Effect of α-lipoic acid on lipid profile in rats fed a high-fructose diet

Experimental Diabesity Research

Volumn 5, Issue 3, 2004, Pages 195-200

  Thirunavukkarasu, V ^a   Anitha Nandhini, A T ^a   Anuradha, C V ^a  

^a ANNAMALAI UNIVERSITY   (India)

Author keywords

lipoic acid; Cholesterol; Fructose; Insulin resistance; Lipoproteins

Indexed keywords

CHOLESTEROL; FATTY ACID; FRUCTOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; INSULIN; LIPID; LIPOPROTEIN LIPASE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PHOSPHATIDYLCHOLINE STEROL ACYLTRANSFERASE; PHOSPHOLIPID; THIOCTIC ACID; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIETARY INTAKE; DRUG MECHANISM; ENZYME ACTIVITY; FATTY ACID BLOOD LEVEL; FEEDING; INSULIN RESISTANCE; KIDNEY; LIPID METABOLISM; LIVER LEVEL; MALE; NONHUMAN; NORMAL VALUE; PHOSPHOLIPID BLOOD LEVEL; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE; TISSUE LEVEL; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; DIET; DOSE-RESPONSE RELATIONSHIP, DRUG; FRUCTOSE; KIDNEY; LIPID METABOLISM; LIPIDS; LIVER; MALE; MUSCLE, SKELETAL; RATS; RATS, WISTAR; THIOCTIC ACID;

EID: 6344289587     PISSN: 15438600     EISSN: None     Source Type: Journal    
DOI: 10.1080/15438600490486778     Document Type: Article

References (33)

