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Volumn 439, Issue 3, 2013, Pages 390-395

Reversal of obesity-induced hypertriglyceridemia by (R)-α-lipoic acid in ZDF (fa/fa) rats

Author keywords

Dyslipidemia; Lipotoxicity; Steatosis; Triglyceride; Zucker rat

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ADENOSINE TRIPHOSPHATE; ADIPONUTRIN; CARNITINE PALMITOYLTRANSFERASE 1 ALPHA; CARNITINE PALMITOYLTRANSFERASE 1 BETA; CARNITINE PALMITOYLTRANSFERASE I; CITRATE SYNTHASE; FATTY ACID; FATTY ACID SYNTHASE; FIBROBLAST GROWTH FACTOR 21; GLYCEROL 3 PHOSPHATE ACYLTRANSFERASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; KETONE BODY; LIVER PROTEIN; PALMITOYL COENZYME A HYDROLASE; PALMITOYL COENZYME A HYDROLASE 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PROTEIN; THIOCTIC ACID; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

EID: 84884588027     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.08.063     Document Type: Article
Times cited : (24)

References (40)
  • 1
    • 0035897696 scopus 로고    scopus 로고
    • NCEP, Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III), Jama
    • NCEP, Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III), Jama 285 (2001) 2486-2497.
    • (2001) , vol.285 , pp. 2486-2497
  • 2
    • 0037116641 scopus 로고    scopus 로고
    • Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey
    • Ford E.S., Giles W.H., Dietz W.H. Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA 2002, 287:356-359.
    • (2002) JAMA , vol.287 , pp. 356-359
    • Ford, E.S.1    Giles, W.H.2    Dietz, W.H.3
  • 3
    • 0033527030 scopus 로고    scopus 로고
    • Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group
    • Rubins H.B., Robins S.J., Collins D., Fye C.L., Anderson J.W., Elam M.B., Faas F.H., Linares E., Schaefer E.J., Schectman G., Wilt T.J., Wittes J. Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group. N. Engl. J. Med. 1999, 341:410-418.
    • (1999) N. Engl. J. Med. , vol.341 , pp. 410-418
    • Rubins, H.B.1    Robins, S.J.2    Collins, D.3    Fye, C.L.4    Anderson, J.W.5    Elam, M.B.6    Faas, F.H.7    Linares, E.8    Schaefer, E.J.9    Schectman, G.10    Wilt, T.J.11    Wittes, J.12
  • 7
    • 84858659956 scopus 로고    scopus 로고
    • One-year efficacy and safety of rosuvastatin+fenofibric acid combination therapy in patients with mixed dyslipidemia: evaluation of dose response
    • Ferdinand K.C., Davidson M.H., Kelly M.T., Setze C.M. One-year efficacy and safety of rosuvastatin+fenofibric acid combination therapy in patients with mixed dyslipidemia: evaluation of dose response. Am. J. Cardiovasc. Drugs : Drugs, Devices, and other Interventions 2012, 12:117-125.
    • (2012) Am. J. Cardiovasc. Drugs : Drugs, Devices, and other Interventions , vol.12 , pp. 117-125
    • Ferdinand, K.C.1    Davidson, M.H.2    Kelly, M.T.3    Setze, C.M.4
  • 9
    • 34248183098 scopus 로고    scopus 로고
    • Management of hypertriglyceridemia
    • Oh R.C., Lanier J.B. Management of hypertriglyceridemia. Am. Fam. Physician 2007, 75:1365-1371.
    • (2007) Am. Fam. Physician , vol.75 , pp. 1365-1371
    • Oh, R.C.1    Lanier, J.B.2
  • 10
    • 84871490319 scopus 로고    scopus 로고
    • Examining the safety of PPAR agonists - current trends and future prospects
    • Bortolini M., Wright M.B., Bopst M., Balas B. Examining the safety of PPAR agonists - current trends and future prospects. Expert Opin. Drug Safety 2013, 12:65-79.
