Inhibition of p-IκBα Ubiquitylation by Autophagy-Related Gene 7 to Regulate Inflammatory Responses to Bacterial Infection

Journal of Infectious Diseases

Volumn 212, Issue 10, 2015, Pages 1816-1826

  Ye, Yan ^a   Tan, Shirui ^a,b   Zhou, Xikun ^a,c   Li, Xuefeng ^a,c   Jundt, Michael C ^a   Lichter, Natalie ^a   Hidebrand, Alec ^a   Dhasarathy, Archana ^a   Wu, Min ^a  

^a UNIVERSITY OF NORTH DAKOTA SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^b YUNNAN UNIVERSITY   (China)

^c SICHUAN UNIVERSITY   (China)

Author keywords

NF ; Alveolar macrophage; Autophagy; B pathway; B ; I ; TLR4; Ubiquitin

Indexed keywords

CYTOKINE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN ATG 7; REGULATOR PROTEIN; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA; UBIQUITIN; UNCLASSIFIED DRUG; ATG7 PROTEIN, MOUSE; AUTOPHAGY RELATED PROTEIN 7; I KAPPA B; MICROTUBULE ASSOCIATED PROTEIN; TLR4 PROTEIN, MOUSE; TOLL LIKE RECEPTOR 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL INFECTION; CELL NUCLEUS; CONTROLLED STUDY; CYTOKINE PRODUCTION; IMMUNOBLOTTING; IMMUNOPRECIPITATION; KLEBSIELLA PNEUMONIAE; KLEBSIELLA PNEUMONIAE INFECTION; LENTIVIRINAE; LUNG ALVEOLUS MACROPHAGE; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; UBIQUITINATION; ANIMAL; AUTOPHAGY; CELL LINE; IMMUNOLOGY; INFLAMMATION; KLEBSIELLA INFECTION; METABOLISM; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

ANIMALS; AUTOPHAGY; AUTOPHAGY-RELATED PROTEIN 7; CELL LINE; I-KAPPA B PROTEINS; INFLAMMATION; KLEBSIELLA INFECTIONS; MACROPHAGES, ALVEOLAR; MICE; MICE, TRANSGENIC; MICROTUBULE-ASSOCIATED PROTEINS; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; UBIQUITINATION;

EID: 84948438613     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiv301     Document Type: Article

References (43)

