Anti-obesity and anti-diabetic effects of flavonoid derivative (Fla-CN) via microRNA in high fat diet induced obesity mice

European Journal of Pharmaceutical Sciences

Volumn 82, Issue , 2016, Pages 52-63

  Qin, Nan ^a   Chen, Ying ^a   Jin, Mei Na ^a   Zhang, Chang ^a   Qiao, Wei ^a   Yue, Xiao Long ^a   Duan, Hong Quan ^a   Niu, Wen Yan ^b  

^a TIANJIN MEDICAL UNIVERSITY   (China)

^b Key Laboratory of Immune Microenvironment and Disease of the Educational Ministry of China   (China)

Author keywords

AMPK; Anti diabetes; Anti obesity; Diet induced obesity; Flavonoid derivative; miR 27

Indexed keywords

3 O [4 (4 CYANOPHENYL) 2 OXOBUT 3 EN 1 YL]KAEMPFEROL; ADIPONECTIN; ANTIDIABETIC AGENT; ANTIOBESITY AGENT; CCAAT ENHANCER BINDING PROTEIN ALPHA; CHOLESTEROL; FATTY ACID; FATTY ACID SYNTHASE; GLUCOSE; HIGH DENSITY LIPOPROTEIN; HORMONE SENSITIVE LIPASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INSULIN; INTERLEUKIN 1BETA; KAEMPFEROL DERIVATIVE; LEPTIN; LOW DENSITY LIPOPROTEIN; MALONALDEHYDE; METFORMIN; MICRORNA; MICRORNA 27; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; S6 KINASE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; SUPEROXIDE DISMUTASE; TRIACYLGLYCEROL; TRIACYLGLYCEROL LIPASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; 3-O-(4-(4-CYANOPHENYL)-2-OXOBUT-3-EN-1-YL)KAEMPFEROL; ACETYL COENZYME A CARBOXYLASE; FLAVONOID; MIRN27 MICRORNA, MOUSE;

ADIPOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ANTIOBESITY EFFECT; ARTICLE; BODY WEIGHT; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DIET INDUCED OBESITY; DOSE RESPONSE; DOWN REGULATION; DRUG EFFECT; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG STRUCTURE; EPIDIDYMIS FAT; FOOD INTAKE; GENE EXPRESSION REGULATION; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; GLUCOSE TOLERANCE; GLUCOSE TOLERANCE TEST; HISTOPATHOLOGY; HYPERINSULINEMIA; IMPAIRED GLUCOSE TOLERANCE; INFRARED SPECTROSCOPY; INSULIN RESISTANCE; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; INTRAABDOMINAL FAT; LIPID DIET; LIVER; MALE; MASS SPECTROMETRY; METABOLIC DISORDER; MOUSE; NONHUMAN; PERIRENAL FAT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTON NUCLEAR MAGNETIC RESONANCE; REAL TIME POLYMERASE CHAIN REACTION; WEIGHT CONTROL; WEIGHT GAIN; ADIPOSE TISSUE; ANIMAL; C57BL MOUSE; DIABETES MELLITUS; DRUG EFFECTS; GENETICS; METABOLISM; OBESITY; PATHOLOGY; SKELETAL MUSCLE;

ACETYL-COA CARBOXYLASE; ADIPOSE TISSUE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ANTI-OBESITY AGENTS; DIABETES MELLITUS; DIET, HIGH-FAT; FLAVONOIDS; HYPOGLYCEMIC AGENTS; INSULIN RESISTANCE; KAEMPFEROLS; LIVER; MALE; MICE, INBRED C57BL; MICRORNAS; MUSCLE, SKELETAL; OBESITY;

EID: 84948437815     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2015.11.013     Document Type: Article

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