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Volumn 81, Issue 5-6, 2015, Pages 210-217

A Fluorescent Imaging Probe Based on a Macrocyclic Scaffold That Binds to Cellular EpCAM

Author keywords

Cancer cell imaging; EpCAM; Fluorescent imaging probe; In vitro selection; Macrocyclic peptide

Indexed keywords

CELL ADHESION MOLECULE; CYCLOPEPTIDE; EPCAM PROTEIN, HUMAN; FLUORESCENT DYE; MOLECULAR PROBE; PEPTIDE APTAMER; PROTEIN BINDING; TUMOR ANTIGEN;

EID: 84948387195     PISSN: 00222844     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00239-015-9710-z     Document Type: Article
Times cited : (33)

References (44)
  • 1
    • 12344289903 scopus 로고    scopus 로고
    • EpCAM: a new therapeutic target for an old cancer antigen
    • COI: 1:CAS:528:DC%2BD3sXps1Kgsbg%3D, PID: 14508099
    • Armstrong A, Eck SL (2003) EpCAM: a new therapeutic target for an old cancer antigen. Cancer Biol Ther 2:320–326
    • (2003) Cancer Biol Ther , vol.2 , pp. 320-326
    • Armstrong, A.1    Eck, S.L.2
  • 2
    • 33846804010 scopus 로고    scopus 로고
    • EpCAM (CD326) finding its role in cancer
    • COI: 1:CAS:528:DC%2BD2sXhtlKjtrg%3D, PID: 17211480
    • Baeuerle PA, Gires O (2007) EpCAM (CD326) finding its role in cancer. Br J Cancer 96:417–423. doi:10.1038/sj.bjc.6603494
    • (2007) Br J Cancer , vol.96 , pp. 417-423
    • Baeuerle, P.A.1    Gires, O.2
  • 3
    • 34247254267 scopus 로고    scopus 로고
    • EpCAM an immunotherapeutic target for gastrointestinal malignancy: current experience and future challenges
    • COI: 1:CAS:528:DC%2BD2sXjsleksrk%3D, PID: 17325709
    • Chaudry MA, Sales K, Ruf P, Lindhofer H, Winslet MC (2007) EpCAM an immunotherapeutic target for gastrointestinal malignancy: current experience and future challenges. Br J Cancer 96:1013–1019. doi:10.1038/sj.bjc.6603505
    • (2007) Br J Cancer , vol.96 , pp. 1013-1019
    • Chaudry, M.A.1    Sales, K.2    Ruf, P.3    Lindhofer, H.4    Winslet, M.C.5
  • 4
    • 0032559827 scopus 로고    scopus 로고
    • KSA antigen Ep-CAM mediates cell-cell adhesion of pancreatic epithelial cells: morphoregulatory roles in pancreatic islet development
    • COI: 1:CAS:528:DyaK1cXitFChsLg%3D, PID: 9508783
    • Cirulli V et al (1998) KSA antigen Ep-CAM mediates cell-cell adhesion of pancreatic epithelial cells: morphoregulatory roles in pancreatic islet development. J Cell Biol 140:1519–1534
    • (1998) J Cell Biol , vol.140 , pp. 1519-1534
    • Cirulli, V.1
  • 5
    • 77953663505 scopus 로고    scopus 로고
    • Antibodies targeting cancer stem cells: a new paradigm in immunotherapy?