1. Park, O. J., Cesar, D., Faix, D., Wu, K., Shackleton, C. H. L., and Hellerstein, M. K. (1992) Mechanism of fructose induced hypertriglyceridemia in rats. Biochem. J., 282, 753-757.
2. Zavaroni, I., Sander, S., Scott, S., and Reaven, G. M. (1980) Effect of fructose feeding on insulin secretion and insulin action in the rat. Metabolism, 10, 970-973.
3. Srividhya, S., and Anuradha, C. V. (2002) Metformin improves liver antioxidant potential in rats fed a high-fructose diet. Asia Pacific J. Clin. Nutr., 11, 319-322.
4. Mayes, P. A. (1993) Intermediary metabolism of fructose. Am. J. Clin. Nutr., 58 (Suppl), 754S-765S.
5. Packer, L., Witt, K. H., and Tritschler, H. J. (1995) α-Lipoic acid as a biological antioxidant. Free Radic. Biol. Med., 19, 227-250.
6. Evans, J. L., and Goldfine, I. D. (2000) α-Lipoic acid a multifunctional antioxidant that improves insulin sensitivity in patients with type 2 diabetes. Diabetes Tech. Ther., 2, 401-413.
7. Ziegler, D., Reljanovic, M., Mehnert, H., and Gries, F. A. (1999) Alpha lipoic acid in the treatment of diabetic polyneuropathy in Germany: Current evidence from clinical trials. Exp. Clin. Endocrinol. Diabetes, 107, 421-430.
8. Malarkodi, K. P., Balachandar, A. V., and Varalakshmi, P. (2003) The influence of lipoic acid on adriamycin-induced hyperlipidemic nephrotoxicity in rats. Mol. Cell. Biochem., 247, 139-145.
9. Sumathi, R., Jayanthi, S., and Varalakshmi, P. (1995) Impaired lipid metabolism in calcium oxalate stone forming rats and dl-α-lipoic acid supplementation. Nutr. Res., 15, 59-70.
10. Folch, J., Loer, M., and Stanley, G. S. H. (1951) A simple method for the isolation and purification of total lipids from animal tissue. J. Biol. Chem., 126, 497-509.
11. Nandhini, A. T. A., Balakrishnan, S. D., and Anuradha, C. V. (2001) Taurine improves lipid profile in rats fed a high-fructose diet. Nutr. Res., 22, 343-348.
12. Korn, E. D. (1955) Clearing factors: A heparin activated lipoprotein lipase. Isolation and characterization of enzyme from normal rats. J. Biol. Chem., 215, 1-26.
13. Hitz, J., Sterinmetz, J., and Surt, G. (1983) Plasma LCAT-reference values and effects of xenobiotics. Clin. Chim. Acta, 133, 85-96.
14. Rao, V., and Ramakrishnan, S. (1975) Indirect assessment of hydroxy methyl glutaryl CoA reductase (NADH) activity in liver tissue. Clin. Chem., 21, 1523-1525.
15. Michaelis, D. C., Nace, C. S., and Szepsi, B. (1975) Demonstration of a specific metabolic effect of dietary dissacharides in the rat. J. Nutr., 105, 1186-1191.
16. Thorburn, A. W., Storlein, L. H., Jenkins, A. B., Khouri, S., and Kraegen, E. W. (1989) Fructose induced in vitro insulin resistance and elevated plasma triglyceride levels in rats. Am. J. Clin. Nutr. 49, 1155-1163.
17. Spence, J. T., Koudelka, A. P., and Tseng-Crank J. C. (1985) Role of protein synthesis in the carbohydrate-induced changes in the activities of acetyl CoA-carboxylase and hydroxymethylglutaryl CoA reductase in cultured rat hepatocytes. Biochem. J., 227, 39-947.
18. Anuradha, C. V., and Balakrishnan, S. D. (1999) Taurine attenuates hypertension and improves insulin sensitivity in the fructose-fed rats, an animal model of insulin resistance. Can. J. Physiol. Pharmacol., 77, 749-754.
19. Bieger, W. P., Michel, G., Barwich, D., and Wirth, A. (1984) Diminished insulin receptors on monocytes and erythrocytes in hypertriglyceridemia. Metabolism, 33, 982-987.
20. Boogaerts, J. R., Malone-McNeal, M., Archambault Schexnayder, J., and Davis, P. A. (1984) Dietary carbohydrates induces lipogenesis and very low density lipoproteins synthesis. Am. J. Physiol., 246, E77-E83.
21. Carmona, A., and Freedland, R. A. (1989) Comparison among the lipogenic potential of various substrates in rat hepatocytes: The differential effects of fructose-containing diets on hepatic lipogenesis. J. Nutr., 119, 1304-1310.
22. Fiebig, R., Griffiths, M. A., Gore, M. T., Baker, D. H., Oscai, L., Ney, D. M., and Ji, L. L. (1998) Exercise training down-regulates hepatic lipogenic enzymes in meal-fed rats: Fructose versus complex-carbohydrate diets. J. Nutr., 128, 810-817.
23. Bar On, H., and Stein, Y. (1967) Effect of glucose and fructose administration on lipid metabolism in the rat. J. Nutr., 94, 95-105.
24. Hallfrisch, J., Reiser, S., and Prather, E. S. (1983) Blood lipid distribution of hyperinsulinemic men consuming three levels of fructose. Am. J. Clin. Nutr., 37, 740-748.
25. Anurag, P., and Anuradha, C. V. (2000) Metformin improved lipid metabolism and attenuates lipid peroxidation in high fructose-fed rats. Diabetes Obes. Metab., 4, 36-42.
26. Boden, G., Jadalin, E, and Kian, Y. (1991) Effect of fat on insulin stimulated carbohydrate metabolism in normal men. J. Clin. Invest., 88, 960-966.
27. Thirunavukkarasu, V., Nandhini, A. T., and Anuradha, C. V. (2003) Lipoic acid restores antioxidant system in tissues of hyperinsulinemic rats. Indian J. Med. Res., 118, 134-140.
28. Slatter, D. A., Bolton, C. N., and Bailey, A. J. (2000) The importance of lipid-derived malondialdehyde in diabetes mellitus. Diabetologia, 43, 550-557.
29. Ohara, Y., Peterson, T. E., and Harrison, D. G. (1993) Hypercholesterolemia increases endothelial superoxide anion production. J. Clin. Invest., 91, 2546-2551.
30. Vasdev, S., Fora, C. A., Parai, S., Longerich, L., and Gadag, V. (2000) Dietary lipoic acid supplementation prevents fructose-induced hypertension in rats. Nutr. Metab. Cardiovasc. Dis., 10, 339-346.
31. Mochizuki, K., Oda, H., and Yokogoshi, H. (1998) Increasing effect of dietary taurine on the serum HDL-cholesterol concentration in rats. Biosci. Biotech. Biochem., 62, 578-579.
32. Ford, I., Cotter, M. A., Greaves, M., and Cameron, N. E. (2001) The effects of treatment with alpha-lipoic acid or evening primrose oil on vascular hemostatic and lipid risk factors, blood flow, and peripheral nerve conduction in the streptozotocin-diabetic rat. Metabolism, 50, 868-875.
33. Reaven, G. M. (1991) Insulin resistance, hyperinsulinemia, hypertriglyceridemia and hypertension: Parallels between human diseases and animal models. Diabetes Care, 14, 195-202.