    • (2013) Expert Opin. Drug Safety , vol.12 , pp. 65-79
    • Bortolini, M.1    Wright, M.B.2    Bopst, M.3    Balas, B.4
  • 11
    • 69949104384 scopus 로고    scopus 로고
    • Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential
    • Shay K.P., Moreau R.F., Smith E.J., Smith A.R., Hagen T.M. Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential. Biochim. Biophys. Acta 2009, 1790:1149-1160.
    • (2009) Biochim. Biophys. Acta , vol.1790 , pp. 1149-1160
    • Shay, K.P.1    Moreau, R.F.2    Smith, E.J.3    Smith, A.R.4    Hagen, T.M.5
  • 13
    • 38349144351 scopus 로고    scopus 로고
    • Dietary alpha-lipoic acid supplementation inhibits atherosclerotic lesion development in apolipoprotein E-deficient and apolipoprotein E/low-density lipoprotein receptor-deficient mice
    • Zhang W.J., Bird K.E., McMillen T.S., LeBoeuf R.C., Hagen T.M., Frei B. Dietary alpha-lipoic acid supplementation inhibits atherosclerotic lesion development in apolipoprotein E-deficient and apolipoprotein E/low-density lipoprotein receptor-deficient mice. Circulation 2008, 117:421-428.
    • (2008) Circulation , vol.117 , pp. 421-428
    • Zhang, W.J.1    Bird, K.E.2    McMillen, T.S.3    LeBoeuf, R.C.4    Hagen, T.M.5    Frei, B.6
  • 14
    • 64549088894 scopus 로고    scopus 로고
    • Lipoic acid improves hypertriglyceridemia by stimulating triacylglycerol clearance and downregulating liver triacylglycerol secretion
    • Butler J.A., Hagen T.M., Moreau R. Lipoic acid improves hypertriglyceridemia by stimulating triacylglycerol clearance and downregulating liver triacylglycerol secretion. Arch. Biochem. Biophys. 2009, 485:63-71.
    • (2009) Arch. Biochem. Biophys. , vol.485 , pp. 63-71
    • Butler, J.A.1    Hagen, T.M.2    Moreau, R.3
  • 15
    • 84868327863 scopus 로고
    • Lipoic acid prevents liver metabolic changes induced by administration of a fructose-rich diet
    • Castro M.C., Massa M.L., Schinella G., Gagliardino J.J., Francini F. Lipoic acid prevents liver metabolic changes induced by administration of a fructose-rich diet. Biochim. Biophys. Acta 1830, 2013:2226-2232.
    • (1830) Biochim. Biophys. Acta , vol.2013 , pp. 2226-2232
    • Castro, M.C.1    Massa, M.L.2    Schinella, G.3    Gagliardino, J.J.4    Francini, F.5
  • 16
    • 84884595022 scopus 로고    scopus 로고
    • Treatment of lipid metabolic disorders using 5-(1,2-dithiolan-3-yl)valeric acid (alpha-lipoic acid) or its physiologically compatible salts, US Patent # 6,518,300
    • R.G. Alken, D. Koegst, G. Fries, Treatment of lipid metabolic disorders using 5-(1,2-dithiolan-3-yl)valeric acid (alpha-lipoic acid) or its physiologically compatible salts, US Patent # 6,518,300 B2 (2003).
    • (2003) , vol.2 B
    • Alken, R.G.1    Koegst, D.2    Fries, G.3
  • 17
    • 79960834542 scopus 로고    scopus 로고
    • Amelioration of lipid abnormalities by alpha-lipoic acid through antioxidative and anti-inflammatory effects
    • Zhang Y., Han P., Wu N., He B., Lu Y., Li S., Liu Y., Zhao S., Liu L., Li Y. Amelioration of lipid abnormalities by alpha-lipoic acid through antioxidative and anti-inflammatory effects. Obesity 2011, 19:1647-1653.