    • PID: 20046569
    • Deonarain MP, Kousparou CA, Epenetos AA (2009) Antibodies targeting cancer stem cells: a new paradigm in immunotherapy? MAbs 1:12–25
    • (2009) MAbs , vol.1 , pp. 12-25
    • Deonarain, M.P.1    Kousparou, C.A.2    Epenetos, A.A.3
  • 6
    • 38349027623 scopus 로고    scopus 로고
    • Reprogramming the translation initiation for the synthesis of physiologically stable cyclic peptides
    • COI: 1:CAS:528:DC%2BD1cXptl2isA%3D%3D, PID: 18215017
    • Goto Y, Ohta A, Sako Y, Yamagishi Y, Murakami H, Suga H (2008) Reprogramming the translation initiation for the synthesis of physiologically stable cyclic peptides. ACS Chem Biol 3:120–129. doi:10.1021/cb700233t
    • (2008) ACS Chem Biol , vol.3 , pp. 120-129
    • Goto, Y.1    Ohta, A.2    Sako, Y.3    Yamagishi, Y.4    Murakami, H.5    Suga, H.6
  • 7
    • 79958158209 scopus 로고    scopus 로고
    • Flexizymes for genetic code reprogramming
    • COI: 1:CAS:528:DC%2BC3MXmvFyqu78%3D, PID: 21637198
    • Goto Y, Katoh T, Suga H (2011) Flexizymes for genetic code reprogramming. Nat Protoc 6:779–790. doi:10.1038/nprot.2011.331
    • (2011) Nat Protoc , vol.6 , pp. 779-790
    • Goto, Y.1    Katoh, T.2    Suga, H.3
  • 8
    • 0034793787 scopus 로고    scopus 로고
    • Ep-CAM transfection in thymic epithelial cell lines triggers the formation of dynamic actin-rich protrusions involved in the organization of epithelial cell layers
    • COI: 1:CAS:528:DC%2BD3MXnvFOmu74%3D, PID: 11702195
    • Guillemot JC, Naspetti M, Malergue F, Montcourrier P, Galland F, Naquet P (2001) Ep-CAM transfection in thymic epithelial cell lines triggers the formation of dynamic actin-rich protrusions involved in the organization of epithelial cell layers. Histochem Cell Biol 116:371–378. doi:10.1007/s004180100329
    • (2001) Histochem Cell Biol , vol.116 , pp. 371-378
    • Guillemot, J.C.1    Naspetti, M.2    Malergue, F.3    Montcourrier, P.4    Galland, F.5    Naquet, P.6
  • 9
    • 84858657128 scopus 로고    scopus 로고
    • In vitro selection of anti-Akt2 thioether-macrocyclic peptides leading to isoform-selective inhibitors
    • COI: 1:CAS:528:DC%2BC38XhtFemtrs%3D, PID: 22273180
    • Hayashi Y, Morimoto J, Suga H (2012) In vitro selection of anti-Akt2 thioether-macrocyclic peptides leading to isoform-selective inhibitors. ACS Chem Biol 7:607–613. doi:10.1021/cb200388k
    • (2012) ACS Chem Biol , vol.7 , pp. 607-613
    • Hayashi, Y.1    Morimoto, J.2    Suga, H.3
  • 10
    • 84907200767 scopus 로고    scopus 로고
    • EpCAM-selective elimination of carcinoma cells by a novel MAP-based cytolytic fusion protein
    • COI: 1:CAS:528:DC%2BC2cXhsVOitLvJ, PID: 24980949
    • Hristodorov D et al (2014) EpCAM-selective elimination of carcinoma cells by a novel MAP-based cytolytic fusion protein. Mol Cancer Ther 13:2194–2202. doi:10.1158/1535-7163.MCT-13-0781
    • (2014) Mol Cancer Ther , vol.13 , pp. 2194-2202
    • Hristodorov, D.1
  • 11
    • 0033058420 scopus 로고    scopus 로고
    • A recombinant, fully human monoclonal antibody with antitumor activity constructed from phage-displayed antibody fragments
    • COI: 1:CAS:528:DyaK1MXhs1Chtbk%3D, PID: 10096296
