6):1279-1289.
    • (2011) J Exp Med , vol.208 , Issue.6 , pp. 1279-1289
    • Moran, A.E.1
  • 14
    • 68949105350 scopus 로고    scopus 로고
    • Impact of the TCR signal on regulatory T cell homeostasis, function, and trafficking
    • Kim JK, et al. (2009) Impact of the TCR signal on regulatory T cell homeostasis, function, and trafficking. PLoS One 4(8):e6580.
    • (2009) PLoS One , vol.4 , Issue.8
    • Kim, J.K.1
  • 15
    • 84912113033 scopus 로고    scopus 로고
    • Continuous T cell receptor signals maintain a functional regulatory T cell pool
    • Vahl JC, et al. (2014) Continuous T cell receptor signals maintain a functional regulatory T cell pool. Immunity 41(5):722-736.
    • (2014) Immunity , vol.41 , Issue.5 , pp. 722-736
    • Vahl, J.C.1
  • 16
    • 84908123494 scopus 로고    scopus 로고
    • Continuous requirement for the TCR in regulatory T cell function
    • Levine AG, Arvey A, Jin W, Rudensky AY (2014) Continuous requirement for the TCR in regulatory T cell function. Nat Immunol 15(11):1070-1078.
    • (2014) Nat Immunol , vol.15 , Issue.11 , pp. 1070-1078
    • Levine, A.G.1    Arvey, A.2    Jin, W.3    Rudensky, A.Y.4
  • 17
    • 0031647622 scopus 로고    scopus 로고
    • Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: Induction of autoimmune disease by breaking their anergic/suppressive state
    • Takahashi T, et al. (1998) Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: Induction of autoimmune disease by breaking their anergic/suppressive state. Int Immunol 10(12):1969-1980.
    • (1998) Int Immunol , vol.10 , Issue.12 , pp. 1969-1980
    • Takahashi, T.1
  • 18
    • 77951158406 scopus 로고    scopus 로고
    • Protein kinase C-theta mediates negative feedback on regulatory T cell function
    • Zanin-Zhorov A, et al. (2010) Protein kinase C-theta mediates negative feedback on regulatory T cell function. Science 328(5976):372-376.
    • (2010) Science , vol.328 , Issue.5976 , pp. 372-376
    • Zanin-Zhorov, A.1
  • 19
    • 84889254459 scopus 로고    scopus 로고
    • The ζ isoform of diacylglycerol kinase plays a predominant role in regulatory T cell development and TCR-mediated ras signaling
    • Joshi RP, et al. (2013) The ζ isoform of diacylglycerol kinase plays a predominant role in regulatory T cell development and TCR-mediated ras signaling. Sci Signal 6(303):ra102.
    • (2013) Sci Signal , vol.6 , Issue.303 , pp. ra102
    • Joshi, R.P.1
  • 20
    • 63849121372 scopus 로고    scopus 로고
    • SHIP limits immunoregulatory capacity in the T-cell compartment
    • Collazo MM, et al. (2009) SHIP limits immunoregulatory capacity in the T-cell compartment. Blood 113(13):2934-2944.
    • (2009) Blood , vol.113 , Issue.13 , pp. 2934-2944
    • Collazo, M.M.1
  • 21
    • 84863133195 scopus 로고    scopus 로고
    • Scaffold protein Disc large homolog 1 is required for Tcell receptor-induced activation of regulatory T-cell function
    • Zanin-Zhorov A, et al. (2012) Scaffold protein Disc large homolog 1 is required for Tcell receptor-induced activation of regulatory T-cell function. Proc Natl Acad Sci USA 109(5):1625-1630.
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.5 , pp. 1625-1630
    • Zanin-Zhorov, A.1
  • 22
  • 23
    • 27644503683 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T-cell lines from human cord blood have functional and molecular properties of T-cell anergy
    • Li L, et al. (2005) CD4+CD25+ regulatory T-cell lines from human cord blood have functional and molecular properties of T-cell anergy. Blood 106(9):3068-3073.
    • (2005) Blood , vol.106 , Issue.9 , pp. 3068-3073
    • Li, L.1
  • 24
    • 84914106706 scopus 로고    scopus 로고
    • Single-cell mass cytometry of TCR signaling: Amplification of small initial differences results in low ERK activation in NOD mice
    • Mingueneau M, et al. (2014) Single-cell mass cytometry of TCR signaling: Amplification of small initial differences results in low ERK activation in NOD mice. Proc Natl Acad Sci USA 111(46):16466-16471.
    • (2014) Proc Natl Acad Sci USA , vol.111 , Issue.46 , pp. 16466-16471
    • Mingueneau, M.1
  • 25
    • 50149099154 scopus 로고    scopus 로고
    • Differentiation of regulatory Foxp3+ T cells in the thymic cortex
    • Liston A, et al. (2008) Differentiation of regulatory Foxp3+ T cells in the thymic cortex. Proc Natl Acad Sci USA 105(33):11903-11908.
