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Volumn 56, Issue 2, 2017, Pages 591-601

Ellagic acid in Emblica officinalis exerts anti-diabetic activity through the action on β-cells of pancreas

Author keywords

Antioxidant; Ellagic acid; Emblica officinalis; Insulin secretion; Non obese type 2 diabetes; Cell function

Indexed keywords

ELLAGIC ACID; EMBLICA OFFICINALIS EXTRACT; GLIBENCLAMIDE; GLUCAGON; GLUCOSE; GLUTATHIONE; INSULIN; METHANOL; THIOBARBITURIC ACID REACTIVE SUBSTANCE; ANTIDIABETIC AGENT; ANTIOXIDANT; GLUCOSE BLOOD LEVEL; PLANT EXTRACT;

EID: 84948145183     PISSN: 14366207     EISSN: 14366215     Source Type: Journal    
DOI: 10.1007/s00394-015-1103-y     Document Type: Article
Times cited : (125)

References (38)
  • 1
    • 80051986265 scopus 로고    scopus 로고
    • Globalization of diabetes: the role of diet, lifestyle, and genes
    • Hu FB (2011) Globalization of diabetes: the role of diet, lifestyle, and genes. Diabetes Care 34(6):1249–1257. doi:10.2337/dc11-0442
    • (2011) Diabetes Care , vol.34 , Issue.6 , pp. 1249-1257
    • Hu, F.B.1
  • 2
    • 33646028804 scopus 로고    scopus 로고
    • Molecular targets of dietary agents for prevention and therapy of cancer
    • COI: 1:CAS:528:DC%2BD28Xjs1Gls74%3D
    • Aggarwal BB, Shishodia S (2006) Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol 71:1397–1421. doi:10.1016/j.bcp.2006.02.009
    • (2006) Biochem Pharmacol , vol.71 , pp. 1397-1421
    • Aggarwal, B.B.1    Shishodia, S.2
  • 3
    • 77951226118 scopus 로고    scopus 로고
    • Traditional herbal medicines used for the treatment of diabetes among two major tribal groups in south Tamil Nadu, India
    • Ayyanar M, Sankarasivaraman K, Ignacimuthu S (2008) Traditional herbal medicines used for the treatment of diabetes among two major tribal groups in south Tamil Nadu, India. Ethnobot Leafl 12:276–280. doi:10.1016/j.fitote.2008.06.003
    • (2008) Ethnobot Leafl , vol.12 , pp. 276-280
    • Ayyanar, M.1    Sankarasivaraman, K.2    Ignacimuthu, S.3
  • 4
    • 77955146207 scopus 로고    scopus 로고
    • Roles of Emblica officinalis in medicine—a review
    • COI: 1:CAS:528:DC%2BD1MXhsVSlsb7N
    • Khan KH (2009) Roles of Emblica officinalis in medicine—a review. Bot Res Int 2(4):218–228
    • (2009) Bot Res Int , vol.2 , Issue.4 , pp. 218-228
    • Khan, K.H.1
  • 5
    • 77953153977 scopus 로고    scopus 로고
    • Therapeutic potential of Phyllanthus emblica (amla): the ayurvedic wonder
    • Mirunalini S, Krishnaveni M (2010) Therapeutic potential of Phyllanthus emblica (amla): the ayurvedic wonder. J Basic Clin Physiol Pharmacol 21(1):93–105. doi:10.1515/JBCPP.2010.21.1.93
    • (2010) J Basic Clin Physiol Pharmacol , vol.21 , Issue.1 , pp. 93-105
    • Mirunalini, S.1    Krishnaveni, M.2
  • 6
    • 84896995106 scopus 로고    scopus 로고
    • Anti-diabetic effects of the Indian indigenous fruit Emblica officinalis Gaertn: active constituents and modes of action
    • D’souza JJ, D’souza PP, Fazal F, Kumar A, Bhat HP, Baliga MS (2014) Anti-diabetic effects of the Indian indigenous fruit Emblica officinalis Gaertn: active constituents and modes of action. Food Funct 5:635–644. doi:10.1039/C3FO60366K
    • (2014) Food Funct , vol.5 , pp. 635-644