    • Huls GA et al (1999) A recombinant, fully human monoclonal antibody with antitumor activity constructed from phage-displayed antibody fragments. Nat Biotechnol 17:276–281. doi:10.1038/7023
    • (1999) Nat Biotechnol , vol.17 , pp. 276-281
    • Huls, G.A.1
  • 12
    • 33846199148 scopus 로고    scopus 로고
    • Chemosensitization of carcinoma cells using epithelial cell adhesion molecule-targeted liposomal antisense against bcl-2/bcl-xL
    • COI: 1:CAS:528:DC%2BD28XhtlagsbvJ, PID: 17172421
    • Hussain S, Pluckthun A, Allen TM, Zangemeister-Wittke U (2006) Chemosensitization of carcinoma cells using epithelial cell adhesion molecule-targeted liposomal antisense against bcl-2/bcl-xL. Mol Cancer Ther 5:3170–3180. doi:10.1158/1535-7163.MCT-06-0412
    • (2006) Mol Cancer Ther , vol.5 , pp. 3170-3180
    • Hussain, S.1    Pluckthun, A.2    Allen, T.M.3    Zangemeister-Wittke, U.4
  • 13
    • 84924674930 scopus 로고    scopus 로고
    • Artificial human Met agonists based on macrocycle scaffolds
    • COI: 1:CAS:528:DC%2BC2MXosFegu74%3D, PID: 25758345
    • Ito K et al (2015) Artificial human Met agonists based on macrocycle scaffolds. Nat Commun 6:6373. doi:10.1038/ncomms7373
    • (2015) Nat Commun , vol.6 , pp. 6373
    • Ito, K.1
  • 14
    • 84863894996 scopus 로고    scopus 로고
    • Selective thioether macrocyclization of peptides having the N-terminal 2-chloroacetyl group and competing two or three cysteine residues in translation
    • COI: 1:CAS:528:DC%2BC38XhtVSmu7fK, PID: 22419118
    • Iwasaki K, Goto Y, Katoh T, Suga H (2012) Selective thioether macrocyclization of peptides having the N-terminal 2-chloroacetyl group and competing two or three cysteine residues in translation. Org Biomol Chem 10:5783–5786. doi:10.1039/c2ob25306b
    • (2012) Org Biomol Chem , vol.10 , pp. 5783-5786
    • Iwasaki, K.1    Goto, Y.2    Katoh, T.3    Suga, H.4
  • 15
    • 84907833554 scopus 로고    scopus 로고
    • Aptamer-based cell imaging reagents capable of fluorescence switching
    • COI: 1:CAS:528:DC%2BC2cXhsVWksrbI
    • Jung YK, Woo MA, Soh HT, Park HG (2014) Aptamer-based cell imaging reagents capable of fluorescence switching. Chem Commun (Camb) 50:12329–12332. doi:10.1039/c4cc03888f
    • (2014) Chem Commun (Camb) , vol.50 , pp. 12329-12332
    • Jung, Y.K.1    Woo, M.A.2    Soh, H.T.3    Park, H.G.4
  • 16
    • 84896512558 scopus 로고    scopus 로고
    • Structural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog
    • COI: 1:CAS:528:DC%2BC2cXjtl2msbs%3D, PID: 24591620
    • Kodan A et al (2014) Structural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog. Proc Natl Acad Sci USA 111:4049–4054. doi:10.1073/pnas.1321562111
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. 4049-4054
    • Kodan, A.1
  • 17
    • 84875912167 scopus 로고    scopus 로고
    • Straightforward thiol-mediated protein labelling with DTPA: Synthesis of a highly active 111In-annexin A5-DTPA tracer
    • PID: 22541756
    • Kratz H, Haeckel A, Michel R, Schonzart L, Hanisch U, Hamm B, Schellenberger E (2012) Straightforward thiol-mediated protein labelling with DTPA: Synthesis of a highly active 111In-annexin A5-DTPA tracer. EJNMMI Res 2:17. doi:10.1186/2191-219X-2-17
    • (2012) EJNMMI Res , vol.2 , pp. 17