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.33 , pp. 11903-11908
    • Liston, A.1
  • 26
    • 85047694553 scopus 로고    scopus 로고
    • Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity
    • Stratmann T, et al. (2003) Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity. J Clin Invest 112(6):902-914.
    • (2003) J Clin Invest , vol.112 , Issue.6 , pp. 902-914
    • Stratmann, T.1
  • 27
    • 0030825384 scopus 로고    scopus 로고
    • Differential T cell receptor-mediated signaling in naive and memory CD4 T cells
    • Farber DL, Acuto O, Bottomly K (1997) Differential T cell receptor-mediated signaling in naive and memory CD4 T cells. Eur J Immunol 27(8):2094-2101.
    • (1997) Eur J Immunol , vol.27 , Issue.8 , pp. 2094-2101
    • Farber, D.L.1    Acuto, O.2    Bottomly, K.3
  • 28
    • 10744221289 scopus 로고    scopus 로고
    • Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells
    • Huehn J, et al. (2004) Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells. J Exp Med 199(3):303-313.
    • (2004) J Exp Med , vol.199 , Issue.3 , pp. 303-313
    • Huehn, J.1
  • 29
    • 2442484053 scopus 로고    scopus 로고
    • Naturally arising CD4+ regulatory t cells for immunologic selftolerance and negative control of immune responses
    • Sakaguchi S (2004) Naturally arising CD4+ regulatory t cells for immunologic selftolerance and negative control of immune responses. Annu Rev Immunol 22:531-562.
    • (2004) Annu Rev Immunol , vol.22 , pp. 531-562
    • Sakaguchi, S.1
  • 30
    • 84355162741 scopus 로고    scopus 로고
    • Response to self antigen imprints regulatory memory in tissues
    • Rosenblum MD, et al. (2011) Response to self antigen imprints regulatory memory in tissues. Nature 480(7378):538-542.
    • (2011) Nature , vol.480 , Issue.7378 , pp. 538-542
    • Rosenblum, M.D.1
  • 32
    • 84928586624 scopus 로고    scopus 로고
    • Selective IL-2 responsiveness of regulatory T cells through multiple intrinsic mechanisms supports the use of low-dose IL-2 therapy in type 1 diabetes
    • Yu A, et al. (2015) Selective IL-2 responsiveness of regulatory T cells through multiple intrinsic mechanisms supports the use of low-dose IL-2 therapy in type 1 diabetes. Diabetes 64(6):2172-2183.
    • (2015) Diabetes , vol.64 , Issue.6 , pp. 2172-2183
    • Yu, A.1
  • 33
    • 79957750936 scopus 로고    scopus 로고
    • The immunomodulatory properties of the CD5 lymphocyte receptor in health and disease
    • Soldevila G, Raman C, Lozano F (2011) The immunomodulatory properties of the CD5 lymphocyte receptor in health and disease. Curr Opin Immunol 23(3):310-318.
    • (2011) Curr Opin Immunol , vol.23 , Issue.3 , pp. 310-318
    • Soldevila, G.1    Raman, C.2    Lozano, F.3
  • 34
    • 47149108867 scopus 로고    scopus 로고
    • CD5 plays an inhibitory role in the suppressive function of murine CD4(+) CD25(+) T(reg) cells
    • Dasu T, et al. (2008) CD5 plays an inhibitory role in the suppressive function of murine CD4(+) CD25(+) T(reg) cells. Immunol Lett 119(1-2):103-113.
    • (2008) Immunol Lett , vol.119 , Issue.1-2 , pp. 103-113
    • Dasu, T.1
  • 35
    • 84924988088 scopus 로고    scopus 로고
    • CD5 instructs extrathymic regulatory T cell development in response to self and tolerizing antigens
    • Henderson JG, Opejin A, Jones A, Gross C, Hawiger D (2015) CD5 instructs extrathymic regulatory T cell development in response to self and tolerizing antigens. Immunity 42(3):471-483.
    • (2015) Immunity , vol.42 , Issue.3 , pp. 471-483
    • Henderson, J.G.1    Opejin, A.2    Jones, A.3    Gross, C.4    Hawiger, D.5
  • 36
    • 65349119978 scopus 로고    scopus 로고
    • CD28 and CTLA-4 coreceptor expression and signal transduction
    • Rudd CE, Taylor A, Schneider H (2009) CD28 and CTLA-4 coreceptor expression and signal transduction. Immunol Rev 229(1):12-26.