    • D’souza, J.J.1    D’souza, P.P.2    Fazal, F.3    Kumar, A.4    Bhat, H.P.5    Baliga, M.S.6
  • 7
    • 79961201714 scopus 로고    scopus 로고
    • Effect of Amla fruit (Emblica officinalis Gaertn.) on blood glucose and lipid profile of normal subjects and type 2 diabetic patients
    • COI: 1:CAS:528:DC%2BC3MXps1Oht7s%3D
    • Akhtar MS, Ramzan A, Ali A, Ahmad M (2011) Effect of Amla fruit (Emblica officinalis Gaertn.) on blood glucose and lipid profile of normal subjects and type 2 diabetic patients. Int J Food Sci Nutr 62:609–616. doi:10.3109/09637486.2011.560565
    • (2011) Int J Food Sci Nutr , vol.62 , pp. 609-616
    • Akhtar, M.S.1    Ramzan, A.2    Ali, A.3    Ahmad, M.4
  • 8
    • 80053345565 scopus 로고    scopus 로고
    • Emblica officinalis corrects functional, biochemical and molecular deficits in experimental diabetic neuropathy by targeting the oxido-nitrosative stress mediated inflammatory cascade
    • Tiwari V, Kuhad A, Chopra K (2011) Emblica officinalis corrects functional, biochemical and molecular deficits in experimental diabetic neuropathy by targeting the oxido-nitrosative stress mediated inflammatory cascade. Phytother Res 25:1527–1536. doi:10.1002/ptr.3440
    • (2011) Phytother Res , vol.25 , pp. 1527-1536
    • Tiwari, V.1    Kuhad, A.2    Chopra, K.3
  • 9
    • 84936944755 scopus 로고    scopus 로고
    • Experimental study on effect of hydroalcoholic extract of Emblica officinalis fruits on glucose homeostasis and metabolic parameters
    • Patel SS, Goyal RK, Shah RS, Tirgar PR, Jadav PD (2013) Experimental study on effect of hydroalcoholic extract of Emblica officinalis fruits on glucose homeostasis and metabolic parameters. AYU 34:440. doi:10.4103/0974-8520.127731
    • (2013) AYU , vol.34 , pp. 440
    • Patel, S.S.1    Goyal, R.K.2    Shah, R.S.3    Tirgar, P.R.4    Jadav, P.D.5
  • 10
    • 84892144492 scopus 로고    scopus 로고
    • Emblica officinalis improves glycemic status and oxidative stress in STZ induced type 2 diabetic model rats
    • COI: 1:CAS:528:DC%2BC2cXhsVynsb0%3D
    • Ansari A, Shahriar MSZ, Hassan MM, Das SR, Rokeya B, Haque MA, Sarkar T (2014) Emblica officinalis improves glycemic status and oxidative stress in STZ induced type 2 diabetic model rats. Asian Pac J Trop Med 7:21–25. doi:10.1016/S1995-7645(13)60185-6
    • (2014) Asian Pac J Trop Med , vol.7 , pp. 21-25
    • Ansari, A.1    Shahriar, M.S.Z.2    Hassan, M.M.3    Das, S.R.4    Rokeya, B.5    Haque, M.A.6    Sarkar, T.7
  • 11
    • 34250845834 scopus 로고    scopus 로고
    • Separation and evaluation of free radical-scavenging activity of phenol components of Emblica officinalis extract by using an HPTLC–DPPH method
    • COI: 1:CAS:528:DC%2BD2sXnt1Ghsrc%3D
    • Pozharitskaya ON, Ivanova SA, Shikov AN, Makarov VG (2007) Separation and evaluation of free radical-scavenging activity of phenol components of Emblica officinalis extract by using an HPTLC–DPPH method. J Sep Sci 30:1250–1254. doi:10.1002/jssc.200600532
    • (2007) J Sep Sci , vol.30 , pp. 1250-1254
    • Pozharitskaya, O.N.1    Ivanova, S.A.2    Shikov, A.N.3    Makarov, V.G.4
  • 12
    • 0034722012 scopus 로고    scopus 로고
    • High-performance liquid chromatographic determination with photodiode array detection of ellagic acid in fresh and processed fruits