    • Kratz, H.1    Haeckel, A.2    Michel, R.3    Schonzart, L.4    Hanisch, U.5    Hamm, B.6    Schellenberger, E.7
  • 19
    • 24944433106 scopus 로고    scopus 로고
    • The cell-cell adhesion molecule EpCAM interacts directly with the tight junction protein claudin-7
    • COI: 1:CAS:528:DC%2BD2MXhtVWnsbbL, PID: 16054130
    • Ladwein M et al (2005) The cell-cell adhesion molecule EpCAM interacts directly with the tight junction protein claudin-7. Exp Cell Res 309:345–357. doi:10.1016/j.yexcr.2005.06.013
    • (2005) Exp Cell Res , vol.309 , pp. 345-357
    • Ladwein, M.1
  • 20
    • 77951596808 scopus 로고    scopus 로고
    • Catumaxomab: clinical development and future directions
    • PID: 20190561
    • Linke R, Klein A, Seimetz D (2010) Catumaxomab: clinical development and future directions. MAbs 2:129–136
    • (2010) MAbs , vol.2 , pp. 129-136
    • Linke, R.1    Klein, A.2    Seimetz, D.3
  • 21
    • 0030731464 scopus 로고    scopus 로고
    • Epithelial cell adhesion molecule (Ep-CAM) modulates cell-cell interactions mediated by classic cadherins
    • COI: 1:CAS:528:DyaK2sXnvFeqsb8%3D, PID: 9382878
    • Litvinov SV et al (1997) Epithelial cell adhesion molecule (Ep-CAM) modulates cell-cell interactions mediated by classic cadherins. J Cell Biol 139:1337–1348
    • (1997) J Cell Biol , vol.139 , pp. 1337-1348
    • Litvinov, S.V.1
  • 22
    • 59749103834 scopus 로고    scopus 로고
    • Nuclear signalling by tumour-associated antigen EpCAM
    • COI: 1:CAS:528:DC%2BD1MXht1Oqt7w%3D, PID: 19136966
    • Maetzel D et al (2009) Nuclear signalling by tumour-associated antigen EpCAM. Nat Cell Biol 11:162–171. doi:10.1038/ncb1824
    • (2009) Nat Cell Biol , vol.11 , pp. 162-171
    • Maetzel, D.1
  • 23
    • 78751503899 scopus 로고    scopus 로고
    • A novel fusion toxin derived from an EpCAM-specific designed ankyrin repeat protein has potent antitumor activity
    • PID: 21075824
    • Martin-Killias P, Stefan N, Rothschild S, Pluckthun A, Zangemeister-Wittke U (2011) A novel fusion toxin derived from an EpCAM-specific designed ankyrin repeat protein has potent antitumor activity. Clin Cancer Res 17:100–110. doi:10.1158/1078-0432.CCR-10-1303
    • (2011) Clin Cancer Res , vol.17 , pp. 100-110
    • Martin-Killias, P.1    Stefan, N.2    Rothschild, S.3    Pluckthun, A.4    Zangemeister-Wittke, U.5
  • 24
    • 84859239807 scopus 로고    scopus 로고
    • Discovery of macrocyclic peptides armed with a mechanism-based warhead: isoform-selective inhibition of human deacetylase SIRT2
    • COI: 1:CAS:528:DC%2BC38XivV2qs7g%3D, PID: 22374802
    • Morimoto J, Hayashi Y, Suga H (2012) Discovery of macrocyclic peptides armed with a mechanism-based warhead: isoform-selective inhibition of human deacetylase SIRT2. Angew Chem Int Ed Engl 51:3423–3427. doi:10.1002/anie.201108118
    • (2012) Angew Chem Int Ed Engl , vol.51 , pp. 3423-3427
    • Morimoto, J.1    Hayashi, Y.2    Suga, H.3
  • 25
    • 84923008655 scopus 로고    scopus 로고
    • Selection-based discovery of macrocyclic peptides for the next generation therapeutics
    • COI: 1:CAS:528:DC%2BC2MXktFyitrg%3D, PID: 25703142
    • Morioka T, Loik ND, Hipolito CJ, Goto Y, Suga H (2015) Selection-based discovery of macrocyclic peptides for the next generation therapeutics. Curr Opin Chem Biol 26:34–41. doi:10.1016/j.cbpa.2015.01.023