1. Moore TA, Standiford TJ. The role of cytokines in bacterial pneumonia: an inflammatory balancing act. Proc Assoc Am Physicians 1998; 110:297-305.
2. Jones RN. Microbial etiologies of hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia. Clin Infect Dis 2010; 51(suppl 1):S81-7.
3. Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell 2008; 132:27-42.
4. Levine B, Klionsky DJ. Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell 2004; 6:463-77.
5. Mizushima N. Autophagy: process and function. Genes Dev 2007; 21:2861-73.
6. Glick D, Barth S, Macleod KF. Autophagy: cellular and molecular mechanisms. J Pathol 2010; 221:3-12.
7. Komatsu M,Waguri S, Ueno T, et al. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol 2005; 169:425-34.
8. Kuma A, Hatano M, Matsui M, et al. The role of autophagy during the early neonatal starvation period. Nature 2004; 432:1032-6.
9. Shrivastava S, Raychoudhuri A, Steele R, Ray R, Ray RB. Knockdown of autophagy enhances the innate immune response in hepatitis C virusinfected hepatocytes. Hepatology 2011; 53:406-14.
10. Lenz HD, Vierstra RD, Nurnberger T, Gust AA. ATG7 contributes to plant basal immunity towards fungal infection. Plant Signal Behav 2011; 6:1040-2.
11. Inoue J, Nishiumi S, Fujishima Y, et al. Autophagy in the intestinal epithelium regulates Citrobacter rodentium infection. Arch Biochem Biophys 2012; 521:95-101.
12. Ye Y, Li X, Wang W, et al. Atg7 deficiency impairs host defense against Klebsiella pneumoniae by impacting bacterial clearance, survival and inflammatory responses in mice. Am J Physiol Lung Cell Mol Physiol 2014; 307:L355-63.
13. Beutler B, Cerami A. The biology of cachectin/TNF-A primary mediator of the host response. Annu Rev Immunol 1989; 7:625-55.
14. Sha WC. Regulation of immune responses by NF-κB/Rel transcription factor. J Exp Med 1998; 187:143-6.
15. Chen J, Chen ZJ. Regulation of NF-κB by ubiquitination. Curr Opin Immunol 2013; 25:4-12.
16. Wojcik S. Crosstalk between autophagy and proteasome protein degradation systems: possible implications for cancer therapy. Folia Histochem Cytobiol 2013; 51:249-64.
17. Consumption of raw or unpasteurized milk and milk products by pregnant women and children. Pediatrics 2014; 133:175-9.
18. Jia W, Pua HH, Li QJ, He YW. Autophagy regulates endoplasmic reticulum homeostasis and calcium mobilization in T lymphocytes. J Immunol 2011; 186:1564-74.
19. Vooijs M, Jonkers J, Berns A. A highly efficient ligand-regulated Cre recombinase mouse line shows that LoxP recombination is position dependent. EMBO Rep 2001; 2:292-7.
20. Lawlor MS, Hsu J, Rick PD, Miller VL. Identification of Klebsiella pneumoniae virulence determinants using an intranasal infection model. Mol Microbiol 2005; 58:1054-73.
21. Li X, Zhou X, Ye Y, et al. Lyn regulates inflammatory responses in Klebsiella pneumoniae infection via the p38/NF-κB pathway. Eur J Immunol 2014; 44:763-73.
22. Yuan K, Huang C, Fox J, et al. Autophagy plays an essential role in the clearance of Pseudomonas aeruginosa by alveolar macrophages. J Cell Sci 2012; 125:507-15.
23. Kimura S, Noda T, Yoshimori T. Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3. Autophagy 2007; 3:452-60.
24. Wilson AA, Kwok LW, Porter EL, et al. Lentiviral delivery of RNAi for in vivo lineage-specific modulation of gene expression in mouse lung macrophages. Mol Ther 2013; 21:825-33.
25. Wilson AA, Murphy GJ, Hamakawa H, et al. Amelioration of emphysema in mice through lentiviral transduction of long-lived pulmonary alveolar macrophages. J Clin Invest 2010; 120:379-89.
26. Kannan S, Audet A, Huang H, Chen LJ, Wu M. Cholesterol-rich membrane rafts and Lyn are involved in phagocytosis during Pseudomonas aeruginosa infection. J Immunol 2008; 180:2396-408.
27. Yuan K, Huang C, Fox J, et al. Elevated inflammatory response in caveolin-1-deficient mice with Pseudomonas aeruginosa infection is mediated by STAT3 protein and nuclear factor κB (NF-κB). J Biol Chem 2011; 286:21814-25.
28. Wu M, Hussain S, He YH, Pasula R, Smith PA, Martin WJ II. Genetically engineered macrophages expressing IFN-γ restore alveolar immune function in scid mice. Proc Natl Acad Sci U S A 2001; 98:14589-94.
29. Wu M, Huang H, ZhangW, et al. Host DNA repair proteins in response to Pseudomonas aeruginosa in lung epithelial cells and in mice. Infect Immun 2011; 79:75-87.
30. Jia K, Thomas C, Akbar M, et al. Autophagy genes protect against Salmonella typhimurium infection and mediate insulin signalingregulated pathogen resistance. Proc Natl Acad Sci U S A 2009; 106: 14564-9.
31. Tanida I, Fukasawa M, Ueno T, Kominami E, Wakita T, Hanada K. Knockdown of autophagy-related gene decreases the production of infectious hepatitis C virus particles. Autophagy 2009; 5:937-45.
32. Amer AO, Byrne BG, Swanson MS. Macrophages rapidly transfer pathogens from lipid raft vacuoles to autophagosomes. Autophagy 2005; 1:53-8.
33. Knecht E, Aguado C, Carcel J, et al. Intracellular protein degradation in mammalian cells: recent developments. Cell Mol Life Sci 2009; 66: 2427-43.
34. Errafiy R, Aguado C, Ghislat G, et al. PTEN increases autophagy and inhibits the ubiquitin-proteasome pathway in glioma cells independently of its lipid phosphatase activity. PLoS One 2013; 8:e83318.
35. Korolchuk VI, Menzies FM, Rubinsztein DC. Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems. FEBS Lett 2010; 584:1393-8.
36. Zhang X, Li W, Wang C, et al. Inhibition of autophagy enhances apoptosis induced by proteasome inhibitor bortezomib in human glioblastoma U87 and U251 cells. Mol Cell Biochem 2014; 385: 265-75.
37. Alkalay I, Yaron A, Hatzubai A, Orian A, Ciechanover A, Ben-Neriah Y. Stimulation-dependent IκBα phosphorylation marks the NF-κB inhibitor for degradation via the ubiquitin-proteasome pathway. Proc Natl Acad Sci U S A 1995; 92:10599-603.
38. Mathew R, Karp CM, Beaudoin B, et al. Autophagy suppresses tumorigenesis through elimination of p62. Cell 2009; 137:1062-75.
39. Meng Q, Cai D. Defective hypothalamic autophagy directs the central pathogenesis of obesity via the IκB kinase β (IKKβ)/NF-κB pathway. J Biol Chem 2011; 286:32324-32.
40. Chen ZJ, Parent L, Maniatis T. Site-specific phosphorylation of IκBα by a novel ubiquitination-dependent protein kinase activity. Cell 1996; 84:853-62.
41. Kanarek N, London N, Schueler-Furman O, Ben-Neriah Y. Ubiquitination and degradation of the inhibitors of NF-κB. Cold Spring Harb Perspect Biol 2010; 2:a000166.
42. Neal MD, Sodhi CP, Dyer M, et al. A critical role for TLR4 induction of autophagy in the regulation of enterocyte migration and the pathogenesis of necrotizing enterocolitis. J Immunol 2013; 190: 3541-51.
43. Xu Y, Jagannath C, Liu XD, Sharafkhaneh A, Kolodziejska KE, Eissa NT. Toll-like receptor 4 is a sensor for autophagy associated with innate immunity. Immunity 2007; 27:135-44.