    • COI: 1:CAS:528:DC%2BD3cXntlGqt7k%3D
    • Amakura Y, Okada M, Tsuji S, Tonogai Y (2000) High-performance liquid chromatographic determination with photodiode array detection of ellagic acid in fresh and processed fruits. J Chromatogr A 896(1):87–93. doi:10.1016/S0021-9673(00)00414-3
    • (2000) J Chromatogr A , vol.896 , Issue.1 , pp. 87-93
    • Amakura, Y.1    Okada, M.2    Tsuji, S.3    Tonogai, Y.4
  • 13
    • 79960100531 scopus 로고    scopus 로고
    • Antidiabetic efficacy of ellagic acid in streptozotocin induced diabetes mellitus in albino Wistar rats
    • Malini P, Kanchana G, Rajadurai M (2011) Antidiabetic efficacy of ellagic acid in streptozotocin induced diabetes mellitus in albino Wistar rats. Asian J Pharm Clin Res 4:124–128
    • (2011) Asian J Pharm Clin Res , vol.4 , pp. 124-128
    • Malini, P.1    Kanchana, G.2    Rajadurai, M.3
  • 14
    • 23744450065 scopus 로고    scopus 로고
    • Biological functionality of ellagic acid: a review
    • COI: 1:CAS:528:DC%2BD2MXnslynsLw%3D
    • Vattem DA, Shetty K (2005) Biological functionality of ellagic acid: a review. J Food Biochem 29(3):234–266. doi:10.1111/j.1745-4514.2005.00031.x
    • (2005) J Food Biochem , vol.29 , Issue.3 , pp. 234-266
    • Vattem, D.A.1    Shetty, K.2
  • 15
    • 84919346547 scopus 로고    scopus 로고
    • A review of the health benefit potentials of herbal plant infusions and their mechanism of actions
    • Farzaneh V, Carvalho IS (2015) A review of the health benefit potentials of herbal plant infusions and their mechanism of actions. Ind Crop Prod 65:247–258. doi:10.1016/j.indcrop.2014.10.057
    • (2015) Ind Crop Prod , vol.65 , pp. 247-258
    • Farzaneh, V.1    Carvalho, I.S.2
  • 16
    • 0037283601 scopus 로고    scopus 로고
    • The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes
    • COI: 1:CAS:528:DC%2BD3sXhtVKkt74%3D
    • Kahn SE (2003) The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes. Diabetologia 46:3–19
    • (2003) Diabetologia , vol.46 , pp. 3-19
    • Kahn, S.E.1
  • 17
    • 84875685376 scopus 로고    scopus 로고
    • Type 2 diabetes in South Asians: similarities and differences with white Caucasian and other populations
    • Gujral UP, Pradeepa R, Weber MB, Narayan KM, Mohan V (2013) Type 2 diabetes in South Asians: similarities and differences with white Caucasian and other populations. Ann N Y Acad Sci 1281(1):51–63. doi:10.1111/j.1749-6632.2012.06838.x
    • (2013) Ann N Y Acad Sci , vol.1281 , Issue.1 , pp. 51-63
    • Gujral, U.P.1    Pradeepa, R.2    Weber, M.B.3    Narayan, K.M.4    Mohan, V.5
  • 18
    • 84875641584 scopus 로고    scopus 로고
    • Type 2 diabetes in East Asians: similarities and differences with populations in Europe and the United States
    • Ma RC, Chan JC (2013) Type 2 diabetes in East Asians: similarities and differences with populations in Europe and the United States. Ann N Y Acad Sci 1281(1):64–91. doi:10.1111/nyas.12098
    • (2013) Ann N Y Acad Sci , vol.1281 , Issue.1 , pp. 64-91
    • Ma, R.C.1    Chan, J.C.2
  • 19
    • 84878362355 scopus 로고    scopus 로고
    • Promoting research for better diabetes care in Asia: Kyoto declaration on diabetes