    • (2015) Curr Opin Chem Biol , vol.26 , pp. 34-41
    • Morioka, T.1    Loik, N.D.2    Hipolito, C.J.3    Goto, Y.4    Suga, H.5
  • 26
    • 4143065769 scopus 로고    scopus 로고
    • The carcinoma-associated antigen EpCAM upregulates c-myc and induces cell proliferation
    • PID: 15195135
    • Munz M, Kieu C, Mack B, Schmitt B, Zeidler R, Gires O (2004) The carcinoma-associated antigen EpCAM upregulates c-myc and induces cell proliferation. Oncogene 23:5748–5758. doi:10.1038/sj.onc.1207610
    • (2004) Oncogene , vol.23 , pp. 5748-5758
    • Munz, M.1    Kieu, C.2    Mack, B.3    Schmitt, B.4    Zeidler, R.5    Gires, O.6
  • 27
    • 0031559943 scopus 로고    scopus 로고
    • In vitro virus: bonding of mRNA bearing puromycin at the 3′-terminal end to the C-terminal end of its encoded protein on the ribosome in vitro
    • COI: 1:CAS:528:DyaK2sXlslChtbg%3D, PID: 9315729
    • Nemoto N, Miyamoto-Sato E, Husimi Y, Yanagawa H (1997) In vitro virus: bonding of mRNA bearing puromycin at the 3′-terminal end to the C-terminal end of its encoded protein on the ribosome in vitro. FEBS Lett 414:405–408
    • (1997) FEBS Lett , vol.414 , pp. 405-408
    • Nemoto, N.1    Miyamoto-Sato, E.2    Husimi, Y.3    Yanagawa, H.4
  • 28
    • 7044231033 scopus 로고    scopus 로고
    • Biological role of Ep-CAM in the physical interaction between epithelial cells and lymphocytes in intestinal epithelium
    • COI: 1:CAS:528:DC%2BD2cXovVKltL8%3D, PID: 15507398
    • Nochi T et al (2004) Biological role of Ep-CAM in the physical interaction between epithelial cells and lymphocytes in intestinal epithelium. Clin Immunol 113:326–339. doi:10.1016/j.clim.2004.08.013
    • (2004) Clin Immunol , vol.113 , pp. 326-339
    • Nochi, T.1
  • 29
    • 4143074922 scopus 로고    scopus 로고
    • EpCAM is overexpressed in breast cancer and is a potential target for breast cancer gene therapy
    • COI: 1:CAS:528:DC%2BD2cXmslaks74%3D, PID: 15313925
    • Osta WA et al (2004) EpCAM is overexpressed in breast cancer and is a potential target for breast cancer gene therapy. Cancer Res 64:5818–5824. doi:10.1158/0008-5472.CAN-04-0754
    • (2004) Cancer Res , vol.64 , pp. 5818-5824
    • Osta, W.A.1
  • 30
    • 84902176344 scopus 로고    scopus 로고
    • Selection-based discovery of druglike macrocyclic peptides
    • COI: 1:CAS:528:DC%2BC2cXhtFOhtrnE, PID: 24580641
    • Passioura T, Katoh T, Goto Y, Suga H (2014) Selection-based discovery of druglike macrocyclic peptides. Annu Rev Biochem 83:727–752. doi:10.1146/annurev-biochem-060713-035456
    • (2014) Annu Rev Biochem , vol.83 , pp. 727-752
    • Passioura, T.1    Katoh, T.2    Goto, Y.3    Suga, H.4
  • 31
    • 84855952224 scopus 로고    scopus 로고
    • Epithelial cell adhesion molecule expression (CD326) in cancer: a short review
    • COI: 1:CAS:528:DC%2BC3MXhsFCqs73M, PID: 21576002
    • Patriarca C, Macchi RM, Marschner AK, Mellstedt H (2012) Epithelial cell adhesion molecule expression (CD326) in cancer: a short review. Cancer Treat Rev 38:68–75. doi:10.1016/j.ctrv.2011.04.002
    • (2012) Cancer Treat Rev , vol.38 , pp. 68-75
    • Patriarca, C.1    Macchi, R.M.2    Marschner, A.K.3    Mellstedt, H.4
