Dihydroquercetin (DHQ) ameliorated concanavalin A-induced mouse experimental fulminant hepatitis and enhanced HO-1 expression through MAPK/Nrf2 antioxidant pathway in RAW cells

International Immunopharmacology

Volumn 28, Issue 2, 2015, Pages 938-944

  Zhao, Mingyi ^a,b   Chen, Jiajie ^a,c   Zhu, Ping ^a,d   Fujino, Masayuki ^a,e   Takahara, Terumi ^f   Toyama, Sumika ^a   Tomita, Amy ^a,g   Zhao, Lingling ^b   Yang, Zuocheng ^b   Hei, Mingyan ^b   Zhong, Liang ^c   Zhuang, Jian ^d   Kimura, Shuichi ^g   Li, Xiao Kang ^a  

^a NATIONAL RESEARCH INSTITUTE FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

^b CENTRAL SOUTH UNIVERSITY   (China)

^c FUDAN UNIVERSITY   (China)

^d GUANGDONG PROVINCIAL PEOPLE'S HOSPITAL   (China)

^e AIDS Research Center   (Japan)

^f UNIVERSITY OF TOYAMA   (Japan)

^g Research Institute for Nutrition and Aging   (Japan)

Author keywords

Antioxidant; ConA; DHQ; Hepatitis; HO 1; Mitogen activated protein kinases; Nrf2

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ALANINE AMINOTRANSFERASE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ASPARTATE AMINOTRANSFERASE; GAMMA INTERFERON; HEME OXYGENASE 1; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; TAXIFOLIN; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR ALPHA; ANTIOXIDANT; CONCANAVALIN A; HMOX1 PROTEIN, MOUSE; MEMBRANE PROTEIN; NFE2L2 PROTEIN, MOUSE; QUERCETIN;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL NUCLEUS; CONCANAVALIN A-INDUCED HEPATITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOPLASM; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HISTOPATHOLOGY; IMMUNOPATHOGENESIS; IN VITRO STUDY; KUPFFER CELL; LIVER FAILURE; LIVER INJURY; LIVER NECROSIS; LIVER PROTECTION; MACROPHAGE; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SURVIVAL RATE; UPREGULATION; ANALOGS AND DERIVATIVES; ANIMAL; AUTOIMMUNE DISEASES; C57BL MOUSE; CELL LINE; DRUG EFFECTS; GENETICS; HEPATITIS; HUMAN; IMMUNITY; IMMUNOLOGY; METABOLISM;

ANIMALS; ANTIOXIDANTS; AUTOIMMUNE DISEASES; CELL LINE; CONCANAVALIN A; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HEME OXYGENASE-1; HEPATITIS; HUMANS; IMMUNITY; INTERFERON-GAMMA; MACROPHAGES; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MODELS, ANIMAL; NF-E2-RELATED FACTOR 2; QUERCETIN; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84948570585     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2015.04.032     Document Type: Article

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