    • (2011) Obesity , vol.19 , pp. 1647-1653
    • Zhang, Y.1    Han, P.2    Wu, N.3    He, B.4    Lu, Y.5    Li, S.6    Liu, Y.7    Zhao, S.8    Liu, L.9    Li, Y.10
  • 18
    • 18244382304 scopus 로고    scopus 로고
    • Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
    • Donnelly K.L., Smith C.I., Schwarzenberg S.J., Jessurun J., Boldt M.D., Parks E.J. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J. Clin. Invest. 2005, 115:1343-1351.
    • (2005) J. Clin. Invest. , vol.115 , pp. 1343-1351
    • Donnelly, K.L.1    Smith, C.I.2    Schwarzenberg, S.J.3    Jessurun, J.4    Boldt, M.D.5    Parks, E.J.6
  • 19
    • 0026637968 scopus 로고
    • Hexanoate and octanoate inhibit transcription of the malic enzyme and fatty acid synthase genes in chick embryo hepatocytes in culture
    • Roncero C., Goodridge A.G. Hexanoate and octanoate inhibit transcription of the malic enzyme and fatty acid synthase genes in chick embryo hepatocytes in culture. J. Biol. Chem. 1992, 267:14918-14927.
    • (1992) J. Biol. Chem. , vol.267 , pp. 14918-14927
    • Roncero, C.1    Goodridge, A.G.2
  • 20
    • 0031440658 scopus 로고    scopus 로고
    • Arachidonate and medium-chain fatty acids inhibit transcription of the acetyl-CoA carboxylase gene in hepatocytes in culture
    • Hillgartner F.B., Charron T. Arachidonate and medium-chain fatty acids inhibit transcription of the acetyl-CoA carboxylase gene in hepatocytes in culture. J. Lipid Res. 1997, 38:2548-2557.
    • (1997) J. Lipid Res. , vol.38 , pp. 2548-2557
    • Hillgartner, F.B.1    Charron, T.2
  • 21
    • 34548164420 scopus 로고    scopus 로고
    • The acyl-CoA thioesterase I is regulated by PPARalpha and HNF4alpha via a distal response element in the promoter
    • Dongol B., Shah Y., Kim I., Gonzalez F.J., Hunt M.C. The acyl-CoA thioesterase I is regulated by PPARalpha and HNF4alpha via a distal response element in the promoter. J. Lipid Res. 2007, 48:1781-1791.
    • (2007) J. Lipid Res. , vol.48 , pp. 1781-1791
    • Dongol, B.1    Shah, Y.2    Kim, I.3    Gonzalez, F.J.4    Hunt, M.C.5
  • 22
    • 0035956863 scopus 로고    scopus 로고
    • Fatty acids and hypolipidemic drugs regulate peroxisome proliferator-activated receptors alpha - and gamma-mediated gene expression via liver fatty acid binding protein: a signaling path to the nucleus
    • Wolfrum C., Borrmann C.M., Borchers T., Spener F. Fatty acids and hypolipidemic drugs regulate peroxisome proliferator-activated receptors alpha - and gamma-mediated gene expression via liver fatty acid binding protein: a signaling path to the nucleus. Proc. Nat. Acad. Sci. U.S.A. 2001, 98:2323-2328.
    • (2001) Proc. Nat. Acad. Sci. U.S.A. , vol.98 , pp. 2323-2328
    • Wolfrum, C.1    Borrmann, C.M.2    Borchers, T.3    Spener, F.4
  • 23
    • 34547588219 scopus 로고    scopus 로고
    • Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle: evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents
    • Turner N., Bruce C.R., Beale S.M., Hoehn K.L., So T., Rolph M.S., Cooney G.J. Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle: evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents. Diabetes 2007, 56:2085-2092.