    • (2009) Immunol Rev , vol.229 , Issue.1 , pp. 12-26
    • Rudd, C.E.1    Taylor, A.2    Schneider, H.3
  • 37
    • 82255192901 scopus 로고    scopus 로고
    • The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses
    • Walker LS, Sansom DM (2011) The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses. Nat Rev Immunol 11(12):852-863.
    • (2011) Nat Rev Immunol , vol.11 , Issue.12 , pp. 852-863
    • Walker, L.S.1    Sansom, D.M.2
  • 38
    • 65349118810 scopus 로고    scopus 로고
    • PD-1 signaling in primary T cells
    • Riley JL
    • Riley JL (2009) PD-1 signaling in primary T cells. Immunol Rev 229(1):114-125.
    • (2009) Immunol Rev , vol.229 , Issue.1 , pp. 114-125
  • 39
    • 84895910372 scopus 로고    scopus 로고
    • Targeting DUSPs in glioblastomas-Wielding a doubleedged sword?
    • Prabhakar S, et al. (2014) Targeting DUSPs in glioblastomas-Wielding a doubleedged sword? Cell Biol Int 38(2):145-153.
    • (2014) Cell Biol Int , vol.38 , Issue.2 , pp. 145-153
    • Prabhakar, S.1
  • 40
    • 43049101029 scopus 로고    scopus 로고
    • Dual-specificity MAP kinase phosphatases (MKPs) and cancer
    • Keyse SM (2008) Dual-specificity MAP kinase phosphatases (MKPs) and cancer. Cancer Metastasis Rev 27(2):253-261.
    • (2008) Cancer Metastasis Rev , vol.27 , Issue.2 , pp. 253-261
    • Keyse, S.M.1
  • 41
    • 84874425321 scopus 로고    scopus 로고
    • Unrestrained p38 MAPK activation in Dusp1/4 doublenull mice induces cardiomyopathy
    • Auger-Messier M, et al. (2013) Unrestrained p38 MAPK activation in Dusp1/4 doublenull mice induces cardiomyopathy. Circ Res 112(1):48-56.
    • (2013) Circ Res , vol.112 , Issue.1 , pp. 48-56
    • Auger-Messier, M.1
  • 42
    • 84872551703 scopus 로고    scopus 로고
    • Convergent and divergent effects of costimulatory molecules in conventional and regulatory CD4+ T cells
    • Wakamatsu E, Mathis D, Benoist C (2013) Convergent and divergent effects of costimulatory molecules in conventional and regulatory CD4+ T cells. Proc Natl Acad Sci USA 110(3):1023-1028.
    • (2013) Proc Natl Acad Sci USA , vol.110 , Issue.3 , pp. 1023-1028
    • Wakamatsu, E.1    Mathis, D.2    Benoist, C.3
  • 43
    • 67649138829 scopus 로고    scopus 로고
    • Regulatory T cells in the control of host-microorganism interactions (∗)
    • Belkaid Y, Tarbell K (2009) Regulatory T cells in the control of host-microorganism interactions (∗). Annu Rev Immunol 27:551-589.
    • (2009) Annu Rev Immunol , vol.27 , pp. 551-589
    • Belkaid, Y.1    Tarbell, K.2
  • 44
    • 84923040695 scopus 로고    scopus 로고
    • THEMIS: A critical TCR signal regulator for ligand discrimination
    • Gascoigne NR, Acuto O (2015) THEMIS: A critical TCR signal regulator for ligand discrimination. Curr Opin Immunol 33:86-92.
    • (2015) Curr Opin Immunol , vol.33 , pp. 86-92
    • Gascoigne, N.R.1    Acuto, O.2
  • 45
    • 80555154007 scopus 로고    scopus 로고
    • SOCS1 is essential for regulatory T cell functions by preventing loss of Foxp3 expression as well as IFN-gamma and IL-17A production
    • Takahashi R, et al. (2011) SOCS1 is essential for regulatory T cell functions by preventing loss of Foxp3 expression as well as IFN-gamma and IL-17A production. J Exp Med 208(10):2055-2067.
    • (2011) J Exp Med , vol.208 , Issue.10 , pp. 2055-2067
    • Takahashi, R.1
  • 46
    • 0032545452 scopus 로고    scopus 로고
    • Molecular basis of T cell inactivation by CTLA-4
    • Lee K-M, et al. (1998) Molecular basis of T cell inactivation by CTLA-4. Science 282(5397):2263-2266.
    • (1998) Science , vol.282 , Issue.5397 , pp. 2263-2266
    • Lee, K.-M.1
  • 47
    • 36048978911 scopus 로고    scopus 로고
    • Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature
    • Hill JA, et al. (2007) Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature. Immunity 27(5):786-800.
    • (2007) Immunity , vol.27 , Issue.5 , pp. 786-800
    • Hill, J.A.1


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