    • Asian Association for the Study of Diabetes (2013) Promoting research for better diabetes care in Asia: Kyoto declaration on diabetes. J Diabetes Investig 4:222–224. doi:10.1111/jdi.12073
    • (2013) J Diabetes Investig , vol.4 , pp. 222-224
  • 20
    • 84896491806 scopus 로고    scopus 로고
    • The many faces of diabetes: a disease with increasing heterogeneity
    • Tuomi T, Santoro N, Caprio S, Cai M, Weng J, Groop L (2014) The many faces of diabetes: a disease with increasing heterogeneity. Lancet 383:1084–1094
    • (2014) Lancet , vol.383 , pp. 1084-1094
    • Tuomi, T.1    Santoro, N.2    Caprio, S.3    Cai, M.4    Weng, J.5    Groop, L.6
  • 21
    • 0024348805 scopus 로고
    • The rat models of non-insulin dependent diabetes induced by neonatal streptozotocin
    • COI: 1:CAS:528:DyaL1MXmtFalsrY%3D
    • Portha B, Blondel O, Serradas P et al (1989) The rat models of non-insulin dependent diabetes induced by neonatal streptozotocin. Diabete Metab 15:61–75
    • (1989) Diabete Metab , vol.15 , pp. 61-75
    • Portha, B.1    Blondel, O.2    Serradas, P.3
  • 22
    • 4444319488 scopus 로고    scopus 로고
    • Neonatal streptozotocin-induced rat model of type 2 diabetes mellitus: A glance
    • Arulmozhi DK, Veeranjaneyulu A, Bodhankar SL (2004) Neonatal streptozotocin-induced rat model of type 2 diabetes mellitus: A glance. Indian J Pharmacol 36:217–221
    • (2004) Indian J Pharmacol , vol.36 , pp. 217-221
    • Arulmozhi, D.K.1    Veeranjaneyulu, A.2    Bodhankar, S.L.3
  • 23
    • 85014464007 scopus 로고    scopus 로고
    • Neonatally streptozotocin-induced (n-STZ) diabetic rats: a family of type 2 diabetes models
    • Shafrir E, (ed), CRC Press, Boca Raton
    • Portha B, Movassat J, Cuzin-Tourrel C et al (2007) Neonatally streptozotocin-induced (n-STZ) diabetic rats: a family of type 2 diabetes models. In: Shafrir E (ed) Animal models of diabetes, 2nd edn. CRC Press, Boca Raton, pp 223–250
    • (2007) Animal models of diabetes , pp. 223-250
    • Portha, B.1    Movassat, J.2    Cuzin-Tourrel, C.3
  • 24
    • 79951740993 scopus 로고    scopus 로고
    • Modulation of pancreatic β-cells in neonatally streptozotocin-induced type 2 diabetic rats by the ethanolic extract of Momordica charantia fruit pulp
    • COI: 1:CAS:528:DC%2BC3MXhvFCgt7s%3D
    • Hafizur RM, Kabir N, Chishti S (2011) Modulation of pancreatic β-cells in neonatally streptozotocin-induced type 2 diabetic rats by the ethanolic extract of Momordica charantia fruit pulp. Nat Prod Res 25:353–367. doi:10.1080/14786411003766904
    • (2011) Nat Prod Res , vol.25 , pp. 353-367
    • Hafizur, R.M.1    Kabir, N.2    Chishti, S.3
  • 25
    • 84869994075 scopus 로고    scopus 로고
    • Asparagus officinalis extract controls blood glucose by improving insulin secretion and β-cell function in streptozotocin-induced type 2 diabetic rats
    • COI: 1:CAS:528:DC%2BC38Xhs12lsrbN
    • Hafizur RM, Kabir N, Chishti S (2012) Asparagus officinalis extract controls blood glucose by improving insulin secretion and β-cell function in streptozotocin-induced type 2 diabetic rats. Br J Nutr 108:1586–1595. doi:10.1017/S0007114511007148
    • (2012) Br J Nutr , vol.108 , pp. 1586-1595
    • Hafizur, R.M.1    Kabir, N.2    Chishti, S.3
  • 26
    • 20944440765 scopus 로고    scopus 로고