  • 32
    • 0030817279 scopus 로고    scopus 로고
    • RNA-peptide fusions for the in vitro selection of peptides and proteins
    • COI: 1:CAS:528:DyaK2sXns1ylsrc%3D, PID: 9356443
    • Roberts RW, Szostak JW (1997) RNA-peptide fusions for the in vitro selection of peptides and proteins. Proc Natl Acad Sci USA 94:12297–12302
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 12297-12302
    • Roberts, R.W.1    Szostak, J.W.2
  • 33
    • 33646863688 scopus 로고    scopus 로고
    • Site-specific PEGylation of native disulfide bonds in therapeutic proteins
    • COI: 1:CAS:528:DC%2BD28Xkslemuro%3D, PID: 16633351
    • Shaunak S et al (2006) Site-specific PEGylation of native disulfide bonds in therapeutic proteins. Nat Chem Biol 2:312–313. doi:10.1038/nchembio786
    • (2006) Nat Chem Biol , vol.2 , pp. 312-313
    • Shaunak, S.1
  • 34
    • 84876264381 scopus 로고    scopus 로고
    • Selection of DNA aptamers against epithelial cell adhesion molecule for cancer cell imaging and circulating tumor cell capture
    • COI: 1:CAS:528:DC%2BC3sXjslGgt78%3D, PID: 23480100
    • Song Y et al (2013) Selection of DNA aptamers against epithelial cell adhesion molecule for cancer cell imaging and circulating tumor cell capture. Anal Chem 85:4141–4149. doi:10.1021/ac400366b
    • (2013) Anal Chem , vol.85 , pp. 4141-4149
    • Song, Y.1
  • 35
    • 4043147142 scopus 로고    scopus 로고
    • High Ep-CAM expression is associated with poor prognosis in node-positive breast cancer
    • COI: 1:CAS:528:DC%2BD2cXmt1Kqt74%3D, PID: 15567937
    • Spizzo G et al (2004) High Ep-CAM expression is associated with poor prognosis in node-positive breast cancer. Breast Cancer Res Treat 86:207–213. doi:10.1023/B:BREA.0000036787.59816.01
    • (2004) Breast Cancer Res Treat , vol.86 , pp. 207-213
    • Spizzo, G.1
  • 36
    • 33750165279 scopus 로고    scopus 로고
    • Overexpression of epithelial cell adhesion molecule (Ep-CAM) is an independent prognostic marker for reduced survival of patients with epithelial ovarian cancer
    • COI: 1:CAS:528:DC%2BD28XhtFegtbfK, PID: 16678891
    • Spizzo G et al (2006) Overexpression of epithelial cell adhesion molecule (Ep-CAM) is an independent prognostic marker for reduced survival of patients with epithelial ovarian cancer. Gynecol Oncol 103:483–488. doi:10.1016/j.ygyno.2006.03.035
    • (2006) Gynecol Oncol , vol.103 , pp. 483-488
    • Spizzo, G.1
  • 37
    • 80054870896 scopus 로고    scopus 로고
    • DARPins recognizing the tumor-associated antigen EpCAM selected by phage and ribosome display and engineered for multivalency
    • COI: 1:CAS:528:DC%2BC3MXhtlKisbvK, PID: 21963989
    • Stefan N, Martin-Killias P, Wyss-Stoeckle S, Honegger A, Zangemeister-Wittke U, Pluckthun A (2011) DARPins recognizing the tumor-associated antigen EpCAM selected by phage and ribosome display and engineered for multivalency. J Mol Biol 413:826–843. doi:10.1016/j.jmb.2011.09.016
    • (2011) J Mol Biol , vol.413 , pp. 826-843
    • Stefan, N.1    Martin-Killias, P.2    Wyss-Stoeckle, S.3    Honegger, A.4    Zangemeister-Wittke, U.5    Pluckthun, A.6
  • 38
    • 84907153988 scopus 로고    scopus 로고
    • A strain-promoted alkyne-azide cycloaddition (SPAAC) reaction of a novel EpCAM aptamer-fluorescent conjugate for imaging of cancer cells