    • (2007) Diabetes , vol.56 , pp. 2085-2092
    • Turner, N.1    Bruce, C.R.2    Beale, S.M.3    Hoehn, K.L.4    So, T.5    Rolph, M.S.6    Cooney, G.J.7
  • 24
    • 71549149354 scopus 로고
    • Role of fatty acid uptake and fatty acid beta-oxidation in mediating insulin resistance in heart and skeletal muscle
    • Zhang L., Keung W., Samokhvalov V., Wang W., Lopaschuk G.D. Role of fatty acid uptake and fatty acid beta-oxidation in mediating insulin resistance in heart and skeletal muscle. Biochim. Biophys. Acta 1801, 2010:1-22.
    • (1801) Biochim. Biophys. Acta , vol.2010 , pp. 1-22
    • Zhang, L.1    Keung, W.2    Samokhvalov, V.3    Wang, W.4    Lopaschuk, G.D.5
  • 29
    • 12144271041 scopus 로고    scopus 로고
    • Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: prevention of diabetes and ectopic lipid deposition
    • Yu X., McCorkle S., Wang M., Lee Y., Li J., Saha A.K., Unger R.H., Ruderman N.B. Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: prevention of diabetes and ectopic lipid deposition. Diabetologia 2004, 47:2012-2021.
    • (2004) Diabetologia , vol.47 , pp. 2012-2021
    • Yu, X.1    McCorkle, S.2    Wang, M.3    Lee, Y.4    Li, J.5    Saha, A.K.6    Unger, R.H.7    Ruderman, N.B.8
  • 31
    • 0037370773 scopus 로고    scopus 로고
    • AMPK expression and phosphorylation are increased in rodent muscle after chronic leptin treatment
    • Steinberg G.R., Rush J.W., Dyck D.J. AMPK expression and phosphorylation are increased in rodent muscle after chronic leptin treatment. Am. J. Physiol. Endocrinol. Metab. 2003, 284:E648-E654.
    • (2003) Am. J. Physiol. Endocrinol. Metab. , vol.284
    • Steinberg, G.R.1    Rush, J.W.2    Dyck, D.J.3
  • 38
    • 84859529243 scopus 로고    scopus 로고
    • Sodium Butyrate Stimulates Expression of Fibroblast Growth Factor 21 in Liver by Inhibition of Histone Deacetylase 3
    • Li H., Gao Z., Zhang J., Ye X., Xu A., Ye J., Jia W. Sodium Butyrate Stimulates Expression of Fibroblast Growth Factor 21 in Liver by Inhibition of Histone Deacetylase 3. Diabetes 2012, 61:797-806.
    • (2012) Diabetes , vol.61 , pp. 797-806
    • Li, H.1    Gao, Z.2    Zhang, J.3    Ye, X.4    Xu, A.5    Ye, J.6    Jia, W.7
  • 39
    • 34249711964 scopus 로고    scopus 로고
    • Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states
    • Badman M.K., Pissios P., Kennedy A.R., Koukos G., Flier J.S., Maratos-Flier E. Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab. 2007, 5:426-437.
    • (2007) Cell Metab. , vol.5 , pp. 426-437
    • Badman, M.K.1    Pissios, P.2    Kennedy, A.R.3    Koukos, G.4    Flier, J.S.5    Maratos-Flier, E.6
  • 40
    • 84857837563 scopus 로고    scopus 로고
    • R-alpha-lipoic acid does not reverse hepatic inflammation of aging, but lowers lipid anabolism, while accentuating circadian rhythm transcript profiles, American journal of physiology
    • Finlay L.A., Michels A.J., Butler J.A., Smith E.J., Monette J.S., Moreau R.F., Petersen S.K., Frei B., Hagen T.M. R-alpha-lipoic acid does not reverse hepatic inflammation of aging, but lowers lipid anabolism, while accentuating circadian rhythm transcript profiles, American journal of physiology. Regul. Integr. Comp. Physiol. 2012, 302:R587-R597.
    • (2012) Regul. Integr. Comp. Physiol. , vol.302
    • Finlay, L.A.1    Michels, A.J.2    Butler, J.A.3    Smith, E.J.4    Monette, J.S.5    Moreau, R.F.6    Petersen, S.K.7    Frei, B.8    Hagen, T.M.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.