    • The oxidant and antioxidant effects of 25-hydroxyvitamin D3 in liver, kidney and heart tissues of diabetic rats
    • COI: 1:CAS:528:DC%2BD2MXks1Oit7Y%3D
    • Noyan T, Balaharoğlu R, Kömüroğlu U (2005) The oxidant and antioxidant effects of 25-hydroxyvitamin D3 in liver, kidney and heart tissues of diabetic rats. Clin Exp Med 5:31–36
    • (2005) Clin Exp Med , vol.5 , pp. 31-36
    • Noyan, T.1    Balaharoğlu, R.2    Kömüroğlu, U.3
  • 27
    • 0018384650 scopus 로고
    • Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
    • COI: 1:CAS:528:DyaE1MXksFaisbk%3D
    • Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351–358
    • (1979) Anal Biochem , vol.95 , pp. 351-358
    • Ohkawa, H.1    Ohishi, N.2    Yagi, K.3
  • 28
    • 0036288220 scopus 로고    scopus 로고
    • Inhibition of fiber cell globulization and hyperglycemia-induced lens opacification by aminopeptidase inhibitor bestatin
    • Chandra D, Ramana KV, Wang L, Christensen BN, Bhatnagar A, Srivastava SK (2002) Inhibition of fiber cell globulization and hyperglycemia-induced lens opacification by aminopeptidase inhibitor bestatin. Invest Ophthalmol Vis Sci 43:2285–2292
    • (2002) Invest Ophthalmol Vis Sci , vol.43 , pp. 2285-2292
    • Chandra, D.1    Ramana, K.V.2    Wang, L.3    Christensen, B.N.4    Bhatnagar, A.5    Srivastava, S.K.6
  • 29
    • 84900357351 scopus 로고    scopus 로고
    • Two new compounds from the aerial parts of Bergenia himalaica Boriss and their anti-hyperglycemic effect in streptozotocin-nicotinamide induced diabetic rats
    • COI: 1:CAS:528:DC%2BC2cXjsFyrur4%3D
    • Siddiqui BS, Hasan M, Mairaj F, Mehmood I, Hafizur RM, Hameed A, Khan Shinwari Z (2014) Two new compounds from the aerial parts of Bergenia himalaica Boriss and their anti-hyperglycemic effect in streptozotocin-nicotinamide induced diabetic rats. J Ethnopharmacol 152(3):561–567. doi:10.1016/j.jep.2014.02.002
    • (2014) J Ethnopharmacol , vol.152 , Issue.3 , pp. 561-567
    • Siddiqui, B.S.1    Hasan, M.2    Mairaj, F.3    Mehmood, I.4    Hafizur, R.M.5    Hameed, A.6    Khan Shinwari, Z.7
  • 30
    • 84964258887 scopus 로고    scopus 로고
    • Cinnamic acid exerts anti-diabetic activity by improving glucose tolerance in vivo and by stimulating insulin secretion in vitro
    • COI: 1:CAS:528:DC%2BC2MXhtlWhsbs%3D
    • Hafizur RM, Hameed A, Shukrana M, Raza SA, Chishti S, Kabir N, Siddiqui RA (2015) Cinnamic acid exerts anti-diabetic activity by improving glucose tolerance in vivo and by stimulating insulin secretion in vitro. Phytomedicine 22(2):297–300. doi:10.1016/j.phymed.2015.01.003
    • (2015) Phytomedicine , vol.22 , Issue.2 , pp. 297-300
    • Hafizur, R.M.1    Hameed, A.2    Shukrana, M.3    Raza, S.A.4    Chishti, S.5    Kabir, N.6    Siddiqui, R.A.7
  • 31
    • 0034650163 scopus 로고    scopus 로고
    • Evaluation of simple indices of insulin sensitivity and insulin secretion for use in epidemioiogic studies
    • COI: 1:STN:280:DC%2BD3c7gvVChsg%3D%3D
    • Hanson RL, Pratley RE, Bogardus C, Narayan KV, Roumain JM, Imperatore G, Knowler WC (2000) Evaluation of simple indices of insulin sensitivity and insulin secretion for use in epidemioiogic studies. Am J Epidemiol 151:190–198
    • (2000) Am J Epidemiol , vol.151 , pp. 190-198