    • COI: 1:CAS:528:DC%2BC2cXhtFaktL%2FE
    • Subramanian N, Sreemanthula JB, Balaji B, Kanwar JR, Biswas J, Krishnakumar S (2014) A strain-promoted alkyne-azide cycloaddition (SPAAC) reaction of a novel EpCAM aptamer-fluorescent conjugate for imaging of cancer cells. Chem Commun (Camb) 50:11810–11813. doi:10.1039/c4cc02996h
    • (2014) Chem Commun (Camb) , vol.50 , pp. 11810-11813
    • Subramanian, N.1    Sreemanthula, J.B.2    Balaji, B.3    Kanwar, J.R.4    Biswas, J.5    Krishnakumar, S.6
  • 39
    • 84876297961 scopus 로고    scopus 로고
    • Structural basis for the drug extrusion mechanism by a MATE multidrug transporter
    • COI: 1:CAS:528:DC%2BC3sXkvFOrtrk%3D, PID: 23535598
    • Tanaka Y et al (2013) Structural basis for the drug extrusion mechanism by a MATE multidrug transporter. Nature 496:247–251. doi:10.1038/nature12014
    • (2013) Nature , vol.496 , pp. 247-251
    • Tanaka, Y.1
  • 40
    • 34548324283 scopus 로고    scopus 로고
    • Epithelial cell adhesion molecule: more than a carcinoma marker and adhesion molecule
    • COI: 1:CAS:528:DC%2BD2sXpsFaitLg%3D, PID: 17600130
    • Trzpis M, McLaughlin PM, de Leij LM, Harmsen MC (2007) Epithelial cell adhesion molecule: more than a carcinoma marker and adhesion molecule. Am J Pathol 171:386–395. doi:10.2353/ajpath.2007.070152
    • (2007) Am J Pathol , vol.171 , pp. 386-395
    • Trzpis, M.1    McLaughlin, P.M.2    de Leij, L.M.3    Harmsen, M.C.4
  • 42
    • 30644472381 scopus 로고    scopus 로고
    • Frequent high-level expression of the immunotherapeutic target Ep-CAM in colon, stomach, prostate and lung cancers
    • COI: 1:CAS:528:DC%2BD28XisVGgug%3D%3D, PID: 16404366
    • Went P et al (2006) Frequent high-level expression of the immunotherapeutic target Ep-CAM in colon, stomach, prostate and lung cancers. Br J Cancer 94:128–135. doi:10.1038/sj.bjc.6602924
    • (2006) Br J Cancer , vol.94 , pp. 128-135
    • Went, P.1
  • 43
    • 84555190565 scopus 로고    scopus 로고
    • Natural product-like macrocyclic N-methyl-peptide inhibitors against a ubiquitin ligase uncovered from a ribosome-expressed de novo library
    • COI: 1:CAS:528:DC%2BC3MXhs12htrnI, PID: 22195558
    • Yamagishi Y, Shoji I, Miyagawa S, Kawakami T, Katoh T, Goto Y, Suga H (2011) Natural product-like macrocyclic N-methyl-peptide inhibitors against a ubiquitin ligase uncovered from a ribosome-expressed de novo library. Chem Biol 18:1562–1570. doi:10.1016/j.chembiol.2011.09.013
    • (2011) Chem Biol , vol.18 , pp. 1562-1570
    • Yamagishi, Y.1    Shoji, I.2    Miyagawa, S.3    Kawakami, T.4    Katoh, T.5    Goto, Y.6    Suga, H.7
  • 44
    • 84911899117 scopus 로고    scopus 로고
    • Shark Attack: high affinity binding proteins derived from shark vNAR domains by stepwise in vitro affinity maturation
    • COI: 1:CAS:528:DC%2BC2cXpslKmu70%3D, PID: 24862193
    • Zielonka S et al (2014) Shark Attack: high affinity binding proteins derived from shark vNAR domains by stepwise in vitro affinity maturation. J Biotechnol 191:236–245. doi:10.1016/j.jbiotec.2014.04.023
    • (2014) J Biotechnol , vol.191 , pp. 236-245
    • Zielonka, S.1


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