    • Hanson, R.L.1    Pratley, R.E.2    Bogardus, C.3    Narayan, K.V.4    Roumain, J.M.5    Imperatore, G.6    Knowler, W.C.7
  • 32
    • 33750562169 scopus 로고    scopus 로고
    • Systemic oxidative stress is associated with visceral fat accumulation and the metabolic syndrome
    • COI: 1:CAS:528:DC%2BD28Xht1GktbzJ
    • Fujita K, Nishizawa H, Funahashi T, Shimomura I, Shimabukuro M (2006) Systemic oxidative stress is associated with visceral fat accumulation and the metabolic syndrome. Circ J 70:1437–1442. doi:10.1253/circj.70.1437
    • (2006) Circ J , vol.70 , pp. 1437-1442
    • Fujita, K.1    Nishizawa, H.2    Funahashi, T.3    Shimomura, I.4    Shimabukuro, M.5
  • 33
    • 33644633736 scopus 로고    scopus 로고
    • Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans
    • Vincent HK, Taylor AG (2005) Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans. Int J Obes (Lond) 30:400–418. doi:10.1038/sj.ijo.0803177
    • (2005) Int J Obes (Lond) , vol.30 , pp. 400-418
    • Vincent, H.K.1    Taylor, A.G.2
  • 34
    • 58749111275 scopus 로고    scopus 로고
    • Identification of bioactive compounds in Phyllanthus emblica L. fruit and their free radical scavenging activities
    • COI: 1:CAS:528:DC%2BD1MXht1alur8%3D
    • Luo W, Zhao M, Yang B, Shen G, Rao G (2009) Identification of bioactive compounds in Phyllanthus emblica L. fruit and their free radical scavenging activities. Food Chem 114(2):499–504. doi:10.1016/j.foodchem.2008.09.077
    • (2009) Food Chem , vol.114 , Issue.2 , pp. 499-504
    • Luo, W.1    Zhao, M.2    Yang, B.3    Shen, G.4    Rao, G.5
  • 36
    • 73749085671 scopus 로고    scopus 로고
    • Appraisal of antinociceptive and anti-inflammatory potential of extract and fractions from the leaves of Torreya grandis Fort Ex. Lindl
    • Saeed MK, Deng Y, Dai R, Li W, Yu Y, Iqbal Z (2010) Appraisal of antinociceptive and anti-inflammatory potential of extract and fractions from the leaves of Torreya grandis Fort Ex. Lindl. J Ethnopharmacol 127:414–418
    • (2010) J Ethnopharmacol , vol.127 , pp. 414-418
    • Saeed, M.K.1    Deng, Y.2    Dai, R.3    Li, W.4    Yu, Y.5    Iqbal, Z.6
  • 37
    • 68949132695 scopus 로고    scopus 로고
    • Antioxidant and anticancer activities of wampee [Clausena lansium (Lour.) Skeels] peel
    • Prasad KN, Hao J, Yi C, Zhang D, Qiu S, Jiang Y et al (2009) Antioxidant and anticancer activities of wampee [Clausena lansium (Lour.) Skeels] peel. BioMed Res Int 2009. doi:10.1155/2009/612805
    • (2009) BioMed Res Int , pp. 2009
    • Prasad, K.N.1    Hao, J.2    Yi, C.3    Zhang, D.4    Qiu, S.5    Jiang, Y.6
  • 38
    • 47749138130 scopus 로고    scopus 로고
    • A study on antioxidant, free radical scavenging, anti-inflammatory and hepatoprotective actions of Aegiceras corniculatum (stem) extracts
    • COI: 1:CAS:528:DC%2BD1cXptVKgsLg%3D
    • Roome T, Dar A, Ali S, Naqvi S, Choudhary MI (2008) A study on antioxidant, free radical scavenging, anti-inflammatory and hepatoprotective actions of Aegiceras corniculatum (stem) extracts. J Ethnopharmacol 118:514–521
    • (2008) J Ethnopharmacol , vol.118 , pp. 514-521
    • Roome, T.1    Dar, A.2    Ali, S.3    Naqvi, S.4    Choudhary, M.I.5


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